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Aliases for DDR2 Gene

Aliases for DDR2 Gene

  • Discoidin Domain Receptor Tyrosine Kinase 2 2 3
  • NTRKR3 3 4 6
  • TKT 3 4 6
  • Discoidin Domain-Containing Receptor Tyrosine Kinase 2 3 4
  • Neurotrophic Tyrosine Kinase, Receptor-Related 3 3 4
  • Discoidin Domain Receptor Family, Member 2 2 3
  • Receptor Protein-Tyrosine Kinase TKT 3 4
  • CD167 Antigen-Like Family Member B 3 4
  • Tyrosine-Protein Kinase TYRO10 3 4
  • Discoidin Domain Receptor 2 3 4
  • EC 2.7.10.1 4 63
  • TYRO10 3 4
  • Neurotrophic Tyrosine Kinase Receptor Related 3 3
  • Discoidin Domain-Containing Receptor 2 3
  • Cell Migration-Inducing Protein 20 3
  • Migration-Inducing Gene 16 Protein 3
  • Hydroxyaryl-Protein Kinase 3
  • Tyrosylprotein Kinase 3
  • CD167b Antigen 4
  • EC 2.7.10 63
  • MIG20a 3

External Ids for DDR2 Gene

Previous HGNC Symbols for DDR2 Gene

  • TYRO10
  • NTRKR3

Previous GeneCards Identifiers for DDR2 Gene

  • GC01P160237
  • GC01P158253
  • GC01P159297
  • GC01P159789
  • GC01P159333
  • GC01P160868
  • GC01P162601
  • GC01P133847

Summaries for DDR2 Gene

Entrez Gene Summary for DDR2 Gene

  • Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDR2 Gene

DDR2 (Discoidin Domain Receptor Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with DDR2 include spondyloepimetaphyseal dysplasia - short limb - abnormal calcification and spondylometaepiphyseal dysplasia, short limb-hand type. Among its related pathways are GPCR Pathway and Akt Signaling. GO annotations related to this gene include collagen binding and protein tyrosine kinase collagen receptor activity. An important paralog of this gene is ALK.

UniProtKB/Swiss-Prot for DDR2 Gene

  • Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

Gene Wiki entry for DDR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDR2 Gene

Genomics for DDR2 Gene

Regulatory Elements for DDR2 Gene

Genomic Location for DDR2 Gene

Start:
162,631,265 bp from pter
End:
162,787,400 bp from pter
Size:
156,136 bases
Orientation:
Plus strand

Genomic View for DDR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDR2 Gene

Proteins for DDR2 Gene

  • Protein details for DDR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16832-DDR2_HUMAN
    Recommended name:
    Discoidin domain-containing receptor 2
    Protein Accession:
    Q16832
    Secondary Accessions:
    • Q7Z730

    Protein attributes for DDR2 Gene

    Size:
    855 amino acids
    Molecular mass:
    96736 Da
    Quaternary structure:
    • Binds hydroxyproline-rich sequence motifs in fibrillar, glycosylated collagen, such as the GQOGVMGFO motif, where O stands for hydroxyproline. Interacts with SRC. Interacts (tyrosine phosphorylated) with SHC1.

    Three dimensional structures from OCA and Proteopedia for DDR2 Gene

neXtProt entry for DDR2 Gene

Proteomics data for DDR2 Gene at MOPED

Post-translational modifications for DDR2 Gene

  • N-glycosylated.
  • Tyrosine phosphorylated in response to collagen binding. Phosphorylated by SRC; this is required for activation and subsequent autophosphorylation on additional tyrosine residues.
  • Glycosylation at Asn121, Asn213, Asn261, Asn280, and Asn372
  • Modification sites at PhosphoSitePlus

Other Protein References for DDR2 Gene

Domains for DDR2 Gene

Graphical View of Domain Structure for InterPro Entry

Q16832

UniProtKB/Swiss-Prot:

DDR2_HUMAN :
  • Q16832
Domain:
  • Contains 1 F5/8 type C domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
genes like me logo Genes that share domains with DDR2: view

Function for DDR2 Gene

Molecular function for DDR2 Gene

GENATLAS Biochemistry: discoidin domain recptor family,member 2,expressed in heart and lung
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Present in an inactive state in the absence of collagen binding and phosphorylation by SRC. Tyrosine phosphorylation enhances the affinity for ATP and the catalytic activity.
UniProtKB/Swiss-Prot Function: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
UniProtKB/Swiss-Prot Induction: Up-regulated during osteoblast differentiation (in vitro). Up-regulated in cartilage from osteoarthritis patients.

Enzyme Numbers (IUBMB) for DDR2 Gene

Gene Ontology (GO) - Molecular Function for DDR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IDA 20004161
GO:0005515 protein binding IPI 17703188
GO:0005518 collagen binding IDA 20004161
genes like me logo Genes that share ontologies with DDR2: view
genes like me logo Genes that share phenotypes with DDR2: view

Animal Models for DDR2 Gene

MGI Knock Outs for DDR2:

miRNA for DDR2 Gene

miRTarBase miRNAs that target DDR2

No data available for Transcription Factor Targeting and HOMER Transcription for DDR2 Gene

Localization for DDR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDR2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDR2 Gene COMPARTMENTS Subcellular localization image for DDR2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DDR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0016324 apical plasma membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DDR2: view

Pathways for DDR2 Gene

genes like me logo Genes that share pathways with DDR2: view

Gene Ontology (GO) - Biological Process for DDR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0003416 endochondral bone growth ISS --
GO:0006468 protein phosphorylation --
GO:0007155 cell adhesion TAS 9659899
GO:0007165 signal transduction TAS 9659899
genes like me logo Genes that share ontologies with DDR2: view

Compounds for DDR2 Gene

(2) HMDB Compounds for DDR2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(1) Novoseek inferred chemical compound relationships for DDR2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 66.1 31
genes like me logo Genes that share compounds with DDR2: view

Transcripts for DDR2 Gene

Unigene Clusters for DDR2 Gene

Discoidin domain receptor tyrosine kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDR2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for DDR2 Gene

GeneLoc Exon Structure for
DDR2
ECgene alternative splicing isoforms for
DDR2

Expression for DDR2 Gene

mRNA expression in normal human tissues for DDR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DDR2 Gene

This gene is overexpressed in Adrenal Gland (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDR2 Gene

SOURCE GeneReport for Unigene cluster for DDR2 Gene Hs.275757

mRNA Expression by UniProt/SwissProt for DDR2 Gene

Q16832-DDR2_HUMAN
Tissue specificity: Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney.
genes like me logo Genes that share expressions with DDR2: view

Orthologs for DDR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DDR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDR2 35
  • 99.84 (n)
  • 99.88 (a)
DDR2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDR2 35
  • 92.36 (n)
  • 97.31 (a)
DDR2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDR2 35
  • 92.25 (n)
  • 96.95 (a)
DDR2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddr2 35
  • 90.24 (n)
  • 96.02 (a)
Ddr2 16
Ddr2 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDR2 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDR2 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddr2 35
  • 90.09 (n)
  • 95.43 (a)
chicken
(Gallus gallus)
Aves DDR2 35
  • 76.75 (n)
  • 85.77 (a)
lizard
(Anolis carolinensis)
Reptilia DDR2 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497889 35
  • 75.13 (n)
  • 83.56 (a)
zebrafish
(Danio rerio)
Actinopterygii ddr2a 35
  • 72.78 (n)
  • 79.25 (a)
ddr2a 36
  • 76 (a)
OneToMany
ddr2b 36
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG34380 36
  • 24 (a)
ManyToMany
Ddr 35
  • 49.78 (n)
  • 42.03 (a)
Ddr 36
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ddr-2 35
  • 47.54 (n)
  • 36.81 (a)
ddr-2 36
  • 33 (a)
OneToMany
F11D5.3a 37
  • 32 (a)
F11D5.3b 37
  • 32 (a)
C25F6.4 37
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1149 36
  • 37 (a)
OneToMany
Species with no ortholog for DDR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDR2 Gene

