Aliases for NPPA Gene
External Ids for NPPA Gene
Previous HGNC Symbols for NPPA Gene
Previous GeneCards Identifiers for NPPA Gene
The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009]
GeneCards Summary for NPPA Gene
NPPA (Natriuretic Peptide A) is a Protein Coding gene. Diseases associated with NPPA include atrial fibrillation, familial, 6 and atrial standstill 2. Among its related pathways are Disease and Human Embryonic Stem Cell Pluripotency. GO annotations related to this gene include receptor binding and peptide hormone receptor binding.
UniProtKB/Swiss-Prot for NPPA Gene
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl cyclase activity. There are three isoforms of NP receptors; NPR1, NPR2 and NPR3, which have conserved catalytic and regulatory domains and divergent ligand binding domains. Natruiretic peptide receptors bind alpha-atrial natriuretic peptide, brain natriuretic peptide and type C-natriuretic peptide with varying affinity and are found in the brain, vasculature and kidney. The main physiological role of NP receptors is in homeostasis of body fluid volume.