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Aliases for NTRK3 Gene

Aliases for NTRK3 Gene

  • Neurotrophic Receptor Tyrosine Kinase 3 2 3 5
  • Neurotrophic Tyrosine Kinase, Receptor, Type 3 2 3
  • EC 4 58
  • GP145-TrkC 3 4
  • TRKC 3 4
  • ETS Related Protein-Neurotrophic Receptor Tyrosine Kinase Fusion Protein 3
  • Neurotrophic Tyrosine Kinase Receptor Type 3 4
  • NT-3 Growth Factor Receptor 3
  • Tyrosine Kinase Receptor C 3
  • TrkC Tyrosine Kinase 4
  • ETV6-NTRK3 Fusion 3
  • Gp145(TrkC) 3
  • EC 2.7.10 58
  • Trk-C 4

External Ids for NTRK3 Gene

Previous GeneCards Identifiers for NTRK3 Gene

  • GC15M084556
  • GC15M081649
  • GC15M086007
  • GC15M086149
  • GC15M086221
  • GC15M088402
  • GC15M064532
  • GC15M088418

Summaries for NTRK3 Gene

Entrez Gene Summary for NTRK3 Gene

  • This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

CIViC summary for NTRK3 Gene

GeneCards Summary for NTRK3 Gene

NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with NTRK3 include Differentiated Thyroid Carcinoma and Cerebral Sarcoma. Among its related pathways are p70S6K Signaling and Akt Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NTRK2.

UniProtKB/Swiss-Prot for NTRK3 Gene

  • Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.

Gene Wiki entry for NTRK3 Gene

Additional gene information for NTRK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTRK3 Gene

Genomics for NTRK3 Gene

Regulatory Elements for NTRK3 Gene

Enhancers for NTRK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H088380 0.5 dbSUPER 6.5 -127.1 -127068 6.1 ZFHX2 CTBP1 NFIB FOS EGR2 MRPS11 MRPL46 ENSG00000173867 NTRK3 LOC105370959
GH15H088255 0.5 FANTOM5 4.7 +1.5 1521 0.2 MXI1 EZH2 NTRK3 NTRK3-AS1
GH15H088010 0.3 FANTOM5 3.6 +246.4 246385 0.3 NTRK3 MED28P6 GC15M087860
GH15H088302 0.5 FANTOM5 2 -45.5 -45472 0.4 ZFHX2 EGR2 NTRK3 LOC105370958 LOC105370959
GH15H088256 0.6 ENCODE 0.7 +1.0 1012 0.2 MXI1 ZNF341 CTBP2 SIN3A ZIC2 ZBTB26 EZH2 NTRK3-AS1 NTRK3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NTRK3 on UCSC Golden Path with GeneCards custom track

Promoters for NTRK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000080754 496 201 CTCF ZNF692 ZNF341 CTBP2 ZNF600 ZBTB7A EZH2

Transcription factor binding sites by QIAGEN in the NTRK3 gene promoter:

Genomic Locations for NTRK3 Gene

Genomic Locations for NTRK3 Gene
397,046 bases
Minus strand

Genomic View for NTRK3 Gene

Genes around NTRK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTRK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTRK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTRK3 Gene

Proteins for NTRK3 Gene

  • Protein details for NTRK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NT-3 growth factor receptor
    Protein Accession:
    Secondary Accessions:
    • B7Z4C5
    • E9PG56
    • H0YND1
    • O75682
    • Q12827
    • Q16289

    Protein attributes for NTRK3 Gene

    839 amino acids
    Molecular mass:
    94428 Da
    Quaternary structure:
    • Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts with PTPRS (PubMed:25385546).

