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Aliases for NPPA Gene

Aliases for NPPA Gene

  • Natriuretic Peptide A 2 3
  • ANP 3 4 6
  • PND 3 4 6
  • Natriuretic Peptide Precursor A 2 3
  • Cardiodilatin-Related Peptide 3 4
  • Prepronatriodilatin 3 4
  • Cardiodilatin 3 4
  • CDD-ANF 3 4
  • ATFB6 3 6
  • CDD 3 4
  • CDP 3 4
  • Natriuretic Peptides A 3
  • Cardionatrin 3
  • Atriopeptin 3
  • ATRST2 3
  • ANF 3

External Ids for NPPA Gene

Previous HGNC Symbols for NPPA Gene

  • ANP
  • PND

Previous GeneCards Identifiers for NPPA Gene

  • GC01U990120
  • GC01M011750
  • GC01M011515
  • GC01M011615
  • GC01M011840
  • GC01M011828
  • GC01M011061

Summaries for NPPA Gene

Entrez Gene Summary for NPPA Gene

  • The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009]

GeneCards Summary for NPPA Gene

NPPA (Natriuretic Peptide A) is a Protein Coding gene. Diseases associated with NPPA include atrial fibrillation, familial, 6 and atrial standstill 2. Among its related pathways are Disease and Human Embryonic Stem Cell Pluripotency. GO annotations related to this gene include receptor binding and peptide hormone receptor binding.

UniProtKB/Swiss-Prot for NPPA Gene

  • Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Tocris Summary for NPPA Gene

  • Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl cyclase activity. There are three isoforms of NP receptors; NPR1, NPR2 and NPR3, which have conserved catalytic and regulatory domains and divergent ligand binding domains. Natruiretic peptide receptors bind alpha-atrial natriuretic peptide, brain natriuretic peptide and type C-natriuretic peptide with varying affinity and are found in the brain, vasculature and kidney. The main physiological role of NP receptors is in homeostasis of body fluid volume.

Gene Wiki entry for NPPA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPPA Gene

Genomics for NPPA Gene

Regulatory Elements for NPPA Gene

Genomic Location for NPPA Gene

Start:
11,845,709 bp from pter
End:
11,848,345 bp from pter
Size:
2,637 bases
Orientation:
Minus strand

Genomic View for NPPA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPPA Gene

Proteins for NPPA Gene

  • Protein details for NPPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01160-ANF_HUMAN
    Recommended name:
    Natriuretic peptides A
    Protein Accession:
    P01160
    Secondary Accessions:
    • Q13766
    • Q5JZE1

    Protein attributes for NPPA Gene

    Size:
    153 amino acids
    Molecular mass:
    16708 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA15955.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NPPA Gene

neXtProt entry for NPPA Gene

Proteomics data for NPPA Gene at MOPED

Post-translational modifications for NPPA Gene

  • Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.
  • Cleaved by CORIN upon secretion to produce the functional hormone.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPPA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NPPA Gene

Domains for NPPA Gene

Gene Families for NPPA Gene

HGNC:

Protein Domains for NPPA Gene

Suggested Antigen Peptide Sequences for NPPA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01160

UniProtKB/Swiss-Prot:

ANF_HUMAN :
  • P01160
Family:
  • Belongs to the natriuretic peptide family.
genes like me logo Genes that share domains with NPPA: view

Function for NPPA Gene

Molecular function for NPPA Gene

GENATLAS Biochemistry: pronatriodilatin,mainly expressed in the cardiac atria and ventricles,present in the circulation and directly influencing blood pressure and body fluid homeostasis,conferring protection from nephropathy and microvascular damage in type 1 diabetes
UniProtKB/Swiss-Prot Function: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Gene Ontology (GO) - Molecular Function for NPPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 1660465
GO:0005179 hormone activity --
GO:0005184 neuropeptide hormone activity IMP 19646991
GO:0005515 protein binding IPI 25416956
GO:0051428 peptide hormone receptor binding IEA --
genes like me logo Genes that share ontologies with NPPA: view
genes like me logo Genes that share phenotypes with NPPA: view

Animal Models for NPPA Gene

MGI Knock Outs for NPPA:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NPPA Gene

Localization for NPPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPPA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPPA Gene COMPARTMENTS Subcellular localization image for NPPA gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
golgi apparatus 2
lysosome 2
mitochondrion 2
nucleus 2
vacuole 2

Gene Ontology (GO) - Cellular Components for NPPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0042629 mast cell granule IEA --
genes like me logo Genes that share ontologies with NPPA: view

Pathways for NPPA Gene

genes like me logo Genes that share pathways with NPPA: view

Gene Ontology (GO) - Biological Process for NPPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0003085 negative regulation of systemic arterial blood pressure IEA --
GO:0006182 cGMP biosynthetic process IDA 1672777
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007168 receptor guanylyl cyclase signaling pathway IDA 1672777
genes like me logo Genes that share ontologies with NPPA: view

Compounds for NPPA Gene

(4) Tocris Compounds for NPPA Gene

Compound Action Cas Number
Atrial natriuretic factor (1-28) (human, porcine) Endogenous peptide regulating blood pressure [91917-63-4]
C-type natriuretic peptide (1-22) (human, rat, swine) Endogenous peptide agonist at NPR2 [127869-51-6]
Atrial natriuretic factor (1-28) (rat) Endogenous peptide regulating blood pressure [88898-17-3]
Brain natriuretic peptide (1-32) (human) Endogenous peptide agonist at ANP receptor A (NPR1) [124584-08-3]