ENSEMBL:
Gene Tree for DDR2 (if available)
TreeFam:
Gene Tree for DDR2 (if available)

Paralogs for DDR2 Gene

Paralogs for DDR2 Gene

Selected SIMAP similar genes for DDR2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DDR2: view

Variants for DDR2 Gene

Sequence variations from dbSNP and Humsavar for DDR2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2332 -- 162,744,185(+) tctct(G/T)aacaa intron-variant
rs2333 -- 162,744,207(+) taata(C/T)accgt intron-variant
rs11338 -- 162,784,259(+) AGGAA(A/G)TATGC utr-variant-3-prime
rs12311 -- 162,784,045(+) AAACA(C/T)CAAAA utr-variant-3-prime
rs15941 -- 162,780,244(+) ACGAG(C/T)GATGC stop-lost, reference

Structural Variations from Database of Genomic Variants (DGV) for DDR2 Gene

Variant ID Type Subtype PubMed ID
nsv516482 CNV Gain+Loss 19592680
nsv3299 CNV Insertion 18451855
esv268951 CNV Insertion 20981092

Relevant External Links for DDR2 Gene

HapMap Linkage Disequilibrium report
DDR2
Human Gene Mutation Database (HGMD)
DDR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDR2 Gene

Disorders for DDR2 Gene

(1) OMIM Diseases for DDR2 Gene (191311)

UniProtKB/Swiss-Prot

DDR2_HUMAN
  • Spondyloepimetaphyseal dysplasia short limb-hand type (SEMD-SL) [MIM:271665]: A bone disease characterized by short-limbed dwarfism, a narrow chest with pectus excavatum, brachydactyly in the hands and feet, a characteristic craniofacial appearance and premature calcifications. The radiological findings are distinctive and comprise short long bones throughout the skeleton with striking epiphyses that are stippled, flattened and fragmented and flared, irregular metaphyses. Platyspondyly in the spine with wide intervertebral spaces is observed and some vertebral bodies are pear-shaped with central humps, anterior protrusions and posterior scalloping. {ECO:0000269 PubMed:19110212, ECO:0000269 PubMed:20223752}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for DDR2 Gene

(5) Novoseek inferred disease relationships for DDR2 Gene

Disease -log(P) Hits PubMed IDs
osteoarthritis 44.4 6
liver fibrosis 42.9 3
fibrosarcoma 26.4 1
atherosclerosis 0 1
tumors 0 3

Relevant External Links for DDR2

Genetic Association Database (GAD)
DDR2
Human Genome Epidemiology (HuGE) Navigator
DDR2
genes like me logo Genes that share disorders with DDR2: view

Publications for DDR2 Gene

  1. Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII- like domain. (PMID: 8247548) Karn T. … Strebhardt K. (Oncogene 1993) 3 4 23
  2. Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen. (PMID: 16186104) Wall S.J. … DeClerck Y.A. (J. Biol. Chem. 2005) 3 4 23
  3. Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation. (PMID: 16186108) Yang K. … Yang B.S. (J. Biol. Chem. 2005) 3 4 23
  4. Structural basis of the collagen-binding mode of discoidin domain receptor 2. (PMID: 17703188) Ichikawa O. … Shimada I. (EMBO J. 2007) 3 4 23
  5. Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen. (PMID: 18201965) Konitsiotis A.D. … Leitinger B. (J. Biol. Chem. 2008) 3 4 23

Products for DDR2 Gene

  • Addgene plasmids for DDR2

Sources for DDR2 Gene

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