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Aliases for NODAL Gene

Aliases for NODAL Gene

  • Nodal Growth Differentiation Factor 2 3
  • HTX5 3 6
  • Nodal, Mouse, Homolog 2
  • Nodal Homolog (Mouse) 2
  • Nodal Homolog 3

External Ids for NODAL Gene

Previous GeneCards Identifiers for NODAL Gene

  • GC10U990041
  • GC10P072086
  • GC10M071536
  • GC10M071862
  • GC10M072191
  • GC10M066185

Summaries for NODAL Gene

Entrez Gene Summary for NODAL Gene

  • The protein encoded by this gene is a member of the TGF-beta superfamily. Studies of the mouse counterpart suggested that this gene may be essential for mesoderm formation and subsequent organization of axial structures in early embryonic development. [provided by RefSeq, Jul 2008]

GeneCards Summary for NODAL Gene

NODAL (Nodal Growth Differentiation Factor) is a Protein Coding gene. Diseases associated with NODAL include heterotaxy, visceral, 5 and situs inversus. Among its related pathways are L1CAM interactions and Cardiac Progenitor Differentiation. GO annotations related to this gene include cytokine activity and receptor agonist activity. An important paralog of this gene is BMP15.

UniProtKB/Swiss-Prot for NODAL Gene

  • Essential for mesoderm formation and axial patterning during embryonic development.

Gene Wiki entry for NODAL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NODAL Gene

Genomics for NODAL Gene

Regulatory Elements for NODAL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NODAL Gene

70,431,936 bp from pter
70,447,951 bp from pter
16,016 bases
Minus strand

Genomic View for NODAL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NODAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NODAL Gene

Proteins for NODAL Gene

  • Protein details for NODAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nodal homolog
    Protein Accession:
    Secondary Accessions:
    • Q2M3A5
    • Q8N4V3

    Protein attributes for NODAL Gene

    347 amino acids
    Molecular mass:
    39561 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for NODAL Gene

neXtProt entry for NODAL Gene

Proteomics data for NODAL Gene at MOPED

Post-translational modifications for NODAL Gene

  • Glycosylation at Asn72 and Asn199

Other Protein References for NODAL Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NODAL Gene

Domains for NODAL Gene

Suggested Antigen Peptide Sequences for NODAL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96S42
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with NODAL: view

No data available for Gene Families for NODAL Gene

Function for NODAL Gene

Molecular function for NODAL Gene

GENATLAS Biochemistry:
NODAL,homolog of the mouse nodal,TGFB family member,involved in the control of the direction of cardiac looping and the development of left-right asymetry
UniProtKB/Swiss-Prot Function:
Essential for mesoderm formation and axial patterning during embryonic development.

Gene Ontology (GO) - Molecular Function for NODAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0005515 protein binding --
GO:0008083 growth factor activity IEA --
GO:0016015 morphogen activity NAS 21159651
genes like me logo Genes that share ontologies with NODAL: view
genes like me logo Genes that share phenotypes with NODAL: view

Animal Models for NODAL Gene

MGI Knock Outs for NODAL:

Animal Model Products

miRNA for NODAL Gene

miRTarBase miRNAs that target NODAL

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NODAL Gene

Localization for NODAL Gene

Subcellular locations from UniProtKB/Swiss-Prot for NODAL Gene


Subcellular locations from

Jensen Localization Image for NODAL Gene COMPARTMENTS Subcellular localization image for NODAL gene
Compartment Confidence
extracellular 4
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NODAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IDA 21656830
genes like me logo Genes that share ontologies with NODAL: view

Pathways for NODAL Gene

genes like me logo Genes that share pathways with NODAL: view

Pathways by source for NODAL Gene

1 KEGG pathway for NODAL Gene
1 GeneGo (Thomson Reuters) pathway for NODAL Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for NODAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001701 in utero embryonic development --
GO:0001702 gastrulation with mouth forming second --
GO:0001707 mesoderm formation --
GO:0001829 trophectodermal cell differentiation --
genes like me logo Genes that share ontologies with NODAL: view

Compounds for NODAL Gene

(1) Novoseek inferred chemical compound relationships for NODAL Gene

Compound -log(P) Hits PubMed IDs
bromodeoxyuridine 39.3 2
genes like me logo Genes that share compounds with NODAL: view

Transcripts for NODAL Gene

mRNA/cDNA for NODAL Gene

(4) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NODAL Gene

Nodal growth differentiation factor:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NODAL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NODAL Gene

No ASD Table

Relevant External Links for NODAL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NODAL Gene

mRNA expression in normal human tissues for NODAL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NODAL Gene

This gene is overexpressed in Muscle - Skeletal (6.5).

