Aliases for NRL Gene
Aliases for NRL Gene
External Ids for NRL Gene
- HGNC: 8002
- Entrez Gene: 4901
- Ensembl: ENSG00000129535
- OMIM: 162080
- UniProtKB: P54845
Previous GeneCards Identifiers for NRL Gene
- GC14M021921
- GC14M018336
- GC14M022539
- GC14M023619
- GC14M024549
- GC14M004664
Summaries for NRL Gene
-
This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. [provided by RefSeq, Jul 2008]
GeneCards Summary for NRL Gene
NRL (Neural Retina Leucine Zipper) is a Protein Coding gene. Diseases associated with NRL include Retinitis Pigmentosa 27 and Enhanced S-Cone Syndrome. Among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is MAFA.
UniProtKB/Swiss-Prot for NRL Gene
-
Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds in a sequence-specific manner to the rhodopsin promoter (PubMed:17335001).
Additional gene information for NRL Gene
- Monarch Initiative
- Search for NRL at DataMed
- Search for NRL at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRL Gene
Genomics for NRL Gene
GeneHancer (GH) Regulatory Elements for NRL Gene
Promoters and enhancers for NRL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NRL on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NRL gene promoter:
Regulatory Element Products
Genomic Locations for NRL Gene
Genomic Locations for NRL Gene
- chr14:24,078,693-24,115,014
- (GRCh38/hg38)
- Size:
- 36,322 bases
- Orientation:
- Minus strand
- chr14:24,549,316-24,584,223
- (GRCh37/hg19)
Genomic View for NRL Gene
Genes around NRL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q12 by Ensembl
- 14q11.2-q12 by Entrez Gene
- 14q11.2-q12 by HGNC
NRL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NRL Gene
Proteins for NRL Gene
-
Protein details for NRL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P54845-NRL_HUMAN
- Recommended name:
- Neural retina-specific leucine zipper protein
- Protein Accession:
- P54845
- A8MX14
- Q53XD0
Protein attributes for NRL Gene
- Size:
- 237 amino acids
- Molecular mass:
- 25940 Da
- Quaternary structure:
-
- Interacts with FIZ1; this interaction represses transactivation (By similarity). Interacts (via the leucine-zipper domain) with CRX (PubMed:10887186).
Protein Expression for NRL Gene
Post-translational modifications for NRL Gene
- Disumoylated at Lys-20. Sumoylation modulates the transcriptional activity of NRL on RHO and NR2E3 promoters, and is required for normal rod differentiation (By similarity).
- Phosphorylated (PubMed:11477108, PubMed:17335001).
Other Protein References for NRL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for NRL (NRL)
- Novus Biologicals Antibodies for NRL
-
Abcam antibodies for NRL
- Invitrogen Antibodies for NRL
- Search GeneTex for Antibodies for NRL
-
Santa Cruz Biotechnology (SCBT) Antibodies for NRL
Protein Products
-
OriGene Purified Proteins for NRL
- Search Origene for MassSpec and Protein Over-expression Lysates for NRL
- Origene Custom Protein Services for NRL
- antibodies-online: Search results for 3 available NRL Proteins ranked by validation data
- Compare Top NRL Proteins
-
Quality Products:
- Search GeneTex for Proteins for NRL
Assay Products
- antibodies-online: Search results for 1 available NRL Elisa Kits ranked by validation data
- Compare Top NRL Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for NRL Gene
Domains & Families for NRL Gene
Gene Families for NRL Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NRL Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NRL Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P54845UniProtKB/Swiss-Prot:
NRL_HUMAN :- The minimal transactivation domain (MTD) is conserved across the MAF family, it may activate transcription by recruiting TBP and associated factors at the promoters of target genes.
- Belongs to the bZIP family.
- Domain:
-
- The minimal transactivation domain (MTD) is conserved across the MAF family, it may activate transcription by recruiting TBP and associated factors at the promoters of target genes.
- Family:
-
- Belongs to the bZIP family.
Function for NRL Gene
Molecular function for NRL Gene
- GENATLAS Biochemistry:
- neural retinal specific transcript,interacting with CRX,regulating the expression of rhodopsin and other retinal genes,small MAF protein family
- UniProtKB/Swiss-Prot Function:
- Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds in a sequence-specific manner to the rhodopsin promoter (PubMed:17335001).
