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Aliases for NID1 Gene

Aliases for NID1 Gene

  • Nidogen 1 2 3
  • NID 3 4 6
  • Entactin 3 4
  • NID-1 3 4
  • Nidogen (Enactin) 2
  • Nidogen-1 3
  • Enactin 3

External Ids for NID1 Gene

Previous HGNC Symbols for NID1 Gene

  • NID

Previous GeneCards Identifiers for NID1 Gene

  • GC01M232466
  • GC01M234205
  • GC01M236139
  • GC01M206590

Summaries for NID1 Gene

Entrez Gene Summary for NID1 Gene

  • This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes, and may play a role in cell interactions with the extracellular matrix. [provided by RefSeq, Jul 2008]

GeneCards Summary for NID1 Gene

NID1 (Nidogen 1) is a Protein Coding gene. Diseases associated with NID1 include goodpasture syndrome. Among its related pathways are Degradation of the extracellular matrix and Degradation of the extracellular matrix. GO annotations related to this gene include calcium ion binding and laminin-1 binding. An important paralog of this gene is LRP1B.

UniProtKB/Swiss-Prot for NID1 Gene

  • Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions

Gene Wiki entry for NID1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NID1 Gene

Genomics for NID1 Gene

Regulatory Elements for NID1 Gene

Genomic Location for NID1 Gene

Start:
235,975,830 bp from pter
End:
236,065,181 bp from pter
Size:
89,352 bases
Orientation:
Minus strand

Genomic View for NID1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NID1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NID1 Gene

Proteins for NID1 Gene

  • Protein details for NID1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14543-NID1_HUMAN
    Recommended name:
    Nidogen-1
    Protein Accession:
    P14543
    Secondary Accessions:
    • Q14942
    • Q59FL2
    • Q5TAF2
    • Q5TAF3
    • Q86XD7

    Protein attributes for NID1 Gene

    Size:
    1247 amino acids
    Molecular mass:
    136377 Da
    Quaternary structure:
    • Interacts with FBLN1 and LGALS3BP (By similarity). Interacts with PLXDC1.

    Three dimensional structures from OCA and Proteopedia for NID1 Gene

    Alternative splice isoforms for NID1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NID1 Gene

Proteomics data for NID1 Gene at MOPED

Post-translational modifications for NID1 Gene

  • N- and O-glycosylated
  • Glycosylation at Thr310, Thr311, Ser327, Ser330, Ser333, Thr339, Thr347, Thr350, Thr922, and Thr935
  • Modification sites at PhosphoSitePlus

Other Protein References for NID1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NID1 Gene

Domains for NID1 Gene

Suggested Antigen Peptide Sequences for NID1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14543

UniProtKB/Swiss-Prot:

NID1_HUMAN :
  • P14543
Domain:
  • Contains 6 EGF-like domains.
  • Contains 1 NIDO domain.
  • Contains 1 nidogen G2 beta-barrel domain.
  • Contains 1 thyroglobulin type-1 domain.
Similarity:
  • Contains 4 LDL-receptor class B repeats.
genes like me logo Genes that share domains with NID1: view

No data available for Gene Families for NID1 Gene

Function for NID1 Gene

Molecular function for NID1 Gene

UniProtKB/Swiss-Prot Function: Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions

Gene Ontology (GO) - Molecular Function for NID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
GO:0005518 collagen binding IDA 22952693
GO:0043236 laminin binding IDA 22952693
GO:0043237 laminin-1 binding IEA --
genes like me logo Genes that share ontologies with NID1: view
genes like me logo Genes that share phenotypes with NID1: view

Animal Models for NID1 Gene

MGI Knock Outs for NID1:

miRNA for NID1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NID1 Gene

Localization for NID1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NID1 Gene

Secreted, extracellular space, extracellular matrix, basement membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NID1 Gene COMPARTMENTS Subcellular localization image for NID1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
cytosol 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix --
GO:0005604 basement membrane IDA 22952693
GO:0005605 basal lamina IEA --
GO:0031012 colocalizes_with extracellular matrix ISS 22261194
genes like me logo Genes that share ontologies with NID1: view

Pathways for NID1 Gene

genes like me logo Genes that share pathways with NID1: view

Pathways by source for NID1 Gene

1 GeneGo (Thomson Reuters) pathway for NID1 Gene

Gene Ontology (GO) - Biological Process for NID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007160 cell-matrix adhesion IEA --
GO:0010811 positive regulation of cell-substrate adhesion IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
GO:0032836 glomerular basement membrane development IEA --
genes like me logo Genes that share ontologies with NID1: view

Compounds for NID1 Gene

(1) Drugbank Compounds for NID1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Urokinase
  • U-plasminogen activator
9039-53-6 target

(13) Novoseek inferred chemical compound relationships for NID1 Gene

Compound -log(P) Hits PubMed IDs
matrigel 61.1 9
heparan sulfate 46.5 6
guanidine 43.2 2
thioflavin t 41.9 1
fibrinogen 34 13
genes like me logo Genes that share compounds with NID1: view

Transcripts for NID1 Gene

mRNA/cDNA for NID1 Gene

Unigene Clusters for NID1 Gene

Nidogen 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NID1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c
SP1:
SP2: -
SP3: - - -

Relevant External Links for NID1 Gene

GeneLoc Exon Structure for
NID1
ECgene alternative splicing isoforms for
NID1

Expression for NID1 Gene

mRNA expression in normal human tissues for NID1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NID1 Gene

SOURCE GeneReport for Unigene cluster for NID1 Gene Hs.356624

genes like me logo Genes that share expressions with NID1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NID1 Gene

Orthologs for NID1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NID1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NID1 35
  • 99.01 (n)
  • 99.12 (a)
NID1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NID1 35
  • 86.27 (n)
  • 86.78 (a)
NID1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NID1 35
  • 86.79 (n)
  • 88.02 (a)
NID1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nid1 35
  • 83.56 (n)
  • 85.22 (a)
Nid1 16
Nid1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NID1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NID1 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nid1 35
  • 83.04 (n)
  • 84.59 (a)
chicken
(Gallus gallus)
Aves NID1 35
  • 67.96 (n)
  • 68.49 (a)
NID1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NID1 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nid1 35
  • 63 (n)
  • 63.67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9665 35
zebrafish
(Danio rerio)
Actinopterygii mgbb01h02 35
NID1 (1 of 2) 36
  • 49 (a)
OneToMany
nid1a 35
  • 57.65 (n)
  • 53.84 (a)
nid1a 36
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ndg 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nid-1 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3675 36
  • 44 (a)
OneToMany
Species with no ortholog for NID1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NID1 Gene

ENSEMBL:
Gene Tree for NID1 (if available)
TreeFam:
Gene Tree for NID1 (if available)

Paralogs for NID1 Gene

Paralogs for NID1 Gene

Selected SIMAP similar genes for NID1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NID1: view

Variants for NID1 Gene

Sequence variations from dbSNP and Humsavar for NID1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs873 -- 235,977,439(-) TGAGC(C/T)GGGGC utr-variant-3-prime
rs982 -- 235,977,437(-) AGCTG(C/G/T)GGCCT utr-variant-3-prime
rs13984 -- 235,976,059(+) TTTAA(C/T)ATGAA utr-variant-3-prime
rs715956 -- 235,981,845(+) GGTTT(C/T)TCTGA intron-variant
rs715957 -- 235,981,989(+) TGGGT(A/G)TCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NID1 Gene

Variant ID Type Subtype PubMed ID
nsv832958 CNV Loss 17160897
esv9322 CNV Gain 19470904
esv2725363 CNV Deletion 23290073
esv2725374 CNV Deletion 23290073
nsv509679 CNV Insertion 20534489

Relevant External Links for NID1 Gene

HapMap Linkage Disequilibrium report
NID1
Human Gene Mutation Database (HGMD)
NID1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NID1 Gene

Disorders for NID1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NID1 Gene including...

Search for NID1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for NID1 Gene

(16) Novoseek inferred disease relationships for NID1 Gene

Disease -log(P) Hits PubMed IDs
glomerulonephritis 38.3 2
carcinoma adenoid cystic 26.1 1
choriocarcinoma 22.4 1
prostate carcinoma 19.9 3
nephritis 17.5 1

Relevant External Links for NID1

Genetic Association Database (GAD)
NID1
genes like me logo Genes that share disorders with NID1: view

No data available for UniProtKB/Swiss-Prot for NID1 Gene

Publications for NID1 Gene

  1. Genomic sequences and structural organization of the human nidogen gene (NID). (PMID: 7557988) Zimmermann K. … Nischt R. (Genomics 1995) 2 3 4 23
  2. Human nidogen: cDNA cloning, cellular expression, and mapping of the gene to chromosome 1q43. (PMID: 2471408) Olsen D.R. … Uitto J. (Am. J. Hum. Genet. 1989) 2 3 4
  3. Human nidogen gene: structural and functional characterization of the 5'-flanking region. (PMID: 1906509) Fazio M.J. … Uitto J. (J. Invest. Dermatol. 1991) 3 4
  4. Identification of the basement membrane protein nidogen as a candidate ligand for tumor endothelial marker 7 in vitro and in vivo. (PMID: 16574105) Lee H.K. … Park H.T. (FEBS Lett. 2006) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for NID1 Gene

  • Addgene plasmids for NID1

Sources for NID1 Gene

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