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Aliases for OLR1 Gene

Aliases for OLR1 Gene

  • Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 2 3
  • LOX1 3 4 6
  • C-Type Lectin Domain Family 8 Member A 3 4
  • Lectin-Type Oxidized LDL Receptor 1 3 4
  • CLEC8A 3 4
  • HLOX-1 3 4
  • Oxidised Low Density Lipoprotein (Lectin-Like) Receptor 1 2
  • Oxidized Low-Density Lipoprotein Receptor 1, Soluble Form 3
  • Oxidized Low-Density Lipoprotein Receptor 1 3
  • Scavenger Receptor Class E, Member 1 3
  • Lectin-Like Oxidized LDL Receptor 1 4
  • Lectin-Like OxLDL Receptor 1 4
  • Ox LDL Receptor 1 3
  • Ox-LDL Receptor 1 4
  • SCARE1 3
  • LOXIN 3
  • SLOX1 3
  • LOX-1 4

External Ids for OLR1 Gene

Summaries for OLR1 Gene

Entrez Gene Summary for OLR1 Gene

  • This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]

GeneCards Summary for OLR1 Gene

OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1) is a Protein Coding gene. Diseases associated with OLR1 include coronary stenosis and myocardial infarction. Among its related pathways are Hemostasis and Cell surface interactions at the vascular wall. GO annotations related to this gene include carbohydrate binding and low-density lipoprotein receptor activity. An important paralog of this gene is CLEC7A.

UniProtKB/Swiss-Prot for OLR1 Gene

  • Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.

Gene Wiki entry for OLR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLR1 Gene

Genomics for OLR1 Gene

Genomic Location for OLR1 Gene

Start:
10,158,300 bp from pter
End:
10,172,191 bp from pter
Size:
13,892 bases
Orientation:
Minus strand

Genomic View for OLR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OLR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLR1 Gene

Regulatory Elements for OLR1 Gene

Proteins for OLR1 Gene

  • Protein details for OLR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78380-OLR1_HUMAN
    Recommended name:
    Oxidized low-density lipoprotein receptor 1
    Protein Accession:
    P78380
    Secondary Accessions:
    • A8K7V9
    • B4DI48
    • G3V1I4
    • Q2PP00
    • Q7Z484

    Protein attributes for OLR1 Gene

    Size:
    273 amino acids
    Molecular mass:
    30959 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70.

    Three dimensional structures from OCA and Proteopedia for OLR1 Gene

    Alternative splice isoforms for OLR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OLR1 Gene

Proteomics data for OLR1 Gene at MOPED

Post-translational modifications for OLR1 Gene

No data available for DME Specific Peptides for OLR1 Gene

Domains for OLR1 Gene

Gene Families for OLR1 Gene

HGNC:
  • CLEC :C-type lectin domain containing

Protein Domains for OLR1 Gene

UniProtKB/Swiss-Prot:

OLR1_HUMAN
Domain:
  • The cytoplasmic region is required for subcellular sorting on the cell surface:
    • P78380
  • The C-type lectin domain mediates the recognition and binding of oxLDL:
    • P78380
  • Contains 1 C-type lectin domain.:
    • P78380
genes like me logo Genes that share domains with OLR1: view

Function for OLR1 Gene

Molecular function for OLR1 Gene

GENATLAS Biochemistry: oxidized low density lipoprotein receptor 1lectin-like,in the NK (natural killer) complex, taken up by vascular endothelium,most abundant in placenta,also expressed in lung,bone marrow,central nervous system,aorta,testis and kidney,also expressed in macrophages,but not in vascular smooth muscle cells,involved in endothelial dysfunction and atherosclerosis
UniProtKB/Swiss-Prot Function: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
UniProtKB/Swiss-Prot Induction: By inflammatory cytokines such as TNF, IFNG/IFN-gamma, IL6/interleukin-6 and by pathological conditions such as hyperlipidemia, hypertension and diabetes mellitus. Up-regulated in atherosclerotic lesions, by oxLDL, reactive oxygen species and fluid shear stress, suggesting that it may participate in amplification of oxLDL-induced vascular dysfunction.

Gene Ontology (GO) - Molecular Function for OLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005041 low-density lipoprotein receptor activity IEA --
GO:0005515 protein binding IPI 24846140
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with OLR1: view
genes like me logo Genes that share phenotypes with OLR1: view

Animal Models for OLR1 Gene

MGI Knock Outs for OLR1:

miRNA for OLR1 Gene

miRTarBase miRNAs that target OLR1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for OLR1 Gene

Localization for OLR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLR1 Gene

Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane raft. Secreted. Note=A secreted form also exists. Localization to membrane rafts requires palmitoylation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OLR1 Gene COMPARTMENTS Subcellular localization image for OLR1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 3
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for OLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9052782
GO:0016020 membrane TAS 9052782
genes like me logo Genes that share ontologies with OLR1: view

Pathways for OLR1 Gene

genes like me logo Genes that share pathways with OLR1: view

Pathways by source for OLR1 Gene

2 KEGG pathways for OLR1 Gene

Gene Ontology (GO) - Biological Process for OLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS 9052782
GO:0006898 receptor-mediated endocytosis IEA --
GO:0006954 inflammatory response IEA --
GO:0007159 leukocyte cell-cell adhesion IEA --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with OLR1: view

Compounds for OLR1 Gene

(36) Novoseek inferred chemical compound relationships for OLR1 Gene

Compound -log(P) Hits PubMed IDs
atorvastatin 49.7 13
carrageenan 45 5
kappa-carrageenan 44.3 2
fucoidan 42.7 1
isorhamnetin 42.3 2
genes like me logo Genes that share compounds with OLR1: view

Transcripts for OLR1 Gene

Unigene Clusters for OLR1 Gene

Oxidized low density lipoprotein (lectin-like) receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OLR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: -
SP6:
SP7:

Relevant External Links for OLR1 Gene

GeneLoc Exon Structure for
OLR1
ECgene alternative splicing isoforms for
OLR1

Expression for OLR1 Gene

mRNA expression in normal human tissues for OLR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OLR1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (10.4), Brain - Substantia nigra (7.3), and Lung (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OLR1 Gene

SOURCE GeneReport for Unigene cluster for OLR1 Gene Hs.412484

mRNA Expression by UniProt/SwissProt for OLR1 Gene

P78380-OLR1_HUMAN
Tissue specificity: Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level.
genes like me logo Genes that share expressions with OLR1: view

Orthologs for OLR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OLR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLR1 36
  • 99.51 (n)
  • 99.27 (a)
OLR1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OLR1 36
  • 81.16 (n)
  • 72.86 (a)
OLR1 37
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OLR1 36
  • 83.33 (n)
  • 74.07 (a)
OLR1 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olr1 36
  • 73.66 (n)
  • 60.3 (a)
Olr1 16
Olr1 37
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OLR1 37
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1 36
  • 76.24 (n)
  • 66.04 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 35 (a)
OneToMany
Species with no ortholog for OLR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OLR1 Gene

ENSEMBL:
Gene Tree for OLR1 (if available)
TreeFam:
Gene Tree for OLR1 (if available)

Paralogs for OLR1 Gene

Paralogs for OLR1 Gene

genes like me logo Genes that share paralogs with OLR1: view

Variants for OLR1 Gene

Sequence variations from dbSNP and Humsavar for OLR1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1050283 -- 10,159,690(-) AGCTA(C/T)CTGTA utr-variant-3-prime
rs1050286 -- 10,158,964(-) AAACT(A/G)AGCCA utr-variant-3-prime
rs1050289 -- 10,158,567(-) CAATC(A/G)GCTTT utr-variant-3-prime
rs1801809 -- 10,159,313(-) AGACA(C/G)ACACA utr-variant-3-prime
rs2010655 -- 10,165,749(-) GTCTC(A/G)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OLR1 Gene

Variant ID Type Subtype PubMed ID
nsv898757 CNV Gain 21882294
nsv898758 CNV Gain 21882294

Relevant External Links for OLR1 Gene

HapMap Linkage Disequilibrium report
OLR1
Human Gene Mutation Database (HGMD)
OLR1

Disorders for OLR1 Gene

(1) OMIM Diseases for OLR1 Gene (602601)

UniProtKB/Swiss-Prot

OLR1_HUMAN
  • Note=Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction susceptibility.
  • Note=OLR1 may be involved in Alzheimer disease (AD). Involvement in AD is however unclear: according to some authors (PubMed:12354387, PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD, while according to other (PubMed:15000751 and PubMed:15060104) they do not. {ECO:0000269 PubMed:12384789, ECO:0000269 PubMed:12807963, ECO:0000269 PubMed:15860461}.

(3) University of Copenhagen DISEASES for OLR1 Gene

(29) Novoseek inferred disease relationships for OLR1 Gene

Disease -log(P) Hits PubMed IDs
atherosclerosis 76.6 70
atherosclerotic plaque 69.3 23
cardiovascular diseases 46 11
hyperlipidemia 38.1 2
coronary artery disease 35.8 11

Relevant External Links for OLR1

Genetic Association Database (GAD)
OLR1
Human Genome Epidemiology (HuGE) Navigator
OLR1
genes like me logo Genes that share disorders with OLR1: view

Publications for OLR1 Gene

  1. Investigation of oxidized LDL-receptor 1 (OLR1) as the candidate gene for Alzheimer's disease on chromosome 12. (PMID: 12384789) Luedecking-Zimmer E. … Kamboh M.I. (Hum. Genet. 2002) 3 4 23 49
  2. Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction. (PMID: 12646194) Tatsuguchi M. … Matsuoka R. (Biochem. Biophys. Res. Commun. 2003) 3 4 23 49
  3. Association of 3'-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer's disease. (PMID: 12807963) Lambert J.-C. … Amouyel P. (J. Med. Genet. 2003) 3 4 23 49
  4. Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease. (PMID: 12810610) Chen Q. … Kamboh M.I. (Circulation 2003) 3 4 23 49
  5. No association between a previously reported OLR1 3' UTR polymorphism and Alzheimer's disease in a large family sample. (PMID: 15060104) Bertram L. … Tanzi R.E. (J. Med. Genet. 2004) 3 4 23 49

Products for OLR1 Gene

Sources for OLR1 Gene

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