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Aliases for NTS Gene

Aliases for NTS Gene

  • Neurotensin 2 3 5
  • Pro-Neurotensin/Neuromedin 2 3
  • Neuromedin N 2
  • NMN-125 3
  • NT/N 3
  • NTS1 3
  • NT 3
  • NN 3

External Ids for NTS Gene

Previous GeneCards Identifiers for NTS Gene

  • GC12P086784
  • GC12P086201
  • GC12P084770
  • GC12P083324

Summaries for NTS Gene

Entrez Gene Summary for NTS Gene

  • This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014]

GeneCards Summary for NTS Gene

NTS (Neurotensin) is a Protein Coding gene. Diseases associated with NTS include dumping syndrome and duodenogastric reflux. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include neuropeptide hormone activity.

UniProtKB/Swiss-Prot for NTS Gene

  • Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.

Tocris Summary for NTS Gene

  • Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors: the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single transmembrane receptor NTS3 (Sortilin 1).

Gene Wiki entry for NTS Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTS Gene

Genomics for NTS Gene

Regulatory Elements for NTS Gene

Genomic Location for NTS Gene

Chromosome:
12
Start:
85,874,295 bp from pter
End:
85,882,992 bp from pter
Size:
8,698 bases
Orientation:
Plus strand

Genomic View for NTS Gene

Genes around NTS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTS Gene

Proteins for NTS Gene

  • Protein details for NTS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30990-NEUT_HUMAN
    Recommended name:
    Neurotensin/neuromedin N
    Protein Accession:
    P30990

    Protein attributes for NTS Gene

    Size:
    170 amino acids
    Molecular mass:
    19795 Da
    Quaternary structure:
    • Interacts with NTSR1. Interacts with SORT1.

    Three dimensional structures from OCA and Proteopedia for NTS Gene

neXtProt entry for NTS Gene

Proteomics data for NTS Gene at MOPED

Post-translational modifications for NTS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NTS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NTS Gene

Domains & Families for NTS Gene

Gene Families for NTS Gene

Protein Domains for NTS Gene

Suggested Antigen Peptide Sequences for NTS Gene

Graphical View of Domain Structure for InterPro Entry

P30990

UniProtKB/Swiss-Prot:

NEUT_HUMAN :
  • Belongs to the neurotensin family.
Family:
  • Belongs to the neurotensin family.
genes like me logo Genes that share domains with NTS: view

Function for NTS Gene

Molecular function for NTS Gene

GENATLAS Biochemistry:
neurotensin,19.7kDa,tridecapeptide expressed in various brain regions,modulating dopaminergic neuronal activity,and released from the N cells of small intestine,responsible for regulatory and trophic effets,including gut motility
UniProtKB/Swiss-Prot Function:
Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
genes like me logo Genes that share phenotypes with NTS: view

Animal Models for NTS Gene

MGI Knock Outs for NTS:

Animal Model Products

miRNA for NTS Gene

miRTarBase miRNAs that target NTS

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NTS Gene

Localization for NTS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTS Gene

Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Packaged within secretory vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NTS Gene COMPARTMENTS Subcellular localization image for NTS gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NTS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
genes like me logo Genes that share ontologies with NTS: view

Pathways & Interactions for NTS Gene

genes like me logo Genes that share pathways with NTS: view

SIGNOR curated interactions for NTS Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for NTS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0001975 response to amphetamine IEA --
GO:0007165 signal transduction NAS 8954810
GO:0008542 visual learning IEA --
GO:0042220 response to cocaine IEA --
genes like me logo Genes that share ontologies with NTS: view

Drugs & Compounds for NTS Gene

(79) Drugs for NTS Gene - From: Novoseek and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
neurotensin Pharma Full agonist, Agonist Endogenous neurotransmitter and endocrine modulator 0

(61) Additional Compounds for NTS Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
JMV 449
139026-66-7
Kinetensin (human)
103131-69-7
Neuromedin N (rat, mouse, porcine, canine)
92169-45-4
Xenin 8
117442-28-1

(5) Tocris Compounds for NTS Gene

Compound Action Cas Number
JMV 449 Potent neurotensin receptor agonist 139026-66-7
Kinetensin (human) Neurotensin-like peptide 103131-69-7
Neuromedin N (rat, mouse, porcine, canine) Neurotensin-like peptide 92169-45-4
Neurotensin Endogenous neurotransmitter and endocrine modulator 39379-15-2
Xenin 8 Neurotensin-like peptide; potentiates insulin and glucagon secretion 117442-28-1
genes like me logo Genes that share compounds with NTS: view

Transcripts for NTS Gene

mRNA/cDNA for NTS Gene

Unigene Clusters for NTS Gene

Neurotensin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NTS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for NTS Gene

GeneLoc Exon Structure for
NTS
ECgene alternative splicing isoforms for
NTS

Expression for NTS Gene

mRNA expression in normal human tissues for NTS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTS Gene

This gene is overexpressed in Pituitary (x13.7), Brain - Hypothalamus (x10.3), Small Intestine - Terminal Ileum (x8.6), and Brain - Hippocampus (x4.1).

