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Aliases for NTF4 Gene

Aliases for NTF4 Gene

  • Neurotrophin 4 2 3 5
  • Neurotrophin 5 (Neurotrophin 4/5) 2 3
  • Neurotrophic Factor 4 2 3
  • Neutrophic Factor 4 3 4
  • Neurotrophin-5 3 4
  • NTF5 3 4
  • NT-4 3 4
  • NT-5 3 4
  • Neurotrophic Factor 5 3
  • NT-4/5 3
  • GLC10 3
  • GLC1O 3
  • NT5 3
  • NT4 3

External Ids for NTF4 Gene

Previous HGNC Symbols for NTF4 Gene

  • NTF5

Previous GeneCards Identifiers for NTF4 Gene

  • GC19M054257
  • GC19M049564
  • GC19M045941
  • GC19M049565

Summaries for NTF4 Gene

Entrez Gene Summary for NTF4 Gene

  • This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]

GeneCards Summary for NTF4 Gene

NTF4 (Neurotrophin 4) is a Protein Coding gene. Diseases associated with NTF4 include Glaucoma 1, Open Angle, 1O and Open-Angle Glaucoma. Among its related pathways are p70S6K Signaling and ERK Signaling. GO annotations related to this gene include receptor binding and neurotrophin p75 receptor binding. An important paralog of this gene is BDNF.

UniProtKB/Swiss-Prot for NTF4 Gene

  • Target-derived survival factor for peripheral sensory sympathetic neurons.

Gene Wiki entry for NTF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTF4 Gene

Genomics for NTF4 Gene

Regulatory Elements for NTF4 Gene

Enhancers for NTF4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NTF4 on UCSC Golden Path with GeneCards custom track

Promoters for NTF4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NTF4 on UCSC Golden Path with GeneCards custom track

Genomic Location for NTF4 Gene

49,055,793 bp from pter
49,065,076 bp from pter
9,284 bases
Minus strand

Genomic View for NTF4 Gene

Genes around NTF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTF4 Gene

Proteins for NTF4 Gene

  • Protein details for NTF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6FH56

    Protein attributes for NTF4 Gene

    210 amino acids
    Molecular mass:
    22427 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NTF4 Gene

neXtProt entry for NTF4 Gene

Proteomics data for NTF4 Gene at MOPED

Post-translational modifications for NTF4 Gene

  • Glycosylation at Asn 76
  • Modification sites at PhosphoSitePlus

Other Protein References for NTF4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NTF4 Gene

Domains & Families for NTF4 Gene

Gene Families for NTF4 Gene

Suggested Antigen Peptide Sequences for NTF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NGF-beta family.
  • Belongs to the NGF-beta family.
genes like me logo Genes that share domains with NTF4: view

Function for NTF4 Gene

Molecular function for NTF4 Gene

UniProtKB/Swiss-Prot Function:
Target-derived survival factor for peripheral sensory sympathetic neurons.

LifeMap Function Summary for NTF4 Gene

NTF4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
genes like me logo Genes that share phenotypes with NTF4: view

Human Phenotype Ontology for NTF4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NTF4 Gene

MGI Knock Outs for NTF4:

Animal Model Products

CRISPR Products

miRNA for NTF4 Gene

miRTarBase miRNAs that target NTF4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for NTF4 Gene

Localization for NTF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTF4 Gene


Subcellular locations from

Jensen Localization Image for NTF4 Gene COMPARTMENTS Subcellular localization image for NTF4 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
nucleus 3
cytoskeleton 2
cytosol 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for NTF4 Gene

Pathways & Interactions for NTF4 Gene

genes like me logo Genes that share pathways with NTF4: view

Interacting Proteins for NTF4 Gene

SIGNOR curated interactions for NTF4 Gene


Gene Ontology (GO) - Biological Process for NTF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0007267 cell-cell signaling IBA --
GO:0007402 ganglion mother cell fate determination IEA,ISS 10681461
GO:0008544 epidermis development IEA,ISS 9973328
GO:0042490 mechanoreceptor differentiation IEA --
genes like me logo Genes that share ontologies with NTF4: view

Drugs & Compounds for NTF4 Gene

(16) Drugs for NTF4 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AV411 Investigational Pharma Target 0

(5) Additional Compounds for NTF4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NTF4: view

Transcripts for NTF4 Gene

mRNA/cDNA for NTF4 Gene

Unigene Clusters for NTF4 Gene

Neurotrophin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NTF4 Gene

No ASD Table

Relevant External Links for NTF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NTF4 Gene

mRNA expression in normal human tissues for NTF4 Gene

mRNA differential expression in normal tissues according to GTEx for NTF4 Gene

This gene is overexpressed in Prostate (x7.3), Skin - Not Sun Exposed (Suprapubic) (x7.1), Skin - Sun Exposed (Lower leg) (x5.7), Esophagus - Mucosa (x5.0), Muscle - Skeletal (x4.4), Vagina (x4.2), and Bladder (x4.1).

