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Aliases for ROR1 Gene

Aliases for ROR1 Gene

  • Receptor Tyrosine Kinase-Like Orphan Receptor 1 2 3
  • Neurotrophic Tyrosine Kinase, Receptor-Related 1 3 4
  • EC 2.7.10.1 4 64
  • NTRKR1 3 4
  • Tyrosine-Protein Kinase Transmembrane Receptor ROR1 3
  • DJ537F10.1 3
  • NTRKR1, 6

External Ids for ROR1 Gene

Previous Symbols for ROR1 Gene

  • NTRKR1

Summaries for ROR1 Gene

Entrez Gene Summary for ROR1 Gene

  • This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

GeneCards Summary for ROR1 Gene

ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Signaling by GPCR. GO annotations related to this gene include transmembrane receptor protein tyrosine kinase activity and Wnt-protein binding. An important paralog of this gene is ALK.

UniProtKB/Swiss-Prot for ROR1 Gene

  • Tyrosine-protein kinase receptor whose role is not yet clear

Gene Wiki entry for ROR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ROR1 Gene

Genomics for ROR1 Gene

Genomic Location for ROR1 Gene

Start:
63,774,019 bp from pter
End:
64,181,498 bp from pter
Size:
407,480 bases
Orientation:
Plus strand

Genomic View for ROR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ROR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ROR1 Gene

Regulatory Elements for ROR1 Gene

Proteins for ROR1 Gene

  • Protein details for ROR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01973-ROR1_HUMAN
    Recommended name:
    Tyrosine-protein kinase transmembrane receptor ROR1
    Protein Accession:
    Q01973
    Secondary Accessions:
    • Q5VVX6
    • Q66K77
    • Q92776

    Protein attributes for ROR1 Gene

    Size:
    937 amino acids
    Molecular mass:
    104283 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ROR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ROR1 Gene

Proteomics data for ROR1 Gene at MOPED

Selected DME Specific Peptides for ROR1 Gene

Post-translational modifications for ROR1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn47, Asn66, Asn184, and Asn315

Other Protein References for ROR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ROR1 Gene

Gene Families for ROR1 Gene

UniProtKB/Swiss-Prot:

ROR1_HUMAN
Domain:
  • Contains 1 FZ (frizzled) domain.:
    • Q01973
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • Q01973
  • Contains 1 kringle domain.:
    • Q01973
  • Contains 1 protein kinase domain.:
    • Q01973
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.:
    • Q01973
genes like me logo Genes that share domains with ROR1: view

Function for ROR1 Gene

Molecular function for ROR1 Gene

GENATLAS Biochemistry: receptor tyrosine kinase-like orphan receptor 1,with strong homology to the tyrosine kinase domain of growth factor-receptors (TRK),RTK superfamily
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Tyrosine-protein kinase receptor whose role is not yet clear

Enzyme Numbers (IUBMB) for ROR1 Gene

Gene Ontology (GO) - Molecular Function for ROR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA --
GO:0005515 protein binding IPI 22439932
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ROR1: view
genes like me logo Genes that share phenotypes with ROR1: view

Animal Models for ROR1 Gene

MGI Knock Outs for ROR1:

miRNA for ROR1 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for ROR1 Gene

Localization for ROR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ROR1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ROR1 Gene COMPARTMENTS Subcellular localization image for ROR1 gene
Compartment Confidence
plasma membrane 4
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ROR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8875995
GO:0005886 plasma membrane TAS 1334494
GO:0005887 integral component of plasma membrane TAS 1334494
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with ROR1: view

Pathways for ROR1 Gene

genes like me logo Genes that share pathways with ROR1: view

Pathways by source for ROR1 Gene

1 R&D Systems pathway for ROR1 Gene
1 Cell Signaling Technology pathway for ROR1 Gene

Gene Ontology (GO) - Biological Process for ROR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
GO:0018108 peptidyl-tyrosine phosphorylation TAS 8875995
genes like me logo Genes that share ontologies with ROR1: view

Compounds for ROR1 Gene

(2) HMDB Compounds for ROR1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with ROR1: view

Transcripts for ROR1 Gene

Unigene Clusters for ROR1 Gene

Receptor tyrosine kinase-like orphan receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ROR1 Gene

