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Aliases for OGG1 Gene

Aliases for OGG1 Gene

  • 8-Oxoguanine DNA Glycosylase 2 3
  • 8-Hydroxyguanine DNA Glycosylase 2 3
  • MUTM 3 4
  • OGH1 3 4
  • DNA-Apurinic Or Apyrimidinic Site Lyase 3
  • N-Glycosylase/DNA Lyase 3
  • OGG1 Type 1e 2
  • OGG1 Type 1d 2
  • OGG1 Type 1g 2
  • OGG1 Type 1h 2
  • OGG1 Type 1f 3
  • AP Lyase 3
  • HOGG1 3
  • HMMH 3
  • MMH 4

External Ids for OGG1 Gene

Previous GeneCards Identifiers for OGG1 Gene

  • GC03P009720
  • GC03P009782
  • GC03P009766
  • GC03P009767
  • GC03P009768
  • GC03P009769
  • GC03P009770
  • GC03P009771
  • GC03P009772
  • GC03P009773
  • GC03P009774
  • GC03P009791
  • GC03P009727

Summaries for OGG1 Gene

Entrez Gene Summary for OGG1 Gene

  • This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]

GeneCards Summary for OGG1 Gene

OGG1 (8-Oxoguanine DNA Glycosylase) is a Protein Coding gene. Diseases associated with OGG1 include renal cell carcinoma and xeroderma pigmentosum, group f. Among its related pathways are Chks in Checkpoint Regulation and DNA Repair. GO annotations related to this gene include microtubule binding and endonuclease activity.

UniProtKB/Swiss-Prot for OGG1 Gene

  • DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3 to the lesion

Gene Wiki entry for OGG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGG1 Gene

Genomics for OGG1 Gene

Regulatory Elements for OGG1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OGG1 Gene

Start:
9,749,944 bp from pter
End:
9,788,219 bp from pter
Size:
38,276 bases
Orientation:
Plus strand

Genomic View for OGG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OGG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGG1 Gene

Proteins for OGG1 Gene

  • Protein details for OGG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15527-OGG1_HUMAN
    Recommended name:
    N-glycosylase/DNA lyase
    Protein Accession:
    O15527
    Secondary Accessions:
    • A8K1E3
    • O00390
    • O00670
    • O00705
    • O14876
    • O95488
    • P78554
    • Q9BW42
    • Q9UIK0
    • Q9UIK1
    • Q9UIK2
    • Q9UL34
    • Q9Y2C0
    • Q9Y2C1
    • Q9Y6C3
    • Q9Y6C4

    Protein attributes for OGG1 Gene

    Size:
    345 amino acids
    Molecular mass:
    38782 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB84013.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OGG1 Gene

    Alternative splice isoforms for OGG1 Gene

neXtProt entry for OGG1 Gene

Proteomics data for OGG1 Gene at MOPED

Post-translational modifications for OGG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for OGG1 Gene

Domains for OGG1 Gene

Protein Domains for OGG1 Gene

Graphical View of Domain Structure for InterPro Entry

O15527

UniProtKB/Swiss-Prot:

OGG1_HUMAN :
  • O15527
Family:
  • Belongs to the type-1 OGG1 family.
genes like me logo Genes that share domains with OGG1: view

No data available for Gene Families for OGG1 Gene

Function for OGG1 Gene

Molecular function for OGG1 Gene

GENATLAS Biochemistry: 8oxo-7,8-dihydroxyguanine-DNA glycosylase/apurinic,apyrimidic lyase,mut M homolog,ubiquitously expressed with four alternatively spliced isoforms,yeast OGG1 ortholog,involved in the repair of oxidative DNA damage and in carcinogenesis
UniProtKB/Swiss-Prot CatalyticActivity: The C-O-P bond 3 to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3-terminal unsaturated sugar and a product with a terminal 5-phosphate
UniProtKB/Swiss-Prot Function: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3 to the lesion

Gene Ontology (GO) - Molecular Function for OGG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003684 damaged DNA binding IEA --
GO:0003824 catalytic activity --
GO:0004519 endonuclease activity TAS 9223305
GO:0005515 protein binding IPI 15518571
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with OGG1: view
genes like me logo Genes that share phenotypes with OGG1: view

Animal Models for OGG1 Gene

MGI Knock Outs for OGG1:

Animal Model Products

CRISPR Products

miRNA for OGG1 Gene

miRTarBase miRNAs that target OGG1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OGG1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for OGG1 Gene

Localization for OGG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGG1 Gene

Nucleus, nucleoplasm. Nucleus speckle. Nucleus matrix. Note=Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.
Isoform 1A: Nucleus.
Isoform 2A: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OGG1 Gene COMPARTMENTS Subcellular localization image for OGG1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for OGG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19506022
GO:0005654 nucleoplasm TAS --
GO:0005739 mitochondrion IEA --
GO:0016363 nuclear matrix IDA 17148573
GO:0016607 nuclear speck IDA 17148573
genes like me logo Genes that share ontologies with OGG1: view

Pathways for OGG1 Gene

genes like me logo Genes that share pathways with OGG1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for OGG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000737 DNA catabolic process, endonucleolytic --
GO:0002526 acute inflammatory response IEA --
GO:0006281 DNA repair TAS --
GO:0006284 base-excision repair TAS --
GO:0006285 base-excision repair, AP site formation TAS --
genes like me logo Genes that share ontologies with OGG1: view

