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Aliases for NPPC Gene

Aliases for NPPC Gene

  • Natriuretic Peptide C 2 3
  • Natriuretic Peptide Precursor C 2 3
  • CNP2 3 4
  • C-Type Natriuretic Peptide 3
  • CNP 3

External Ids for NPPC Gene

Summaries for NPPC Gene

Entrez Gene Summary for NPPC Gene

  • The protein encoded by this gene is proteolytically processed to form a secreted hormone of the natriuretic peptide family. The encoded hormone regulates the growth and differentiation of cartilaginous growth plate chondrocytes and may also be vasoactive and natriuretic. [provided by RefSeq, Sep 2011]

GeneCards Summary for NPPC Gene

NPPC (Natriuretic Peptide C) is a Protein Coding gene. Diseases associated with NPPC include colon adenocarcinoma and intracranial hypertension. Among its related pathways are Neuroscience and Glial Cell Differentiation. GO annotations related to this gene include protein homodimerization activity and hormone activity.

UniProtKB/Swiss-Prot for NPPC Gene

  • Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity).

Gene Wiki entry for NPPC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPPC Gene

Genomics for NPPC Gene

Genomic Location for NPPC Gene

Start:
231,921,820 bp from pter
End:
231,926,403 bp from pter
Size:
4,584 bases
Orientation:
Minus strand

Genomic View for NPPC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPPC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPPC Gene

Regulatory Elements for NPPC Gene

Proteins for NPPC Gene

  • Protein details for NPPC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23582-ANFC_HUMAN
    Recommended name:
    C-type natriuretic peptide
    Protein Accession:
    P23582
    Secondary Accessions:
    • Q4ZG41

    Protein attributes for NPPC Gene

    Size:
    126 amino acids
    Molecular mass:
    13246 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPPC Gene

neXtProt entry for NPPC Gene

Proteomics data for NPPC Gene at MOPED

Post-translational modifications for NPPC Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr34

Other Protein References for NPPC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPPC Gene

Domains for NPPC Gene

Gene Families for NPPC Gene

HGNC:

Protein Domains for NPPC Gene

UniProtKB/Swiss-Prot:

ANFC_HUMAN
Family:
  • Belongs to the natriuretic peptide family.:
    • P23582
genes like me logo Genes that share domains with NPPC: view

Function for NPPC Gene

Molecular function for NPPC Gene

GENATLAS Biochemistry: natriuretic peptide precursor C homolog of mouse C type (CNP),most strongly expressed in the brain,also expressed in vascular endothelial cells and other tissues,present at extremely low level in circulation,potentially playing a paracrine/autocrine role
UniProtKB/Swiss-Prot Function: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity).

Gene Ontology (GO) - Molecular Function for NPPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 1660465
GO:0005179 hormone activity IEA --
GO:0042803 protein homodimerization activity IEA --
GO:0051428 peptide hormone receptor binding IEA --
genes like me logo Genes that share ontologies with NPPC: view
genes like me logo Genes that share phenotypes with NPPC: view

Animal Models for NPPC Gene

MGI Knock Outs for NPPC:

miRNA for NPPC Gene

miRTarBase miRNAs that target NPPC

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NPPC Gene

Localization for NPPC Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPPC Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPPC Gene COMPARTMENTS Subcellular localization image for NPPC gene
Compartment Confidence
extracellular 5
cytoskeleton 1
cytosol 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NPPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
GO:0030141 secretory granule IEA --
genes like me logo Genes that share ontologies with NPPC: view

Pathways for NPPC Gene

genes like me logo Genes that share pathways with NPPC: view

Pathways by source for NPPC Gene

1 Cell Signaling Technology pathway for NPPC Gene
1 BioSystems pathway for NPPC Gene

Interacting Proteins for NPPC Gene

Gene Ontology (GO) - Biological Process for NPPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0001666 response to hypoxia IEA --
GO:0003418 growth plate cartilage chondrocyte differentiation ISS --
GO:0003419 growth plate cartilage chondrocyte proliferation ISS --
GO:0006182 cGMP biosynthetic process IDA 1672777
genes like me logo Genes that share ontologies with NPPC: view

