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Aliases for ROR1 Gene

Aliases for ROR1 Gene

  • Receptor Tyrosine Kinase Like Orphan Receptor 1 2 3 5
  • Neurotrophic Tyrosine Kinase, Receptor-Related 1 3 4
  • NTRKR1 3 4
  • Inactive Tyrosine-Protein Kinase Transmembrane Receptor ROR1 3
  • EC 2.7.10.1 58
  • DJ537F10.1 3

External Ids for ROR1 Gene

Previous HGNC Symbols for ROR1 Gene

  • NTRKR1

Previous GeneCards Identifiers for ROR1 Gene

  • GC01P064171
  • GC01P063159
  • GC01P063597
  • GC01P063609
  • GC01P063951
  • GC01P062347
  • GC01P064239

Summaries for ROR1 Gene

Entrez Gene Summary for ROR1 Gene

  • This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

GeneCards Summary for ROR1 Gene

ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1) is a Protein Coding gene. Diseases associated with ROR1 include Deafness, Autosomal Recessive 108 and Mantle Cell Lymphoma. Among its related pathways are Akt Signaling and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ROR2.

UniProtKB/Swiss-Prot for ROR1 Gene

  • Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.

Gene Wiki entry for ROR1 Gene

Additional gene information for ROR1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ROR1 Gene

Genomics for ROR1 Gene

Regulatory Elements for ROR1 Gene

Enhancers for ROR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H063522 1.2 ENCODE 18.4 -250.6 -250563 2 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 ZC3H11A NFYC ITGB3BP EFCAB7 ALG6 DLEU2L DOCK7 ROR1 FOXD3-AS1 FOXD3 ENSG00000235545 ATG4C
GH01H063730 1.4 FANTOM5 Ensembl ENCODE 10.9 -42.7 -42664 4 INSM2 KLF17 SIN3A BMI1 ETS1 SCRT2 FOS KLF7 DEK CEBPB ROR1 EFCAB7 ATG4C GC01M063731 GC01M063690
GH01H063746 1.2 Ensembl ENCODE 12 -27.3 -27345 2 INSM2 KLF17 FEZF1 ZNF2 ZNF366 ZSCAN5C FOS KLF7 EGR2 CEBPB DLEU2L ROR1 ITGB3BP UBE2U GC01M063731 GC01P063754
GH01H063793 1.1 Ensembl ENCODE dbSUPER 12 +20.9 20871 2 ZIC2 ZSCAN21 OSR2 ZSCAN16 ZNF692 ZNF341 PRDM10 ZNF600 WT1 SP7 ROR1 UBE2U GC01M063770 GC01P063805
GH01H063691 1.1 Ensembl ENCODE 10.9 -81.8 -81824 1 CTCF ZNF175 ZNF384 CEBPG ZBTB40 RAD21 RFX5 CTBP1 SCRT2 SMC3 ROR1 GC01M063690 GC01M063731
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ROR1 on UCSC Golden Path with GeneCards custom track

Promoters for ROR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000007724 881 2201 ARID4B SIN3A FEZF1 ZNF2 GLIS2 KLF7 MXD4 NFYC REST KAT8

Genomic Location for ROR1 Gene

Chromosome:
1
Start:
63,774,019 bp from pter
End:
64,181,498 bp from pter
Size:
407,480 bases
Orientation:
Plus strand

Genomic View for ROR1 Gene

Genes around ROR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ROR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ROR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ROR1 Gene

Proteins for ROR1 Gene

  • Protein details for ROR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01973-ROR1_HUMAN
    Recommended name:
    Inactive tyrosine-protein kinase transmembrane receptor ROR1
    Protein Accession:
    Q01973
    Secondary Accessions:
    • Q5VVX6
    • Q66K77
    • Q92776

    Protein attributes for ROR1 Gene

    Size:
    937 amino acids
    Molecular mass:
    104283 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ROR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ROR1 Gene

Selected DME Specific Peptides for ROR1 Gene

Q01973:
  • GVVLWEI
  • GLQPYYG

Post-translational modifications for ROR1 Gene

  • Glycosylation at Asn47, isoforms=366, Asn184, and isoforms=3315
  • Modification sites at PhosphoSitePlus

Other Protein References for ROR1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ROR1 (ROR1)

Domains & Families for ROR1 Gene

Suggested Antigen Peptide Sequences for ROR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q01973

UniProtKB/Swiss-Prot:

ROR1_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
genes like me logo Genes that share domains with ROR1: view

Function for ROR1 Gene

Molecular function for ROR1 Gene

GENATLAS Biochemistry:
receptor tyrosine kinase-like orphan receptor 1,with strong homology to the tyrosine kinase domain of growth factor-receptors (TRK),RTK superfamily
UniProtKB/Swiss-Prot Function:
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.

