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NTF3 Gene(Protein Coding)

Neurotrophin 3

GCID:
GC12P005432
GIFtS:
69
Genes Participants
UDN Logo

Aliases for NTF3 Gene

Aliases for NTF3 Gene

  • Neurotrophin 3 2 3 5
  • Nerve Growth Factor 2 3 4
  • Neurotrophic Factor 3 4
  • NGF-2 3 4
  • HDNF 3 4
  • NT-3 3 4
  • NGF2 3
  • NT3 3

External Ids for NTF3 Gene

Previous GeneCards Identifiers for NTF3 Gene

  • GC12U990064
  • GC12P005487
  • GC12P005420
  • GC12P005473
  • GC12P005541

Summaries for NTF3 Gene

Entrez Gene Summary for NTF3 Gene

  • The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]

GeneCards Summary for NTF3 Gene

NTF3 (Neurotrophin 3) is a Protein Coding gene. Diseases associated with NTF3 include Hypochondriasis and Diabetic Autonomic Neuropathy. Among its related pathways are p70S6K Signaling and ERK Signaling. GO annotations related to this gene include receptor binding and chemoattractant activity. An important paralog of this gene is BDNF.

UniProtKB/Swiss-Prot for NTF3 Gene

  • Seems to promote the survival of visceral and proprioceptive sensory neurons.

Gene Wiki entry for NTF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTF3 Gene

Genomics for NTF3 Gene

Products:

  1. Regulatory Element

Regulatory Elements for NTF3 Gene

Enhancers for NTF3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NTF3 on UCSC Golden Path with GeneCards custom track

Promoters for NTF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NTF3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NTF3 gene promoter:

Genomic Location for NTF3 Gene

Chromosome:
12
Start:
5,432,112 bp from pter
End:
5,521,536 bp from pter
Size:
89,425 bases
Orientation:
Plus strand

Genomic View for NTF3 Gene

Genes around NTF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTF3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NTF3 Gene

Proteins for NTF3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NTF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20783-NTF3_HUMAN
    Recommended name:
    Neurotrophin-3
    Protein Accession:
    P20783
    Secondary Accessions:
    • B7Z1T5
    • Q6FH50

    Protein attributes for NTF3 Gene

    Size:
    257 amino acids
    Molecular mass:
    29355 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NTF3 Gene

    Alternative splice isoforms for NTF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NTF3 Gene

Proteomics data for NTF3 Gene at MOPED

Protein Expression for NTF3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NTF3 Gene

  • Glycosylation at Asn 131
  • Modification sites at PhosphoSitePlus

Other Protein References for NTF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NTF3 Gene

Domains & Families for NTF3 Gene

Gene Families for NTF3 Gene

HGNC:

Protein Domains for NTF3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NTF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20783

UniProtKB/Swiss-Prot:

NTF3_HUMAN :
  • Belongs to the NGF-beta family.
Family:
  • Belongs to the NGF-beta family.
genes like me logo Genes that share domains with NTF3: view

Function for NTF3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for NTF3 Gene

GENATLAS Biochemistry:
neurotrophic factor (neurotrophin) 3,29.3kDa,ligand for NTRK3 (TRKC),expressed in retina and the anterior segment of the developing eye
UniProtKB/Swiss-Prot Function:
Seems to promote the survival of visceral and proprioceptive sensory neurons.

LifeMap Function Summary for NTF3 Gene

NTF3 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes for NTF3 Gene

MGI mutant phenotypes for NTF3:
inferred from 10 alleles
GenomeRNAi human phenotypes for NTF3:
genes like me logo Genes that share phenotypes with NTF3: view

Animal Models for NTF3 Gene

MGI Knock Outs for NTF3:

Animal Model Products

miRNA for NTF3 Gene

miRTarBase miRNAs that target NTF3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NTF3 Gene

Localization for NTF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTF3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NTF3 Gene COMPARTMENTS Subcellular localization image for NTF3 gene
Compartment Confidence
extracellular 5
nucleus 3
cytoskeleton 2
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for NTF3 Gene

Pathways & Interactions for NTF3 Gene

genes like me logo Genes that share pathways with NTF3: view

SIGNOR curated interactions for NTF3 Gene

Activates:

Gene Ontology (GO) - Biological Process for NTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 23027130
GO:0002092 positive regulation of receptor internalization IDA 23027130
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IDA 23027130
GO:0007267 cell-cell signaling TAS 2236018
GO:0007399 nervous system development TAS 1542658
genes like me logo Genes that share ontologies with NTF3: view

Drugs & Compounds for NTF3 Gene

Products:

  1. Drug

(43) Drugs for NTF3 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AV411 Investigational Pharma Target 0

(32) Additional Compounds for NTF3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NTF3: view

Transcripts for NTF3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for NTF3 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NTF3 Gene

Neurotrophin 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NTF3 Gene

No ASD Table

Relevant External Links for NTF3 Gene

GeneLoc Exon Structure for
NTF3
ECgene alternative splicing isoforms for
NTF3

Expression for NTF3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for NTF3 Gene

mRNA expression in normal human tissues for NTF3 Gene
mRNA expression by BioGPS for NTF3 GenemRNA expression by GTEx for NTF3 Gene

mRNA differential expression in normal tissues according to GTEx for NTF3 Gene

This gene is overexpressed in Artery - Tibial (x8.1), Artery - Aorta (x6.2), and Artery - Coronary (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NTF3 Gene



