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Aliases for NPPC Gene

Aliases for NPPC Gene

  • Natriuretic Peptide C 2 3
  • CNP2 3 4
  • Natriuretic Peptide Precursor Type C 3
  • Natriuretic Peptide Precursor C 2
  • CNP 3

External Ids for NPPC Gene

Previous GeneCards Identifiers for NPPC Gene

  • GC02M230849
  • GC02M231521
  • GC02M232755
  • GC02M232992
  • GC02M232615
  • GC02M232498
  • GC02M232786
  • GC02M224641

Summaries for NPPC Gene

Entrez Gene Summary for NPPC Gene

  • This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]

GeneCards Summary for NPPC Gene

NPPC (Natriuretic Peptide C) is a Protein Coding gene. Diseases associated with NPPC include paraphimosis and achondroplasia. Among its related pathways are Neuroscience and Glial Cell Differentiation. GO annotations related to this gene include protein homodimerization activity and hormone activity.

UniProtKB/Swiss-Prot for NPPC Gene

  • Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity).

Gene Wiki entry for NPPC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPPC Gene

Genomics for NPPC Gene

Regulatory Elements for NPPC Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NPPC Gene

Chromosome:
2
Start:
231,921,820 bp from pter
End:
231,926,403 bp from pter
Size:
4,584 bases
Orientation:
Minus strand

Genomic View for NPPC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for NPPC Gene

Proteins for NPPC Gene

  • Protein details for NPPC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23582-ANFC_HUMAN
    Recommended name:
    C-type natriuretic peptide
    Protein Accession:
    P23582
    Secondary Accessions:
    • Q4ZG41

    Protein attributes for NPPC Gene

    Size:
    126 amino acids
    Molecular mass:
    13246 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPPC Gene

neXtProt entry for NPPC Gene

Proteomics data for NPPC Gene at MOPED

Post-translational modifications for NPPC Gene

  • Glycosylation at Thr 34
  • Modification sites at PhosphoSitePlus

Other Protein References for NPPC Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NPPC Gene

Domains & Families for NPPC Gene

Gene Families for NPPC Gene

Protein Domains for NPPC Gene

Suggested Antigen Peptide Sequences for NPPC Gene

Graphical View of Domain Structure for InterPro Entry

P23582

UniProtKB/Swiss-Prot:

ANFC_HUMAN :
  • Belongs to the natriuretic peptide family.
Family:
  • Belongs to the natriuretic peptide family.
genes like me logo Genes that share domains with NPPC: view

Function for NPPC Gene

Molecular function for NPPC Gene

GENATLAS Biochemistry:
natriuretic peptide precursor C homolog of mouse C type (CNP),most strongly expressed in the brain,also expressed in vascular endothelial cells and other tissues,present at extremely low level in circulation,potentially playing a paracrine/autocrine role
UniProtKB/Swiss-Prot Function:
Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity).

Gene Ontology (GO) - Molecular Function for NPPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 1660465
GO:0005179 hormone activity IEA --
GO:0042803 protein homodimerization activity IEA --
GO:0051428 peptide hormone receptor binding IEA --
genes like me logo Genes that share ontologies with NPPC: view
genes like me logo Genes that share phenotypes with NPPC: view

Animal Models for NPPC Gene

MGI Knock Outs for NPPC:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPPC

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NPPC Gene

Localization for NPPC Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPPC Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPPC Gene COMPARTMENTS Subcellular localization image for NPPC gene
Compartment Confidence
extracellular 5
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NPPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
GO:0030141 secretory granule IEA --
genes like me logo Genes that share ontologies with NPPC: view

Pathways & Interactions for NPPC Gene

genes like me logo Genes that share pathways with NPPC: view

Pathways by source for NPPC Gene

1 Cell Signaling Technology pathway for NPPC Gene
1 BioSystems pathway for NPPC Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for NPPC Gene

Gene Ontology (GO) - Biological Process for NPPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0001666 response to hypoxia IEA --
GO:0003418 growth plate cartilage chondrocyte differentiation ISS --
GO:0003419 growth plate cartilage chondrocyte proliferation ISS --
GO:0006182 cGMP biosynthetic process IDA 1672777
genes like me logo Genes that share ontologies with NPPC: view

No data available for SIGNOR curated interactions for NPPC Gene

Drugs & Compounds for NPPC Gene

(31) Drugs for NPPC Gene - From: NovoSeek and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atropine Approved Pharma Antagonist MAChRs antagonist 101
Carbachol Approved Pharma Full agonist, Agonist 3
Dexamethasone Approved, Investigational Pharma Agonist 1806
Heparin Approved, Investigational Pharma Antagonist 672,226
Isoproterenol Approved Pharma Full agonist, Agonist 15

(25) Additional Compounds for NPPC Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
18alpha-GLYCYRRHETINIC ACID
2,3-Cyclic nucleotide
8-Bromo cgmp
adenylate
chloride
genes like me logo Genes that share compounds with NPPC: view

Transcripts for NPPC Gene

mRNA/cDNA for NPPC Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPPC Gene

Natriuretic peptide C:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPPC

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPPC Gene

No ASD Table

Relevant External Links for NPPC Gene

GeneLoc Exon Structure for
NPPC
ECgene alternative splicing isoforms for
NPPC

Expression for NPPC Gene

mRNA expression in normal human tissues for NPPC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPPC Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.0).

Protein differential expression in normal tissues from HIPED for NPPC Gene

This gene is overexpressed in Cerebrospinal fluid (49.9) and Bone marrow mesenchymal stem cell (19.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NPPC Gene



SOURCE GeneReport for Unigene cluster for NPPC Gene Hs.247916

genes like me logo Genes that share expression patterns with NPPC: view

Protein tissue co-expression partners for NPPC Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NPPC Gene

Orthologs for NPPC Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPPC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NPPC 35
  • 92.59 (n)
  • 92.86 (a)
NPPC 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPPC 35
  • 93.65 (n)
  • 96.03 (a)
NPPC 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nppc 35
  • 88.36 (n)
  • 91.27 (a)
Nppc 16
Nppc 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NPPC 35
  • 99.74 (n)
  • 99.21 (a)
NPPC 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nppc 35
  • 89.42 (n)
  • 93.65 (a)
oppossum
(Monodelphis domestica)
Mammalia NPPC 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPPC 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nppc 35
  • 66.32 (n)
  • 70.53 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8803 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-126j24.3 35
  • 59.3 (n)
  • 45.26 (a)
NPPC (1 of 2) 36
  • 42 (a)
OneToMany
NPPC (2 of 2) 36
  • 42 (a)
OneToMany
Species with no ortholog for NPPC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPPC Gene

ENSEMBL:
Gene Tree for NPPC (if available)
TreeFam:
Gene Tree for NPPC (if available)

Paralogs for NPPC Gene

No data available for Paralogs for NPPC Gene

Variants for NPPC Gene

Sequence variations from dbSNP and Humsavar for NPPC Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs5261 -- 231,927,673(-) CCTGG(G/T)GACAG upstream-variant-2KB
rs5262 -- 231,927,238(-) ACAGA(A/G)GGAGT upstream-variant-2KB
rs5263 -- 231,927,224(-) CCAGC(A/G)GAGTC upstream-variant-2KB
rs5264 -- 231,926,796(-) ACTTT(A/C)TGCCT upstream-variant-2KB
rs5265 -- 231,926,359(-) GGACC(C/G)TGCTC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NPPC Gene

Variant ID Type Subtype PubMed ID
dgv1292e1 CNV Complex 17122850
nsv428408 CNV Gain+Loss 18775914
dgv1293e1 CNV Complex 17122850
essv10235 CNV CNV 17122850
nsv508892 CNV Insertion 20534489

Variation tolerance for NPPC Gene

Residual Variation Intolerance Score: 84.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPPC Gene

HapMap Linkage Disequilibrium report
NPPC
Human Gene Mutation Database (HGMD)
NPPC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPPC Gene

Disorders for NPPC Gene

MalaCards: The human disease database

(10) MalaCards diseases for NPPC Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
paraphimosis
achondroplasia
  • chondrodystrophia
acromesomelic dysplasia, maroteaux type
  • acromesomelic dysplasia maroteaux type
acromesomelic dysplasia
  • acromesomelic dwarfism
hypochondroplasia
  • hch
- elite association
Search NPPC in MalaCards View complete list of genes associated with diseases

Relevant External Links for NPPC

Genetic Association Database (GAD)
NPPC
Human Genome Epidemiology (HuGE) Navigator
NPPC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPPC
genes like me logo Genes that share disorders with NPPC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPPC Gene

Publications for NPPC Gene

  1. Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC). (PMID: 7698765) Ogawa Y. … Nakao K. (Genomics 1994) 2 23 67
  2. C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid. (PMID: 8330189) Kaneko T. … Hirai O. (Brain Res. 1993) 2 23 67
  3. Genetic variation in the natriuretic peptide system and heart failure. (PMID: 18850266) Lanfear D.E. (Heart Fail Rev 2010) 23 67
  4. Natriuretic peptide-dependent cGMP signal pathway potentiated the relaxation of gastric smooth muscle in streptozotocin-induced diabetic rats. (PMID: 19267196) Xu D.Y. … Xu W.X. (Dig. Dis. Sci. 2010) 23 67
  5. Effect of nutrition on plasma C-type natriuretic peptide forms in adult sheep: evidence for enhanced C-type natriuretic peptide degradation during caloric restriction. (PMID: 20005543) Prickett T.C. … Espiner E.A. (Metab. Clin. Exp. 2010) 23 67

Products for NPPC Gene

Sources for NPPC Gene

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