Aliases for NTS Gene
External Ids for NTS Gene
Previous GeneCards Identifiers for NTS Gene
This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014]
GeneCards Summary for NTS Gene
NTS (Neurotensin) is a Protein Coding gene. Diseases associated with NTS include duodenogastric reflux and dumping syndrome. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include neuropeptide hormone activity.
UniProtKB/Swiss-Prot for NTS Gene
Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle
Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors; the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single transmembrane receptor NTS3 (Sortilin 1). These receptors have many central and peripheral actions including modulation of dopaminergic transmission in nigro-striatal and mesocorticolimbic pathways, modulation of the digestive tract and hypothermic and analgesic effects.