Phenotypes From GWAS Catalog for NRL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 8552602 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 8552602 |
| GO:0003677 | DNA binding | TAS | 1729696 |
| GO:0003700 | DNA binding transcription factor activity | IEA | -- |
| GO:0003713 | transcription coactivator activity | IMP | 17335001 |
Phenotypes for NRL Gene
- MGI mutant phenotypes for NRL:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for NRL:
-
- Mildly decreased CFP-tsO45G cell surface transport
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased lymphocytic choriomeningitis virus (LCMV) infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NRL
-
-
ViGene Biosciences lentiviral particle packaged cDNA for NRL gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NRL gene
- Search ViGene Biosciences for NRL
CRISPR Products
-
OriGene CRISPR knockouts for NRL
- genomics-online: gRNA clones - Search results for 97 available NRL gene related products
- Overview of 97 available NRL gene related products
- Applied Biological Materials CRISPR for NRL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRL
- GenScript: Design CRISPR guide RNA sequences for NRL
miRNA for NRL Gene
- miRTarBase miRNAs that target NRL
-
- hsa-mir-592 (MIRT527413)
- hsa-mir-6792-3p (MIRT527414)
- hsa-mir-4691-5p (MIRT527415)
- hsa-mir-653-3p (MIRT527416)
- hsa-mir-4420 (MIRT527417)
- hsa-mir-181b-3p (MIRT527418)
- hsa-mir-181b-2-3p (MIRT527419)
- hsa-mir-197-3p (MIRT527420)
- hsa-mir-597-5p (MIRT527421)
- hsa-mir-6879-3p (MIRT527422)
- hsa-mir-2116-3p (MIRT527423)
- hsa-mir-361-3p (MIRT527424)
- hsa-mir-1208 (MIRT527425)
- hsa-mir-6760-3p (MIRT527426)
- hsa-mir-1306-5p (MIRT527427)
- hsa-mir-216b-3p (MIRT527428)
- hsa-mir-892a (MIRT527429)
miRNA Products
- Search ViGene Biosciences for NRL
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NRL
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- genomics-online: shRNA clones - Search results for 97 available NRL gene related products
- Overview of 97 available NRL gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NRL gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NRL
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NRL
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NRL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for NRL gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NRL gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NRL gene
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NRL Gene
Localization for NRL Gene
Subcellular locations from UniProtKB/Swiss-Prot for NRL Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 1 |
- Nucleoplasm (3)
- Cytosol (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 11477108 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 11477108 |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for NRL Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics | ||
Pathways by source for NRL Gene
1 PharmGKB pathway for NRL Gene
Interacting Proteins for NRL Gene
Selected Interacting proteins:
ENSP00000380193
P54845-NRL_HUMAN
for NRL Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | TAS | 8939891 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007468 | regulation of rhodopsin gene expression | TAS,IEA | 8939891 |
No data available for SIGNOR curated interactions for NRL Gene
Transcripts for NRL Gene
mRNA/cDNA for NRL Gene
- (13) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (65) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NRL Gene
CRISPR Products
-
OriGene CRISPR knockouts for NRL
- genomics-online: gRNA clones - Search results for 97 available NRL gene related products
- Overview of 97 available NRL gene related products
- Applied Biological Materials CRISPR for NRL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRL
- GenScript: Design CRISPR guide RNA sequences for NRL
miRNA Products
- Search ViGene Biosciences for NRL
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NRL
- Browse OriGene Inhibitory RNA Products For NRL
- genomics-online: shRNA clones - Search results for 97 available NRL gene related products
- Overview of 97 available NRL gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NRL gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NRL
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NRL
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NRL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for NRL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Rod Precursor Cells Outer Nuclear Layer
- Mature Rod Cells Outer Nuclear Layer
- Corneal Epithelium
- Retinal progenitor-like cells(Lamba DA et. al. 2006)
- Optic cup structures(Nakano T et. al. 2012)
-
Neurons
- Rod Precursor Cells Outer Nuclear Layer
- Mature Rod Cells Outer Nuclear Layer
- NULL (Sensory Organs)
This gene is overexpressed in Retina (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NRL Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of NRL Gene:
NRLSOURCE GeneReport for Unigene cluster for NRL Gene:
Hs.652297mRNA Expression by UniProt/SwissProt for NRL Gene:
P54845-NRL_HUMAN
Tissue specificity:
Expressed in the brain and the retina (PubMed:11477108). Expressed strongly in rod and cone cells (at protein level) (PubMed:11477108).
