Aliases for NTF3 Gene
Aliases for NTF3 Gene
External Ids for NTF3 Gene
- HGNC: 8023
- Entrez Gene: 4908
- Ensembl: ENSG00000185652
- OMIM: 162660
- UniProtKB: P20783
Previous GeneCards Identifiers for NTF3 Gene
- GC12U990064
- GC12P005487
- GC12P005420
- GC12P005473
- GC12P005541
Summaries for NTF3 Gene
-
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
GeneCards Summary for NTF3 Gene
NTF3 (Neurotrophin 3) is a Protein Coding gene. Diseases associated with NTF3 include Hypochondriasis and Diabetic Polyneuropathy. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PAK Pathway. Gene Ontology (GO) annotations related to this gene include receptor binding and chemoattractant activity. An important paralog of this gene is BDNF.
UniProtKB/Swiss-Prot for NTF3 Gene
-
Seems to promote the survival of visceral and proprioceptive sensory neurons.
Additional gene information for NTF3 Gene
- Monarch Initiative
- Search for NTF3 at DataMed
- Search for NTF3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTF3 Gene
Genomics for NTF3 Gene
GeneHancer (GH) Regulatory Elements for NTF3 Gene
Promoters and enhancers for NTF3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH12I005429 | Promoter/Enhancer | 2.2 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 566.6 | +0.1 | 75 | 6 | ZSCAN4 YY1 ZNF335 GLIS2 SCRT2 EGR2 RXRA ZBTB11 ZNF398 REST | NTF3 LOC105369620 KCNA5 GC12M005446 | |
| GH12I005494 | Promoter | 0.5 | EPDnew | 550.2 | +62.0 | 61955 | 0.1 | NTF3 GC12M005501 GC12M005461 | ||
| GH12I004537 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 11.3 | -893.1 | -893115 | 3 | HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 | RAD51AP1 C12orf4 NTF3 GC12M004550 | |
| GH12I006166 | Enhancer | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 10.9 | +736.0 | 735978 | 3.9 | PKNOX1 ATF1 ARNT TCF12 ZNF766 ZNF207 ZNF143 ATF7 FOS RUNX3 | PIR38862 CD9 VWF ATN1 NTF3 TNFRSF1A TAPBPL VAMP1 PIR39839 LOC105369623 | |
| GH12I005455 | Enhancer | 1.1 | FANTOM5 Ensembl ENCODE dbSUPER | 13.5 | +24.9 | 24907 | 2.8 | RFX1 POLR2A ZBTB33 BMI1 SPI1 | NTF3 GC12M005446 GC12P005645 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NTF3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for NTF3 Gene
Genomic Locations for NTF3 Gene
- chr12:5,432,112-5,521,536
- (GRCh38/hg38)
- Size:
- 89,425 bases
- Orientation:
- Plus strand
- chr12:5,541,278-5,630,702
- (GRCh37/hg19)
Genomic View for NTF3 Gene
Genes around NTF3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.31 by Ensembl
- 12p13.31 by Entrez Gene
- 12p13.31 by HGNC
NTF3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NTF3 Gene
Proteins for NTF3 Gene
-
Protein details for NTF3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P20783-NTF3_HUMAN
- Recommended name:
- Neurotrophin-3
- Protein Accession:
- P20783
- B7Z1T5
- Q6FH50
Protein attributes for NTF3 Gene
- Size:
- 257 amino acids
- Molecular mass:
- 29355 Da
- Quaternary structure:
- No Data Available
Three dimensional structures from OCA and Proteopedia for NTF3 Gene
Protein Expression for NTF3 Gene
Post-translational modifications for NTF3 Gene
- Glycosylation at Asn131
Other Protein References for NTF3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for NTF3 (NT-3)
- Novus Biologicals Antibodies for NTF3
-
Abcam antibodies for NTF3
-
Cloud-Clone Corp. Antibodies for NTF3
- Invitrogen Antibodies for NTF3
- antibodies-online: Search results for 175 available Neurotrophin 3 Antibodies ranked by validation data
- Compare Top Neurotrophin 3 Antibodies
-
Recommended
- 2 IP Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 36 WB Antibodies (anti-rat)
- 2 IP Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 38 WB Antibodies (anti-mouse)
- 1 Neut Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 2 IP Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 123 WB Antibodies (anti-human)
- GeneTex NTF3 antibody for NTF3
-
Santa Cruz Biotechnology (SCBT) Antibodies for NTF3
Protein Products
- R&D Systems Proteins and Enzymes for NTF3 (NT-3)
-
OriGene Purified Proteins for NTF3
- Search Origene for MassSpec and Protein Over-expression Lysates for NTF3
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- Sino Biological Recombinant Proteins for NTF3
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- ProSpec Recombinant Proteins for NTF3
-
Cloud-Clone Corp. Proteins for NTF3
- GeneTex Proteins for NTF3
-
ProSci Proteins for NTF3
-
Abcam proteins for NTF3
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for NTF3
- R&D Systems Luminex Assays, ELISAs, and other biochemical assays for NTF3 (NT-3)
- antibodies-online: Search results for 101 available Neurotrophin 3 Elisa Kits ranked by validation data
- Compare Top Neurotrophin 3 Elisa Kits
-
Recommended
-
Abcam assays for NTF3
No data available for DME Specific Peptides for NTF3 Gene
Domains & Families for NTF3 Gene
Gene Families for NTF3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for NTF3 Gene
Suggested Antigen Peptide Sequences for NTF3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P20783- Family:
-
- Belongs to the NGF-beta family.