SOURCE GeneReport for Unigene cluster for NODAL Gene Hs.370414

genes like me logo Genes that share expressions with NODAL: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for NODAL Gene

Orthologs for NODAL Gene

This gene was present in the common ancestor of animals.

Orthologs for NODAL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NODAL 35
  • 84.73 (n)
  • 85.8 (a)
  • 85 (a)
(Canis familiaris)
Mammalia NODAL 35
  • 85.69 (n)
  • 85.59 (a)
  • 85 (a)
(Mus musculus)
Mammalia Nodal 35
  • 81.94 (n)
  • 80.4 (a)
Nodal 16
Nodal 36
  • 78 (a)
(Pan troglodytes)
Mammalia NODAL 35
  • 98.46 (n)
  • 98.56 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Nodal 35
  • 81.17 (n)
  • 79.83 (a)
(Monodelphis domestica)
Mammalia NODAL 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia NODAL 36
  • 70 (a)
(Gallus gallus)
Aves NODAL 35
  • 52.47 (n)
  • 40.23 (a)
  • 33 (a)
(Anolis carolinensis)
Reptilia NODAL 36
  • 32 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497218 35
  • 49.83 (n)
  • 42.42 (a)
(Danio rerio)
Actinopterygii ndr2 35
ndr2 36
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta scw 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea tig-2 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for NODAL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NODAL Gene

Gene Tree for NODAL (if available)
Gene Tree for NODAL (if available)

Paralogs for NODAL Gene

Paralogs for NODAL Gene

Selected SIMAP similar genes for NODAL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NODAL: view

Variants for NODAL Gene

Sequence variations from dbSNP and Humsavar for NODAL Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1904589 Benign, - 70,435,683(+) CAGGG(C/T)GCTTC reference, missense
rs2199843 -- 70,439,883(+) CTGGC(C/T)AATAT intron-variant
rs2231947 -- 70,434,098(+) ATCCC(A/G)CCTGA intron-variant
rs2231948 -- 70,434,103(+) GCCTG(A/G)GGCTT intron-variant
rs2231949 -- 70,434,218(+) CACCT(A/G)TAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NODAL Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV Gain+Loss 17666407

Relevant External Links for NODAL Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NODAL Gene

Disorders for NODAL Gene

(1) OMIM Diseases for NODAL Gene (601265)


  • Heterotaxy, visceral, 5, autosomal (HTX5) [MIM:270100]: A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can been associated with variety of congenital defects including cardiac malformations. HTX5 clinical features include situs inversus viscerum or situs ambiguus, congenital heart defect, transposition of the great vessels ventricular septal defect, atrial septal defect, truncus communis, and dextrocardia. {ECO:0000269 PubMed:19064609, ECO:0000269 PubMed:9354794}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for NODAL Gene

Relevant External Links for NODAL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NODAL: view

No data available for Novoseek inferred disease relationships and Genatlas for NODAL Gene

Publications for NODAL Gene

  1. X-linked situs abnormalities result from mutations in ZIC3. (PMID: 9354794) Gebbia M. … Casey B. (Nat. Genet. 1997) 2 3 4
  2. Identification and functional characterization of NODAL rare variants in heterotaxy and isolated cardiovascular malformations. (PMID: 19064609) Mohapatra B. … Ware S.M. (Hum. Mol. Genet. 2009) 3 4 48
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells. (PMID: 15150278) Munir S. … Peng C. (J. Biol. Chem. 2004) 3 23

Products for NODAL Gene

Sources for NODAL Gene

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