Aliases for NTF3 Gene
Aliases for NTF3 Gene
External Ids for NTF3 Gene
- HGNC: 8023
- Entrez Gene: 4908
- Ensembl: ENSG00000185652
- OMIM: 162660
- UniProtKB: P20783
Previous GeneCards Identifiers for NTF3 Gene
- GC12U990064
- GC12P005487
- GC12P005420
- GC12P005473
- GC12P005541
Summaries for NTF3 Gene
-
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
GeneCards Summary for NTF3 Gene
NTF3 (Neurotrophin 3) is a Protein Coding gene. Diseases associated with NTF3 include Hypochondriasis and Diabetic Neuropathy. Among its related pathways are Trk receptor signaling mediated by the MAPK pathway and GPCR Pathway. GO annotations related to this gene include receptor binding and chemoattractant activity. An important paralog of this gene is BDNF.
UniProtKB/Swiss-Prot for NTF3 Gene
-
Seems to promote the survival of visceral and proprioceptive sensory neurons.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTF3 Gene
Genomics for NTF3 Gene
Regulatory Elements for NTF3 Gene
Enhancers for NTF3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH12G005429 | 1.4 | FANTOM5 ENCODE dbSUPER | 16.5 | +0.1 | 76 | 6.0 | ZSCAN4 YY1 GLIS2 SCRT2 EGR2 ZNF263 REST ZNF398 SMARCA4 ZNF341 | NTF3 KCNA5 GC12M005446 |
| GH12G005455 | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 13.5 | +24.9 | 24908 | 2.8 | CTCF RFX1 NFIB BMI1 NFIC POLR2A SMARCA4 ZBTB33 SPI1 | NTF3 GC12M005446 GC12P005469 |
| GH12G006391 | 1.2 | Ensembl ENCODE dbSUPER | 9.7 | +960.3 | 960323 | 2.1 | ZNF362 ZBTB40 ATF2 ZBTB49 ZNF121 ZNF791 MAFF POLR2A KDM5B RBFOX2 | LTBR ENSG00000219410 LOC105369628 TNFRSF1A CD27 NCAPD2 SCARNA10 C12orf57 VAMP1 PHB2 |
| GH12G005496 | 0.9 | ENCODE dbSUPER | 11.2 | +66.9 | 66938 | 4.6 | BHLHE40 CEBPB MAX GABPA YY1 JUND ATF3 HNF4G FOS ZBTB33 | NTF3 GC12M005501 GC12M005461 |
| GH12G005806 | 0.9 | FANTOM5 ENCODE | 9.6 | +376.0 | 375967 | 4.1 | HLF USF2 BCL11B HIC1 ZNF664 SCRT2 FOS EGR2 | NTF3 GC12P005823 GC12P005770 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around NTF3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for NTF3 Gene
- Chromosome:
- 12
- Start:
- 5,432,112 bp from pter
- End:
- 5,521,536 bp from pter
- Size:
- 89,425 bases
- Orientation:
- Plus strand
Genomic View for NTF3 Gene
Genes around NTF3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.31 by Ensembl
- 12p13.31 by Entrez Gene
- 12p13.31 by HGNC
NTF3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NTF3 Gene
Proteins for NTF3 Gene
-
Protein details for NTF3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P20783-NTF3_HUMAN
- Recommended name:
- Neurotrophin-3
- Protein Accession:
- P20783
- B7Z1T5
- Q6FH50
Protein attributes for NTF3 Gene
- Size:
- 257 amino acids
- Molecular mass:
- 29355 Da
- Quaternary structure:
- No Data Available
Three dimensional structures from OCA and Proteopedia for NTF3 Gene
Protein Expression for NTF3 Gene
Post-translational modifications for NTF3 Gene
Other Protein References for NTF3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for NTF3
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-
Cloud-Clone Corp. Antibodies for NTF3
- Invitrogen Antibodies for NTF3
- antibodies-online Antibodies for NTF3: See all 182
- GeneTex NTF3 antibody for NTF3
-
Santa Cruz Biotechnology (SCBT) Antibodies for NTF3
Protein Products
- EMD Millipore Purified and/or Recombinant NTF3 Protein
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-
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-
Cloud-Clone Corp. Proteins for NTF3
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-
ProSci Proteins for NTF3
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for NTF3
- R&D Systems ELISAs and other biochemical assays for NTF3 (NT-3)
- antibodies-online Kits for NTF3: See all 92
-
Abcam assays for NTF3
No data available for DME Specific Peptides for NTF3 Gene
Domains & Families for NTF3 Gene
Gene Families for NTF3 Gene
- HGNC:
Protein Domains for NTF3 Gene
Suggested Antigen Peptide Sequences for NTF3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P20783- Family:
-
- Belongs to the NGF-beta family.
