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Aliases for ZBTB21 Gene

Aliases for ZBTB21 Gene

  • Zinc Finger And BTB Domain Containing 21 2 3 5
  • Zinc Finger Protein 295 2 3 4
  • ZNF295 3 4
  • Zinc Finger And BTB Domain-Containing Protein 21 3
  • KIAA1227 4

External Ids for ZBTB21 Gene

Previous HGNC Symbols for ZBTB21 Gene

  • ZNF295

Previous GeneCards Identifiers for ZBTB21 Gene

  • GC21M043409

Summaries for ZBTB21 Gene

GeneCards Summary for ZBTB21 Gene

ZBTB21 (Zinc Finger And BTB Domain Containing 21) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include methyl-CpG binding. An important paralog of this gene is ZBTB38.

UniProtKB/Swiss-Prot for ZBTB21 Gene

  • Acts as a transcription repressor.

Gene Wiki entry for ZBTB21 Gene

Additional gene information for ZBTB21 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB21 Gene

Genomics for ZBTB21 Gene

GeneHancer (GH) Regulatory Elements for ZBTB21 Gene

Promoters and enhancers for ZBTB21 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I042008 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 570 +0.3 264 3.2 PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZBTB21 ZNF295-AS1 PRDM15 WDR4 ENSG00000233754 ENSG00000227698 C2CD2
GH21I042009 Enhancer 0.4 ENCODE 550.8 +1.9 1908 0 ZNF362 ZNF512 MLLT1 ZBTB21 ZNF295-AS1 C2CD2
GH21I041952 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.8 +56.1 56091 4.3 HDGF PKNOX1 ARNT NEUROD1 SIN3A DMAP1 ZBTB7B POLR2B ZNF207 FOS C2CD2 PRDM15 WDR4 ENSG00000233754 ZBTB21 ZNF295-AS1 ENSG00000251778 ENSG00000227698 ENSG00000236545 UMODL1
GH21I041923 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.5 +81.4 81408 11.6 HDGF FOXA2 SMAD1 MLX ZFP64 DMAP1 IRF4 ZNF48 FOS ATF7 C2CD2 PRDM15 ENSG00000251778 ENSG00000227698 ENSG00000236545 UMODL1 ZNF295-AS1 ZBTB21 UMODL1-AS1 WDR4
GH21I041703 Enhancer 1.4 Ensembl ENCODE dbSUPER 19.9 +304.5 304527 5 PKNOX1 CLOCK FOXA2 ZFP64 ARID4B SIN3A FOS KLF13 SP3 SP5 PRDM15 ZBTB21 ENSG00000227698 LINC00479 LINC00111 GC21P041658
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZBTB21 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZBTB21 Gene

Genomic Locations for ZBTB21 Gene
23,557 bases
Minus strand

Genomic View for ZBTB21 Gene

Genes around ZBTB21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB21 Gene

Proteins for ZBTB21 Gene

  • Protein details for ZBTB21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 21
    Protein Accession:
    Secondary Accessions:
    • Q5R2W1
    • Q5R2W2
    • Q6P4R0

    Protein attributes for ZBTB21 Gene

    1066 amino acids
    Molecular mass:
    118870 Da
    Quaternary structure:
    • Homodimer. Interacts with ZBTB14.
    • Sequence=BAA86541.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZBTB21 Gene

    Alternative splice isoforms for ZBTB21 Gene


neXtProt entry for ZBTB21 Gene

Post-translational modifications for ZBTB21 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZBTB21 Gene

Domains & Families for ZBTB21 Gene

Gene Families for ZBTB21 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB21 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB21: view

No data available for UniProtKB/Swiss-Prot for ZBTB21 Gene

Function for ZBTB21 Gene

Molecular function for ZBTB21 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcription repressor.

Phenotypes From GWAS Catalog for ZBTB21 Gene

Gene Ontology (GO) - Molecular Function for ZBTB21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008327 methyl-CpG binding IDA 21029866
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB21: view
genes like me logo Genes that share phenotypes with ZBTB21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB21 Gene

Localization for ZBTB21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB21 Gene

Nucleus. Note=Colocalizes with ZBTB14 in nucleus in HEK293 cells.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB21 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZBTB21: view

Pathways & Interactions for ZBTB21 Gene

SuperPathways for ZBTB21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB21: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB21 Gene

Drugs & Compounds for ZBTB21 Gene

No Compound Related Data Available

Transcripts for ZBTB21 Gene

Unigene Clusters for ZBTB21 Gene

Zinc finger and BTB domain containing 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB21 Gene

No ASD Table

Relevant External Links for ZBTB21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBTB21 Gene

This gene is overexpressed in Brain (55.1) and Adrenal (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBTB21 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB21 Gene:


SOURCE GeneReport for Unigene cluster for ZBTB21 Gene:


mRNA Expression by UniProt/SwissProt for ZBTB21 Gene:

Tissue specificity: Ubiquitous in fetal and adult tissues.

Evidence on tissue expression from TISSUES for ZBTB21 Gene

  • Nervous system(4.4)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ZBTB21: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB21 Gene

Orthologs for ZBTB21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZBTB21 34
  • 100 (a)
(Mus musculus)
Mammalia Zbtb21 33 16 34
  • 83.04 (n)
(Canis familiaris)
Mammalia ZBTB21 33
  • 81.9 (n)
(Bos Taurus)
Mammalia ZNF295 34
  • 74 (a)
(Gallus gallus)
Aves ZBTB21 34
  • 81 (a)
ZNF295 33
  • 76.59 (n)
(Anolis carolinensis)
Reptilia ZBTB21 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb21 33
  • 64.02 (n)
Str.20411 33
(Danio rerio)
Actinopterygii zbtb21 33 34
  • 58.94 (n)
Species where no ortholog for ZBTB21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB21 Gene

Gene Tree for ZBTB21 (if available)
Gene Tree for ZBTB21 (if available)

Paralogs for ZBTB21 Gene

Paralogs for ZBTB21 Gene

genes like me logo Genes that share paralogs with ZBTB21: view

Variants for ZBTB21 Gene

Sequence variations from dbSNP and Humsavar for ZBTB21 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000112195 -- 42,009,807(-) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000169708 -- 42,009,012(-) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000536399 -- 42,009,660(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000635288 -- 42,005,579(-) G/C intron_variant
rs1000656183 -- 42,010,469(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB21 Gene

Variant ID Type Subtype PubMed ID
nsv587623 CNV loss 21841781
nsv820038 CNV loss 19587683
nsv828882 CNV gain 20364138

Variation tolerance for ZBTB21 Gene

Residual Variation Intolerance Score: 5.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.03; 87.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB21 Gene

Disorders for ZBTB21 Gene

Additional Disease Information for ZBTB21

No disorders were found for ZBTB21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB21 Gene

Publications for ZBTB21 Gene

  1. Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161. (PMID: 15629158) Wang J … Shimizu N (Biochemical and biophysical research communications 2005) 3 4 22 58
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3 4 58
  5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58

Products for ZBTB21 Gene

Sources for ZBTB21 Gene

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