No ASD Table

Relevant External Links for ROR1 Gene

GeneLoc Exon Structure for
ROR1
ECgene alternative splicing isoforms for
ROR1

Expression for ROR1 Gene

mRNA expression in normal human tissues for ROR1 Gene

mRNA differential expression in normal tissues according to GTEx for ROR1 Gene

This gene is overexpressed in Artery - Tibial (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ROR1 Gene

SOURCE GeneReport for Unigene cluster for ROR1 Gene Hs.128753

mRNA Expression by UniProt/SwissProt for ROR1 Gene

Q01973-ROR1_HUMAN
Tissue specificity: Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm
genes like me logo Genes that share expressions with ROR1: view

Orthologs for ROR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ROR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ROR1 36
  • 99.52 (n)
  • 100 (a)
ROR1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ROR1 36
  • 93.06 (n)
  • 98.03 (a)
ROR1 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ROR1 36
  • 91.56 (n)
  • 97.92 (a)
ROR1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ror1 36
  • 89.1 (n)
  • 96.92 (a)
Ror1 16
Ror1 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ROR1 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ROR1 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ror1 36
  • 88.36 (n)
  • 96.7 (a)
chicken
(Gallus gallus)
Aves ROR1 36
  • 81.25 (n)
  • 92.99 (a)
ROR1 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ROR1 37
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ror1 36
  • 77.45 (n)
  • 88.08 (a)
zebrafish
(Danio rerio)
Actinopterygii ror1 36
  • 70.28 (n)
  • 76.46 (a)
ror1 37
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006219 36
  • 53.71 (n)
  • 50.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ror 36
  • 51.53 (n)
  • 49.47 (a)
Ror 37
  • 37 (a)
OneToMany
Ror 38
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea cam-1 37
  • 28 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13123 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
ManyToMany
-- 37
  • 39 (a)
ManyToMany
Species with no ortholog for ROR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ROR1 Gene

ENSEMBL:
Gene Tree for ROR1 (if available)
TreeFam:
Gene Tree for ROR1 (if available)

Paralogs for ROR1 Gene

Paralogs for ROR1 Gene

genes like me logo Genes that share paralogs with ROR1: view

Variants for ROR1 Gene

Sequence variations from dbSNP and Humsavar for ROR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs285335 -- 63,969,942(+) TGCCC(A/T)CTTTT intron-variant
rs285336 -- 63,970,470(+) GTTCT(C/G)TTGGT intron-variant
rs285337 -- 63,970,936(+) TTAGC(C/T)CTAAC intron-variant
rs285338 -- 63,975,930(+) ACTTT(C/T)GTGGG intron-variant
rs285339 -- 63,976,497(+) CTAAT(A/G)TGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ROR1 Gene

Variant ID Type Subtype PubMed ID
esv8740 CNV Gain 19470904
nsv830037 CNV Gain 17160897
nsv871828 CNV Gain 21882294
esv2664106 CNV Deletion 23128226
nsv1154 CNV Loss 18451855
nsv823087 CNV Loss 20364138
esv2749085 CNV Deletion 23290073
esv2676273 CNV Deletion 23128226
esv273965 CNV Insertion 20981092
esv269636 CNV Insertion 20981092
esv993189 CNV Deletion 20482838
nsv871805 CNV Loss 21882294

Relevant External Links for ROR1 Gene

HapMap Linkage Disequilibrium report
ROR1

Disorders for ROR1 Gene

(1) University of Copenhagen DISEASES for ROR1 Gene

Relevant External Links for ROR1

Genetic Association Database (GAD)
ROR1
Human Genome Epidemiology (HuGE) Navigator
ROR1
genes like me logo Genes that share disorders with ROR1: view

No data available for UniProtKB/Swiss-Prot for ROR1 Gene

Publications for ROR1 Gene

  1. Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains. (PMID: 8875995) Reddy U.R. … Pleasure D. (Oncogene 1996) 2 3 4 23
  2. A novel family of cell surface receptors with tyrosine kinase-like domain. (PMID: 1334494) Masiakowski P. … Carroll R.D. (J. Biol. Chem. 1992) 2 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis. (PMID: 9143508) Reddy U.R. … Biegel J.A. (Genomics 1997) 3 23
  5. Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy. (PMID: 18546292) Daneshmanesh A.H. … Rabbani H. (Int. J. Cancer 2008) 3 23

Products for ROR1 Gene

Sources for ROR1 Gene

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