Protein differential expression in normal tissues from HIPED for NTF4 Gene

This gene is overexpressed in Breast (46.1) and Pancreatic juice (21.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NTF4 Gene

SOURCE GeneReport for Unigene cluster for NTF4 Gene Hs.266902

mRNA Expression by UniProt/SwissProt for NTF4 Gene

Tissue specificity: Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.
genes like me logo Genes that share expression patterns with NTF4: view

Protein tissue co-expression partners for NTF4 Gene

Primer Products

Orthologs for NTF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NTF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NTF4 35
  • 88.41 (n)
  • 90.48 (a)
NTF4 36
  • 86 (a)
(Canis familiaris)
Mammalia NTF4 35
  • 88.73 (n)
  • 93.33 (a)
NTF4 36
  • 93 (a)
(Mus musculus)
Mammalia Ntf5 35
  • 83.73 (n)
  • 89.47 (a)
Ntf5 16
Ntf5 36
  • 91 (a)
(Pan troglodytes)
Mammalia NTF4 35
  • 100 (n)
  • 100 (a)
NTF4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ntf4 35
  • 84.05 (n)
  • 89.47 (a)
(Monodelphis domestica)
Mammalia NTF4 36
  • 76 (a)
(Anolis carolinensis)
Reptilia NTF4 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ntf4 35
  • 56.13 (n)
  • 57.47 (a)
(Danio rerio)
Actinopterygii NTF4 36
  • 50 (a)
Species with no ortholog for NTF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTF4 Gene

Gene Tree for NTF4 (if available)
Gene Tree for NTF4 (if available)

Paralogs for NTF4 Gene

Paralogs for NTF4 Gene

(3) SIMAP similar genes for NTF4 Gene using alignment to 4 proteins: Pseudogenes for NTF4 Gene

genes like me logo Genes that share paralogs with NTF4: view

Variants for NTF4 Gene

Sequence variations from dbSNP and Humsavar for NTF4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_063196 -
VAR_063197 -
VAR_063198 -
VAR_063199 -
VAR_063200 -

Structural Variations from Database of Genomic Variants (DGV) for NTF4 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833857 CNV Loss 17160897
nsv912248 CNV Loss 21882294
dgv3970n71 CNV Loss 21882294
nsv833859 CNV Loss 17160897
nsv912251 CNV Loss 21882294
nsv912252 CNV Loss 21882294
nsv520785 CNV Gain 19592680
nsv912254 CNV Loss 21882294
nsv912255 CNV Loss 21882294
nsv912256 CNV Loss 21882294

Variation tolerance for NTF4 Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.00; 74.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NTF4 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTF4 Gene

Disorders for NTF4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NTF4 Gene - From: OMIM, ClinVar, GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
glaucoma 1, open angle, 1o
  • glaucoma 1, open angle, o
open-angle glaucoma
  • glaucoma simplex
chronic cystitis
juvenile glaucoma
  • glaucoma of childhood
glaucoma 1, open angle, e
  • primary open angle glaucoma
- elite association - COSMIC cancer census association via MalaCards
Search NTF4 in MalaCards View complete list of genes associated with diseases


  • Glaucoma 1, open angle, O (GLC1O) [MIM:613100]: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. {ECO:0000269 PubMed:19765683, ECO:0000269 PubMed:20215012}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Relevant External Links for NTF4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NTF4: view

No data available for Genatlas for NTF4 Gene

Publications for NTF4 Gene

  1. Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma. (PMID: 19765683) Pasutto F. … Reis A. (Am. J. Hum. Genet. 2009) 3 4 23 67
  2. Human chromosome 19 contains the neurotrophin-5 gene locus and three related genes that may encode novel acidic neurotrophins. (PMID: 1496419) Berkemeier L.R. … Rosenthal A. (Somat. Cell Mol. Genet. 1992) 2 3 23
  3. Differential expression and regulation by activin of the neurotrophins BDNF and NT4 during human and mouse ovarian development. (PMID: 20175187) Childs A.J. … Anderson R.A. (Dev. Dyn. 2010) 3 23
  4. Effect of neurotrophin-4/5 on bone/cementum-related protein expressions and DNA synthesis in cultures of human periodontal ligament cells. (PMID: 18980528) Mizuno N. … Kurihara H. (J. Periodontol. 2008) 3 23
  5. Neurotrophin effects on intracellular Ca2+ and force in airway smooth muscle. (PMID: 16648236) Prakash Y.S. … Pabelick C.M. (Am. J. Physiol. Lung Cell Mol. Physiol. 2006) 3 23

Products for NTF4 Gene

Sources for NTF4 Gene