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Aliases for OGN Gene

Aliases for OGN Gene

  • Osteoglycin 2 3 4
  • OIF 3 4 6
  • Osteoinductive Factor 3 4
  • Mimecan Proteoglycan 2 3
  • SLRR3A 3 4
  • Corneal Keratan Sulfate Proteoglycan 3
  • Osteoglycin (Osteoinductive Factor) 2
  • Mimecan 3
  • OG 3

External Ids for OGN Gene

Previous GeneCards Identifiers for OGN Gene

  • GC09M085972
  • GC09M086874
  • GC09M088445
  • GC09M090487
  • GC09M092225
  • GC09M094187
  • GC09M095146
  • GC09M064823

Summaries for OGN Gene

Entrez Gene Summary for OGN Gene

  • This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small proteoglycan which contains tandem leucine-rich repeats (LRR). Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for OGN Gene

OGN (Osteoglycin) is a Protein Coding gene. Diseases associated with OGN include vaginal cancer and cornea plana. Among its related pathways are Disease and NF-KappaB Family Pathway. GO annotations related to this gene include growth factor activity. An important paralog of this gene is OPTC.

UniProtKB/Swiss-Prot for OGN Gene

  • Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2

Gene Wiki entry for OGN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGN Gene

Genomics for OGN Gene

Regulatory Elements for OGN Gene

Genomic Location for OGN Gene

Start:
92,383,967 bp from pter
End:
92,404,696 bp from pter
Size:
20,730 bases
Orientation:
Minus strand

Genomic View for OGN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGN Gene

Proteins for OGN Gene

  • Protein details for OGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20774-MIME_HUMAN
    Recommended name:
    Mimecan
    Protein Accession:
    P20774
    Secondary Accessions:
    • Q6FIB0
    • Q9UF90
    • Q9UNK5

    Protein attributes for OGN Gene

    Size:
    298 amino acids
    Molecular mass:
    33922 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OGN Gene

Proteomics data for OGN Gene at MOPED

Post-translational modifications for OGN Gene

  • N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
  • Glycosylation at Thr80, Asn214, and Asn258
  • Modification sites at PhosphoSitePlus

Other Protein References for OGN Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for OGN Gene

Domains for OGN Gene

Gene Families for OGN Gene

HGNC:
  • SLRR :Proteoglycans / Extracellular Matrix : Small leucine-rich repeats

Suggested Antigen Peptide Sequences for OGN Gene

Graphical View of Domain Structure for InterPro Entry

P20774

UniProtKB/Swiss-Prot:

MIME_HUMAN :
  • P20774
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
Similarity:
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with OGN: view

Function for OGN Gene

Molecular function for OGN Gene

UniProtKB/Swiss-Prot Function:
Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2

Gene Ontology (GO) - Molecular Function for OGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with OGN: view
genes like me logo Genes that share phenotypes with OGN: view

Animal Models for OGN Gene

MGI Knock Outs for OGN:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for OGN Gene

Localization for OGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGN Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OGN Gene COMPARTMENTS Subcellular localization image for OGN gene
Compartment Confidence
extracellular 4
golgi apparatus 4
lysosome 4
vacuole 4
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for OGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 20551380
GO:0005796 Golgi lumen TAS --
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
genes like me logo Genes that share ontologies with OGN: view

Pathways for OGN Gene

genes like me logo Genes that share pathways with OGN: view

Gene Ontology (GO) - Biological Process for OGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0018146 keratan sulfate biosynthetic process TAS --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0042339 keratan sulfate metabolic process TAS --
GO:0042340 keratan sulfate catabolic process TAS --
genes like me logo Genes that share ontologies with OGN: view

Compounds for OGN Gene

(2) Novoseek inferred chemical compound relationships for OGN Gene

Compound -log(P) Hits PubMed IDs
leucine 29.4 1
hydroxyapatite 17.7 2
genes like me logo Genes that share compounds with OGN: view

Transcripts for OGN Gene

Unigene Clusters for OGN Gene

Osteoglycin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OGN

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OGN Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -
SP2: - -
SP3:

Relevant External Links for OGN Gene

GeneLoc Exon Structure for
OGN
ECgene alternative splicing isoforms for
OGN

Expression for OGN Gene

mRNA expression in normal human tissues for OGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OGN Gene

This gene is overexpressed in Artery - Aorta (12.5) and Artery - Coronary (11.7).

