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Aliases for OGG1 Gene

Aliases for OGG1 Gene

  • 8-Oxoguanine DNA Glycosylase 2 3
  • 8-Hydroxyguanine DNA Glycosylase 2 3
  • MUTM 3 4
  • OGH1 3 4
  • DNA-Apurinic Or Apyrimidinic Site Lyase 3
  • OGG1 Type 1e 2
  • OGG1 Type 1d 2
  • OGG1 Type 1g 2
  • OGG1 Type 1h 2
  • OGG1 Type 1f 3
  • AP Lyase 3
  • HOGG1 3
  • HMMH 3
  • MMH 4

External Ids for OGG1 Gene

Previous GeneCards Identifiers for OGG1 Gene

  • GC03P009720
  • GC03P009782
  • GC03P009766
  • GC03P009767
  • GC03P009768
  • GC03P009769
  • GC03P009770
  • GC03P009771
  • GC03P009772
  • GC03P009773
  • GC03P009774
  • GC03P009791
  • GC03P009727

Summaries for OGG1 Gene

Entrez Gene Summary for OGG1 Gene

  • This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]

GeneCards Summary for OGG1 Gene

OGG1 (8-Oxoguanine DNA Glycosylase) is a Protein Coding gene. Diseases associated with OGG1 include mucocele of appendix and posterior scleritis. Among its related pathways are Chks in Checkpoint Regulation and DNA Double-Strand Break Repair. GO annotations related to this gene include microtubule binding and endonuclease activity.

UniProtKB/Swiss-Prot for OGG1 Gene

  • DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3 to the lesion

Gene Wiki entry for OGG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGG1 Gene

Genomics for OGG1 Gene

Regulatory Elements for OGG1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OGG1 Gene

Chromosome:
3
Start:
9,749,944 bp from pter
End:
9,788,246 bp from pter
Size:
38,303 bases
Orientation:
Plus strand

Genomic View for OGG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OGG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGG1 Gene

Proteins for OGG1 Gene

  • Protein details for OGG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15527-OGG1_HUMAN
    Recommended name:
    N-glycosylase/DNA lyase
    Protein Accession:
    O15527
    Secondary Accessions:
    • A8K1E3
    • O00390
    • O00670
    • O00705
    • O14876
    • O95488
    • P78554
    • Q9BW42
    • Q9UIK0
    • Q9UIK1
    • Q9UIK2
    • Q9UL34
    • Q9Y2C0
    • Q9Y2C1
    • Q9Y6C3
    • Q9Y6C4

    Protein attributes for OGG1 Gene

    Size:
    345 amino acids
    Molecular mass:
    38782 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB84013.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OGG1 Gene

    Alternative splice isoforms for OGG1 Gene

neXtProt entry for OGG1 Gene

Proteomics data for OGG1 Gene at MOPED

Post-translational modifications for OGG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for OGG1 Gene

Domains & Families for OGG1 Gene

Gene Families for OGG1 Gene

Graphical View of Domain Structure for InterPro Entry

O15527

UniProtKB/Swiss-Prot:

OGG1_HUMAN :
  • Belongs to the type-1 OGG1 family.
Family:
  • Belongs to the type-1 OGG1 family.
genes like me logo Genes that share domains with OGG1: view

Function for OGG1 Gene

Molecular function for OGG1 Gene

GENATLAS Biochemistry:
8oxo-7,8-dihydroxyguanine-DNA glycosylase/apurinic,apyrimidic lyase,mut M homolog,ubiquitously expressed with four alternatively spliced isoforms,yeast OGG1 ortholog,involved in the repair of oxidative DNA damage and in carcinogenesis
UniProtKB/Swiss-Prot CatalyticActivity:
The C-O-P bond 3 to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3-terminal unsaturated sugar and a product with a terminal 5-phosphate
UniProtKB/Swiss-Prot Function:
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3 to the lesion

Gene Ontology (GO) - Molecular Function for OGG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003684 damaged DNA binding IDA 14706345
GO:0003824 catalytic activity --
GO:0004519 endonuclease activity TAS 9223305
GO:0005515 protein binding IPI 15518571
genes like me logo Genes that share ontologies with OGG1: view
genes like me logo Genes that share phenotypes with OGG1: view

Animal Models for OGG1 Gene

MGI Knock Outs for OGG1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OGG1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for OGG1 Gene

Localization for OGG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGG1 Gene

Nucleus, nucleoplasm. Nucleus speckle. Nucleus matrix. Note=Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.
Isoform 1A: Nucleus.
Isoform 2A: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OGG1 Gene COMPARTMENTS Subcellular localization image for OGG1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytoskeleton 1
cytosol 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for OGG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19506022
GO:0005654 nucleoplasm TAS --
GO:0005739 mitochondrion IEA --
GO:0016363 nuclear matrix IDA 17148573
GO:0016607 nuclear speck IDA 17148573
genes like me logo Genes that share ontologies with OGG1: view

Pathways & Interactions for OGG1 Gene

genes like me logo Genes that share pathways with OGG1: view

Pathways by source for OGG1 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for OGG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002526 acute inflammatory response --
GO:0006281 DNA repair TAS --
GO:0006284 base-excision repair TAS --
GO:0006285 base-excision repair, AP site formation TAS --
GO:0006289 nucleotide-excision repair --
genes like me logo Genes that share ontologies with OGG1: view

No data available for SIGNOR curated interactions for OGG1 Gene

Drugs & Compounds for OGG1 Gene

(22) Drugs for OGG1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dopamine Approved Pharma Full agonist, Agonist 2814
Doxycycline Approved, Investigational Pharma 204
Mannitol Approved, Investigational Pharma 220
Nitric Oxide Approved Pharma 540
Zinc Approved Pharma 1404

(39) Additional Compounds for OGG1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Hydroxypyrene
  • 1-Hydroxy pyrene
  • 1-HYDROXYPYRENE
  • 1-Pyrenol
  • Pyren-1-ol
5315-79-7
2,6-Diamino-4-hydroxy-5-formamidopyrimidine
2-deoxyribonolactone
5-formyluracil
5-hydroxyuracil
genes like me logo Genes that share compounds with OGG1: view

Transcripts for OGG1 Gene

Unigene Clusters for OGG1 Gene

8-oxoguanine DNA glycosylase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OGG1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OGG1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d
SP1:
SP2: -
SP3: -
SP4: - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - -

Relevant External Links for OGG1 Gene

GeneLoc Exon Structure for
OGG1
ECgene alternative splicing isoforms for
OGG1

Expression for OGG1 Gene

mRNA expression in normal human tissues for OGG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OGG1 Gene

This gene is overexpressed in Platelet (36.1), CD8 Tcells (20.7), and CD4 Tcells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OGG1 Gene



SOURCE GeneReport for Unigene cluster for OGG1 Gene Hs.380271

mRNA Expression by UniProt/SwissProt for OGG1 Gene

O15527-OGG1_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expression patterns with OGG1: view

Protein tissue co-expression partners for OGG1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for OGG1 Gene

Orthologs for OGG1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OGG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OGG1 35
  • 87.73 (n)
  • 86.38 (a)
OGG1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OGG1 35
  • 86.97 (n)
  • 87.27 (a)
OGG1 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ogg1 35
  • 84.25 (n)
  • 84.93 (a)
Ogg1 16
Ogg1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OGG1 35
  • 99.61 (n)
  • 99.71 (a)
OGG1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ogg1 35
  • 84.66 (n)
  • 84.66 (a)
oppossum
(Monodelphis domestica)
Mammalia OGG1 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OGG1 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves OGG1 35
  • 61.76 (n)
  • 57.68 (a)
OGG1 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OGG1 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ogg1 35
  • 59.72 (n)
  • 57.4 (a)
zebrafish
(Danio rerio)
Actinopterygii ogg1 35
  • 58.36 (n)
  • 57.1 (a)
ogg1 36
  • 46 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1191 35
fruit fly
(Drosophila melanogaster)
Insecta Ogg1 37
  • 36 (a)
Ogg1 35
  • 45.81 (n)
  • 37.09 (a)
Ogg1 36
  • 31 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001854 35
  • 53.76 (n)
  • 46.03 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER127C 35
  • 50.22 (n)
  • 41.06 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05159g 35
  • 46.84 (n)
  • 40.86 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OGG1 35
  • 47.44 (n)
  • 41.64 (a)
OGG1 36
  • 33 (a)
OneToOne
OGG1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons OGG1 35
  • 48.07 (n)
  • 42.24 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03040 35
  • 54.24 (n)
  • 47.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for OGG1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGG1 Gene

ENSEMBL:
Gene Tree for OGG1 (if available)
TreeFam:
Gene Tree for OGG1 (if available)

Paralogs for OGG1 Gene

genes like me logo Genes that share paralogs with OGG1: view

No data available for Paralogs for OGG1 Gene

Variants for OGG1 Gene

Sequence variations from dbSNP and Humsavar for OGG1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs125701 -- 9,748,794(+) AATCC(A/G)CTGCA upstream-variant-2KB
rs159150 -- 9,754,442(-) TTGCT(C/T)CCCTT intron-variant
rs159151 -- 9,753,321(-) tgtcg(C/T)ccagg intron-variant
rs190894 -- 9,775,121(+) tgtaa(C/T)cccag intron-variant
rs293781 -- 9,777,130(+) CTCCC(C/T)GTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OGG1 Gene

Variant ID Type Subtype PubMed ID
nsv821982 CNV Gain 20364138

Variation tolerance for OGG1 Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OGG1 Gene

HapMap Linkage Disequilibrium report
OGG1
Human Gene Mutation Database (HGMD)
OGG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGG1 Gene

Disorders for OGG1 Gene

MalaCards: The human disease database

(22) MalaCards diseases for OGG1 Gene - From: OMIM, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
mucocele of appendix
  • appendicele mucocele
posterior scleritis
  • posterior scleritis [ambiguous]
papillary adenoma
  • glandular papilloma
amyotrophic lateral sclerosis 8
  • amyotrophic lateral sclerosis type 8
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
- elite association
Search OGG1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

OGG1_HUMAN
  • Renal cell carcinoma (RCC) [MIM:144700]: Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Relevant External Links for OGG1

Genetic Association Database (GAD)
OGG1
Human Genome Epidemiology (HuGE) Navigator
OGG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OGG1
genes like me logo Genes that share disorders with OGG1: view

No data available for Genatlas for OGG1 Gene

Publications for OGG1 Gene

  1. Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. (PMID: 9207108) Rosenquist T.A. … Grollman A.P. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 23 67
  2. Folate deficiency alters hepatic and colon MGMT and OGG-1 DNA repair protein expression in rats but has no effect on genome-wide DNA methylation. (PMID: 20051376) Duthie S.J. … Margison G.P. (Cancer Prev Res (Phila) 2010) 23 67
  3. The hOGG1 Ser326Cys polymorphism is not associated with sporadic Parkinson's disease. (PMID: 20193742) CoppedA" F. … Migliore L. (Neurosci. Lett. 2010) 23 67
  4. Genetic alterations in papillary thyroid carcinoma and hashimoto thyroiditis: An analysis of hOGG1 loss of heterozygosity. (PMID: 20231640) Royer M.C. … Kokoska M.S. (Arch. Otolaryngol. Head Neck Surg. 2010) 23 67
  5. Inactivation by oxidation and recruitment into stress granules of hOGG1 but not APE1 in human cells exposed to sub-lethal concentrations of cadmium. (PMID: 19800894) Bravard A. … Radicella J.P. (Mutat. Res. 2010) 23 67

Products for OGG1 Gene

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