Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ATP1A4 Gene

Aliases for ATP1A4 Gene

  • ATPase, Na+/K+ Transporting, Alpha 4 Polypeptide 2 3
  • Sodium Pump Subunit Alpha-4 2 3 4
  • ATP1AL2 3 4 6
  • ATPase, Na+/K+ Transporting, Alpha Polypeptide-Like 2 2 3
  • Sodium/Potassium-Transporting ATPase Subunit Alpha-4 2 3
  • Sodium-Potassium ATPase Catalytic Subunit Alpha-4 2 3
  • Na(+)/K(+) ATPase Alpha-4 Subunit 3 4
  • EC 3.6.3.9 4 63
  • Sodium/Potassium-Transporting ATPase Alpha-4 Chain 3
  • Na+/K+ ATPase, Alpha-D Polypeptide 3
  • Na,K-ATPase Subunit Alpha-C 3
  • Na+/K+ ATPase 4 3
  • Sodium Pump 4 3
  • EC 3.6.3 63
  • ATP1A1 3

External Ids for ATP1A4 Gene

Previous HGNC Symbols for ATP1A4 Gene

  • ATP1AL2

Previous GeneCards Identifiers for ATP1A4 Gene

  • GC01U990013
  • GC01P155853
  • GC01P156899
  • GC01P157338
  • GC01P156934
  • GC01P158387
  • GC01P160121
  • GC01P131478

Summaries for ATP1A4 Gene

Entrez Gene Summary for ATP1A4 Gene

  • The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP1A4 Gene

ATP1A4 (ATPase, Na+/K+ Transporting, Alpha 4 Polypeptide) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Diuretics Pathway, Pharmacodynamics. GO annotations related to this gene include sodium:potassium-exchanging ATPase activity. An important paralog of this gene is ATP4A.

UniProtKB/Swiss-Prot for ATP1A4 Gene

  • This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility

Tocris Summary for ATP1A4 Gene

  • Na+,K+-ATPase is an ion pump responsible for maintaining sodium and potassium electrochemical gradients across the plasma membrane.

Gene Wiki entry for ATP1A4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP1A4 Gene

Genomics for ATP1A4 Gene

Regulatory Elements for ATP1A4 Gene

Genomic Location for ATP1A4 Gene

Start:
160,151,562 bp from pter
End:
160,186,977 bp from pter
Size:
35,416 bases
Orientation:
Plus strand

Genomic View for ATP1A4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP1A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP1A4 Gene

Proteins for ATP1A4 Gene

  • Protein details for ATP1A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13733-AT1A4_HUMAN
    Recommended name:
    Sodium/potassium-transporting ATPase subunit alpha-4
    Protein Accession:
    Q13733
    Secondary Accessions:
    • Q504T2
    • Q7Z4I9
    • Q8TBN8
    • Q8WXA7
    • Q8WXH7
    • Q8WY13

    Protein attributes for ATP1A4 Gene

    Size:
    1029 amino acids
    Molecular mass:
    114166 Da
    Quaternary structure:
    • Composed of three subunits: alpha (catalytic), beta and gamma
    SequenceCaution:
    • Sequence=AAQ07964.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC05228.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ATP1A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP1A4 Gene

Proteomics data for ATP1A4 Gene at MOPED

Post-translational modifications for ATP1A4 Gene

  • Ubiquitination at Lys170, Lys367, Lys385, Lys618, Lys631, and Lys704
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP1A4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ATP1A4 Gene

Gene Families for ATP1A4 Gene

HGNC:
  • PATP :ATPases / P-type
IUPHAR :

Suggested Antigen Peptide Sequences for ATP1A4 Gene

Graphical View of Domain Structure for InterPro Entry

Q13733

UniProtKB/Swiss-Prot:

AT1A4_HUMAN :
  • Q13733
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
genes like me logo Genes that share domains with ATP1A4: view

Function for ATP1A4 Gene

Molecular function for ATP1A4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In)
UniProtKB/Swiss-Prot EnzymeRegulation: Specifically inhibited by an endogenous cardiac glycoside, ouabain.
UniProtKB/Swiss-Prot Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility

Enzyme Numbers (IUBMB) for ATP1A4 Gene

Gene Ontology (GO) - Molecular Function for ATP1A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0005391 sodium:potassium-exchanging ATPase activity TAS 7809153
GO:0005524 ATP binding IEA --
GO:0019829 cation-transporting ATPase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ATP1A4: view

Phenotypes for ATP1A4 Gene

MGI mutant phenotypes for ATP1A4:
inferred from 2 alleles
genes like me logo Genes that share phenotypes with ATP1A4: view

Animal Models for ATP1A4 Gene

MGI Knock Outs for ATP1A4:

Animal Model Products

No data available for Transcription Factor Targeting and HOMER Transcription for ATP1A4 Gene

Localization for ATP1A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP1A4 Gene

Cell membrane; Multi-pass membrane protein. Note=In mature sperm, located in the principle piece of the sperm flagellum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP1A4 Gene COMPARTMENTS Subcellular localization image for ATP1A4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for ATP1A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 7809153
GO:0005890 sodium:potassium-exchanging ATPase complex TAS 7809153
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ATP1A4: view

Pathways for ATP1A4 Gene

genes like me logo Genes that share pathways with ATP1A4: view

Pathways by source for ATP1A4 Gene

Gene Ontology (GO) - Biological Process for ATP1A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006754 ATP biosynthetic process --
GO:0006813 potassium ion transport TAS 7809153
GO:0006814 sodium ion transport TAS 7809153
GO:0007283 spermatogenesis IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ATP1A4: view

Compounds for ATP1A4 Gene

(3) Tocris Compounds for ATP1A4 Gene

Compound Action Cas Number
Digoxin Na+/K+ ATPase inhibitor [20830-75-5]
Ouabain Na+/K+ ATPase inhibitor [630-60-4]
Rostafuroxin Antihypertensive agent; Na+/K+ ATPase modulator [156722-18-8]

(7) HMDB Compounds for ATP1A4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
Phosphate
  • NFB Orthophosphate
14265-44-2
Potassium
  • K+
7440-09-7
genes like me logo Genes that share compounds with ATP1A4: view

Transcripts for ATP1A4 Gene

Unigene Clusters for ATP1A4 Gene

ATPase, Na+/K+ transporting, alpha 4 polypeptide:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP1A4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP1A4 Gene

No ASD Table

Relevant External Links for ATP1A4 Gene

GeneLoc Exon Structure for
ATP1A4
ECgene alternative splicing isoforms for
ATP1A4

Expression for ATP1A4 Gene

mRNA expression in normal human tissues for ATP1A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP1A4 Gene

This gene is overexpressed in Testis (23.9) and Bladder (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP1A4 Gene

SOURCE GeneReport for Unigene cluster for ATP1A4 Gene Hs.662219

mRNA Expression by UniProt/SwissProt for ATP1A4 Gene

Q13733-AT1A4_HUMAN
Tissue specificity: Specifically expressed in testis. Found in very low levels in skeletal muscle. Expressed in mature sperm (at protein level)
genes like me logo Genes that share expressions with ATP1A4: view

In Situ Assay Products

Orthologs for ATP1A4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP1A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP1A4 35
  • 99.39 (n)
  • 99.09 (a)
ATP1A4 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP1A4 35
  • 87.07 (n)
  • 86.49 (a)
ATP1A4 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP1A4 35
  • 84.87 (n)
  • 85.81 (a)
ATP1A4 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp1a4 35
  • 82.31 (n)
  • 83.8 (a)
Atp1a4 16
Atp1a4 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Atp1a4 35
  • 82.94 (n)
  • 83.46 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 79 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii atp1a2a 36
  • 77 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Atpalpha 36
  • 70 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eat-6 36
  • 70 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENA1 36
  • 27 (a)
ManyToMany
ENA2 36
  • 27 (a)
ManyToMany
ENA5 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
OneToMany
Species with no ortholog for ATP1A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ATP1A4 Gene

ENSEMBL:
Gene Tree for ATP1A4 (if available)
TreeFam:
Gene Tree for ATP1A4 (if available)

Paralogs for ATP1A4 Gene

Paralogs for ATP1A4 Gene

Selected SIMAP similar genes for ATP1A4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATP1A4: view

Variants for ATP1A4 Gene

Sequence variations from dbSNP and Humsavar for ATP1A4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs625129 -- 160,171,496(-) CCCCA(C/G)GGATA intron-variant
rs625549 -- 160,171,406(-) TCTAA(A/G)TAGGC reference, synonymous-codon
rs669162 -- 160,171,495(+) TTATC(C/T)CTGGG intron-variant
rs705843 -- 160,172,324(-) CCCAG(C/G)CCTCC intron-variant
rs721547 -- 160,163,162(-) TTCTT(G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP1A4 Gene

Variant ID Type Subtype PubMed ID
nsv872490 CNV Loss 21882294
nsv520399 CNV Loss 19592680
nsv522918 CNV Loss 19592680
nsv819332 CNV Loss 19587683

Relevant External Links for ATP1A4 Gene

HapMap Linkage Disequilibrium report
ATP1A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP1A4 Gene

Disorders for ATP1A4 Gene

Relevant External Links for ATP1A4

Genetic Association Database (GAD)
ATP1A4
genes like me logo Genes that share disorders with ATP1A4: view

No data available for UniProtKB/Swiss-Prot for ATP1A4 Gene

Publications for ATP1A4 Gene

  1. The transcription factor CREMtau and cAMP regulate promoter activity of the Na,K-ATPase alpha4 isoform. (PMID: 16894555) Rodova M. … Blanco G. (Mol. Reprod. Dev. 2006) 3 23
  2. A detailed multipoint gene map of chromosome 1q. (PMID: 1981991) Buetow K.H. … Murray J.C. (Genomics 1990) 2 3
  3. A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis. (PMID: 7809153) Shamraj O.I. … Lingrel J.B. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4
  4. Multiple genes encode the human Na+,K+-ATPase catalytic subunit. (PMID: 3035563) Shull M.M. … Lingrel J.B. (Proc. Natl. Acad. Sci. U.S.A. 1987) 2 3
  5. Physical mapping and characterization of the human Na,K-ATPase isoform, ATP1A4. (PMID: 12119109) Keryanov S. … Gardner K.L. (Gene 2002) 3 4

Products for ATP1A4 Gene

Sources for ATP1A4 Gene

Back to Top

Content