Protein differential expression in normal tissues from HIPED for NTS Gene

This gene is overexpressed in Fetal gut (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NTS Gene



SOURCE GeneReport for Unigene cluster for NTS Gene Hs.80962

genes like me logo Genes that share expression patterns with NTS: view

Protein tissue co-expression partners for NTS Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NTS Gene

Orthologs for NTS Gene

This gene was present in the common ancestor of chordates.

Orthologs for NTS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NTS 35
  • 91.18 (n)
  • 90.59 (a)
NTS 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NTS 35
  • 92.16 (n)
  • 90 (a)
NTS 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nts 35
  • 83.04 (n)
  • 81.66 (a)
Nts 16
Nts 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NTS 35
  • 99.22 (n)
  • 98.82 (a)
NTS 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nts 35
  • 80.47 (n)
  • 77.51 (a)
oppossum
(Monodelphis domestica)
Mammalia NTS 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NTS 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves NTS 35
  • 75.81 (n)
  • 67.07 (a)
NTS 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NTS 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nts 35
  • 71.89 (n)
  • 62.65 (a)
zebrafish
(Danio rerio)
Actinopterygii nts 36
  • 30 (a)
OneToOne
Species with no ortholog for NTS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTS Gene

ENSEMBL:
Gene Tree for NTS (if available)
TreeFam:
Gene Tree for NTS (if available)

Paralogs for NTS Gene

No data available for Paralogs for NTS Gene

Variants for NTS Gene

Sequence variations from dbSNP and Humsavar for NTS Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1050926 -- 85,882,522(+) TAATA(G/T)AAATT utr-variant-3-prime
rs1800832 -- 85,874,401(+) GCTGA(A/G)AGATG utr-variant-5-prime
rs2234762 -- 85,874,237(+) CTGTA(C/G)AATCA upstream-variant-2KB
rs3764039 -- 85,873,672(-) AAAAA(G/T)AAATA upstream-variant-2KB
rs3764040 -- 85,872,347(-) TTCAT(C/T)TTAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NTS Gene

Variant ID Type Subtype PubMed ID
esv1042104 CNV Insertion 17803354

Variation tolerance for NTS Gene

Residual Variation Intolerance Score: 59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NTS Gene

HapMap Linkage Disequilibrium report
NTS
Human Gene Mutation Database (HGMD)
NTS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTS Gene

Disorders for NTS Gene

MalaCards: The human disease database

(27) MalaCards diseases for NTS Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dumping syndrome
  • dumping syndrome
duodenogastric reflux
postgastrectomy syndrome
  • postgastric surgery syndrome
oropouche fever
  • oropouche virus disease
carcinoid syndrome
  • neuroendocrine tumor
- elite association - COSMIC cancer census association via MalaCards
Search NTS in MalaCards View complete list of genes associated with diseases

Relevant External Links for NTS

Genetic Association Database (GAD)
NTS
Human Genome Epidemiology (HuGE) Navigator
NTS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NTS
genes like me logo Genes that share disorders with NTS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NTS Gene

Publications for NTS Gene

  1. Cloning of human neurotensin/neuromedin N genomic sequences and expression in the ventral mesencephalon of schizophrenics and age/sex matched controls. (PMID: 1436492) Bean A.J. … Dobner P.R. (Neuroscience 1992) 3 4 23 67
  2. The regulatory role of neurotensin on the hypothalamic-anterior pituitary axons: emphasis on the control of thyroid-related functions. (PMID: 19878995) Stolakis V. … Liapi C. (Neuropeptides 2010) 3 23
  3. Neurotensin expression and outcome of malignant pleural mesothelioma. (PMID: 19932148) Alifano M. … Forgez P. (Biochimie 2010) 3 23
  4. Genetic association studies of neurotensin gene and restless legs syndrome in French Canadians. (PMID: 17644423) Xiong L. … Rouleau G.A. (Sleep Med. 2008) 3 23
  5. PKD1, PKD2, and their substrate Kidins220 regulate neurotensin secretion in the BON human endocrine cell line. (PMID: 18048355) Li J. … Evers B.M. (J. Biol. Chem. 2008) 3 23

Products for NTS Gene

Sources for NTS Gene

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