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Aliases for NPAT Gene

Aliases for NPAT Gene

  • Nuclear Protein, Ataxia-Telangiectasia Locus 2 3
  • E14 3 4 6
  • Nuclear Protein Of The Ataxia Telangiectasia Mutated Locus 3 4
  • Nuclear Protein Of The ATM Locus 3 4
  • P220 3 4
  • Protein NPAT 3
  • E14/NPAT 3
  • CAND3 4

External Ids for NPAT Gene

Summaries for NPAT Gene

GeneCards Summary for NPAT Gene

NPAT (Nuclear Protein, Ataxia-Telangiectasia Locus) is a Protein Coding gene. Diseases associated with NPAT include ataxia-telangiectasia and ataxia. Among its related pathways are RB in Cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription corepressor activity.

UniProtKB/Swiss-Prot for NPAT Gene

  • Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters.

Gene Wiki entry for NPAT Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPAT Gene

Genomics for NPAT Gene

Genomic Location for NPAT Gene

Start:
108,157,215 bp from pter
End:
108,222,642 bp from pter
Size:
65,428 bases
Orientation:
Minus strand

Genomic View for NPAT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPAT Gene

Regulatory Elements for NPAT Gene

Proteins for NPAT Gene

  • Protein details for NPAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14207-NPAT_HUMAN
    Recommended name:
    Protein NPAT
    Protein Accession:
    Q14207
    Secondary Accessions:
    • A8K1V5
    • A8K6M2
    • Q13632
    • Q14967
    • Q16580
    • Q86W55
    • Q8IWE9

    Protein attributes for NPAT Gene

    Size:
    1427 amino acids
    Molecular mass:
    154290 Da
    Quaternary structure:
    • Interacts with the cylin/CDK complexes CCNE1/CDK2 and CCNA1/CDK2. Interacts with BZW1, CASP8AP2, CREBBP, MIZF and YY1. Interacts with the RUVBL1, RUVBL2 and TRRAP subunits of the NuA4 complex. May also interact with GAPDH, NME1, NME2 and STIP1.
    SequenceCaution:
    • Sequence=AAB02735.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. A chimeric cDNA originating from chromosomes 11 and 4.; Evidence={ECO:0000305}; Sequence=AAH40356.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH50561.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for NPAT Gene

Proteomics data for NPAT Gene at MOPED

Post-translational modifications for NPAT Gene

  • Phosphorylated at Ser-775, Ser-779, Ser-1100, Thr-1270 and Thr-1350 by CCNE1/CDK2 at G1-S transition and until prophase, which promotes association with histone gene clusters and stimulates activation of histone transcription. Also phosphorylated by CCNA1/CDK2 in vitro.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPAT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPAT Gene

Domains for NPAT Gene

Protein Domains for NPAT Gene

Suggested Antigen Peptide Sequences for NPAT Gene

Graphical View of Domain Structure for InterPro Entry

Q14207

UniProtKB/Swiss-Prot:

NPAT_HUMAN
Domain:
  • The LisH domain is required for the activation of histone gene transcription.:
    • Q14207
  • Contains 1 LisH domain.:
    • Q14207
Family:
  • Belongs to the NPAT family.:
    • Q14207
genes like me logo Genes that share domains with NPAT: view

No data available for Gene Families for NPAT Gene

Function for NPAT Gene

Molecular function for NPAT Gene

GENATLAS Biochemistry: nuclear protein,mapped upstream to the AT locus,in opposite orientation,likely transcribed from a bidirectional promoter,with homology
UniProtKB/Swiss-Prot Function: Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters.
UniProtKB/Swiss-Prot Induction: By expression of E2F1, E2F2, E2F3 and E2F4. Expression is reduced in response to radiation-induced DNA damage.

Gene Ontology (GO) - Molecular Function for NPAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IMP 15988025
GO:0003714 transcription corepressor activity IMP 17163457
GO:0005515 protein binding IPI 18850719
GO:0008022 protein C-terminus binding IPI 15988025
GO:0047485 protein N-terminus binding IPI 19170105
genes like me logo Genes that share ontologies with NPAT: view

Phenotypes for NPAT Gene

genes like me logo Genes that share phenotypes with NPAT: view

miRNA for NPAT Gene

miRTarBase miRNAs that target NPAT

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NPAT Gene

Localization for NPAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPAT Gene

Nucleus. Nucleus, Cajal body. Note=Concentrates in two Cajal bodies tethered to histone gene clusters at chromosome 6p21 during G1, S and G2 phases. Also concentrates in two additional Cajal bodies tethered to histone gene clusters at chromosome 1q21 specifically during S and G2 phases.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPAT Gene COMPARTMENTS Subcellular localization image for NPAT gene
Compartment Confidence
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for NPAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15988025
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 17068332
GO:0015030 Cajal body IDA 15988025
GO:0097504 Gemini of coiled bodies IDA 17068332
genes like me logo Genes that share ontologies with NPAT: view

Pathways for NPAT Gene

SuperPathways for NPAT Gene

Superpath Contained pathways
1 RB in Cancer
genes like me logo Genes that share pathways with NPAT: view

Pathways by source for NPAT Gene

1 BioSystems pathway for NPAT Gene

Gene Ontology (GO) - Biological Process for NPAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IMP 15988025
GO:0006351 transcription, DNA-templated IEA --
GO:0010468 regulation of gene expression IMP 15988025
GO:0045893 positive regulation of transcription, DNA-templated IDA 18850719
GO:1903507 negative regulation of nucleic acid-templated transcription IMP 17163457
genes like me logo Genes that share ontologies with NPAT: view

Transcripts for NPAT Gene

Unigene Clusters for NPAT Gene

Nuclear protein, ataxia-telangiectasia locus:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPAT Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b
SP1: - -
SP2:
SP3:
SP4: -

Relevant External Links for NPAT Gene

GeneLoc Exon Structure for
NPAT
ECgene alternative splicing isoforms for
NPAT

Expression for NPAT Gene

mRNA expression in normal human tissues for NPAT Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NPAT Gene

SOURCE GeneReport for Unigene cluster for NPAT Gene Hs.171061

mRNA Expression by UniProt/SwissProt for NPAT Gene

Q14207-NPAT_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with NPAT: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NPAT Gene

Orthologs for NPAT Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPAT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPAT 35
  • 99.53 (n)
  • 99.44 (a)
NPAT 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NPAT 35
  • 87.11 (n)
  • 81.86 (a)
NPAT 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPAT 35
  • 85.92 (n)
  • 79.58 (a)
NPAT 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Npat 35
  • 81.79 (n)
  • 75.51 (a)
Npat 16
Npat 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NPAT 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Npat 35
  • 80.7 (n)
  • 75.23 (a)
chicken
(Gallus gallus)
Aves NPAT 35
  • 61.24 (n)
  • 53.13 (a)
NPAT 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPAT 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8206 35
zebrafish
(Danio rerio)
Actinopterygii npat 35
  • 54.27 (n)
  • 48 (a)
Species with no ortholog for NPAT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPAT Gene

ENSEMBL:
Gene Tree for NPAT (if available)
TreeFam:
Gene Tree for NPAT (if available)

Paralogs for NPAT Gene

genes like me logo Genes that share paralogs with NPAT: view

No data available for Paralogs for NPAT Gene

Variants for NPAT Gene

Sequence variations from dbSNP and Humsavar for NPAT Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs183459 -- 108,218,470(+) TGTTC(G/T)TTAAG intron-variant
rs183460 -- 108,219,983(+) GGAAG(A/C)CAAAG intron-variant
rs228606 -- 108,217,120(+) ccaaa(G/T)atgtg intron-variant
rs228607 -- 108,217,766(+) ggcgc(A/G)tggat intron-variant
rs228608 -- 108,218,173(-) TATTC(A/G)GGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPAT Gene

Variant ID Type Subtype PubMed ID
dgv1315n71 CNV Loss 21882294
esv2670718 CNV Deletion 23128226

Relevant External Links for NPAT Gene

HapMap Linkage Disequilibrium report
NPAT
Human Gene Mutation Database (HGMD)
NPAT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPAT Gene

Disorders for NPAT Gene

(1) University of Copenhagen DISEASES for NPAT Gene

(1) Novoseek inferred disease relationships for NPAT Gene

Disease -log(P) Hits PubMed IDs
breast cancer 0.395 2

Relevant External Links for NPAT

Genetic Association Database (GAD)
NPAT
Human Genome Epidemiology (HuGE) Navigator
NPAT
genes like me logo Genes that share disorders with NPAT: view

No data available for UniProtKB/Swiss-Prot for NPAT Gene

Publications for NPAT Gene

  1. Identification and characterization of a new gene physically linked to the ATM gene. (PMID: 8743993) Imai T. … Hori T. (Genome Res. 1996) 3 4 23
  2. Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S- phase entry. (PMID: 9472014) Zhao J. … Harlow E. (Genes Dev. 1998) 3 4 23
  3. NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. (PMID: 10995386) Zhao J. … Harlow E. (Genes Dev. 2000) 3 4 23
  4. NPAT expression is regulated by E2F and is essential for cell cycle progression. (PMID: 12665581) Gao G. … Zhao J. (Mol. Cell. Biol. 2003) 3 4 23
  5. S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. (PMID: 12887926) Zheng L. … Luo Y. (Cell 2003) 3 4 23

Products for NPAT Gene

Sources for NPAT Gene

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