Enzyme Numbers (IUBMB) for ROR1 Gene

Phenotypes From GWAS Catalog for ROR1 Gene

Gene Ontology (GO) - Molecular Function for ROR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity TAS 8875995
GO:0005515 protein binding IPI 22439932
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with ROR1: view
genes like me logo Genes that share phenotypes with ROR1: view

Animal Models for ROR1 Gene

MGI Knock Outs for ROR1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ROR1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ROR1 Gene

Localization for ROR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ROR1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ROR1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (1)
  • Microtubules (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ROR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS 1334494
GO:0005887 integral component of plasma membrane TAS 1334494
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with ROR1: view

Pathways & Interactions for ROR1 Gene

genes like me logo Genes that share pathways with ROR1: view

SIGNOR curated interactions for ROR1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for ROR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
GO:0014002 astrocyte development IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with ROR1: view

Drugs & Compounds for ROR1 Gene

(1) Drugs for ROR1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Nutra Agonist 0

(1) Additional Compounds for ROR1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with ROR1: view

Transcripts for ROR1 Gene

Unigene Clusters for ROR1 Gene

Receptor tyrosine kinase-like orphan receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ROR1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ROR1 Gene

No ASD Table

Relevant External Links for ROR1 Gene

GeneLoc Exon Structure for
ROR1
ECgene alternative splicing isoforms for
ROR1

Expression for ROR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ROR1 Gene

mRNA differential expression in normal tissues according to GTEx for ROR1 Gene

This gene is overexpressed in Artery - Tibial (x5.4).

Protein differential expression in normal tissues from HIPED for ROR1 Gene

This gene is overexpressed in Serum (34.5) and Synovial fluid (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ROR1 Gene



NURSA nuclear receptor signaling pathways regulating expression of ROR1 Gene:

ROR1

SOURCE GeneReport for Unigene cluster for ROR1 Gene:

Hs.128753

mRNA Expression by UniProt/SwissProt for ROR1 Gene:

Q01973-ROR1_HUMAN
Tissue specificity: Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.

Evidence on tissue expression from TISSUES for ROR1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ROR1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ROR1 Gene

Orthologs for ROR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ROR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ROR1 33 34
  • 99.52 (n)
oppossum
(Monodelphis domestica)
Mammalia ROR1 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ROR1 33 34
  • 93.06 (n)
dog
(Canis familiaris)
Mammalia ROR1 33 34
  • 91.56 (n)
mouse
(Mus musculus)
Mammalia Ror1 33 16 34
  • 89.1 (n)
rat
(Rattus norvegicus)
Mammalia Ror1 33
  • 88.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ROR1 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ROR1 33 34
  • 81.25 (n)
lizard
(Anolis carolinensis)
Reptilia ROR1 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ror1 33
  • 77.45 (n)
zebrafish
(Danio rerio)
Actinopterygii ror1 33 34
  • 70.28 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006219 33
  • 53.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ror 35 33 34
  • 51.53 (n)
worm
(Caenorhabditis elegans)
Secernentea cam-1 34
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13123 33
Species where no ortholog for ROR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ROR1 Gene

ENSEMBL:
Gene Tree for ROR1 (if available)
TreeFam:
Gene Tree for ROR1 (if available)

Paralogs for ROR1 Gene

Paralogs for ROR1 Gene

genes like me logo Genes that share paralogs with ROR1: view

Variants for ROR1 Gene

Sequence variations from dbSNP and Humsavar for ROR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035713 A breast cancer sample
VAR_041779 A metastatic melanoma sample
VAR_041780 An ovarian mucinous carcinoma sample
VAR_041781 A renal clear cell carcinoma sample
VAR_041783 A colorectal adenocarcinoma sample

Structural Variations from Database of Genomic Variants (DGV) for ROR1 Gene

Variant ID Type Subtype PubMed ID
esv2664106 CNV deletion 23128226
esv2676273 CNV deletion 23128226
esv2749085 CNV deletion 23290073
esv3305358 CNV mobile element insertion 20981092
esv3309693 CNV mobile element insertion 20981092
esv3376683 CNV insertion 20981092
esv3411421 CNV insertion 20981092
esv3431289 CNV insertion 20981092
esv3586248 CNV gain 21293372
esv3586249 CNV loss 21293372
esv3586250 CNV loss 21293372
esv3586252 CNV loss 21293372
esv8740 CNV gain 19470904
esv993189 CNV deletion 20482838
nsv1154 CNV deletion 18451855
nsv823087 CNV loss 20364138
nsv830037 CNV gain 17160897
nsv945976 CNV duplication 23825009
nsv945977 CNV duplication 23825009

Variation tolerance for ROR1 Gene

Residual Variation Intolerance Score: 9.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.73; 89.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ROR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ROR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ROR1 Gene

Disorders for ROR1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ROR1 Gene - From: OMIM, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal recessive 108
mantle cell lymphoma
  • lymphoma, mantle cell
- elite association - COSMIC cancer census association via MalaCards
Search ROR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ROR1

Genetic Association Database (GAD)
ROR1
Human Genome Epidemiology (HuGE) Navigator
ROR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ROR1
genes like me logo Genes that share disorders with ROR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ROR1 Gene

Publications for ROR1 Gene

  1. Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains. (PMID: 8875995) Reddy UR … Pleasure D (Oncogene 1996) 2 3 4 22 60
  2. A novel family of cell surface receptors with tyrosine kinase-like domain. (PMID: 1334494) Masiakowski P … Carroll RD (The Journal of biological chemistry 1992) 2 3 4 60
  3. Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains. (PMID: 25029443) Bainbridge TW … Ernst JA (PloS one 2014) 3 4 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60

Products for ROR1 Gene

Sources for ROR1 Gene

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