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Aliases for NTRK2 Gene

Aliases for NTRK2 Gene

  • Neurotrophic Tyrosine Kinase, Receptor, Type 2 2 3
  • TRKB 3 4 6
  • Tropomyosin-Related Kinase B 3 4
  • EC 2.7.10.1 4 64
  • GP145-TrkB 3 4
  • Trk-B 3 4
  • Neurotrophic Tyrosine Kinase Receptor Type 2 4
  • BDNF-Tropomyosine Receptor Kinase B 3
  • BDNF/NT-3 Growth Factors Receptor 3
  • Tyrosine Kinase Receptor B 3
  • TrkB Tyrosine Kinase 4
  • EC 2.7.10 64

External Ids for NTRK2 Gene

Summaries for NTRK2 Gene

Entrez Gene Summary for NTRK2 Gene

  • This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for NTRK2 Gene

NTRK2 (Neurotrophic Tyrosine Kinase, Receptor, Type 2) is a Protein Coding gene. Diseases associated with NTRK2 include obesity, hyperphagia, and developmental delay and pilocytic astrocytoma. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein homodimerization activity and neurotrophin binding. An important paralog of this gene is ALK.

UniProtKB/Swiss-Prot for NTRK2 Gene

  • Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.

Tocris Summary for NTRK2 Gene

  • Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI 3-K and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor. p75NTR lacks tyrosine kinase activity and signals via NF-kappaB activation. Each family member binds different neurotrophins with varying affinities. TrkA potently binds nerve growth factor (NGF) and is involved in differentiation and survival of neurons and in control of gene expression of enzymes involved in neurotransmitter synthesis. TrkB has highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. TrkC is activated by neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons. p75NTR binds neurotrophin precursors with high affinity and retains low affinity to the mature cleaved forms. TrkA was originally identified as an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas.

Gene Wiki entry for NTRK2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTRK2 Gene

Genomics for NTRK2 Gene

Genomic Location for NTRK2 Gene

Start:
84,668,502 bp from pter
End:
85,027,070 bp from pter
Size:
358,569 bases
Orientation:
Plus strand

Genomic View for NTRK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NTRK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTRK2 Gene

Regulatory Elements for NTRK2 Gene

Transcription factor binding sites by QIAGEN in the NTRK2 gene promoter:

Proteins for NTRK2 Gene

  • Protein details for NTRK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16620-NTRK2_HUMAN
    Recommended name:
    BDNF/NT-3 growth factors receptor
    Protein Accession:
    Q16620
    Secondary Accessions:
    • B1ANZ4
    • B4DFV9
    • Q16675
    • Q59GJ1
    • Q8WXJ5
    • Q8WXJ6
    • Q8WXJ7

    Protein attributes for NTRK2 Gene

    Size:
    822 amino acids
    Molecular mass:
    91999 Da
    Quaternary structure:
    • Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Interacts (phosphorylated upon activation by BDNF) with SHC1; mediates SHC1 phosphorylation and activation. Interacts (phosphorylated upon activation by BDNF) with PLCG1 and/or PLCG2; mediates PLCG1 phosphorylation and activation. Interacts with SH2B1 and SH2B2. Interacts with NGFR; may regulate the ligand specificity of the receptor. Interacts (phosphorylated upon ligand-binding) with SH2D1A; regulates NTRK2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts (phosphorylated upon ligand-binding) with FRS2; activates the MAPK signaling pathway.
    Miscellaneous:
    • Trk also stands for tropomyosin-related kinase since the first Trk was isolated as an oncogenic protein which was the result of a fusion between the tropomyosin gene TPM3 and NTRK1

    Three dimensional structures from OCA and Proteopedia for NTRK2 Gene

    Alternative splice isoforms for NTRK2 Gene

neXtProt entry for NTRK2 Gene

Proteomics data for NTRK2 Gene at MOPED

Post-translational modifications for NTRK2 Gene

  • Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors. Isoform TrkB-T-Shc is not phosphorylated.
  • Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor (By similarity).
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn67, Asn95, Asn121, Asn178, Asn205, Asn241, Asn254, Asn280, Asn325, Asn338, and Asn412

Domains for NTRK2 Gene

Gene Families for NTRK2 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing
IUPHAR :

UniProtKB/Swiss-Prot:

NTRK2_HUMAN
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q16620
  • Contains 1 LRRCT domain.:
    • Q16620
  • Contains 1 LRRNT domain.:
    • Q16620
  • Contains 1 protein kinase domain.:
    • Q16620
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.:
    • Q16620
Similarity:
  • Contains 2 LRR (leucine-rich) repeats.:
    • Q16620
genes like me logo Genes that share domains with NTRK2: view

Function for NTRK2 Gene

Molecular function for NTRK2 Gene

GENATLAS Biochemistry: receptor tyrosine kinase B,linking brain derived neurotrophic factor (BDNF),neurotrophin (NTF4)
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: The neuronal activity and the influx of calcium positively regulate the kinase activity and the internalization of the receptor which are both important for active signaling. Regulated by NGFR that may control the internalization of the receptor. NGFR may also stimulate the activation by BDNF compared to NTF3 and NTF4. SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades. The formation of active receptors dimers able to fully transduce the ligand-mediated signal, may be negatively regulated by the formation of inactive heterodimers with the non-catalytic isoforms (By similarity).
UniProtKB/Swiss-Prot Function: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.

Enzyme Numbers (IUBMB) for NTRK2 Gene

Gene Ontology (GO) - Molecular Function for NTRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0004714 transmembrane receptor protein tyrosine kinase activity --
GO:0005030 neurotrophin receptor activity --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with NTRK2: view
genes like me logo Genes that share phenotypes with NTRK2: view

Animal Models for NTRK2 Gene

MGI Knock Outs for NTRK2:

miRNA for NTRK2 Gene

miRTarBase miRNAs that target NTRK2

No data available for Transcription Factor Targeting and HOMER Transcription for NTRK2 Gene

Localization for NTRK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTRK2 Gene

Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Note=Internalized to endosomes upon ligand-binding. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NTRK2 Gene COMPARTMENTS Subcellular localization image for NTRK2 gene
Compartment Confidence
endosome 5
plasma membrane 5
cytoskeleton 2
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NTRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005768 endosome --
GO:0005791 rough endoplasmic reticulum IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane --
genes like me logo Genes that share ontologies with NTRK2: view

Pathways for NTRK2 Gene

genes like me logo Genes that share pathways with NTRK2: view

Gene Ontology (GO) - Biological Process for NTRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IEA --
GO:0001764 neuron migration ISS --
GO:0006468 protein phosphorylation --
GO:0006954 inflammatory response IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS --
genes like me logo Genes that share ontologies with NTRK2: view

Compounds for NTRK2 Gene

(5) Tocris Compounds for NTRK2 Gene

Compound Action Cas Number
7,8-Dihydroxyflavone TrkB agonist [38183-03-8]
ANA 12 TrkB receptor antagonist [219766-25-3]
BDNF (human) Activates TrkB and p75 receptors [218441-99-7]
GNF 5837 Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC [1033769-28-6]
TLQP 21 VGF-derived peptide [869988-94-3]

(2) HMDB Compounds for NTRK2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(1) Drugbank Compounds for NTRK2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Amitriptyline
  • Amitriprolidine
50-48-6 target agonist

(53) Novoseek inferred chemical compound relationships for NTRK2 Gene

Compound -log(P) Hits PubMed IDs
k252a 88.8 19
tyrosine 82.5 149
lestaurtinib 75 1
liga 20 67.1 2
nmda 46.2 17

(1) PharmGKB related drug/compound annotations for NTRK2 Gene

Drug/compound Annotation
methadone CA
genes like me logo Genes that share compounds with NTRK2: view

Transcripts for NTRK2 Gene

Unigene Clusters for NTRK2 Gene

Neurotrophic tyrosine kinase, receptor, type 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NTRK2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - -
SP7:
SP8:
SP9: -
SP10:

ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b
SP1: - - -
SP2: -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for NTRK2 Gene

GeneLoc Exon Structure for
NTRK2
ECgene alternative splicing isoforms for
NTRK2

Expression for NTRK2 Gene

mRNA expression in normal human tissues for NTRK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTRK2 Gene

This gene is overexpressed in Brain - Amygdala (6.6), Brain - Caudate (basal ganglia) (5.2), Brain - Nucleus accumbens (basal ganglia) (4.9), and Brain - Putamen (basal ganglia) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NTRK2 Gene

SOURCE GeneReport for Unigene cluster for NTRK2 Gene Hs.494312

mRNA Expression by UniProt/SwissProt for NTRK2 Gene

Q16620-NTRK2_HUMAN
Tissue specificity: Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain.
genes like me logo Genes that share expressions with NTRK2: view

