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Aliases for NFYA Gene

Aliases for NFYA Gene

  • Nuclear Transcription Factor Y, Alpha 2 3
  • Nuclear Transcription Factor Y Subunit A 3 4
  • CAAT Box DNA-Binding Protein Subunit A 3 4
  • NF-YA 3 4
  • CCAAT-Binding Transcription Factor Subunit B 3
  • Nuclear Transcription Factor Y Subunit Alpha 3
  • CAAT-Box DNA Binding Protein Subunit A 3
  • Transcription Factor NF-Y, A Subunit 3
  • HAP2 CCAAT-Binding Protein 3
  • CBF-A 3
  • CBF-B 3
  • HAP2 3

External Ids for NFYA Gene

Summaries for NFYA Gene

Entrez Gene Summary for NFYA Gene

  • The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for NFYA Gene

NFYA (Nuclear Transcription Factor Y, Alpha) is a Protein Coding gene. Among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Metabolism. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot for NFYA Gene

  • Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1.

Gene Wiki entry for NFYA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFYA Gene

Genomics for NFYA Gene

Genomic Location for NFYA Gene

Start:
41,072,945 bp from pter
End:
41,102,407 bp from pter
Size:
29,463 bases
Orientation:
Plus strand

Genomic View for NFYA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFYA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFYA Gene

Regulatory Elements for NFYA Gene

Proteins for NFYA Gene

  • Protein details for NFYA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23511-NFYA_HUMAN
    Recommended name:
    Nuclear transcription factor Y subunit alpha
    Protein Accession:
    P23511
    Secondary Accessions:
    • Q8IXU0

    Protein attributes for NFYA Gene

    Size:
    347 amino acids
    Molecular mass:
    36877 Da
    Quaternary structure:
    • Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with SP1; the interaction is inhibited by glycosylation of SP1. Interacts with ZHX1. Interacts (via N-terminus) with ZHX2 (via homeobox domain). Interacts with ZFX3.

    Three dimensional structures from OCA and Proteopedia for NFYA Gene

    Alternative splice isoforms for NFYA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFYA Gene

Proteomics data for NFYA Gene at MOPED

Post-translational modifications for NFYA Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys270

Other Protein References for NFYA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NFYA Gene

Domains for NFYA Gene

Protein Domains for NFYA Gene

UniProtKB/Swiss-Prot:

NFYA_HUMAN
Domain:
  • Contains 1 NFYA/HAP2-type DNA-binding domain.:
    • P23511
Family:
  • Belongs to the NFYA/HAP2 subunit family.:
    • P23511
genes like me logo Genes that share domains with NFYA: view

No data available for Gene Families for NFYA Gene

Function for NFYA Gene

Molecular function for NFYA Gene

GENATLAS Biochemistry: nuclear transcription factor NF-Y,A subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs in a variety of promoters,interacting with P/CAF
UniProtKB/Swiss-Prot Function: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1.

Gene Ontology (GO) - Molecular Function for NFYA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0001221 transcription cofactor binding IEA --
GO:0003677 DNA binding IDA 15243141
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 10571058
genes like me logo Genes that share ontologies with NFYA: view

Phenotypes for NFYA Gene

genes like me logo Genes that share phenotypes with NFYA: view

Animal Models for NFYA Gene

MGI Knock Outs for NFYA:

miRNA for NFYA Gene

Transcription Factor Targeting for NFYA Gene

Selected GeneGlobe predicted Target genes for NFYA
Targeting motifs for NFYA Gene
HOMER Transcription Factor Regulatory Elements motif NFYA
  • Consensus sequence: AGCCAATCGG Submotif: canonical Cell Type: NA

No data available for Enzyme Numbers (IUBMB) for NFYA Gene

Localization for NFYA Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFYA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFYA Gene COMPARTMENTS Subcellular localization image for NFYA gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NFYA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15243141
GO:0005654 nucleoplasm TAS --
GO:0016602 CCAAT-binding factor complex IDA 15243141
GO:0032993 protein-DNA complex IDA 11256944
genes like me logo Genes that share ontologies with NFYA: view

Pathways for NFYA Gene

genes like me logo Genes that share pathways with NFYA: view

Gene Ontology (GO) - Biological Process for NFYA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IDA 15243141
GO:0006366 transcription from RNA polymerase II promoter TAS 2000400
GO:0044255 cellular lipid metabolic process --
GO:0044281 small molecule metabolic process TAS --
GO:0045893 positive regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with NFYA: view