Compounds for NPPC Gene

(55) Novoseek inferred chemical compound relationships for NPPC Gene

Compound -log(P) Hits PubMed IDs
urodilatin 90.8 22
cgmp 85.2 128
guanylate 74.4 18
8-bromo cgmp 72.6 12
2,3-cyclic nucleotide 65.1 7
genes like me logo Genes that share compounds with NPPC: view

Transcripts for NPPC Gene

mRNA/cDNA for NPPC Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPPC Gene

Natriuretic peptide C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPPC Gene

No ASD Table

Relevant External Links for NPPC Gene

GeneLoc Exon Structure for
NPPC
ECgene alternative splicing isoforms for
NPPC

Expression for NPPC Gene

mRNA expression in normal human tissues for NPPC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPPC Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NPPC Gene

SOURCE GeneReport for Unigene cluster for NPPC Gene Hs.247916

genes like me logo Genes that share expressions with NPPC: view

Orthologs for NPPC Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPPC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPPC 36
  • 99.74 (n)
  • 99.21 (a)
NPPC 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NPPC 36
  • 92.59 (n)
  • 92.86 (a)
NPPC 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPPC 36
  • 93.65 (n)
  • 96.03 (a)
NPPC 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nppc 36
  • 88.36 (n)
  • 91.27 (a)
Nppc 16
Nppc 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NPPC 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPPC 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nppc 36
  • 89.42 (n)
  • 93.65 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8803 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nppc 36
  • 66.32 (n)
  • 70.53 (a)
zebrafish
(Danio rerio)
Actinopterygii NPPC (1 of 2) 37
  • 42 (a)
OneToMany
NPPC (2 of 2) 37
  • 42 (a)
OneToMany
si:ch211-126j24.3 36
  • 59.3 (n)
  • 45.26 (a)
Species with no ortholog for NPPC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPPC Gene

ENSEMBL:
Gene Tree for NPPC (if available)
TreeFam:
Gene Tree for NPPC (if available)

Paralogs for NPPC Gene

No data available for Paralogs for NPPC Gene

Variants for NPPC Gene

Sequence variations from dbSNP and Humsavar for NPPC Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs5261 -- 231,927,673(-) CCTGG(G/T)GACAG upstream-variant-2KB
rs5262 -- 231,927,238(-) ACAGA(A/G)GGAGT upstream-variant-2KB
rs5263 -- 231,927,224(-) CCAGC(A/G)GAGTC upstream-variant-2KB
rs5264 -- 231,926,796(-) ACTTT(A/C)TGCCT upstream-variant-2KB
rs5265 -- 231,926,359(-) GGACC(C/G)TGCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NPPC Gene

Variant ID Type Subtype PubMed ID
dgv1292e1 CNV Complex 17122850
nsv428408 CNV Gain+Loss 18775914
dgv1293e1 CNV Complex 17122850
essv10235 CNV CNV 17122850
nsv508892 CNV Insertion 20534489

Relevant External Links for NPPC Gene

HapMap Linkage Disequilibrium report
NPPC
Human Gene Mutation Database (HGMD)
NPPC

Disorders for NPPC Gene

(4) University of Copenhagen DISEASES for NPPC Gene

(44) Novoseek inferred disease relationships for NPPC Gene

Disease -log(P) Hits PubMed IDs
heart failure 54.6 13
heart failure congestive 51.2 6
skeletal dysplasia 46.6 3
dwarfism 44 3
achondroplasia 40.3 3

Relevant External Links for NPPC

Genetic Association Database (GAD)
NPPC
Human Genome Epidemiology (HuGE) Navigator
NPPC
genes like me logo Genes that share disorders with NPPC: view

No data available for UniProtKB/Swiss-Prot for NPPC Gene

Publications for NPPC Gene

  1. Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC). (PMID: 7698765) Ogawa Y. … Nakao K. (Genomics 1994) 2 3 23
  2. Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). (PMID: 1672777) Koller K.J. … Goeddel D.V. (Science 1991) 3 4 23
  3. C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid. (PMID: 8330189) Kaneko T. … Hirai O. (Brain Res. 1993) 2 3 23
  4. Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1. (PMID: 1472040) Ishizaka Y. … Matsuo H. (Biochem. Biophys. Res. Commun. 1992) 3 4 23
  5. Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera. (PMID: 1660465) Bennett B.D. … Lowe D.G. (J. Biol. Chem. 1991) 3 23

Products for NPPC Gene

Sources for NPPC Gene

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