Function for NTF3 Gene
Molecular function for NTF3 Gene
- GENATLAS Biochemistry:
- neurotrophic factor (neurotrophin) 3,29.3kDa,ligand for NTRK3 (TRKC),expressed in retina and the anterior segment of the developing eye
- UniProtKB/Swiss-Prot Function:
- Seems to promote the survival of visceral and proprioceptive sensory neurons.
LifeMap Function Summary for NTF3 Gene
NTF3 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Neurons
- Spinal Cord
- Brain
- Glial Cells
- Peripheral Nervous System
-
and also in
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | receptor binding | TAS | 2236018 |
| GO:0005165 | neurotrophin receptor binding | IEA | -- |
| GO:0005166 | neurotrophin p75 receptor binding | IBA | -- |
| GO:0005515 | protein binding | IPI | -- |
| GO:0008083 | growth factor activity | IDA | 23027130 |
Phenotypes for NTF3 Gene
- MGI mutant phenotypes for NTF3:
- inferred from 10 alleles
- GenomeRNAi human phenotypes for NTF3:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability in esophageal squamous lineage
- Decreased viability ratio
- Decreased NF-kappaB reporter expression
- Increased shRNA abundance (Z-score > 2)
- Decreased viability after Maraba virus infection
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for NTF3 Gene
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for NTF3 gene
-
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CRISPR Products
-
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-
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miRNA for NTF3 Gene
- miRTarBase miRNAs that target NTF3
miRNA Products
- Search ViGene Biosciences for NTF3
Inhibitory RNA Products
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Clone Products
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Cell Line Products
-
Horizon Cell Lines for NTF3
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NTF3 Gene
Localization for NTF3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NTF3 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IBA,IEA | -- |
| GO:0031410 | cytoplasmic vesicle | IBA | -- |
Pathways & Interactions for NTF3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 2 | GPCR Pathway |
.73
.62
|
.55
|
| 3 | ERK Signaling |
.61
.58
|
.49
|
| 4 | TGF-Beta Pathway |
.60
.57
|
.51
|
| 5 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
Pathways by source for NTF3 Gene
4 BioSystems pathways for NTF3 Gene
2 KEGG pathways for NTF3 Gene
2 GeneGo (Thomson Reuters) pathways for NTF3 Gene
2 R&D Systems pathways for NTF3 Gene
Interacting Proteins for NTF3 Gene
Selected Interacting proteins:
ENSP00000397297
P20783-NTF3_HUMAN
for NTF3 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | IDA | 23027130 |
| GO:0002092 | positive regulation of receptor internalization | IDA | 23027130 |
| GO:0007165 | signal transduction | TAS | 2236018 |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IDA | 23027130 |
| GO:0007267 | cell-cell signaling | TAS | 2236018 |
Drugs & Compounds for NTF3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| AV411 | Investigational | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for NTF3 Gene
mRNA/cDNA for NTF3 Gene
- (3) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (5) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NTF3 Gene
- Neurotrophin 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for NTF3
-
Santa Cruz Biotechnology (SCBT) CRISPR for NTF3
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miRNA Products
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Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for NTF3
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-
ViGene Biosciences ready-to-package AAV shRNAs for NTF3 gene
Clone Products
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Flow Cytometry Products
Expression for NTF3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Spinal Cord (Nervous System)
- VA2 Fibrous Astrocyte Cells Spinal Cord White Matter
- VA3 Fibrous Astrocyte Cells Spinal Cord White Matter
- VA1 Fibrous Astrocyte Cells Spinal Cord White Matter
- Motor neuron progenitor cells(Rossi SL et. al. 2010)
-
Glial Cells
- VA2 Fibrous Astrocyte Cells Spinal Cord White Matter
- VA3 Fibrous Astrocyte Cells Spinal Cord White Matter
- VA1 Fibrous Astrocyte Cells Spinal Cord White Matter
- Schwann-like cells(Martens W et. al. 2013)
- Neural Tube (Nervous System)
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Epithelial Cells
- Basal Cells Trachea
-
Ovary (Reproductive System)
- Ovarian Somatic Cells Ovigerous Cord
- Brain (Nervous System)
- Neural Ectoderm (Nervous System)
- Motor Neurons (Nervous System)
- Neurons
- Peripheral Nervous System (Nervous System)
mRNA differential expression in normal tissues according to GTEx for NTF3 Gene
This gene is overexpressed in Artery - Tibial (x8.1), Artery - Aorta (x6.2), and Artery - Coronary (x6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NTF3 Gene
NURSA nuclear receptor signaling pathways regulating expression of NTF3 Gene:
NTF3SOURCE GeneReport for Unigene cluster for NTF3 Gene:
Hs.99171mRNA Expression by UniProt/SwissProt for NTF3 Gene:
P20783-NTF3_HUMAN
Tissue specificity:
Brain and peripheral tissues.
