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Aliases for ATP1B3 Gene

Aliases for ATP1B3 Gene

  • ATPase, Na+/K+ Transporting, Beta 3 Polypeptide 2 3
  • Sodium-Potassium ATPase Subunit Beta 3 (Non-Catalytic) 2 3
  • Sodium/Potassium-Transporting ATPase Subunit Beta-3 2 3
  • Sodium/Potassium-Dependent ATPase Subunit Beta-3 3 4
  • Sodium Pump Subunit Beta-3 2 3
  • ATPB-3 3 4
  • Sodium/Potassium-Transporting ATPase Beta-3 Chain 3
  • Sodium/Potassium-Dependent ATPase Beta-3 Subunit 3
  • Na, K-ATPase Beta-3 Polypeptide 3
  • CD298 Antigen 4
  • CD298 3

External Ids for ATP1B3 Gene

Previous GeneCards Identifiers for ATP1B3 Gene

  • GC03P138528
  • GC03P142424
  • GC03P142876
  • GC03P142916
  • GC03P143078
  • GC03P141594
  • GC03P138968

Summaries for ATP1B3 Gene

Entrez Gene Summary for ATP1B3 Gene

  • The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP1B3 Gene

ATP1B3 (ATPase, Na+/K+ Transporting, Beta 3 Polypeptide) is a Protein Coding gene. Among its related pathways are Hemostasis and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include sodium:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1B4.

UniProtKB/Swiss-Prot for ATP1B3 Gene

  • This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known

Tocris Summary for ATP1B3 Gene

  • Na+,K+-ATPase is an ion pump responsible for maintaining sodium and potassium electrochemical gradients across the plasma membrane.

Gene Wiki entry for ATP1B3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP1B3 Gene

Genomics for ATP1B3 Gene

Regulatory Elements for ATP1B3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATP1B3 Gene

141,876,124 bp from pter
141,926,540 bp from pter
50,417 bases
Plus strand

Genomic View for ATP1B3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP1B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP1B3 Gene

Proteins for ATP1B3 Gene

  • Protein details for ATP1B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/potassium-transporting ATPase subunit beta-3
    Protein Accession:
    Secondary Accessions:
    • B7Z1N7

    Protein attributes for ATP1B3 Gene

    279 amino acids
    Molecular mass:
    31513 Da
    Quaternary structure:
    • Composed of three subunits: alpha (catalytic), beta and gamma

    Alternative splice isoforms for ATP1B3 Gene


neXtProt entry for ATP1B3 Gene

Proteomics data for ATP1B3 Gene at MOPED

Post-translational modifications for ATP1B3 Gene

  • Ubiquitination at Lys7, Lys115, and Lys194
  • Glycosylation at Asn124 and Asn240
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP1B3 Gene

Antibody Products

No data available for DME Specific Peptides for ATP1B3 Gene

Domains for ATP1B3 Gene

Gene Families for ATP1B3 Gene

  • PATP :ATPases / P-type
  • CD :CD molecules

Protein Domains for ATP1B3 Gene

Graphical View of Domain Structure for InterPro Entry



  • P54709
  • The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties.
  • Belongs to the X(+)/potassium ATPases subunit beta family.
genes like me logo Genes that share domains with ATP1B3: view

Function for ATP1B3 Gene

Molecular function for ATP1B3 Gene

GENATLAS Biochemistry:
ATPase,Na+K+,beta 3 polypeptide,widely expressed throughout the CNS,dimerizing with ATP alpha 1,2 or 3,with structural homology to ATP1B2 and ATP4B
UniProtKB/Swiss-Prot Function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known

Gene Ontology (GO) - Molecular Function for ATP1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IDA 10636900
GO:0005391 contributes_to sodium:potassium-exchanging ATPase activity IDA 10636900
GO:0005515 protein binding --
GO:0051117 ATPase binding IPI 10636900
genes like me logo Genes that share ontologies with ATP1B3: view
genes like me logo Genes that share phenotypes with ATP1B3: view

Animal Model Products

miRNA for ATP1B3 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP1B3 Gene

Localization for ATP1B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP1B3 Gene

Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

Jensen Localization Image for ATP1B3 Gene COMPARTMENTS Subcellular localization image for ATP1B3 gene
Compartment Confidence
plasma membrane 5
chloroplast 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ATP1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005886 plasma membrane TAS --
GO:0005890 sodium:potassium-exchanging ATPase complex IDA 10636900
GO:0005901 caveola IEA --
GO:0042470 melanosome IEA --
genes like me logo Genes that share ontologies with ATP1B3: view

Pathways for ATP1B3 Gene

genes like me logo Genes that share pathways with ATP1B3: view

Gene Ontology (GO) - Biological Process for ATP1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8798450
GO:0006813 potassium ion transport --
GO:0006814 sodium ion transport --
GO:0006883 cellular sodium ion homeostasis IDA 10636900
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with ATP1B3: view

Compounds for ATP1B3 Gene

(3) Tocris Compounds for ATP1B3 Gene

Compound Action Cas Number
Digoxin Na+/K+ ATPase inhibitor [20830-75-5]
Ouabain Na+/K+ ATPase inhibitor [630-60-4]
Rostafuroxin Antihypertensive agent; Na+/K+ ATPase modulator [156722-18-8]

(7) HMDB Compounds for ATP1B3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • Magnesium
  • NFB Orthophosphate
  • K+
genes like me logo Genes that share compounds with ATP1B3: view

Transcripts for ATP1B3 Gene

Unigene Clusters for ATP1B3 Gene

ATPase, Na+/K+ transporting, beta 3 polypeptide:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP1B3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP1B3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP2: -
SP3: - - -
SP4: - - - - -

Relevant External Links for ATP1B3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP1B3 Gene

mRNA expression in normal human tissues for ATP1B3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP1B3 Gene

SOURCE GeneReport for Unigene cluster for ATP1B3 Gene Hs.477789

genes like me logo Genes that share expressions with ATP1B3: view

Expression partners for ATP1B3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATP1B3 Gene

Orthologs for ATP1B3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP1B3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ATP1B3 35
  • 83.03 (n)
  • 77.42 (a)
ATP1B3 36
  • 77 (a)
(Canis familiaris)
Mammalia ATP1B3 35
  • 86.57 (n)
  • 82.89 (a)
ATP1B3 36
  • 79 (a)
(Mus musculus)
Mammalia Atp1b3 35
  • 79.38 (n)
  • 73.74 (a)
Atp1b3 16
Atp1b3 36
  • 74 (a)
(Pan troglodytes)
Mammalia ATP1B3 35
  • 99.88 (n)
  • 99.64 (a)
ATP1B3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Atp1b3 35
  • 80.41 (n)
  • 74.91 (a)
(Ornithorhynchus anatinus)
Mammalia ATP1B3 36
  • 60 (a)
(Gallus gallus)
Aves ATP1B3 35
  • 67.27 (n)
  • 61.45 (a)
ATP1B3 36
  • 60 (a)
(Anolis carolinensis)
Reptilia ATP1B3 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atp1b3 35
  • 61.42 (n)
  • 59.34 (a)
MGC76183 35
(Danio rerio)
Actinopterygii -- 35
atp1b3a 35
  • 56.73 (n)
  • 55.09 (a)
atp1b3a 36
  • 53 (a)
atp1b3b 36
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta nrv1 36
  • 29 (a)
nrv2 36
  • 23 (a)
nrv3 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea nkb-1 36
  • 26 (a)
nkb-3 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10387 36
  • 27 (a)
Species with no ortholog for ATP1B3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP1B3 Gene

Gene Tree for ATP1B3 (if available)
Gene Tree for ATP1B3 (if available)

Paralogs for ATP1B3 Gene

Paralogs for ATP1B3 Gene Pseudogenes for ATP1B3 Gene

genes like me logo Genes that share paralogs with ATP1B3: view

Variants for ATP1B3 Gene

Sequence variations from dbSNP and Humsavar for ATP1B3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs11844 -- 141,925,932(+) GGACC(C/G)GTGAA utr-variant-3-prime
rs13577 -- 141,925,954(+) AAACA(C/T)GTAGG utr-variant-3-prime
rs1050190 -- 141,925,966(+) TGGGG(G/T)TCTTG utr-variant-3-prime
rs1053970 -- 141,926,430(+) TTAAT(C/T)TGTAC utr-variant-3-prime
rs1072982 -- 141,893,531(+) GCCCA(C/G)TGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP1B3 Gene

Variant ID Type Subtype PubMed ID
esv25294 CNV Loss 19812545
esv33484 CNV Gain 17666407
esv2656624 CNV Deletion 23128226

Relevant External Links for ATP1B3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP1B3 Gene

Disorders for ATP1B3 Gene

No disorders were found for ATP1B3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ATP1B3 Gene

Publications for ATP1B3 Gene

  1. Identification of the mammalian Na,K-ATPase 3 subunit. (PMID: 8798450) Malik N. … Levenson R. (J. Biol. Chem. 1996) 2 3 4
  2. Structural organization and chromosomal localization of the human Na,K- ATPase beta 3 subunit gene and pseudogene. (PMID: 9457675) Malik N. … Levenson R. (Mamm. Genome 1998) 2 3 4
  3. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PMID: 12754519) Zhang H. … Aebersold R. (Nat. Biotechnol. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ATP1B3 Gene

Sources for ATP1B3 Gene

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