(133) Novoseek inferred chemical compound relationships for NPPA Gene

Compound -log(P) Hits PubMed IDs
hanp 94.5 109
cgmp 90.3 415
urodilatin 89.4 133
sodium 86 303
anaritide 80.7 8

(2) PharmGKB related drug/compound annotations for NPPA Gene

Drug/compound Annotation
amlodipine CA
chlorthalidone CA
genes like me logo Genes that share compounds with NPPA: view

Transcripts for NPPA Gene

mRNA/cDNA for NPPA Gene

(223) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPPA Gene

Natriuretic peptide A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPPA Gene

No ASD Table

Relevant External Links for NPPA Gene

GeneLoc Exon Structure for
NPPA
ECgene alternative splicing isoforms for
NPPA

Expression for NPPA Gene

mRNA expression in normal human tissues for NPPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPPA Gene

This gene is overexpressed in Heart - Atrial Appendage (52.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NPPA Gene

SOURCE GeneReport for Unigene cluster for NPPA Gene Hs.75640

genes like me logo Genes that share expressions with NPPA: view

No data available for mRNA Expression by UniProt/SwissProt for NPPA Gene

Orthologs for NPPA Gene

This gene was present in the common ancestor of mammals.

Orthologs for NPPA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPPA 35
  • 99.56 (n)
  • 100 (a)
NPPA 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NPPA 35
  • 87.53 (n)
  • 85.71 (a)
NPPA 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPPA 35
  • 85.94 (n)
  • 85.71 (a)
NPPA 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nppa 35
  • 82.22 (n)
  • 80.67 (a)
Nppa 16
Nppa 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NPPA 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPPA 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nppa 35
  • 84.48 (n)
  • 84.73 (a)
Species with no ortholog for NPPA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPPA Gene

ENSEMBL:
Gene Tree for NPPA (if available)
TreeFam:
Gene Tree for NPPA (if available)

Paralogs for NPPA Gene

No data available for Paralogs for NPPA Gene

Variants for NPPA Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NPPA Gene

P01160-ANF_HUMAN
There are two different prepronatriodilatin alleles. One codes for 2 Arg residues at the C-terminus that are cleaved to form the mature peptide, while the other ends in a termination codon immediately after the last codon of the mature peptide

Sequence variations from dbSNP and Humsavar for NPPA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs198372 -- 11,849,457(+) tattg(A/G)ttgct upstream-variant-2KB
rs198373 -- 11,849,478(+) ctagc(A/G)ctgtg upstream-variant-2KB
rs1003632 -- 11,849,352(+) CCTAC(C/T)TTGCA upstream-variant-2KB
rs5772478 -- 11,849,398(+) CAACA(-/C)CATAA upstream-variant-2KB
rs6695740 -- 11,848,235(+) AGCCA(A/G)CAGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NPPA Gene

Variant ID Type Subtype PubMed ID
nsv527521 CNV Loss 19592680

Relevant External Links for NPPA Gene

HapMap Linkage Disequilibrium report
NPPA
Human Gene Mutation Database (HGMD)
NPPA

Disorders for NPPA Gene

(1) OMIM Diseases for NPPA Gene (108780)

UniProtKB/Swiss-Prot

ANF_HUMAN
  • Atrial standstill 2 (ATRST2) [MIM:615745]: A rare arrhythmia characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm. {ECO:0000269 PubMed:23275345}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Atrial fibrillation, familial, 6 (ATFB6) [MIM:612201]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO:0000269 PubMed:18614783}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(96) Novoseek inferred disease relationships for NPPA Gene

Disease -log(P) Hits PubMed IDs
heart failure 82.5 235
heart failure congestive 81.5 137
essential hypertension 77 161
fluid overload 72.3 37
ventricular dysfunction left 71.2 52

Relevant External Links for NPPA

Genetic Association Database (GAD)
NPPA
Human Genome Epidemiology (HuGE) Navigator
NPPA
genes like me logo Genes that share disorders with NPPA: view

Publications for NPPA Gene

  1. Polymorphisms in the hANP (human atrial natriuretic peptide) gene, albuminuria, and hypertension. (PMID: 11408388) Nannipieri M. … Ferrannini E. (Hypertension 2001) 3 23 48
  2. Atrial natriuretic peptide gene G664A polymorphism and the risk of ischemic cerebrovascular disease. (PMID: 11706124) Hassan A. … Markus H.S. (Neurology 2001) 3 23 48
  3. [Study of genotype frequencies of ANP 664G/A polymorphism in normal subjects and CVD patients, and its association with plasma ANP levels]. (PMID: 11985060) Ohta A. … Watanabe K. (Rinsho Byori 2002) 3 23 48
  4. The ScaI gene polymorphism of the atrial natriuretic factor and essential arterial hypertension in childhood. (PMID: 15666592) Zorc-PleskoviA8 R. … Teran N. (Coll Antropol 2004) 3 23 48
  5. Atrial natriuretic peptide gene polymorphisms and risk of ischemic stroke in humans. (PMID: 15017020) Rubattu S. … Volpe M. (Stroke 2004) 3 23 48

Products for NPPA Gene

Sources for NPPA Gene

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