    Three dimensional structures from OCA and Proteopedia for NTRK3 Gene

    Alternative splice isoforms for NTRK3 Gene


neXtProt entry for NTRK3 Gene

Selected DME Specific Peptides for NTRK3 Gene


Post-translational modifications for NTRK3 Gene

  • Ligand-mediated auto-phosphorylation.
  • Glycosylation at posLast=7272, Asn79, posLast=133133, posLast=163163, posLast=203203, posLast=218218, Asn232, Asn259, Asn267, Asn272, Asn294, posLast=375375, and posLast=388388
  • Modification sites at PhosphoSitePlus

Domains & Families for NTRK3 Gene

Gene Families for NTRK3 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
genes like me logo Genes that share domains with NTRK3: view

Function for NTRK3 Gene

Molecular function for NTRK3 Gene

GENATLAS Biochemistry:
receptor tyrosine kinase C,linking neurotrophin 3 (NTF3),containing a CGG repeat in 5utr,with a translocation t(12;15)(p13;q25) in congenital fibrosarcoma (CFS) and in congenital mesoblastic nephroma (CMN),involved in the survival and differentiation of nervous system and heart,and in tumour development
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.

Enzyme Numbers (IUBMB) for NTRK3 Gene

Phenotypes From GWAS Catalog for NTRK3 Gene

Gene Ontology (GO) - Molecular Function for NTRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 23027130
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA --
GO:0005004 GPI-linked ephrin receptor activity IEA --
genes like me logo Genes that share ontologies with NTRK3: view
genes like me logo Genes that share phenotypes with NTRK3: view

Animal Models for NTRK3 Gene

MGI Knock Outs for NTRK3:

Animal Model Products

Clone Products

  • Addgene plasmids for NTRK3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NTRK3 Gene

Localization for NTRK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTRK3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NTRK3 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
nucleus 3
cytosol 3
extracellular 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NTRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NTRK3: view

Pathways & Interactions for NTRK3 Gene

genes like me logo Genes that share pathways with NTRK3: view

SIGNOR curated interactions for NTRK3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NTRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 23027130
GO:0001764 neuron migration IEA --
GO:0001933 negative regulation of protein phosphorylation IDA 23027130
GO:0001934 positive regulation of protein phosphorylation TAS 19036963
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with NTRK3: view

Drugs & Compounds for NTRK3 Gene

(15) Drugs for NTRK3 Gene - From: ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Crizotinib Approved Pharma C-MET/ALK inhibitor,potent and ATP-competitve, cMET Inhibitors, Kinase Inhibitors, Anaplastic lymphoma kinase (ALK) inhibitor 106
neurotrophin-3 Pharma 0
tyrosine Nutra 728
7,8-Dihydroxyflavone Pharma 0
BDNF (human) Pharma 0

(9) Additional Compounds for NTRK3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(4) ApexBio Compounds for NTRK3 Gene

Compound Action Cas Number
7,8-Dihydroxyflavone 38183-03-8
BDNF (human) 218441-99-7
LM 22A4 37988-18-4
NTR 368 197230-90-3
genes like me logo Genes that share compounds with NTRK3: view

Drug Products

Transcripts for NTRK3 Gene

Unigene Clusters for NTRK3 Gene

Neurotrophic tyrosine kinase, receptor, type 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for NTRK3

Alternative Splicing Database (ASD) splice patterns (SP) for NTRK3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
SP1: - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -

ExUns: 24b

Relevant External Links for NTRK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NTRK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NTRK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTRK3 Gene

This gene is overexpressed in Artery - Tibial (x6.0) and Artery - Coronary (x4.2).

Protein differential expression in normal tissues from HIPED for NTRK3 Gene

This gene is overexpressed in Frontal cortex (29.9), Fetal Brain (17.7), and Brain (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NTRK3 Gene

Protein tissue co-expression partners for NTRK3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NTRK3 Gene:


SOURCE GeneReport for Unigene cluster for NTRK3 Gene:


mRNA Expression by UniProt/SwissProt for NTRK3 Gene:

Tissue specificity: Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.

Evidence on tissue expression from TISSUES for NTRK3 Gene

  • Nervous system(4.9)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NTRK3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • endocrine
  • skeleton
Head and neck:
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
  • thyroid
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
  • pelvis
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with NTRK3: view

