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Aliases for OAS1 Gene

Aliases for OAS1 Gene

  • 2'-5'-Oligoadenylate Synthetase 1 2
  • 2-5-Oligoadenylate Synthetase 1 2 3 5
  • 2-5-Oligoadenylate Synthetase 1, 40/46kDa 2 3
  • (2-5)Oligo(A) Synthase 1 3 4
  • 2-5A Synthase 1 3 4
  • E18/E16 3 4
  • OIAS 3 4
  • 2,5-Oligoadenylate Synthetase 1 (40-46 KD) 2
  • 2-5-Oligoisoadenylate Synthetase 1 3
  • 2-5-Oligoadenylate Synthase 1 3
  • E16 (2-5) Oligo A Synthetase 3
  • 2,5-Oligo A Synthetase 1 3
  • 2-5A Synthetase 1 3
  • P46/P42 OAS 4
  • EC 2.7.7.84 4
  • EC 2.7.7 56
  • IFI-4 3
  • OIASI 3

External Ids for OAS1 Gene

Previous HGNC Symbols for OAS1 Gene

  • OIAS

Previous GeneCards Identifiers for OAS1 Gene

  • GC12P112239
  • GC12P112864
  • GC12P113127
  • GC12P111756
  • GC12P111807
  • GC12P113344
  • GC12P110357

Summaries for OAS1 Gene

Entrez Gene Summary for OAS1 Gene

  • This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, Feb 2016]

GeneCards Summary for OAS1 Gene

OAS1 (2'-5'-Oligoadenylate Synthetase 1) is a Protein Coding gene. Diseases associated with OAS1 include Diabetes Mellitus, Insulin-Dependent and Hand, Foot And Mouth Disease. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include RNA binding and transferase activity. An important paralog of this gene is OAS3.

UniProtKB/Swiss-Prot for OAS1 Gene

  • Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2-5-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.

Gene Wiki entry for OAS1 Gene

Additional gene information for OAS1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OAS1 Gene

Genomics for OAS1 Gene

GeneHancer (GH) Regulatory Elements for OAS1 Gene

Promoters and enhancers for OAS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I112905 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 562.2 +0.5 480 3.9 PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 YY1 ZNF143 ATF7 RUNX3 OAS1 GC12M112897 GC12M112917 ENSG00000257452
GH12I112904 Enhancer 0.6 ENCODE 560.8 -2.0 -1986 1 CEBPB REST EP300 BRCA1 RFX5 SP1 MAFF STAT3 ZBTB33 FOSL2 OAS1 GC12M112897 GC12M112885
GH12I113207 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.8 +301.9 301929 2.6 HDGF PKNOX1 ATF1 IRF4 ZNF766 ZNF207 ATF7 RUNX3 RXRA JUNB GC12M113226 PIR32722 PIR59579 PIR32241 RASAL1 OAS1 RITA1 TPCN1 IQCD
GH12I112976 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 6.1 +72.3 72304 5.1 HDGF PKNOX1 FOXA2 RB1 RAD21 RFX5 YY1 ZNF143 ETV6 IKZF2 OAS2 GC12M112972 OAS3 DTX1 OAS1 SLC8B1 SDSL GC12M112984 ENSG00000257452
GH12I112936 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5 +31.0 31049 3 HDGF ATF1 ARID4B SIN3A DMAP1 IRF4 ZNF48 ETS1 YY1 E2F8 OAS3 TRAFD1 OAS1 GC12M112917 ENSG00000257452
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OAS1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OAS1 gene promoter:

Genomic Locations for OAS1 Gene

Genomic Locations for OAS1 Gene
chr12:112,906,777-112,933,222
(GRCh38/hg38)
Size:
26,446 bases
Orientation:
Plus strand
chr12:113,344,582-113,369,990
(GRCh37/hg19)

Genomic View for OAS1 Gene

Genes around OAS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OAS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OAS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OAS1 Gene

Proteins for OAS1 Gene

  • Protein details for OAS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00973-OAS1_HUMAN
    Recommended name:
    2-5-oligoadenylate synthase 1
    Protein Accession:
    P00973
    Secondary Accessions:
    • A8K4N8
    • P04820
    • P29080
    • P29081
    • P78485
    • P78486
    • Q16700
    • Q16701
    • Q1PG42
    • Q3ZM01
    • Q53GC5
    • Q53YA4
    • Q6A1Z3
    • Q6IPC6
    • Q6P7N9
    • Q96J61

    Protein attributes for OAS1 Gene

    Size:
    400 amino acids
    Molecular mass:
    46029 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer (PubMed:9407111). Homotetramer (PubMed:9407111, PubMed:23319625).
    SequenceCaution:
    • Sequence=AAA39857.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA39858.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA59955.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD96726.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA26497.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAA30164.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OAS1 Gene

    Alternative splice isoforms for OAS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OAS1 Gene

Selected DME Specific Peptides for OAS1 Gene

P00973:
  • RPTKLKSLIRLVKHWYQ
  • KVVKGGSSGKGTTL
  • SDADLVVF
  • GEFSTCFT
  • LDPADPT

Post-translational modifications for OAS1 Gene

No Post-translational modifications

Domains & Families for OAS1 Gene

Gene Families for OAS1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P00973

UniProtKB/Swiss-Prot:

OAS1_HUMAN :
  • Belongs to the 2-5A synthase family.
Family:
  • Belongs to the 2-5A synthase family.
genes like me logo Genes that share domains with OAS1: view

Function for OAS1 Gene

Molecular function for OAS1 Gene

GENATLAS Biochemistry:
2,5-oligoisoadenylate synthetase 1,40kDa,46kDa,ubiquitously expressed,interferon induced
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.31 mM for ATP {ECO:0000269 PubMed:12799444};
UniProtKB/Swiss-Prot CatalyticActivity:
3 ATP = pppA2p5A2p5A + 2 diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Produced as a latent enzyme which is activated by dsRNA generated during the course of viral infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2-hydroxyl group is tolerated. ssRNA or dsDNA do not act as activators.
UniProtKB/Swiss-Prot Function:
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2-5-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.
UniProtKB/Swiss-Prot Induction:
By type I interferon (IFN) and viruses.

Enzyme Numbers (IUBMB) for OAS1 Gene

Phenotypes From GWAS Catalog for OAS1 Gene

Gene Ontology (GO) - Molecular Function for OAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001730 2-5-oligoadenylate synthetase activity IDA,IEA 12799444
GO:0003723 RNA binding IEA --
GO:0003725 double-stranded RNA binding IDA,IEA 12799444
GO:0005515 protein binding IPI 15039538
GO:0005524 ATP binding TAS,IEA 21142819
genes like me logo Genes that share ontologies with OAS1: view

Phenotypes for OAS1 Gene

genes like me logo Genes that share phenotypes with OAS1: view

Animal Models for OAS1 Gene

MGI Knock Outs for OAS1:

miRNA for OAS1 Gene

miRTarBase miRNAs that target OAS1

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OAS1 Gene

Localization for OAS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OAS1 Gene

Cytoplasm. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Secreted. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions. {ECO:0000269 PubMed:19923450}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OAS1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
mitochondrion 3
endoplasmic reticulum 3
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for OAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IEA --
GO:0005737 colocalizes_with cytoplasm IEA,IDA 21245038
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with OAS1: view

Pathways & Interactions for OAS1 Gene

genes like me logo Genes that share pathways with OAS1: view

Pathways by source for OAS1 Gene

Gene Ontology (GO) - Biological Process for OAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006006 glucose metabolic process IMP 23575436
GO:0006955 immune response IEA --
GO:0009615 response to virus IDA 18931074
GO:0042593 glucose homeostasis IMP 23575436
genes like me logo Genes that share ontologies with OAS1: view

No data available for SIGNOR curated interactions for OAS1 Gene

Drugs & Compounds for OAS1 Gene

(2) Drugs for OAS1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cysteine-S-Acetamide Experimental Pharma Target 0

(1) Additional Compounds for OAS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with OAS1: view

Transcripts for OAS1 Gene

Unigene Clusters for OAS1 Gene

2-5-oligoadenylate synthetase 1, 40/46kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OAS1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - - -
SP2: -
SP3: - - -
SP4: -
SP5: - -
SP6:
SP7: - - - - - -

Relevant External Links for OAS1 Gene

GeneLoc Exon Structure for
OAS1
ECgene alternative splicing isoforms for
OAS1

Expression for OAS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OAS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OAS1 Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for OAS1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.1), Stomach (16.0), Salivary gland (9.9), Monocytes (9.1), and Spleen (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OAS1 Gene



NURSA nuclear receptor signaling pathways regulating expression of OAS1 Gene:

OAS1

SOURCE GeneReport for Unigene cluster for OAS1 Gene:

Hs.524760

Evidence on tissue expression from TISSUES for OAS1 Gene

  • Intestine(4.6)
  • Blood(4.5)
  • Liver(4.5)
  • Nervous system(4.5)
  • Lung(2.3)
  • Spleen(2)
genes like me logo Genes that share expression patterns with OAS1: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OAS1 Gene

Orthologs for OAS1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OAS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OAS1 33 34
  • 98.67 (n)
dog
(Canis familiaris)
Mammalia OAS1 33 34
  • 77.84 (n)
cow
(Bos Taurus)
Mammalia OAS1X 33
  • 77.81 (n)
OAS1Y 34
  • 67 (a)
OneToMany
OAS1Z 34
  • 65 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Oas1g 33 16 34
  • 75 (n)
Oas1a 34
  • 66 (a)
OneToMany
Oas1b 34
  • 58 (a)
OneToMany
Oas1f 34
  • 55 (a)
OneToMany
Oas1e 34
  • 51 (a)
OneToMany
Oas1c 34
  • 50 (a)
OneToMany
Oas1d 34
  • 50 (a)
OneToMany
Oas1h 34
  • 49 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Oas1a 33
  • 74.58 (n)
oppossum
(Monodelphis domestica)
Mammalia OAS1 34
  • 59 (a)
OneToOne
Species where no ortholog for OAS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OAS1 Gene

ENSEMBL:
Gene Tree for OAS1 (if available)
TreeFam:
Gene Tree for OAS1 (if available)

Paralogs for OAS1 Gene

Paralogs for OAS1 Gene

genes like me logo Genes that share paralogs with OAS1: view

Variants for OAS1 Gene

Sequence variations from dbSNP and Humsavar for OAS1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs10774671 risk-factor, Diabetes mellitus, type 1, susceptibility to 112,919,388(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant, splice_acceptor_variant
rs1131454 risk-factor, Diabetes mellitus, type 1, susceptibility to 112,911,065(+) G/A/C coding_sequence_variant, intron_variant, missense_variant
rs1000101788 -- 112,929,102(+) C/A genic_downstream_transcript_variant, intron_variant
rs1000290508 -- 112,911,094(+) C/G/T coding_sequence_variant, intron_variant, synonymous_variant
rs1000349725 -- 112,929,292(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OAS1 Gene

Variant ID Type Subtype PubMed ID
esv3630790 CNV loss 21293372
nsv1042636 CNV gain 25217958
nsv1047747 CNV gain 25217958
nsv832515 CNV gain 17160897
nsv832516 CNV gain 17160897

Variation tolerance for OAS1 Gene

Residual Variation Intolerance Score: 96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.22; 62.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OAS1 Gene

Human Gene Mutation Database (HGMD)
OAS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OAS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OAS1 Gene

Disorders for OAS1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for OAS1 Gene - From: HGMD, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, insulin-dependent
  • iddm
hand, foot and mouth disease
  • vesicular stomatitis and exanthem
west nile encephalitis
  • west nile fever encephalitis
tick-borne encephalitis
  • central european encephalitis
yellow fever
  • jungle yellow fever
- elite association - COSMIC cancer census association via MalaCards
Search OAS1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OAS1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OAS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OAS1 Gene

Publications for OAS1 Gene

  1. Polymorphism of OAS-1 determines liver fibrosis progression in hepatitis C by reduced ability to inhibit viral replication. (PMID: 19515215) Li CZ … Omata M (Liver international : official journal of the International Association for the Study of the Liver 2009) 3 22 44 58
  2. Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection. (PMID: 19923450) Lin RJ … Lin YL (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 4 22 58
  3. Evolution of the 2'-5'-oligoadenylate synthetase family in eukaryotes and bacteria. (PMID: 19904482) Kjaer KH … Justesen J (Journal of molecular evolution 2009) 3 4 22 58
  4. Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? (PMID: 16014697) Tessier MC … Polychronakos C (Journal of medical genetics 2006) 3 22 44 58
  5. OAS1 gene haplotype confers susceptibility to multiple sclerosis. (PMID: 17092260) Fedetz M … Alcina A (Tissue antigens 2006) 3 22 44 58

Products for OAS1 Gene

Sources for OAS1 Gene

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