Orthologs for NTRK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NTRK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTRK2 36
  • 99.56 (n)
  • 100 (a)
NTRK2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NTRK2 36
  • 91.61 (n)
  • 92.54 (a)
NTRK2 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NTRK2 36
  • 92.88 (n)
  • 98.33 (a)
NTRK2 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ntrk2 36
  • 87.62 (n)
  • 94.03 (a)
Ntrk2 16
Ntrk2 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NTRK2 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NTRK2 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ntrk2 36
  • 87.54 (n)
  • 93.67 (a)
chicken
(Gallus gallus)
Aves NTRK2 36
  • 76.98 (n)
  • 78 (a)
NTRK2 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NTRK2 37
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia trkb-B-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ntrk2 36
  • 68.01 (n)
  • 71.88 (a)
Str.17749 36
zebrafish
(Danio rerio)
Actinopterygii ntrk2a 37
  • 63 (a)
OneToMany
ntrk2b 36
  • 64.79 (n)
  • 64.71 (a)
ntrk2b 37
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trk-1 37
  • 22 (a)
OneToMany
Species with no ortholog for NTRK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NTRK2 Gene

ENSEMBL:
Gene Tree for NTRK2 (if available)
TreeFam:
Gene Tree for NTRK2 (if available)

Paralogs for NTRK2 Gene

Paralogs for NTRK2 Gene

Selected SIMAP similar genes for NTRK2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NTRK2: view

Variants for NTRK2 Gene

Sequence variations from dbSNP and Humsavar for NTRK2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1221 -- 84,877,695(-) GGTCC(A/G)CTCCC intron-variant, utr-variant-3-prime
rs2265 -- 84,716,691(-) GATTT(A/G)GGAGA intron-variant
rs2409 -- 85,025,574(-) AAAGA(G/T)TCAAA utr-variant-3-prime
rs3654 -- 84,815,576(-) TACAG(A/G)AAATG utr-variant-3-prime, intron-variant
rs7816 -- 84,815,606(-) TAAAA(A/T)TTTTT utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NTRK2 Gene

Variant ID Type Subtype PubMed ID
nsv436717 OTHER Inversion 17901297
esv2667995 CNV Deletion 23128226
esv2434739 CNV Deletion 19546169
esv2214442 CNV Deletion 18987734
esv1009365 CNV Deletion 20482838
esv2738670 CNV Deletion 23290073
esv2424316 CNV Deletion 19546169
esv1919120 CNV Deletion 18987734
esv23628 CNV Loss 19812545
esv2662088 CNV Deletion 23128226
esv267573 CNV Insertion 20981092
esv2738671 CNV Deletion 23290073
esv4028 CNV Deletion 18987735
esv7446 CNV Loss 19470904
esv2738672 CNV Deletion 23290073
esv2533224 CNV Insertion 19546169
esv273858 CNV Insertion 20981092
esv269202 CNV Insertion 20981092
esv994018 CNV Gain 20482838
esv23418 CNV Loss 19812545

Relevant External Links for NTRK2 Gene

HapMap Linkage Disequilibrium report
NTRK2
Human Gene Mutation Database (HGMD)
NTRK2

Disorders for NTRK2 Gene

(1) OMIM Diseases for NTRK2 Gene (600456)

UniProtKB/Swiss-Prot

NTRK2_HUMAN
  • Obesity, hyperphagia, and developmental delay (OBHD) [MIM:613886]: A disorder characterized by early-onset obesity, hyperphagia, and severe developmental delay in motor function, speech, and language. {ECO:0000269 PubMed:15494731}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for NTRK2 Gene

(49) Novoseek inferred disease relationships for NTRK2 Gene

Disease -log(P) Hits PubMed IDs
sensory neuropathy hereditary 50.1 1
neurodegenerative diseases 45.7 1
medulloblastoma 41.3 4
ganglioneuroma 34.2 2
dysautonomia familial 33.3 3

Relevant External Links for NTRK2

Genetic Association Database (GAD)
NTRK2
Human Genome Epidemiology (HuGE) Navigator
NTRK2
Tumor Gene Database (TGDB):
NTRK2
genes like me logo Genes that share disorders with NTRK2: view

Publications for NTRK2 Gene

  1. Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2). (PMID: 7789988) Nakagawara A. … Brodeur G.M. (Genomics 1995) 2 3 4 23
  2. A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. (PMID: 15494731) Yeo G.S. … Farooqi I.S. (Nat. Neurosci. 2004) 3 4 23
  3. Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, harm avoidance and minimum body mass index. (PMID: 15838534) Ribases M. … Estivill X. (Mol. Psychiatry 2005) 3 23 49
  4. Association of specific haplotypes of neurotrophic tyrosine kinase receptor 2 gene (NTRK2) with vulnerability to nicotine dependence in African-Americans and European-Americans. (PMID: 16713586) Beuten J. … Li M.D. (Biol. Psychiatry 2007) 3 23 49
  5. Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence. (PMID: 17200667) Xu K. … Lipsky R.H. (Pharmacogenomics J. 2007) 3 23 49

Products for NTRK2 Gene

  • Addgene plasmids for NTRK2

Sources for NTRK2 Gene

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