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Aliases for NODAL Gene

Aliases for NODAL Gene

  • Nodal Growth Differentiation Factor 2 3 5
  • Nodal, Mouse, Homolog 2
  • Nodal Homolog (Mouse) 2
  • HTX5 3

External Ids for NODAL Gene

Previous GeneCards Identifiers for NODAL Gene

  • GC10U990041
  • GC10P072086
  • GC10M071536
  • GC10M071862
  • GC10M072191
  • GC10M066185

Summaries for NODAL Gene

Entrez Gene Summary for NODAL Gene

  • The protein encoded by this gene is a member of the TGF-beta superfamily. Studies of the mouse counterpart suggested that this gene may be essential for mesoderm formation and subsequent organization of axial structures in early embryonic development. [provided by RefSeq, Jul 2008]

GeneCards Summary for NODAL Gene

NODAL (Nodal Growth Differentiation Factor) is a Protein Coding gene. Diseases associated with NODAL include Heterotaxy, Visceral, 5 and Dextrocardia With Situs Inversus. Among its related pathways are Integrated Pancreatic Cancer Pathway and Developmental Biology. GO annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is GDF10.

UniProtKB/Swiss-Prot for NODAL Gene

  • Essential for mesoderm formation and axial patterning during embryonic development.

Gene Wiki entry for NODAL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NODAL Gene

Genomics for NODAL Gene

Regulatory Elements for NODAL Gene

Enhancers for NODAL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NODAL on UCSC Golden Path with GeneCards custom track

Genomic Location for NODAL Gene

70,431,936 bp from pter
70,447,951 bp from pter
16,016 bases
Minus strand

Genomic View for NODAL Gene

Genes around NODAL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NODAL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NODAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NODAL Gene

Proteins for NODAL Gene

  • Protein details for NODAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nodal homolog
    Protein Accession:
    Secondary Accessions:
    • Q2M3A5
    • Q8N4V3

    Protein attributes for NODAL Gene

    347 amino acids
    Molecular mass:
    39561 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for NODAL Gene

neXtProt entry for NODAL Gene

Proteomics data for NODAL Gene at MOPED

Post-translational modifications for NODAL Gene

  • Glycosylation at Asn 72 and Asn 199

Other Protein References for NODAL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NODAL Gene

Domains & Families for NODAL Gene

Suggested Antigen Peptide Sequences for NODAL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TGF-beta family.
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with NODAL: view

No data available for Gene Families for NODAL Gene

Function for NODAL Gene

Molecular function for NODAL Gene

GENATLAS Biochemistry:
NODAL,homolog of the mouse nodal,TGFB family member,involved in the control of the direction of cardiac looping and the development of left-right asymetry
UniProtKB/Swiss-Prot Function:
Essential for mesoderm formation and axial patterning during embryonic development.

Gene Ontology (GO) - Molecular Function for NODAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005160 transforming growth factor beta receptor binding IBA --
genes like me logo Genes that share ontologies with NODAL: view
genes like me logo Genes that share phenotypes with NODAL: view

Human Phenotype Ontology for NODAL Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NODAL Gene

MGI Knock Outs for NODAL:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NODAL Gene

Localization for NODAL Gene

Subcellular locations from UniProtKB/Swiss-Prot for NODAL Gene


Subcellular locations from

Jensen Localization Image for NODAL Gene COMPARTMENTS Subcellular localization image for NODAL gene
Compartment Confidence
extracellular 5
cytoskeleton 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for NODAL Gene

Pathways & Interactions for NODAL Gene

genes like me logo Genes that share pathways with NODAL: view

Gene Ontology (GO) - Biological Process for NODAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001702 gastrulation with mouth forming second IEA --
GO:0001707 mesoderm formation IEA --
GO:0001829 trophectodermal cell differentiation IEA --
genes like me logo Genes that share ontologies with NODAL: view

No data available for SIGNOR curated interactions for NODAL Gene

Drugs & Compounds for NODAL Gene

(1) Drugs for NODAL Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NODAL: view

Transcripts for NODAL Gene

mRNA/cDNA for NODAL Gene

Unigene Clusters for NODAL Gene

Nodal growth differentiation factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NODAL Gene

No ASD Table

Relevant External Links for NODAL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NODAL Gene

mRNA expression in normal human tissues for NODAL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NODAL Gene

This gene is overexpressed in Muscle - Skeletal (x6.5).

SOURCE GeneReport for Unigene cluster for NODAL Gene Hs.370414

genes like me logo Genes that share expression patterns with NODAL: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NODAL Gene

Orthologs for NODAL Gene

This gene was present in the common ancestor of animals.

Orthologs for NODAL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NODAL 35
  • 84.73 (n)
  • 85.8 (a)
  • 85 (a)
(Canis familiaris)
Mammalia NODAL 35
  • 85.69 (n)
  • 85.59 (a)
  • 85 (a)
(Mus musculus)
Mammalia Nodal 35
  • 81.94 (n)
  • 80.4 (a)
Nodal 16
Nodal 36
  • 78 (a)
(Pan troglodytes)
Mammalia NODAL 35
  • 98.46 (n)
  • 98.56 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Nodal 35
  • 81.17 (n)
  • 79.83 (a)
(Monodelphis domestica)
Mammalia NODAL 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia NODAL 36
  • 70 (a)
(Gallus gallus)
Aves NODAL 35
  • 52.47 (n)
  • 40.23 (a)
  • 33 (a)
(Anolis carolinensis)
Reptilia NODAL 36
  • 32 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497218 35
  • 49.83 (n)
  • 42.42 (a)
(Danio rerio)
Actinopterygii ndr2 35
ndr2 36
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta scw 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea tig-2 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for NODAL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NODAL Gene

Gene Tree for NODAL (if available)
Gene Tree for NODAL (if available)

Paralogs for NODAL Gene

Paralogs for NODAL Gene

(8) SIMAP similar genes for NODAL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NODAL: view

Variants for NODAL Gene

Sequence variations from dbSNP and Humsavar for NODAL Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs104894169 Heterotaxy, visceral, 5, autosomal (HTX5) 70,435,629(-) GCCGC(A/G)GCCCC reference, missense
VAR_036202 A colorectal cancer sample
rs1904589 - 70,435,683(+) CAGGG(C/T)GCTTC reference, missense
rs10999334 Heterotaxy, visceral, 5, autosomal (HTX5) 70,435,570(+) CTGCT(C/T)CTGCG reference, missense
VAR_062281 Heterotaxy, visceral, 5, autosomal (HTX5)

Structural Variations from Database of Genomic Variants (DGV) for NODAL Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV Gain+Loss 17666407

Variation tolerance for NODAL Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NODAL Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NODAL Gene

Disorders for NODAL Gene

MalaCards: The human disease database

(44) MalaCards diseases for NODAL Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NODAL in MalaCards View complete list of genes associated with diseases


  • Heterotaxy, visceral, 5, autosomal (HTX5) [MIM:270100]: A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can been associated with variety of congenital defects including cardiac malformations. HTX5 clinical features include situs inversus viscerum or situs ambiguus, congenital heart defect, transposition of the great vessels ventricular septal defect, atrial septal defect, truncus communis, and dextrocardia. {ECO:0000269 PubMed:19064609, ECO:0000269 PubMed:9354794}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for NODAL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NODAL: view

No data available for Genatlas for NODAL Gene

Publications for NODAL Gene

  1. Identification and functional characterization of NODAL rare variants in heterotaxy and isolated cardiovascular malformations. (PMID: 19064609) Mohapatra B. … Ware S.M. (Hum. Mol. Genet. 2009) 3 4 48 67
  2. Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells. (PMID: 15150278) Munir S. … Peng C. (J. Biol. Chem. 2004) 3 23
  3. X-linked situs abnormalities result from mutations in ZIC3. (PMID: 9354794) Gebbia M. … Casey B. (Nat. Genet. 1997) 2 3
  4. Expression of Nodal, Cripto, SMAD3, phosphorylated SMAD3, and SMAD4 in the proliferative endometrium of women with endometriosis. (PMID: 25228630) Cruz C.D. … Reis F.M. (Reprod Sci 2015) 3
  5. An epigenetic regulatory element of the Nodal gene in the mouse and human genomes. (PMID: 25528267) Arai D. … Shiota K. (Mech. Dev. 2015) 3

Products for NODAL Gene

Sources for NODAL Gene