Compounds for OGG1 Gene

(61) Novoseek inferred chemical compound relationships for OGG1 Gene

Compound -log(P) Hits PubMed IDs
8-oxoguanine 98.2 137
8-hydroxyguanine 94 43
8-oxo-dg 87 52
formamidopyrimidine 82.6 7
8-oxo-dgtp 79.6 3
genes like me logo Genes that share compounds with OGG1: view

Transcripts for OGG1 Gene

Unigene Clusters for OGG1 Gene

8-oxoguanine DNA glycosylase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OGG1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OGG1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d
SP1:
SP2: -
SP3: -
SP4: - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - -

Relevant External Links for OGG1 Gene

GeneLoc Exon Structure for
OGG1
ECgene alternative splicing isoforms for
OGG1

Expression for OGG1 Gene

mRNA expression in normal human tissues for OGG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OGG1 Gene

SOURCE GeneReport for Unigene cluster for OGG1 Gene Hs.380271

mRNA Expression by UniProt/SwissProt for OGG1 Gene

O15527-OGG1_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with OGG1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for OGG1 Gene

Orthologs for OGG1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OGG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OGG1 35
  • 99.61 (n)
  • 99.71 (a)
OGG1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OGG1 35
  • 87.73 (n)
  • 86.38 (a)
OGG1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OGG1 35
  • 86.97 (n)
  • 87.27 (a)
OGG1 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ogg1 35
  • 84.25 (n)
  • 84.93 (a)
Ogg1 16
Ogg1 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OGG1 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OGG1 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ogg1 35
  • 84.66 (n)
  • 84.66 (a)
chicken
(Gallus gallus)
Aves OGG1 35
  • 61.76 (n)
  • 57.68 (a)
OGG1 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OGG1 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ogg1 35
  • 59.72 (n)
  • 57.4 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1191 35
zebrafish
(Danio rerio)
Actinopterygii ogg1 35
  • 58.36 (n)
  • 57.1 (a)
ogg1 36
  • 46 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001854 35
  • 53.76 (n)
  • 46.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ogg1 35
  • 45.81 (n)
  • 37.09 (a)
Ogg1 36
  • 31 (a)
OneToOne
Ogg1 37
  • 36 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER127C 35
  • 50.22 (n)
  • 41.06 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OGG1 35
  • 47.44 (n)
  • 41.64 (a)
OGG1 36
  • 33 (a)
OneToOne
OGG1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05159g 35
  • 46.84 (n)
  • 40.86 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons OGG1 35
  • 48.07 (n)
  • 42.24 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03040 35
  • 54.24 (n)
  • 47.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for OGG1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGG1 Gene

ENSEMBL:
Gene Tree for OGG1 (if available)
TreeFam:
Gene Tree for OGG1 (if available)

Paralogs for OGG1 Gene

genes like me logo Genes that share paralogs with OGG1: view

No data available for Paralogs for OGG1 Gene

Variants for OGG1 Gene

Sequence variations from dbSNP and Humsavar for OGG1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs125701 -- 9,748,794(+) AATCC(A/G)CTGCA upstream-variant-2KB
rs159150 -- 9,754,442(-) TTGCT(C/T)CCCTT intron-variant
rs159151 -- 9,753,321(-) tgtcg(C/T)ccagg intron-variant
rs190894 -- 9,775,121(+) tgtaa(C/T)cccag intron-variant
rs293781 -- 9,777,130(+) CTCCC(C/T)GTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OGG1 Gene

Variant ID Type Subtype PubMed ID
nsv821982 CNV Gain 20364138

Relevant External Links for OGG1 Gene

HapMap Linkage Disequilibrium report
OGG1
Human Gene Mutation Database (HGMD)
OGG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGG1 Gene

Disorders for OGG1 Gene

(1) OMIM Diseases for OGG1 Gene (601982)

UniProtKB/Swiss-Prot

OGG1_HUMAN
  • Renal cell carcinoma (RCC) [MIM:144700]: Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype. Note=The disease may be caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for OGG1 Gene

(47) Novoseek inferred disease relationships for OGG1 Gene

Disease -log(P) Hits PubMed IDs
group b cockayne syndrome 66.7 1
cancer lung 58.9 53
adenocarcinoma lung 56.1 5
cancer 55.9 49
xeroderma pigmentosum 52.7 6

Relevant External Links for OGG1

Genetic Association Database (GAD)
OGG1
Human Genome Epidemiology (HuGE) Navigator
OGG1
genes like me logo Genes that share disorders with OGG1: view

Publications for OGG1 Gene

  1. Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. (PMID: 9207108) Rosenquist T.A. … Grollman A.P. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae. (PMID: 9223305) Radicella J.P. … Boiteux S. (Proc. Natl. Acad. Sci. U.S.A. 1997) 3 4 23
  3. Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers. (PMID: 9348312) Kuo F.C. … Sklar J.L. (J. Exp. Med. 1997) 3 4 23
  4. Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue. (PMID: 9187114) Aburatani H. … Nishimura S. (Cancer Res. 1997) 3 4 23
  5. A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer. (PMID: 9197244) Lu R. … Verdine G.L. (Curr. Biol. 1997) 3 4 23

Products for OGG1 Gene

  • Addgene plasmids for OGG1

Sources for OGG1 Gene

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