Evidence on tissue expression from TISSUES for NTF3 Gene
- Nervous system(4.7)
- Blood(4.2)
- Muscle(2.3)
- Adrenal gland(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for NTF3
-
OriGene qPCR primer pairs for NTF3
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NTF3 Gene
Orthologs for NTF3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NTF3 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NTF3 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NTF3 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ntf3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ntf3 34 16 35 |
|
||
| cow (Bos Taurus) |
Mammalia | NTF3 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | NT-3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NTF3 35 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | NTF3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ntf3 34 |
|
||
| Str.3752 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.1074 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ntf3 35 34 |
|
OneToOne |
- Species where no ortholog for NTF3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for NTF3 Gene
Variants for NTF3 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for NTF3 Gene
- NTF3_HUMAN-P20783
- Variant Glu-76 (frequently reported as Glu-63) was thought to be associated with severe forms of schizophrenia. This does not seem to be the case.
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs540320780 | Uncertain significance | 5,494,440(+) | GGGGA(A/G)GGCCC | reference, missense | |
| rs1000021071 | -- | 5,453,330(+) | CCAGC(A/T)CTCTC | intron-variant | |
| rs1000075380 | -- | 5,460,408(+) | GTTTC(A/G)CCTTT | intron-variant | |
| rs1000114211 | -- | 5,474,007(+) | ACCTT(G/T)AAAGG | intron-variant | |
| rs1000135888 | -- | 5,469,381(+) | TGCTG(C/T)GAAGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1348n100 | CNV | gain | 25217958 |
| esv2559368 | CNV | insertion | 19546169 |
| esv3358188 | CNV | duplication | 20981092 |
| nsv1040098 | CNV | gain | 25217958 |
| nsv1051126 | CNV | gain | 25217958 |
| nsv1110206 | CNV | duplication | 24896259 |
| nsv1152910 | CNV | duplication | 26484159 |
| nsv468988 | CNV | gain | 19166990 |
| nsv470262 | CNV | gain | 18288195 |
| nsv473788 | CNV | novel sequence insertion | 20440878 |
| nsv478052 | CNV | novel sequence insertion | 20440878 |
| nsv513347 | CNV | insertion | 21212237 |
| nsv523152 | CNV | gain | 19592680 |
| nsv524170 | CNV | gain | 19592680 |
| nsv557155 | CNV | gain | 21841781 |
| nsv592 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.35;
70.82% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for NTF3 Gene
Disorders for NTF3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypochondriasis |
|
|
| diabetic neuropathy |
|
|
| diabetic autonomic neuropathy |
|
|
| demyelinating disease |
|
|
| pediatric fibrosarcoma |
|
|
Search NTF3 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for NTF3
No data available for UniProtKB/Swiss-Prot and Genatlas for NTF3 Gene
Publications for NTF3 Gene
- Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. (PMID: 1889806) Maisonpierre P.C. … Yancopoulos G.D. (Genomics 1991) 2 3 4 22 64
- Association of neurotrophin-3 gene variant with severe forms of schizophrenia. (PMID: 7733919) Hattori M. … Nanko S. (Biochem. Biophys. Res. Commun. 1995) 3 4 46 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- NT-3 gene modified Schwann cells promote TrkC gene modified mesenchymal stem cells to differentiate into neuron-like cells in vitro. (PMID: 19680743) Zhang Y.Q. … Zeng Y.S. (Anat Sci Int 2010) 3 22 64
- Increased neurotrophin-3 in drug-free subjects with bipolar disorder during manic and depressive episodes. (PMID: 20060128) Fernandes B.S. … Kapczinski F. (J Psychiatr Res 2010) 3 22 64
Products for NTF3 Gene
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- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for NTF3
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for NTF3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
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