Protein differential expression in normal tissues for OGN Gene

This gene is overexpressed in Adipocyte (10.2) and Gallbladder (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OGN Gene

SOURCE GeneReport for Unigene cluster for OGN Gene Hs.109439

mRNA Expression by UniProt/SwissProt for OGN Gene

P20774-MIME_HUMAN
Tissue specificity: Bone
genes like me logo Genes that share expressions with OGN: view

Expression partners for OGN Gene

In Situ Assay Products

Orthologs for OGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for OGN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OGN 35
  • 92.37 (n)
  • 92.93 (a)
OGN 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OGN 35
  • 90.57 (n)
  • 90.91 (a)
OGN 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ogn 35
  • 88.7 (n)
  • 85.23 (a)
Ogn 16
Ogn 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OGN 35
  • 99.89 (n)
  • 99.66 (a)
OGN 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910855 35
  • 88.7 (n)
  • 85.57 (a)
oppossum
(Monodelphis domestica)
Mammalia OGN 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OGN 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves OGN 35
  • 70.47 (n)
  • 66.78 (a)
OGN 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OGN 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ogn 35
  • 69.31 (n)
  • 70.56 (a)
African clawed frog
(Xenopus laevis)
Amphibia ogn-prov 35
zebrafish
(Danio rerio)
Actinopterygii ogn 35
  • 64.97 (n)
  • 68.06 (a)
ogn 36
  • 53 (a)
OneToMany
OGN (1 of 2) 36
  • 56 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7827 35
Species with no ortholog for OGN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGN Gene

ENSEMBL:
Gene Tree for OGN (if available)
TreeFam:
Gene Tree for OGN (if available)

Paralogs for OGN Gene

Paralogs for OGN Gene

Selected SIMAP similar genes for OGN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with OGN: view

Variants for OGN Gene

Structural Variations from Database of Genomic Variants (DGV) for OGN Gene

Variant ID Type Subtype PubMed ID
nsv893573 CNV Gain 21882294

Relevant External Links for OGN Gene

HapMap Linkage Disequilibrium report
OGN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for OGN Gene

Disorders for OGN Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for OGN Gene in MalaCards »

(2) Diseases for OGN Gene including...

(1) University of Copenhagen DISEASES for OGN Gene

Relevant External Links for OGN

Genetic Association Database (GAD)
OGN
Human Genome Epidemiology (HuGE) Navigator
OGN
genes like me logo Genes that share disorders with OGN: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for OGN Gene

Publications for OGN Gene

  1. Molecular cloning of a novel bone-forming compound: osteoinductive factor. (PMID: 2372374) Madisen L. … Purchio A.F. (DNA Cell Biol. 1990) 2 3 4 23
  2. The bovine mimecan gene. Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon. (PMID: 10373482) Tasheva E.S. … Conrad G.W. (J. Biol. Chem. 1999) 3 4 23
  3. Mutations in KERA, encoding keratocan, cause cornea plana. (PMID: 10802664) Pellegata N.S. … de la Chapelle A. (Nat. Genet. 2000) 3 4 23
  4. Assignment of mimecan gene (OGN) to human chromosome band 9q22 by in situ hybridization. (PMID: 10828622) Tasheva E.S. … Conrad G.W. (Cytogenet. Cell Genet. 2000) 3 23
  5. Osteoinductive factor inhibits formation of human osteoclast-like cells. (PMID: 2326263) Kukita A. … Roodman G.D. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 23

Products for OGN Gene

Sources for OGN Gene

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