Evidence on tissue expression from TISSUES for NRL Gene
- Eye(4.9)
Phenotype-based relationships between genes and organs from Gene ORGANizer for NRL Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- immune
- integumentary
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
Organs:
Head and neck:
- brain
- cerebellum
- cranial nerve
- ear
- eye
- eyelid
- face
- head
- middle ear
- nose
- outer ear
- skull
Pelvis:
- penis
- testicle
General:
- blood
- blood vessel
- peripheral nervous system
- red blood cell
- skin
Primer Products
-
OriGene qPCR primer pairs and template standards for NRL
-
OriGene qPCR primer pairs for NRL
No data available for mRNA differential expression in normal tissues for NRL Gene
Orthologs for NRL Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NRL 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | NRL 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | NRL 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Nrl 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Nrl 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NRL 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | NRL 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | nrl 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | l-maf-A 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | nrl 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | tj 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | maf-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany |
- Species where no ortholog for NRL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for NRL Gene
Variants for NRL Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs104894459 | pathogenic, Retinitis pigmentosa 27, Retinitis pigmentosa 27 (RP27) [MIM:613750] | 24,082,701(-) | A/T | coding_sequence_variant, intron_variant, missense_variant | |
| rs104894463 | pathogenic, Retinal degeneration, autosomal recessive, clumped pigment type, Retinal degeneration autosomal recessive clumped pigment type (RDCP) [MIM:613750] | 24,081,471(-) | A/G | coding_sequence_variant, missense_variant | |
| rs1051718 | likely-benign, Retinitis Pigmentosa, Dominant | 24,080,402(-) | C/G | 3_prime_UTR_variant | |
| rs113119768 | uncertain-significance, Retinitis Pigmentosa, Dominant | 24,080,109(-) | A/G | 3_prime_UTR_variant | |
| rs114327952 | likely-benign, Retinitis Pigmentosa, Dominant | 24,080,678(-) | G/A | 3_prime_UTR_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1036658 | CNV | loss | 25217958 |
| nsv1052180 | CNV | loss | 25217958 |
| nsv516023 | CNV | loss | 19592680 |
| nsv564057 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.66;
14.03% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NRL Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRL Gene
Disorders for NRL Gene
(9) MalaCards diseases for NRL Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinitis pigmentosa 27 |
|
|
| enhanced s-cone syndrome |
|
|
| goldmann-favre syndrome |
|
|
| retinitis pigmentosa |
|
|
| retinal degeneration |
|
Search NRL in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
NRL_HUMAN- Retinal degeneration autosomal recessive clumped pigment type (RDCP) [MIM:613750]: A retinopathy characterized by night blindness since early childhood, consistent with a severe reduction in rod function. Color vision is normal although there is a relatively enhanced function of short-wavelength-sensitive cones in the macula. Signs of retinal degeneration and clusters of clumped pigment deposits in the peripheral fundus at the level of the retinal pigment epithelium are present. {ECO:0000269 PubMed:15591106, ECO:0000269 PubMed:17335001}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Retinitis pigmentosa 27 (RP27) [MIM:613750]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. {ECO:0000269 PubMed:10192380, ECO:0000269 PubMed:11385710, ECO:0000269 PubMed:11879142, ECO:0000269 PubMed:15591106, ECO:0000269 PubMed:15994872, ECO:0000269 PubMed:17335001, ECO:0000269 PubMed:21981118, ECO:0000269 PubMed:22334370}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for NRL
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for NRL Gene
Publications for NRL Gene
- Association of NR2E3 but not NRL mutations with retinitis pigmentosa in the Chinese population. (PMID: 19933183) Yang Y … Pang CP (Investigative ophthalmology & visual science 2010) 3 22 44 58
- Retinopathy mutations in the bZIP protein NRL alter phosphorylation and transcriptional activity. (PMID: 17335001) Kanda A … Swaroop A (Human mutation 2007) 3 4 22 58
- Novel mutations in the NRL gene and associated clinical findings in patients with dominant retinitis pigmentosa. (PMID: 11879142) DeAngelis MM … Dryja TP (Archives of ophthalmology (Chicago, Ill. : 1960) 2002) 3 4 44 58
- Mutations P51U and G122E in retinal transcription factor NRL associated with autosomal dominant and sporadic retinitis pigmentosa. (PMID: 11385710) Martinez-Gimeno M … Carballo M (Human mutation 2001) 4 22 44 58
- Multiple phosphorylated isoforms of NRL are expressed in rod photoreceptors. (PMID: 11477108) Swain PK … Swaroop A (The Journal of biological chemistry 2001) 3 4 22 58
Products for NRL Gene
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for NRL
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for NRL
- VectorBuilder custom plasmid, inducible vectors for NRL
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NRL
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 19 available NRL Antibodies ranked by validation data
- Compare Top NRL Antibodies
- antibodies-online: Search results for 1 available NRL Elisa Kits ranked by validation data
- Compare Top NRL Elisa Kits
- Quality Products:
- antibodies-online: Search results for 3 available NRL Proteins ranked by validation data
- Compare Top NRL Proteins
- Quality Products:
- Search GeneTex for Antibodies for NRL
- Search GeneTex for Proteins for NRL
- ViGene Biosciences adenoviral particle packaged cDNA for NRL gene
- ViGene Biosciences lentiviral particle packaged cDNA for NRL gene
- ViGene Biosciences ready-to-package AAV shRNAs for NRL gene
- Search ViGene Biosciences for NRL
- Santa Cruz Biotechnology (SCBT) Antibodies for NRL
- Search Santa Cruz Biotechnology (SCBT) for NRL siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NRL
- genomics-online: cdna clones - Search results for 97 available NRL gene related products
- Overview of 97 available NRL gene related products
- orf clones - Search results for 97 available NRL gene related products
- Overview of 97 available NRL gene related products
- genomics-online: gRNA clones - Search results for 97 available NRL gene related products
- Overview of 97 available NRL gene related products
- genomics-online: primer clones - Search results for 97 available NRL gene related products
- Overview of 97 available NRL gene related products
- genomics-online: shRNA clones - Search results for 97 available NRL gene related products
- Overview of 97 available NRL gene related products
Sources for NRL Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew