Aliases for OPRK1 Gene
External Ids for OPRK1 Gene
Previous GeneCards Identifiers for OPRK1 Gene
GeneCards Summary for OPRK1 Gene
OPRK1 (Opioid Receptor, Kappa 1) is a Protein Coding gene. Diseases associated with OPRK1 include morphine dependence and phobic disorder. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and opioid receptor activity. An important paralog of this gene is GALR2.
UniProtKB/Swiss-Prot for OPRK1 Gene
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
The kappa opioid receptor, (also known as OP2, KOP, KOR), is a member of the opioid family of G-protein-coupled receptors that also includes mu, delta and NOP receptors. Three variants of the receptor (designated kappa1, kappa2, and kappa3) have been characterized.