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Aliases for ZBTB21 Gene

Aliases for ZBTB21 Gene

  • Zinc Finger And BTB Domain Containing 21 2 3 5
  • Zinc Finger Protein 295 2 3 4
  • ZNF295 3 4
  • KIAA1227 4

External Ids for ZBTB21 Gene

Previous HGNC Symbols for ZBTB21 Gene

  • ZNF295

Previous GeneCards Identifiers for ZBTB21 Gene

  • GC21M043409

Summaries for ZBTB21 Gene

GeneCards Summary for ZBTB21 Gene

ZBTB21 (Zinc Finger And BTB Domain Containing 21) is a Protein Coding gene. GO annotations related to this gene include methyl-CpG binding. An important paralog of this gene is ZBTB4.

UniProtKB/Swiss-Prot for ZBTB21 Gene

  • Acts as a transcription repressor.

Gene Wiki entry for ZBTB21 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB21 Gene

Genomics for ZBTB21 Gene

Regulatory Elements for ZBTB21 Gene

Enhancers for ZBTB21 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZBTB21 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZBTB21 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZBTB21 Gene

Chromosome:
21
Start:
41,986,831 bp from pter
End:
42,010,387 bp from pter
Size:
23,557 bases
Orientation:
Minus strand

Genomic View for ZBTB21 Gene

Genes around ZBTB21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB21 Gene

Proteins for ZBTB21 Gene

  • Protein details for ZBTB21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULJ3-ZBT21_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 21
    Protein Accession:
    Q9ULJ3
    Secondary Accessions:
    • Q5R2W1
    • Q5R2W2
    • Q6P4R0

    Protein attributes for ZBTB21 Gene

    Size:
    1066 amino acids
    Molecular mass:
    118870 Da
    Quaternary structure:
    • Homodimer. Interacts with ZBTB14.
    SequenceCaution:
    • Sequence=BAA86541.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZBTB21 Gene

    Alternative splice isoforms for ZBTB21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB21 Gene

Proteomics data for ZBTB21 Gene at MOPED

Post-translational modifications for ZBTB21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZBTB21 Gene

Domains & Families for ZBTB21 Gene

Gene Families for ZBTB21 Gene

Protein Domains for ZBTB21 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULJ3

UniProtKB/Swiss-Prot:

ZBT21_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 8 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB21: view

Function for ZBTB21 Gene

Molecular function for ZBTB21 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcription repressor.
genes like me logo Genes that share phenotypes with ZBTB21: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB21 Gene

Localization for ZBTB21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB21 Gene

Nucleus. Note=Colocalizes with ZBTB14 in nucleus in HEK293 cells.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ZBTB21 Gene

Pathways & Interactions for ZBTB21 Gene

SuperPathways for ZBTB21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated IDA 15629158
genes like me logo Genes that share ontologies with ZBTB21: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB21 Gene

Drugs & Compounds for ZBTB21 Gene

No Compound Related Data Available

Transcripts for ZBTB21 Gene

Unigene Clusters for ZBTB21 Gene

Zinc finger and BTB domain containing 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB21 Gene

No ASD Table

Relevant External Links for ZBTB21 Gene

GeneLoc Exon Structure for
ZBTB21
ECgene alternative splicing isoforms for
ZBTB21

Expression for ZBTB21 Gene

mRNA expression in normal human tissues for ZBTB21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBTB21 Gene

This gene is overexpressed in Brain (55.1) and Adrenal (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBTB21 Gene



SOURCE GeneReport for Unigene cluster for ZBTB21 Gene Hs.434947

mRNA Expression by UniProt/SwissProt for ZBTB21 Gene

Q9ULJ3-ZBT21_HUMAN
Tissue specificity: Ubiquitous in fetal and adult tissues.
genes like me logo Genes that share expression patterns with ZBTB21: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ZBTB21 Gene

Orthologs for ZBTB21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB21 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ZBTB21 35
  • 81.9 (n)
  • 86.47 (a)
mouse
(Mus musculus)
Mammalia Zbtb21 35
  • 83.04 (n)
  • 86.83 (a)
Zbtb21 16
Zbtb21 36
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF295 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZBTB21 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF295 35
  • 76.59 (n)
  • 81.52 (a)
ZBTB21 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB21 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20411 35
zbtb21 35
  • 64.02 (n)
  • 62.65 (a)
zebrafish
(Danio rerio)
Actinopterygii zbtb21 35
  • 58.94 (n)
  • 56.97 (a)
zbtb21 36
  • 55 (a)
OneToOne
Species with no ortholog for ZBTB21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB21 Gene

ENSEMBL:
Gene Tree for ZBTB21 (if available)
TreeFam:
Gene Tree for ZBTB21 (if available)

Paralogs for ZBTB21 Gene

Paralogs for ZBTB21 Gene

genes like me logo Genes that share paralogs with ZBTB21: view

Variants for ZBTB21 Gene

Sequence variations from dbSNP and Humsavar for ZBTB21 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs871545 - 41,993,542(-) GGCCA(A/G)TACCA reference, missense
rs871546 - 41,993,444(-) ATGCA(A/C)AGTCT reference, missense
rs390853 -- 41,986,468(+) TAGAT(A/T)ATCAA downstream-variant-500B
rs397663 -- 41,986,548(+) ATTTA(C/G)CCCCC downstream-variant-500B
rs423235 -- 41,994,887(+) ttctc(A/G)tgata intron-variant

Variation tolerance for ZBTB21 Gene

Residual Variation Intolerance Score: 5.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.03; 87.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB21 Gene

HapMap Linkage Disequilibrium report
ZBTB21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZBTB21 Gene

Disorders for ZBTB21 Gene

Relevant External Links for ZBTB21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB21

No disorders were found for ZBTB21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB21 Gene

Publications for ZBTB21 Gene

  1. Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161. (PMID: 15629158) Wang J. … Shimizu N. (Biochem. Biophys. Res. Commun. 2005) 3 4 23 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for ZBTB21 Gene

Sources for ZBTB21 Gene

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