SOURCE GeneReport for Unigene cluster for NTF3 Gene Hs.99171

mRNA Expression by UniProt/SwissProt for NTF3 Gene

P20783-NTF3_HUMAN
Tissue specificity: Brain and peripheral tissues.
genes like me logo Genes that share expression patterns with NTF3: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for NTF3 Gene

Orthologs for NTF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NTF3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia NTF3 35
  • 89.68 (n)
  • 96.43 (a)
NTF3 36
  • 96 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia NTF3 35
  • 92.1 (n)
  • 95.93 (a)
NTF3 36
  • 96 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ntf3 35
  • 90 (n)
  • 95.93 (a)
Ntf3 16
Ntf3 36
  • 96 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia NTF3 35
  • 98.7 (n)
  • 98.83 (a)
NTF3 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Ntf3 35
  • 90.62 (n)
  • 95.93 (a)
oppossum
(Monodelphis domestica)
 Mammalia NTF3 36
  • 93 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia NT-3 36
  • 88 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves NTF3 35
  • 78.89 (n)
  • 88.52 (a)
NTF3 36
  • 89 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia NTF3 36
  • 77 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ntf3 35
  • 73.28 (n)
  • 81.32 (a)
Str.3752 35
African clawed frog
(Xenopus laevis)
 Amphibia Xl.1074 35
zebrafish
(Danio rerio)
 Actinopterygii ntf3 35
  • 59.48 (n)
  • 58.04 (a)
ntf3 36
  • 55 (a)
 OneToOne
Species with no ortholog for NTF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTF3 Gene

ENSEMBL:
Gene Tree for NTF3 (if available)
TreeFam:
Gene Tree for NTF3 (if available)

Paralogs for NTF3 Gene

Paralogs for NTF3 Gene

(3) SIMAP similar genes for NTF3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NTF3: view

Variants for NTF3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NTF3 Gene

NTF3_HUMAN-P20783
Variant Glu-76 (frequently reported as Glu-63) was thought to be associated with severe forms of schizophrenia. This does not seem to be the case.

Sequence variations from dbSNP and Humsavar for NTF3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1805149 - 5,494,441(+) GGGAG(A/G)GCCCG reference, missense
rs1978390 -- 5,450,728(-) gtttc(A/C)gttgc intron-variant
rs2052355 -- 5,467,777(-) GACGG(C/T)GGCAT intron-variant
rs6332 -- 5,494,466(+) CAGCC(A/G/T)GTGAT reference, synonymous-codon
rs7134801 -- 5,479,506(+) CTGCT(A/G)GGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NTF3 Gene

Variant ID Type Subtype PubMed ID
nsv470262 CNV Gain 18288195
nsv468988 CNV Gain 19166990
nsv523152 CNV Gain 19592680
nsv592 CNV Insertion 18451855
nsv524170 CNV Gain 19592680
esv2559368 CNV Insertion 19546169
nsv513347 CNV Insertion 21212237
nsv898627 CNV Gain 21882294

Variation tolerance for NTF3 Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.35; 70.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NTF3 Gene

Human Gene Mutation Database (HGMD)
NTF3

Disorders for NTF3 Gene

MalaCards: The human disease database

(21) MalaCards diseases for NTF3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypochondriasis
  • hypochondria
diabetic autonomic neuropathy
  • diabetic neuropathies
diabetic neuropathy
  • diabetic neuropathies
demyelinating disease
  • demyelinating disorder
limb ischemia
- elite association - COSMIC cancer census association via MalaCards
Search NTF3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NTF3

Genetic Association Database (GAD)
NTF3
Human Genome Epidemiology (HuGE) Navigator
NTF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NTF3
genes like me logo Genes that share disorders with NTF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NTF3 Gene

Publications for NTF3 Gene

  1. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. (PMID: 1889806) Maisonpierre P.C. … Yancopoulos G.D. (Genomics 1991) 2 3 4 23 67
  2. NT-3 gene modified Schwann cells promote TrkC gene modified mesenchymal stem cells to differentiate into neuron-like cells in vitro. (PMID: 19680743) Zhang Y.Q. … Zeng Y.S. (Anat Sci Int 2010) 3 23
  3. Increased neurotrophin-3 in drug-free subjects with bipolar disorder during manic and depressive episodes. (PMID: 20060128) Fernandes B.S. … Kapczinski F. (J Psychiatr Res 2010) 3 23
  4. Neurotrophin-3 and FLT3 tyrosine kinase receptor in perinatal life. (PMID: 15770067) Malamitsi-Puchner A. … Vrachnis N. (Mediators Inflamm. 2005) 3 23
  5. Decreased potassium channel IK1 and its regulator neurotrophin-3 (NT-3) in inflamed human bowel. (PMID: 12598727) Arnold S.J. … Anand P. (Neuroreport 2003) 3 23

Products for NTF3 Gene

  • Addgene plasmids for NTF3

Sources for NTF3 Gene

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