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Aliases for NPPA Gene

Aliases for NPPA Gene

  • Natriuretic Peptide A 2 3 5
  • Cardiodilatin-Related Peptide 3 4
  • Prepronatriodilatin 3 4
  • CDD-ANF 3 4
  • CDD 3 4
  • CDP 3 4
  • ANP 3 4
  • PND 3 4
  • Natriuretic Peptide Precursor A Variant 1 3
  • Natriuretic Peptide Precursor A 2
  • Cardiodilatin 4
  • Cardionatrin 3
  • Atriopeptin 3
  • ATRST2 3
  • ATFB6 3
  • ANF 3

External Ids for NPPA Gene

Previous HGNC Symbols for NPPA Gene

  • ANP
  • PND

Previous GeneCards Identifiers for NPPA Gene

  • GC01U990120
  • GC01M011750
  • GC01M011515
  • GC01M011615
  • GC01M011840
  • GC01M011828
  • GC01M011061

Summaries for NPPA Gene

Entrez Gene Summary for NPPA Gene

  • The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by RefSeq, Oct 2015]

GeneCards Summary for NPPA Gene

NPPA (Natriuretic Peptide A) is a Protein Coding gene. Diseases associated with NPPA include atrial standstill 2 and atrial fibrillation, familial, 6. Among its related pathways are Gene Expression and Transport to the Golgi and subsequent modification. GO annotations related to this gene include receptor binding and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for NPPA Gene

  • Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Tocris Summary for NPPA Gene

  • Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl cyclase activity. There are three isoforms of NP receptors; NPR1-3, which have conserved catalytic and regulatory domains and divergent ligand binding domains.

Gene Wiki entry for NPPA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPPA Gene

Genomics for NPPA Gene

Regulatory Elements for NPPA Gene

Genomic Location for NPPA Gene

11,845,709 bp from pter
11,848,345 bp from pter
2,637 bases
Minus strand

Genomic View for NPPA Gene

Genes around NPPA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPPA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPPA Gene

Proteins for NPPA Gene

  • Protein details for NPPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Natriuretic peptides A
    Protein Accession:
    Secondary Accessions:
    • Q13766
    • Q5JZE1

    Protein attributes for NPPA Gene

    153 amino acids
    Molecular mass:
    16708 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAA15955.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NPPA Gene

neXtProt entry for NPPA Gene

Proteomics data for NPPA Gene at MOPED

Post-translational modifications for NPPA Gene

  • Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.
  • Cleaved by CORIN upon secretion to produce the functional hormone.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPPA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for NPPA (Atrial Natriuretic Peptide/ANP)

No data available for DME Specific Peptides for NPPA Gene

Domains & Families for NPPA Gene

Gene Families for NPPA Gene

Protein Domains for NPPA Gene

Suggested Antigen Peptide Sequences for NPPA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the natriuretic peptide family.
  • Belongs to the natriuretic peptide family.
genes like me logo Genes that share domains with NPPA: view

Function for NPPA Gene

Molecular function for NPPA Gene

GENATLAS Biochemistry:
pronatriodilatin,mainly expressed in the cardiac atria and ventricles,present in the circulation and directly influencing blood pressure and body fluid homeostasis,conferring protection from nephropathy and microvascular damage in type 1 diabetes
UniProtKB/Swiss-Prot Function:
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

LifeMap Function Summary for NPPA Gene

It affects the following cells:
genes like me logo Genes that share phenotypes with NPPA: view

Human Phenotype Ontology for NPPA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NPPA Gene

MGI Knock Outs for NPPA:

Animal Model Products

miRNA for NPPA Gene

miRTarBase miRNAs that target NPPA

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for NPPA Gene

Localization for NPPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPPA Gene


Subcellular locations from

Jensen Localization Image for NPPA Gene COMPARTMENTS Subcellular localization image for NPPA gene
Compartment Confidence
extracellular 5
nucleus 3
vacuole 3
cytoskeleton 2
cytosol 2
lysosome 2
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NPPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042629 mast cell granule IEA --
genes like me logo Genes that share ontologies with NPPA: view

Pathways & Interactions for NPPA Gene

genes like me logo Genes that share pathways with NPPA: view

SIGNOR curated interactions for NPPA Gene


Gene Ontology (GO) - Biological Process for NPPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0003085 negative regulation of systemic arterial blood pressure IEA --
GO:0006182 cGMP biosynthetic process IEA,IDA 1672777
GO:0007168 receptor guanylyl cyclase signaling pathway IDA 1672777
GO:0007218 neuropeptide signaling pathway IDA 19646991
genes like me logo Genes that share ontologies with NPPA: view

Drugs & Compounds for NPPA Gene

(87) Drugs for NPPA Gene - From: Novoseek, PharmGKB, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chlorthalidone Approved Pharma 57
Amlodipine Approved Pharma Calcium channel blocker 449
BNP (1-32), human Pharma Brain natriuretic peptide 0

(53) Additional Compounds for NPPA Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AP 811
Atrial natriuretic factor (1-28) (human, porcine)
Atrial natriuretic factor (1-28) (rat)
Brain natriuretic peptide (1-32) (human)
C-type natriuretic peptide (1-22) (human, rat, swine)
genes like me logo Genes that share compounds with NPPA: view

Transcripts for NPPA Gene

mRNA/cDNA for NPPA Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(223) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPPA Gene

Natriuretic peptide A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPPA Gene

No ASD Table

Relevant External Links for NPPA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPPA Gene

mRNA expression in normal human tissues for NPPA Gene

mRNA differential expression in normal tissues according to GTEx for NPPA Gene

This gene is overexpressed in Heart - Atrial Appendage (x52.3).

Protein differential expression in normal tissues from HIPED for NPPA Gene

This gene is overexpressed in Fetal heart (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NPPA Gene

SOURCE GeneReport for Unigene cluster for NPPA Gene Hs.75640

genes like me logo Genes that share expression patterns with NPPA: view

Protein tissue co-expression partners for NPPA Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NPPA Gene

Orthologs for NPPA Gene

This gene was present in the common ancestor of mammals.

Orthologs for NPPA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NPPA 35
  • 99.56 (n)
  • 100 (a)
  • 99 (a)
(Bos Taurus)
Mammalia NPPA 36
  • 84 (a)
  • 87.53 (n)
  • 85.71 (a)
(Canis familiaris)
Mammalia NPPA 35
  • 85.94 (n)
  • 85.71 (a)
  • 85 (a)
(Mus musculus)
Mammalia Nppa 36
  • 79 (a)
Nppa 16
Nppa 35
  • 82.22 (n)
  • 80.67 (a)
(Monodelphis domestica)
Mammalia NPPA 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia NPPA 36
  • 64 (a)
(Rattus norvegicus)
Mammalia Nppa 35
  • 84.48 (n)
  • 84.73 (a)
Species with no ortholog for NPPA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPPA Gene

Gene Tree for NPPA (if available)
Gene Tree for NPPA (if available)

Paralogs for NPPA Gene

No data available for Paralogs for NPPA Gene

Variants for NPPA Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NPPA Gene

There are two different prepronatriodilatin alleles. One codes for 2 Arg residues at the C-terminus that are cleaved to form the mature peptide, while the other ends in a termination codon immediately after the last codon of the mature peptide.

Sequence variations from dbSNP and Humsavar for NPPA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_014579 -
VAR_071307 Atrial standstill 2 (ATRST2)
rs198373 -- 11,849,478(+) ctagc(A/G)ctgtg upstream-variant-2KB
rs5772478 -- 11,849,398(+) CAACA(-/C)CATAA upstream-variant-2KB
rs13305986 -- 11,848,448(-) TCTTG(C/G)TATTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NPPA Gene

Variant ID Type Subtype PubMed ID
nsv527521 CNV Loss 19592680

Variation tolerance for NPPA Gene

Residual Variation Intolerance Score: 78.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.80; 79.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPPA Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for NPPA Gene

MalaCards: The human disease database

(44) MalaCards diseases for NPPA Gene - From: OMIM, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
atrial standstill 2
  • atrial dilated cardiomyopathy with atrial standstill
atrial fibrillation, familial, 6
  • atfb6
atrial standstill
  • atrial cardiomyopathy with heart block
familial atrial fibrillation
  • atrial fibrillation, familial, 1
nppa-related familial atrial fibrillation 6
  • atrial fibrillation, familial, 6
- elite association - COSMIC cancer census association via MalaCards
Search NPPA in MalaCards View complete list of genes associated with diseases


  • Atrial standstill 2 (ATRST2) [MIM:615745]: A rare arrhythmia characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm. {ECO:0000269 PubMed:23275345}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Atrial fibrillation, familial, 6 (ATFB6) [MIM:612201]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO:0000269 PubMed:18614783}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for NPPA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NPPA: view

No data available for Genatlas for NPPA Gene

Publications for NPPA Gene

  1. A polymorphism in the NPPA gene associates with asthma. (PMID: 18294255) Lima J.J. … Sylvester J.E. (Clin. Exp. Allergy 2008) 3 23 48 67
  2. Evidence for cross-talk between atrial natriuretic peptide and nitric oxide receptors. (PMID: 20024606) Kotlo K.U. … Danziger R.S. (Mol. Cell. Biochem. 2010) 3 23
  3. Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation. (PMID: 19646991) Abraham R.L. … Darbar D. (J. Mol. Cell. Cardiol. 2010) 3 23
  4. The relationship between tumor necrosis factor-I+, brain natriuretic peptide and atrial natriuretic peptide in patients with chronic heart failure. (PMID: 19155075) Vaz PAcrez A. … Rauchhaus M. (Int. J. Cardiol. 2010) 3 23
  5. Natural antisense transcript of natriuretic peptide precursor A (NPPA): structural organization and modulation of NPPA expression. (PMID: 19671135) Annilo T. … Laan M. (BMC Mol. Biol. 2009) 3 23

Products for NPPA Gene

Sources for NPPA Gene

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