Orthologs for NTRK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NTRK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NTRK3 33 34
  • 99.39 (n)
(Bos Taurus)
Mammalia -- 34
  • 97 (a)
NTRK3 33 34
  • 92.98 (n)
(Monodelphis domestica)
Mammalia NTRK3 34
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 94 (a)
-- 34
  • 85 (a)
(Canis familiaris)
Mammalia NTRK3 33 34
  • 91.45 (n)
(Mus musculus)
Mammalia Ntrk3 33 16 34
  • 91.03 (n)
(Rattus norvegicus)
Mammalia Ntrk3 33
  • 90.98 (n)
(Gallus gallus)
Aves NTRK3 33 34
  • 82.12 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 90 (a)
-- 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ntrk3 33
  • 75.09 (n)
(Danio rerio)
Actinopterygii ntrk3b 34
  • 77 (a)
ntrk3a 33 34
  • 71.42 (n)
ntrk1 33
(Caenorhabditis elegans)
Secernentea Y69E1A.3 35
  • 33 (a)
trk-1 34
  • 22 (a)
Species where no ortholog for NTRK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NTRK3 Gene

Gene Tree for NTRK3 (if available)
Gene Tree for NTRK3 (if available)

Paralogs for NTRK3 Gene

Paralogs for NTRK3 Gene

genes like me logo Genes that share paralogs with NTRK3: view

Variants for NTRK3 Gene

Sequence variations from dbSNP and Humsavar for NTRK3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs368222977 A gastric adenocarcinoma sample 88,147,353(+) TCAGC(A/C/G)TCTGG nc-transcript-variant, reference, missense
VAR_041473 A lung adenocarcinoma sample
VAR_041474 A lung adenocarcinoma sample
VAR_041475 A lung adenocarcinoma sample
VAR_046521 A lung carcinoma sample

Structural Variations from Database of Genomic Variants (DGV) for NTRK3 Gene

Variant ID Type Subtype PubMed ID
nsv952021 CNV deletion 24416366
nsv952020 CNV duplication 24416366
nsv94255 CNV deletion 16902084
nsv827427 CNV gain 20364138
nsv527970 CNV gain 19592680
nsv1108973 CNV deletion 24896259
esv3637167 CNV loss 21293372
esv3637165 CNV loss 21293372
esv3552816 CNV deletion 23714750
esv3386964 CNV insertion 20981092
esv3307702 CNV mobile element insertion 20981092
esv2749991 CNV deletion 23290073
esv2608620 CNV deletion 19546169

Variation tolerance for NTRK3 Gene

Residual Variation Intolerance Score: 3.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NTRK3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTRK3 Gene

Disorders for NTRK3 Gene

MalaCards: The human disease database

(30) MalaCards diseases for NTRK3 Gene - From: HGMD, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
cerebral sarcoma
  • fibrosarcoma
congenital mesoblastic nephroma
  • nephroma, mesoblastic
congenital fibrosarcoma
  • infantile fibrosarcoma
pediatric fibrosarcoma
  • childhood fibrosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search NTRK3 in MalaCards View complete list of genes associated with diseases


  • Note=Defects in NTRK3 are associated with susceptibility to congenital heart defects (CHD). A disease characterized by congenital developmental abnormalities involving structures of the heart. CHD are the most common major birth defects and the leading cause of death from congenital malformations. {ECO:0000269 PubMed:25196463}.

Relevant External Links for NTRK3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Tumor Gene Database (TGDB):
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NTRK3: view

No data available for Genatlas for NTRK3 Gene

Publications for NTRK3 Gene

  1. Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant. (PMID: 7806211) McGregor LM … Nelkin BD (Genomics 1994) 2 3 4 22 60
  2. A novel point variant in NTRK3, R645C, suggests a role of this gene in the pathogenesis of Hirschsprung disease. (PMID: 19040714) Fernández RM … Borrego S (Annals of human genetics 2009) 3 22 45 60
  3. Evidence for a possible association of neurotrophin receptor (NTRK-3) gene polymorphisms with hippocampal function and schizophrenia. (PMID: 19344762) Otnaess MK … Andreassen OA (Neurobiology of disease 2009) 3 22 45 60
  4. Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders. (PMID: 19370765) Muiños-Gimeno M … Espinosa-Parrilla Y (Human mutation 2009) 3 22 45 60
  5. Association of the neurotrophic tyrosine kinase receptor 3 (NTRK3) gene and childhood-onset mood disorders. (PMID: 18347002) Feng Y … International Consortium for Childhood-Onset Mood Disorders (The American journal of psychiatry 2008) 3 22 45 60

Products for NTRK3 Gene

  • Addgene plasmids for NTRK3

Sources for NTRK3 Gene

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