Compounds for NFYA Gene

(4) Novoseek inferred chemical compound relationships for NFYA Gene

Compound -log(P) Hits PubMed IDs
methylmethanesulfonate 42.9 2
serine 11 6
glutamine 4.06 4
retinoic acid 2.93 1
genes like me logo Genes that share compounds with NFYA: view

Transcripts for NFYA Gene

Unigene Clusters for NFYA Gene

Nuclear transcription factor Y, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NFYA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: -
SP2: -
SP3: - -
SP4: -
SP5: - - - -

Relevant External Links for NFYA Gene

GeneLoc Exon Structure for
NFYA
ECgene alternative splicing isoforms for
NFYA

Expression for NFYA Gene

mRNA expression in normal human tissues for NFYA Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NFYA Gene

SOURCE GeneReport for Unigene cluster for NFYA Gene Hs.10441

genes like me logo Genes that share expressions with NFYA: view

Orthologs for NFYA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NFYA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFYA 36
  • 99.52 (n)
  • 100 (a)
NFYA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFYA 36
  • 93.65 (n)
  • 99.41 (a)
NFYA 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFYA 36
  • 95.1 (n)
  • 100 (a)
NFYA 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfya 36
  • 91.45 (n)
  • 99.71 (a)
Nfya 16
Nfya 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NFYA 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFYA 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfya 36
  • 91.3 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves NFYA 36
  • 82.6 (n)
  • 94.16 (a)
NFYA 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFYA 37
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.418 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76011 36
nfya 36
  • 78.2 (n)
  • 92.48 (a)
zebrafish
(Danio rerio)
Actinopterygii nfya 36
nfya 37
  • 79 (a)
OneToMany
nfyal 36
  • 75 (n)
  • 85 (a)
nfyal 37
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Nf-YA 37
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nfya-1 37
  • 15 (a)
OneToMany
nfya-2 37
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAP2 37
  • 28 (a)
OneToOne
HAP2 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
OneToOne
Species with no ortholog for NFYA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NFYA Gene

ENSEMBL:
Gene Tree for NFYA (if available)
TreeFam:
Gene Tree for NFYA (if available)

Paralogs for NFYA Gene

No data available for Paralogs for NFYA Gene

Variants for NFYA Gene

Sequence variations from dbSNP and Humsavar for NFYA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs717883 -- 41,077,531(+) GTTTA(C/T)AGCCA intron-variant
rs767497 -- 41,079,868(-) CTTTT(A/C)TATAT intron-variant
rs1042256 -- 41,097,818(+) CTAGA(A/C/T)AGCAT utr-variant-3-prime
rs1059008 -- 41,075,985(+) CTGTA(G/T)GATGA intron-variant
rs1883596 -- 41,098,559(+) TGGAA(A/G)GCACT utr-variant-3-prime

Relevant External Links for NFYA Gene

HapMap Linkage Disequilibrium report
NFYA

No data available for Structural Variations from Database of Genomic Variants (DGV) for NFYA Gene

Disorders for NFYA Gene

(1) Novoseek inferred disease relationships for NFYA Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for NFYA

Human Genome Epidemiology (HuGE) Navigator
NFYA
genes like me logo Genes that share disorders with NFYA: view

No data available for UniProtKB/Swiss-Prot for NFYA Gene

Publications for NFYA Gene

  1. Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. (PMID: 12659632) Yamada K. … Miyamoto K. (Biochem. J. 2003) 3 4 23
  2. O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y. (PMID: 19302979) Lim K. … Chang H.I. (Biochem. Biophys. Res. Commun. 2009) 3 4 23
  3. Transcription factors NF-YA regulate the induction of human OGG1 following DNA-alkylating agent methylmethane sulfonate (MMS) treatment. (PMID: 14688259) Lee M.R. … You H.J. (J. Biol. Chem. 2004) 3 23
  4. Evolutionary variation of the CCAAT-binding transcription factor NF- Y. (PMID: 1549471) Li X.-Y. … Mathis D. (Nucleic Acids Res. 1992) 3 4
  5. Synergistic regulation of human cystathionine-beta-synthase-1b promoter by transcription factors NF-YA isoforms and Sp1. (PMID: 12427542) Ge Y. … Taub J.W. (Biochim. Biophys. Acta 2002) 3 23

Products for NFYA Gene

Sources for NFYA Gene

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