Aliases for OPRK1 Gene
External Ids for OPRK1 Gene
Previous GeneCards Identifiers for OPRK1 Gene
GeneCards Summary for OPRK1 Gene
OPRK1 (Opioid Receptor, Kappa 1) is a Protein Coding gene. Diseases associated with OPRK1 include morphine dependence and uremic pruritus. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include opioid receptor activity and dynorphin receptor activity. An important paralog of this gene is GALR2.
UniProtKB/Swiss-Prot for OPRK1 Gene
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
The kappa opioid receptor, (also known as OP2, KOP, KOR), is a member of the opioid family of G-protein-coupled receptors that also includes mu, delta and NOP receptors. Three variants of the receptor designated kappa1, kappa2, and kappa3 have been characterized. However only one cDNA clone has been identified, hence these receptor subtypes are likely to arise from interaction of one kappa-opioid receptor protein with other membrane associated proteins. kappa Opioid receptors are located predominantly in the cerebral cortex, nucleus accumbens, claustrum and hypothalamus and have been implicated in the regulation of nociception, diuresis, feeding and neuroendocrine secretions. Dynorphins A and B and alpha-neoendorphin appear to be the endogenous ligands. The human gene encoding the kappa opioid receptor has been localized to chromosome 8 (8q11.2).