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Aliases for NONO Gene

Aliases for NONO Gene

  • Non-POU Domain Containing, Octamer-Binding 2 3
  • NRB54 3 4 6
  • DNA-Binding P52/P100 Complex, 52 KDa Subunit 3 4
  • 54 KDa Nuclear RNA- And DNA-Binding Protein 3 4
  • 55 KDa Nuclear Protein 3 4
  • P54(Nrb) 3 4
  • P54NRB 3 4
  • NMT55 3 4
  • Non-Pou Domain-Containing Octamer (ATGCAAAT) Binding Protein 2
  • Non-POU Domain-Containing Octamer (ATGCAAAT) Binding Protein 3
  • Non-POU Domain-Containing Octamer-Binding Protein 3
  • Protein Phosphatase 1, Regulatory Subunit 114 3
  • Non-POU-Domain-Containing, Octamer-Binding 2
  • Nuclear RNA-Binding Protein 2
  • Regulatory Subunit 114 2
  • Protein Phosphatase 1 2
  • NonO Protein 4
  • PPP1R114 3
  • 54-KD 2
  • P54 3

External Ids for NONO Gene

Previous GeneCards Identifiers for NONO Gene

  • GC0XP066677
  • GC16M070209
  • GC16M069524
  • GC16M069565
  • GC0XP069370
  • GC0XP070286
  • GC0XP070420
  • GC0XP070503
  • GC0XP064319

Summaries for NONO Gene

Entrez Gene Summary for NONO Gene

  • This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]

GeneCards Summary for NONO Gene

NONO (Non-POU Domain Containing, Octamer-Binding) is a Protein Coding gene. Diseases associated with NONO include translocation renal cell carcinoma and renal cell carcinoma. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Circadian rhythm pathway. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SFPQ.

UniProtKB/Swiss-Prot for NONO Gene

  • DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3 side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.

Gene Wiki entry for NONO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NONO Gene

Genomics for NONO Gene

Regulatory Elements for NONO Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NONO Gene

Start:
71,283,192 bp from pter
End:
71,301,168 bp from pter
Size:
17,977 bases
Orientation:
Plus strand

Genomic View for NONO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NONO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NONO Gene

Proteins for NONO Gene

  • Protein details for NONO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15233-NONO_HUMAN
    Recommended name:
    Non-POU domain-containing octamer-binding protein
    Protein Accession:
    Q15233
    Secondary Accessions:
    • B7Z4C2
    • D3DVV4
    • F5GYZ3
    • O00201
    • P30807
    • Q12786
    • Q9BQC5

    Protein attributes for NONO Gene

    Size:
    471 amino acids
    Molecular mass:
    54232 Da
    Quaternary structure:
    • Monomer and component of the SFPQ-NONO complex, which is probably a heterotetramer of two 52 kDa (NONO) and two 100 kDa (SFPQ) subunits. NONO is a component of spliceosome and U5.4/6 snRNP complexes. Forms heterodimers with PSPC1; this involves formation of a coiled coil domain by helices from both proteins. Interacts with PSPC1 and SNRPA/U1A. Part of complex consisting of SFPQ, NONO and MATR3. Part of a complex consisting of SFPQ, NONO and NR5A1. Part of a complex consisting of SFPQ, NONO and TOP1. Interacts with SPI1. Interacts with RNF43. Interacts with PER1 and PER2.

    Three dimensional structures from OCA and Proteopedia for NONO Gene

    Alternative splice isoforms for NONO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NONO Gene

Proteomics data for NONO Gene at MOPED

Post-translational modifications for NONO Gene

  • The N-terminus is blocked
  • Ubiquitination at Lys11, Lys68, Lys99, Lys107, Lys109, Lys126, Lys198, Lys239, Lys243, Lys272, Lys279, Lys295, Lys336, Lys338, and Lys371
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NONO Gene

Domains for NONO Gene

Gene Families for NONO Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for NONO Gene

Suggested Antigen Peptide Sequences for NONO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15233

UniProtKB/Swiss-Prot:

NONO_HUMAN :
  • Q15233
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with NONO: view

Function for NONO Gene

Molecular function for NONO Gene

UniProtKB/Swiss-Prot Function: DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3 side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.

Gene Ontology (GO) - Molecular Function for NONO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001047 core promoter binding ISS --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 15790595
GO:0042802 identical protein binding IPI 16148043
genes like me logo Genes that share ontologies with NONO: view
genes like me logo Genes that share phenotypes with NONO: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NONO

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NONO Gene

Localization for NONO Gene

Subcellular locations from UniProtKB/Swiss-Prot for NONO Gene

Nucleus. Nucleus, nucleolus. Nucleus speckle. Note=Detected in punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NONO Gene COMPARTMENTS Subcellular localization image for NONO gene
Compartment Confidence
nucleus 5
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for NONO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
GO:0016020 membrane IDA 19946888
GO:0016363 nuclear matrix IDA 19874820
genes like me logo Genes that share ontologies with NONO: view

Pathways for NONO Gene

genes like me logo Genes that share pathways with NONO: view

Pathways by source for NONO Gene

2 BioSystems pathways for NONO Gene
1 GeneGo (Thomson Reuters) pathway for NONO Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NONO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006397 mRNA processing IEA --
GO:0007623 circadian rhythm ISS --
genes like me logo Genes that share ontologies with NONO: view

Compounds for NONO Gene

(1) HMDB Compounds for NONO Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4

(2) Novoseek inferred chemical compound relationships for NONO Gene

Compound -log(P) Hits PubMed IDs
pyrimidine 38.2 1
testosterone 4.74 4
genes like me logo Genes that share compounds with NONO: view

Transcripts for NONO Gene

Unigene Clusters for NONO Gene

Non-POU domain containing, octamer-binding:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NONO

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NONO Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - -
SP2: -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8: - -

Relevant External Links for NONO Gene

GeneLoc Exon Structure for
NONO
ECgene alternative splicing isoforms for
NONO

Expression for NONO Gene

mRNA expression in normal human tissues for NONO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NONO Gene

SOURCE GeneReport for Unigene cluster for NONO Gene Hs.533282

mRNA Expression by UniProt/SwissProt for NONO Gene

Q15233-NONO_HUMAN
Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Also found in a number of breast tumor cell lines.
genes like me logo Genes that share expressions with NONO: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NONO Gene

Orthologs for NONO Gene

This gene was present in the common ancestor of animals.

Orthologs for NONO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NONO 35
  • 100 (n)
  • 100 (a)
NONO 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NONO 35
  • 94.96 (n)
  • 99.57 (a)
NONO 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
NONO 35
  • 94.61 (n)
  • 99.79 (a)
mouse
(Mus musculus)
Mammalia Nono 35
  • 91.72 (n)
  • 98.3 (a)
Nono 16
Nono 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NONO 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nono 35
  • 91.93 (n)
  • 97.88 (a)
chicken
(Gallus gallus)
Aves NONO 35
  • 79.22 (n)
  • 87.66 (a)
NONO 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NONO 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia efna2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nono 35
  • 72.27 (n)
  • 76.94 (a)
Str.5997 35
zebrafish
(Danio rerio)
Actinopterygii efna2 35
nono 35
  • 64.7 (n)
  • 63.95 (a)
nono 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nonA 36
  • 23 (a)
ManyToMany
nonA-l 36
  • 25 (a)
ManyToMany
nonA-l 37
  • 42 (a)
nonA 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea nono-1 36
  • 28 (a)
OneToMany
F25B5.7a 37
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for NONO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NONO Gene

ENSEMBL:
Gene Tree for NONO (if available)
TreeFam:
Gene Tree for NONO (if available)

Paralogs for NONO Gene

Paralogs for NONO Gene

Selected SIMAP similar genes for NONO Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for NONO Gene

genes like me logo Genes that share paralogs with NONO: view

Variants for NONO Gene

Sequence variations from dbSNP and Humsavar for NONO Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs5937078 -- 71,293,676(+) gccca(G/T)gctgg intron-variant
rs5937079 -- 71,293,677(+) cccat(A/G)ctgga intron-variant
rs5937080 -- 71,293,687(+) agtgc(A/G)gtggc intron-variant
rs5980751 -- 71,290,941(+) CGATG(C/G)AAAAG intron-variant
rs5981099 -- 71,285,438(+) AACGA(C/T)GTTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NONO Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
esv33082 CNV Loss 17666407
nsv508781 CNV Insertion 20534489

Relevant External Links for NONO Gene

HapMap Linkage Disequilibrium report
NONO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NONO Gene

Disorders for NONO Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for NONO Gene including...

Search for NONO Gene in MalaCards »

UniProtKB/Swiss-Prot

NONO_HUMAN
  • Note=A chromosomal aberration involving NONO may be a cause of papillary renal cell carcinoma (PRCC). Translocation t(X;X)(p11.2;q13.1) with TFE3.

Relevant External Links for NONO

Human Genome Epidemiology (HuGE) Navigator
NONO
genes like me logo Genes that share disorders with NONO: view

Publications for NONO Gene

  1. Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6. (PMID: 8371983) Dong B. … Krainer A.R. (Nucleic Acids Res. 1993) 2 3 4 23
  2. Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma. (PMID: 9393982) Clark J. … Cooper C.S. (Oncogene 1997) 3 4 23
  3. The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction. (PMID: 9756848) Straub T. … Boege F. (J. Biol. Chem. 1998) 3 4 23
  4. P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner. (PMID: 16148043) Fox A.H. … Lamond A.I. (Mol. Biol. Cell 2005) 3 4 23
  5. Identification of the polypyrimidine tract binding protein-associated splicing factor.p54(nrb) complex as a candidate DNA double-strand break rejoining factor. (PMID: 15590677) Bladen C.L. … Dynan W.S. (J. Biol. Chem. 2005) 3 4 23

Products for NONO Gene

  • Addgene plasmids for NONO

Sources for NONO Gene

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