Function for NTF3 Gene
Molecular function for NTF3 Gene
- GENATLAS Biochemistry:
- neurotrophic factor (neurotrophin) 3,29.3kDa,ligand for NTRK3 (TRKC),expressed in retina and the anterior segment of the developing eye
- UniProtKB/Swiss-Prot Function:
- Seems to promote the survival of visceral and proprioceptive sensory neurons.
LifeMap Function Summary for NTF3 Gene
NTF3 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Neurons
- Spinal Cord
- Brain
- Glial Cells
- Peripheral Nervous System
-
and also in
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | receptor binding | TAS | 2236018 |
| GO:0005165 | neurotrophin receptor binding | IEA | -- |
| GO:0005166 | neurotrophin p75 receptor binding | IBA | -- |
| GO:0005515 | protein binding | IPI | 18596692 |
| GO:0008083 | growth factor activity | IDA | 23027130 |
Phenotypes for NTF3 Gene
- MGI mutant phenotypes for NTF3:
- inferred from 10 alleles
- GenomeRNAi human phenotypes for NTF3:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability in esophageal squamous lineage
- Decreased viability ratio
- Decreased NF-kappaB reporter expression
- Increased shRNA abundance (Z-score > 2)
- Decreased viability after Maraba virus infection
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for NTF3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NTF3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for NTF3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NTF3 gene
- Search ViGene Biosciences for NTF3
CRISPR Products
-
OriGene CRISPR knockouts for NTF3
- Applied Biological Materials CRISPR for NTF3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NTF3
- GenScript: Design CRISPR guide RNA sequences for NTF3
miRNA for NTF3 Gene
- miRTarBase miRNAs that target NTF3
miRNA Products
- Search ViGene Biosciences for NTF3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NTF3
- Browse OriGene Inhibitory RNA Products For NTF3
- genomics-online: shRNA clones - Search results for 160 available Neurotrophin 3 gene related products
- Overview of 160 available Neurotrophin 3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NTF3 gene
Clone Products
- Sino Biological Human cDNA Clone for NTF3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NTF3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NTF3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NTF3
- genomics-online: cdna clones - Search results for 160 available Neurotrophin 3 gene related products
- Overview of 160 available Neurotrophin 3 gene related products
- orf clones - Search results for 160 available Neurotrophin 3 gene related products
- Overview of 160 available Neurotrophin 3 gene related products
- Applied Biological Materials Clones for NTF3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NTF3
-
ViGene Biosciences adenoviral particle packaged cDNA for NTF3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NTF3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NTF3 gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NTF3 Gene
Localization for NTF3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NTF3 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IBA | -- |
| GO:0031410 | cytoplasmic vesicle | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for NTF3 Gene
Pathways & Interactions for NTF3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 2 | GPCR Pathway |
.73
.62
|
.55
|
| 3 | ERK Signaling |
.61
.58
|
.49
|
| 4 | TGF-Beta Pathway |
.60
.57
|
.51
|
| 5 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
Pathways by source for NTF3 Gene
4 BioSystems pathways for NTF3 Gene
4 KEGG pathways for NTF3 Gene
2 GeneGo (Thomson Reuters) pathways for NTF3 Gene
1 R&D Systems pathway for NTF3 Gene
Interacting Proteins for NTF3 Gene
Selected Interacting proteins:
P20783-NTF3_HUMAN
ENSP00000397297
for NTF3 Gene via
UniProtKB
IID
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | IDA | 23027130 |
| GO:0002092 | positive regulation of receptor internalization | IDA | 23027130 |
| GO:0007165 | signal transduction | TAS | 2236018 |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IDA | 23027130 |
| GO:0007267 | cell-cell signaling | TAS | 2236018 |
Transcripts for NTF3 Gene
mRNA/cDNA for NTF3 Gene
- (3) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (5) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NTF3 Gene
- Neurotrophin 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for NTF3
- Applied Biological Materials CRISPR for NTF3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NTF3
- GenScript: Design CRISPR guide RNA sequences for NTF3
miRNA Products
- Search ViGene Biosciences for NTF3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NTF3
- Browse OriGene Inhibitory RNA Products For NTF3
- genomics-online: shRNA clones - Search results for 160 available Neurotrophin 3 gene related products
- Overview of 160 available Neurotrophin 3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NTF3 gene
Clone Products
- Sino Biological Human cDNA Clone for NTF3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NTF3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NTF3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NTF3
- genomics-online: cdna clones - Search results for 160 available Neurotrophin 3 gene related products
- Overview of 160 available Neurotrophin 3 gene related products
- orf clones - Search results for 160 available Neurotrophin 3 gene related products
- Overview of 160 available Neurotrophin 3 gene related products
- Applied Biological Materials Clones for NTF3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for NTF3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Spinal Cord (Nervous System)
- VA2 Fibrous Astrocyte Cells Spinal Cord White Matter
- VA3 Fibrous Astrocyte Cells Spinal Cord White Matter
- VA1 Fibrous Astrocyte Cells Spinal Cord White Matter
- Motor neuron progenitor cells(Rossi SL et. al. 2010)
-
Glial Cells
- VA2 Fibrous Astrocyte Cells Spinal Cord White Matter
- VA3 Fibrous Astrocyte Cells Spinal Cord White Matter
- VA1 Fibrous Astrocyte Cells Spinal Cord White Matter
- Schwann-like cells(Martens W et. al. 2013)
- Neural Tube (Nervous System)
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Epithelial Cells
- Basal Cells Trachea
-
Ovary (Reproductive System)
- Ovarian Somatic Cells Ovigerous Cord
- Brain (Nervous System)
- Neural Ectoderm (Nervous System)
- Motor Neurons (Nervous System)
- Neurons
- Peripheral Nervous System (Nervous System)
mRNA differential expression in normal tissues according to GTEx for NTF3 Gene
This gene is overexpressed in Artery - Tibial (x8.1), Artery - Aorta (x6.2), and Artery - Coronary (x6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NTF3 Gene
NURSA nuclear receptor signaling pathways regulating expression of NTF3 Gene:
NTF3SOURCE GeneReport for Unigene cluster for NTF3 Gene:
Hs.99171mRNA Expression by UniProt/SwissProt for NTF3 Gene:
P20783-NTF3_HUMAN
Tissue specificity:
Brain and peripheral tissues.
Evidence on tissue expression from TISSUES for NTF3 Gene
- Nervous system(4.7)
- Blood(4.2)
- Muscle(2.3)
- Adrenal gland(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for NTF3
-
OriGene qPCR primer pairs for NTF3
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NTF3 Gene
Orthologs for NTF3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NTF3 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NTF3 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NTF3 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ntf3 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ntf3 33 16 34 |
|
||
| cow (Bos Taurus) |
Mammalia | NTF3 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | NT-3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NTF3 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | NTF3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ntf3 33 |
|
||
| Str.3752 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.1074 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ntf3 33 34 |
|
- Species where no ortholog for NTF3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for NTF3 Gene
Variants for NTF3 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for NTF3 Gene
- NTF3_HUMAN-P20783
- Variant Glu-76 (frequently reported as Glu-63) was thought to be associated with severe forms of schizophrenia. This does not seem to be the case.
