Aliases for SIX6 Gene
External Ids for SIX6 Gene
Previous HGNC Symbols for SIX6 Gene
Previous GeneCards Identifiers for SIX6 Gene
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008]
GeneCards Summary for SIX6 Gene
SIX6 (SIX Homeobox 6) is a Protein Coding gene. Diseases associated with SIX6 include Optic Disc Anomalies With Retinal And/Or Macular Dystrophy and Colobomatous Optic Disc-Macular Atrophy-Chorioretinopathy Syndrome. GO annotations related to this gene include transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding. An important paralog of this gene is SIX2.
UniProtKB/Swiss-Prot for SIX6 Gene
May be involved in eye development.