Aliases for NPAS2 Gene
Aliases for NPAS2 Gene
External Ids for NPAS2 Gene
- HGNC: 7895
- Entrez Gene: 4862
- Ensembl: ENSG00000170485
- OMIM: 603347
- UniProtKB: Q99743
Previous GeneCards Identifiers for NPAS2 Gene
- GC02P099300
- GC02P099889
- GC02P101041
- GC02P101058
- GC02P100895
- GC02P101436
- GC02P095284
Summaries for NPAS2 Gene
-
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008]
GeneCards Summary for NPAS2 Gene
NPAS2 (Neuronal PAS Domain Protein 2) is a Protein Coding gene. Diseases associated with NPAS2 include Restless Legs Syndrome. Among its related pathways are Circadian rhythm pathway and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein dimerization activity. An important paralog of this gene is CLOCK.
UniProtKB/Swiss-Prot for NPAS2 Gene
-
Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots circa (about) and diem (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for timegivers). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5-CACGTG-3) within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK NPAS2-ARNTL/BMAL1 ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. NPAS2 plays an important role in sleep homeostasis and in maintaining circadian behaviors in normal light/dark and feeding conditions and in the effective synchronization of feeding behavior with scheduled food availability. Regulates the gene transcription of key metabolic pathways in the liver and is involved in DNA damage response by regulating several cell cycle and DNA repair genes.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPAS2 Gene
Genomics for NPAS2 Gene
GeneHancer (GH) Regulatory Elements for NPAS2 Gene
Promoters and enhancers for NPAS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NPAS2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for NPAS2 Gene
Genomic Locations for NPAS2 Gene
- chr2:100,820,151-100,996,829
- (GRCh38/hg38)
- Size:
- 176,679 bases
- Orientation:
- Plus strand
- chr2:101,436,613-101,613,291
- (GRCh37/hg19)
Genomic View for NPAS2 Gene
Genes around NPAS2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q11.2 by Ensembl
- 2q11.2 by Entrez Gene
- 2q11.2 by HGNC
NPAS2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NPAS2 Gene
Proteins for NPAS2 Gene
-
Protein details for NPAS2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99743-NPAS2_HUMAN
- Recommended name:
- Neuronal PAS domain-containing protein 2
- Protein Accession:
- Q99743
- Q4ZFV9
- Q53SQ3
- Q86V96
- Q99629
Protein attributes for NPAS2 Gene
- Size:
- 824 amino acids
- Molecular mass:
- 91791 Da
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
-
- Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with ARNTL/BMAL1 and this heterodimerization is required for E-box-dependent transactivation. Interacts with NCOA3, KAT2B, CREBBP and EP300.
Protein Expression for NPAS2 Gene
Post-translational modifications for NPAS2 Gene
No Post-translational modifications
Other Protein References for NPAS2 Gene
Antibody Products
- Novus Biologicals Antibodies for NPAS2
-
Abcam antibodies for NPAS2
- Invitrogen Antibodies for NPAS2
- GeneTex NPAS2 antibody for NPAS2
-
Santa Cruz Biotechnology (SCBT) Antibodies for NPAS2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NPAS2
- Origene Custom Protein Services for NPAS2
- Search GeneTex for Proteins for NPAS2
-
Abcam proteins for NPAS2
Assay Products
No data available for DME Specific Peptides for NPAS2 Gene
Domains & Families for NPAS2 Gene
Gene Families for NPAS2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NPAS2 Gene
Suggested Antigen Peptide Sequences for NPAS2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for NPAS2 Gene
Function for NPAS2 Gene
Molecular function for NPAS2 Gene
- GENATLAS Biochemistry:
- neuronal PAS domain protein 2,expressed in the central nervous system
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Carbon monoxide (CO) and the redox state of the cell can modulate the transcriptional activity of the NPAS2-ARNTL/BMAL1 heterodimer. NADH and NADPH enhance the DNA-binding activity of the heterodimer whereas CO binds the heme group in NPAS2 and inhibits the DNA-binding activity of the heterodimer.
- UniProtKB/Swiss-Prot Function:
- Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots circa (about) and diem (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for timegivers). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5-CACGTG-3) within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK NPAS2-ARNTL/BMAL1 ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. NPAS2 plays an important role in sleep homeostasis and in maintaining circadian behaviors in normal light/dark and feeding conditions and in the effective synchronization of feeding behavior with scheduled food availability. Regulates the gene transcription of key metabolic pathways in the liver and is involved in DNA damage response by regulating several cell cycle and DNA repair genes.
Phenotypes From GWAS Catalog for NPAS2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001047 | core promoter binding | ISS | -- |
| GO:0003677 | DNA binding | IPI | 9576906 |
| GO:0003700 | DNA binding transcription factor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 14645221 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for NPAS2 Gene
- MGI mutant phenotypes for NPAS2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for NPAS2:
Animal Models for NPAS2 Gene
- MGI Knock Outs for NPAS2:
-
- Npas2 tm1Slm
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NPAS2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for NPAS2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NPAS2 gene
- Search ViGene Biosciences for NPAS2
CRISPR Products
-
OriGene CRISPR knockouts for NPAS2
- genomics-online: gRNA clones - Search results for available NPAS2 gene related products
- Applied Biological Materials CRISPR for NPAS2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NPAS2
- GenScript: Design CRISPR guide RNA sequences for NPAS2
miRNA for NPAS2 Gene
- miRTarBase miRNAs that target NPAS2
Targeted motifs for NPAS2 Gene
HOMER Transcription Factor Regulatory Elements motif NPAS2
- Consensus sequence: KCCACGTGAC Submotif: canonical Cell Type: Liver GEO ID: GSE39860
miRNA Products
- Search ViGene Biosciences for NPAS2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NPAS2
- Browse OriGene Inhibitory RNA Products For NPAS2
- genomics-online: shRNA clones - Search results for available NPAS2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NPAS2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NPAS2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NPAS2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available NPAS2 gene related products
- orf clones - Search results for available NPAS2 gene related products
- Applied Biological Materials Clones for NPAS2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NPAS2
-
ViGene Biosciences adenoviral particle packaged cDNA for NPAS2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NPAS2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NPAS2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for NPAS2 Gene
Localization for NPAS2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NPAS2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 14645221 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IEA,IPI | 9576906 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for NPAS2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | BMAL1-CLOCK,NPAS2 activates circadian gene expression |
.68
|
|
| 2 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 3 | Metabolism |
.37
|
|
| 4 | Circadian rhythm |
.30
|
|
| 5 | Metabolic States and Circadian Oscillators | ||
Pathways by source for NPAS2 Gene
2 BioSystems pathways for NPAS2 Gene
1 KEGG pathway for NPAS2 Gene
1 Qiagen pathway for NPAS2 Gene
Interacting Proteins for NPAS2 Gene
Selected Interacting proteins:
ENSP00000338283
Q99743-NPAS2_HUMAN
for NPAS2 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006974 | cellular response to DNA damage stimulus | IEA | -- |
| GO:0007417 | central nervous system development | TAS | 9012850 |
| GO:0007623 | circadian rhythm | TAS | -- |
No data available for SIGNOR curated interactions for NPAS2 Gene
Transcripts for NPAS2 Gene
mRNA/cDNA for NPAS2 Gene
- (11) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (158) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NPAS2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NPAS2
- genomics-online: gRNA clones - Search results for available NPAS2 gene related products
- Applied Biological Materials CRISPR for NPAS2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NPAS2
- GenScript: Design CRISPR guide RNA sequences for NPAS2
miRNA Products
- Search ViGene Biosciences for NPAS2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NPAS2
- Browse OriGene Inhibitory RNA Products For NPAS2
- genomics-online: shRNA clones - Search results for available NPAS2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NPAS2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NPAS2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NPAS2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available NPAS2 gene related products
- orf clones - Search results for available NPAS2 gene related products
- Applied Biological Materials Clones for NPAS2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | · | 18c | ^ | 19 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
| ExUns: | 20 | ^ | 21a | · | 21b |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | - | ||||
| SP6: |
Expression for NPAS2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- T Helper Cells Peripheral Blood
- T-Cytotoxic Cells Peripheral Blood
- Endothelium (Cardiovascular System)
This gene is overexpressed in Liver (31.5), Ovary (25.2), and Salivary gland (12.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NPAS2 Gene
NURSA nuclear receptor signaling pathways regulating expression of NPAS2 Gene:
NPAS2SOURCE GeneReport for Unigene cluster for NPAS2 Gene:
Hs.156832Evidence on tissue expression from TISSUES for NPAS2 Gene
- Lung(4.9)
- Nervous system(4.7)
- Intestine(3.7)
- Kidney(3.1)
- Pancreas(3)
- Eye(2.9)
- Liver(2.9)
- Skin(2.8)
- Heart(2.4)
Primer Products
-
OriGene qPCR primer pairs for NPAS2
- genomics-online: primer clones - Search results for available NPAS2 gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPAS2 Gene
Orthologs for NPAS2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NPAS2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | NPAS2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | NPAS2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Npas2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Npas2 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NPAS2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | NPAS2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NPAS2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | NPAS2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | npas2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | npas2 34 |
|
OneToOne | |
| -- 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Clk 35 34 |
|
- Species where no ortholog for NPAS2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for NPAS2 Gene
Paralogs for NPAS2 Gene
(8) SIMAP similar genes for NPAS2 Gene using alignment to 10 proteins:
Variants for NPAS2 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for NPAS2 Gene
- NPAS2_HUMAN-Q99743
- Variants in NPAS2 show a susceptibility to seasonal affective disorder (SAD) [MIM:608516]. SAD is a depressive condition resulting from seasonal changes, and with diurnal preference.
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs879253743 | likely-pathogenic, Non-obstructive azoospermia | 100,975,538(+) | C/A/G | coding_sequence_variant, missense_variant | |
| rs1000002027 | -- | 100,976,864(+) | A/G | intron_variant | |
| rs1000002731 | -- | 100,983,579(+) | G/T | 3_prime_UTR_variant, intron_variant | |
| rs1000012549 | -- | 100,897,426(+) | A/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000045001 | -- | 100,897,601(+) | C/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2667827 | CNV | deletion | 23128226 |
| esv2720445 | CNV | deletion | 23290073 |
| esv3559853 | CNV | deletion | 23714750 |
| esv3591761 | CNV | loss | 21293372 |
| nsv1072011 | CNV | deletion | 25765185 |
| nsv1114120 | CNV | deletion | 24896259 |
| nsv1136301 | CNV | deletion | 24896259 |
| nsv1143948 | CNV | deletion | 24896259 |
| nsv582532 | CNV | gain | 21841781 |
| nsv829584 | CNV | gain | 20364138 |
| nsv834315 | CNV | gain | 17160897 |
| nsv834316 | CNV | gain | 17160897 |
| nsv953496 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
48.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
14.59;
96.53% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NPAS2 Gene
Disorders for NPAS2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| restless legs syndrome |
|
|
Search NPAS2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NPAS2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NPAS2 Gene
Publications for NPAS2 Gene
- Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk. (PMID: 17453337) Zhu Y … Zheng T (Breast cancer research and treatment 2008) 3 4 22 44 58
- Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma. (PMID: 17096334) Zhu Y … Zheng T (International journal of cancer 2007) 3 4 22 44 58
- The circadian gene NPAS2 is a novel prognostic biomarker for breast cancer. (PMID: 19649706) Yi C … Katsaro D (Breast cancer research and treatment 2010) 3 22 44 58
- The circadian gene NPAS2, a putative tumor suppressor, is involved in DNA damage response. (PMID: 18819933) Hoffman AE … Zhu Y (Molecular cancer research : MCR 2008) 3 4 22 58
- Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. (PMID: 9012850) Zhou YD … McKnight SL (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 58
Products for NPAS2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NPAS2
- Origene Custom Protein Services for NPAS2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NPAS2
- Browse OriGene Inhibitory RNA Products For NPAS2
- OriGene qPCR primer pairs for NPAS2
- OriGene CRISPR knockouts for NPAS2
- OriGene ORF clones in human for NPAS2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NPAS2
- GenScript: Next-day shipping of latest version cDNA ORF clones for NPAS2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for NPAS2
- GenScript Custom Assay Services for NPAS2
- GenScript Custom overexpressing Cell Line Services for NPAS2
- GenScript: Design CRISPR guide RNA sequences for NPAS2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for NPAS2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for NPAS2
- Novus Biologicals lysates and proteins for NPAS2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for NPAS2
- Abcam proteins for NPAS2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for NPAS2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for NPAS2
- VectorBuilder custom plasmid, inducible vectors for NPAS2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NPAS2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 57 available NPAS2 Antibodies ranked by validation data
- Compare Top NPAS2 Antibodies
- antibodies-online: Search results for available NPAS2 related products ranked by validation data
- antibodies-online: Search results for 4 available NPAS2 Proteins ranked by validation data
- Compare Top NPAS2 Proteins
- GeneTex NPAS2 antibody for NPAS2
- Search GeneTex for Proteins for NPAS2
- ViGene Biosciences adenoviral particle packaged cDNA for NPAS2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for NPAS2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for NPAS2 gene
- Search ViGene Biosciences for NPAS2
- Santa Cruz Biotechnology (SCBT) Antibodies for NPAS2
- Search Santa Cruz Biotechnology (SCBT) for NPAS2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NPAS2
- Horizon Cell Lines for NPAS2
- genomics-online: cdna clones - Search results for available NPAS2 gene related products
- orf clones - Search results for available NPAS2 gene related products
- genomics-online: gRNA clones - Search results for available NPAS2 gene related products
- genomics-online: primer clones - Search results for available NPAS2 gene related products
- genomics-online: shRNA clones - Search results for available NPAS2 gene related products
Sources for NPAS2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew