Aliases for NOS3 Gene
External Ids for NOS3 Gene
Previous GeneCards Identifiers for NOS3 Gene
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
GeneCards Summary for NOS3 Gene
NOS3 (Nitric Oxide Synthase 3 (Endothelial Cell)) is a Protein Coding gene. Diseases associated with NOS3 include preeclampsia/eclampsia 1 and thromboangiitis obliterans. Among its related pathways are PI3K-Akt signaling pathway and Immune System. GO annotations related to this gene include oxidoreductase activity and iron ion binding. An important paralog of this gene is NOS1.
UniProtKB/Swiss-Prot for NOS3 Gene
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets
Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1
Endothelial nitric oxide synthase (eNOS), along with inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nNOS), catalyze nitric oxide and L-citrulline generation from L-arginine and molecular oxygen. eNOS is activated at calcium concentrations over 100 nM.