Aliases for NTSR1 Gene
External Ids for NTSR1 Gene
Previous GeneCards Identifiers for NTSR1 Gene
Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008]
GeneCards Summary for NTSR1 Gene
NTSR1 (Neurotensin Receptor 1 (High Affinity)) is a Protein Coding gene. Diseases associated with NTSR1 include hyperglycemia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled neurotensin receptor activity. An important paralog of this gene is GPR39.
UniProtKB/Swiss-Prot for NTSR1 Gene
G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.
Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors; the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single transmembrane receptor NTS3 (Sortilin 1). These receptors have many central and peripheral actions including modulation of dopaminergic transmission in nigro-striatal and mesocorticolimbic pathways, modulation of the digestive tract and hypothermic and analgesic effects. NTS1 is distributed widely throughout the brain and gastrointestinal tract, whilst NTS2 is confined to areas of the brain involved in the descending control of nociception, including the periaqueductal gray and dorsal raphe. The human genes encoding NTS1 and NTS2 receptors are located on chromosomes 20q13 and 2p25.1 respectively.