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs540320780 | uncertain-significance, Hirschsprung disease 1 | 5,494,440(+) | G/A | coding_sequence_variant, missense_variant | |
| rs1000021071 | -- | 5,453,330(+) | T/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000075380 | -- | 5,460,408(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000114211 | -- | 5,474,007(+) | T/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000135888 | -- | 5,469,381(+) | C/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1348n100 | CNV | gain | 25217958 |
| esv2559368 | CNV | insertion | 19546169 |
| esv3358188 | CNV | duplication | 20981092 |
| nsv1040098 | CNV | gain | 25217958 |
| nsv1051126 | CNV | gain | 25217958 |
| nsv1110206 | CNV | duplication | 24896259 |
| nsv1152910 | CNV | duplication | 26484159 |
| nsv468988 | CNV | gain | 19166990 |
| nsv470262 | CNV | gain | 18288195 |
| nsv473788 | CNV | novel sequence insertion | 20440878 |
| nsv478052 | CNV | novel sequence insertion | 20440878 |
| nsv513347 | CNV | insertion | 21212237 |
| nsv523152 | CNV | gain | 19592680 |
| nsv524170 | CNV | gain | 19592680 |
| nsv557155 | CNV | gain | 21841781 |
| nsv592 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.35;
70.82% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NTF3 Gene
Disorders for NTF3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypochondriasis |
|
|
| diabetic polyneuropathy |
|
|
| diabetic neuropathy |
|
|
| diabetic autonomic neuropathy |
|
|
| demyelinating disease |
|
Search NTF3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NTF3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NTF3 Gene
Publications for NTF3 Gene
- Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. (PMID: 1889806) Maisonpierre PC … Yancopoulos GD (Genomics 1991) 2 3 4 22 58
- Association of neurotrophin-3 gene variant with severe forms of schizophrenia. (PMID: 7733919) Hattori M … Nanko S (Biochemical and biophysical research communications 1995) 3 4 44 58
- Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease. (PMID: 20219210) Gratacòs M … Estivill X (Journal of psychiatric research 2010) 3 44 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- NT-3 gene modified Schwann cells promote TrkC gene modified mesenchymal stem cells to differentiate into neuron-like cells in vitro. (PMID: 19680743) Zhang YQ … Zeng YS (Anatomical science international 2010) 3 22 58
Products for NTF3 Gene
- R&D Systems Antibodies for NTF3 (NT-3)
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- Browse Primary Antibodies
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- Custom Antibody ServicesOriGene Antibodies for NTF3
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- OriGene qPCR primer pairs and template standards for NTF3
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- Browse OriGene miRNA Products For NTF3
- GenScript: Next-day shipping of latest version cDNA ORF clones for NTF3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for NTF3
- GenScript Custom Assay Services for NTF3
- GenScript Custom overexpressing Cell Line Services for NTF3
- GenScript: Design CRISPR guide RNA sequences for NTF3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for NTF3
- Sino Biological Human cDNA Clone for NTF3
- Sino Biological Recombinant Proteins for NTF3
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for NTF3
- Novus Biologicals proteins and lysates for NTF3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for NTF3
- Abcam proteins for NTF3
- Abcam assays for NTF3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for NTF3
- Cloud-Clone Corp. Antibodies for NTF3
- Cloud-Clone Corp. Proteins for NTF3
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for NTF3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for NTF3
- VectorBuilder custom plasmid, inducible vectors for NTF3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NTF3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NTF3
- antibodies-online: Search results for 175 available Neurotrophin 3 Antibodies ranked by validation data
- Compare Top Neurotrophin 3 Antibodies
- Recommended
- 123 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 1 Neut Antibody (anti-human)
- 38 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 36 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- antibodies-online: Search results for 101 available Neurotrophin 3 Elisa Kits ranked by validation data
- Compare Top Neurotrophin 3 Elisa Kits
- Recommended
- antibodies-online: Search results for 52 available Neurotrophin 3 Proteins ranked by validation data
- Compare Top Neurotrophin 3 Proteins
- GeneTex NTF3 antibody for NTF3
- GeneTex Proteins for NTF3
- ViGene Biosciences adenoviral particle packaged cDNA for NTF3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for NTF3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for NTF3 gene
- Search ViGene Biosciences for NTF3
- Santa Cruz Biotechnology (SCBT) Antibodies for NTF3
- Search Santa Cruz Biotechnology (SCBT) for NTF3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NTF3
- Horizon Cell Lines for NTF3
- genomics-online: cdna clones - Search results for 160 available Neurotrophin 3 gene related products
- Overview of 160 available Neurotrophin 3 gene related products
- orf clones - Search results for 160 available Neurotrophin 3 gene related products
- Overview of 160 available Neurotrophin 3 gene related products
- genomics-online: gRNA clones - Search results for 160 available Neurotrophin 3 gene related products
- Overview of 160 available Neurotrophin 3 gene related products
- genomics-online: primer clones - Search results for 160 available Neurotrophin 3 gene related products
- Overview of 160 available Neurotrophin 3 gene related products
- genomics-online: shRNA clones - Search results for 160 available Neurotrophin 3 gene related products
- Overview of 160 available Neurotrophin 3 gene related products
Sources for NTF3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew