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Aliases for NFX1 Gene

Aliases for NFX1 Gene

  • Nuclear Transcription Factor, X-Box Binding 1 2 3
  • Nuclear Transcription Factor, X Box-Binding Protein 1 3 4
  • NFX2 3 4
  • Transcriptional Repressor NF-X1 3
  • EC 6.3.2.- 4
  • TEG-42 3
  • Tex42 3

External Ids for NFX1 Gene

Summaries for NFX1 Gene

Entrez Gene Summary for NFX1 Gene

  • MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for NFX1 Gene

NFX1 (Nuclear Transcription Factor, X-Box Binding 1) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and ligase activity. An important paralog of this gene is NFXL1.

UniProtKB/Swiss-Prot for NFX1 Gene

  • Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.

Gene Wiki entry for NFX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFX1 Gene

Genomics for NFX1 Gene

Genomic Location for NFX1 Gene

Start:
33,290,420 bp from pter
End:
33,371,157 bp from pter
Size:
80,738 bases
Orientation:
Plus strand

Genomic View for NFX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFX1 Gene

Regulatory Elements for NFX1 Gene

Proteins for NFX1 Gene

  • Protein details for NFX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12986-NFX1_HUMAN
    Recommended name:
    Transcriptional repressor NF-X1
    Protein Accession:
    Q12986
    Secondary Accessions:
    • A8K6H8
    • Q5VXW6
    • Q96EL5
    • Q9BXI1

    Protein attributes for NFX1 Gene

    Size:
    1120 amino acids
    Molecular mass:
    124395 Da
    Quaternary structure:
    • Isoform 1 and isoform 3 interact with human papillomavirus (HPV) type-16 E6 oncoprotein. Isoform 1 interacts with PABPC1 and PABPC4.
    SequenceCaution:
    • Sequence=AAA69517.1; Type=Frameshift; Positions=78, 202, 284; Evidence={ECO:0000305};

    Alternative splice isoforms for NFX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFX1 Gene

Proteomics data for NFX1 Gene at MOPED

Post-translational modifications for NFX1 Gene

  • Isoform 3 is polyubiquitinated in the presence of HPV16 E6 protein; which leads to proteasomal degradation. Isoform 1 is not polyubiquitinated
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys548 and Lys885

Other Protein References for NFX1 Gene

No data available for DME Specific Peptides for NFX1 Gene

Domains for NFX1 Gene

UniProtKB/Swiss-Prot:

NFX1_HUMAN
Domain:
  • The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination:
    • Q12986
  • Contains 1 R3H domain.:
    • Q12986
Family:
  • Belongs to the NFX1 family.:
    • Q12986
Similarity:
  • Contains 8 NF-X1-type zinc fingers.:
    • Q12986
  • Contains 1 RING-type zinc finger.:
    • Q12986
genes like me logo Genes that share domains with NFX1: view

No data available for Gene Families for NFX1 Gene

Function for NFX1 Gene

Molecular function for NFX1 Gene

UniProtKB/Swiss-Prot Function: Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.
UniProtKB/Swiss-Prot Induction: By IFNG/IFN-gamma

Enzyme Numbers (IUBMB) for NFX1 Gene

Gene Ontology (GO) - Molecular Function for NFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 7964459
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 7964459
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 7964459
genes like me logo Genes that share ontologies with NFX1: view

Phenotypes for NFX1 Gene

genes like me logo Genes that share phenotypes with NFX1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NFX1 Gene

Localization for NFX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFX1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFX1 Gene COMPARTMENTS Subcellular localization image for NFX1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with NFX1: view

Pathways for NFX1 Gene

genes like me logo Genes that share pathways with NFX1: view

Gene Ontology (GO) - Biological Process for NFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 7964459
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter TAS 7964459
GO:0006954 inflammatory response TAS 7964459
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with NFX1: view

Transcripts for NFX1 Gene

Unigene Clusters for NFX1 Gene

Nuclear transcription factor, X-box binding 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NFX1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b
SP1: -
SP2: -
SP3: - -
SP4:
SP5: - -
SP6: - -
SP7:
SP8:
SP9:

Relevant External Links for NFX1 Gene

GeneLoc Exon Structure for
NFX1
ECgene alternative splicing isoforms for
NFX1

Expression for NFX1 Gene

mRNA expression in normal human tissues for NFX1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NFX1 Gene

SOURCE GeneReport for Unigene cluster for NFX1 Gene Hs.413074

genes like me logo Genes that share expressions with NFX1: view

Orthologs for NFX1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NFX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFX1 36
  • 99.58 (n)
  • 100 (a)
NFX1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFX1 36
  • 90.62 (n)
  • 90.95 (a)
NFX1 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFX1 36
  • 92.24 (n)
  • 92.93 (a)
NFX1 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfx1 36
  • 87.64 (n)
  • 88.69 (a)
Nfx1 16
Nfx1 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NFX1 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFX1 37
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfx1 36
  • 87.34 (n)
  • 88.78 (a)
chicken
(Gallus gallus)
Aves NFX1 36
  • 66.76 (n)
  • 62.52 (a)
lizard
(Anolis carolinensis)
Reptilia NFX1 37
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfx1 36
  • 63.95 (n)
  • 60.62 (a)
Str.18256 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10796 36
zebrafish
(Danio rerio)
Actinopterygii Dr.16086 36
LOC562071 36
  • 59.52 (n)
  • 55.43 (a)
NFX1 37
  • 51 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008728 36
  • 48.9 (n)
  • 47.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta stc 36
  • 49.16 (n)
  • 42.93 (a)
stc 37
  • 32 (a)
OneToOne
stc 38
  • 43 (a)
CG15011 38
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea nfx-1 36
  • 47.56 (n)
  • 40.62 (a)
nfx-1 37
  • 30 (a)
OneToOne
C16A3.7 38
  • 40 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL213W 36
  • 46.81 (n)
  • 38.12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAP1 36
  • 47.09 (n)
  • 36.96 (a)
FAP1 37
  • 26 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E08317g 36
  • 46.92 (n)
  • 37.54 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons NFXL1 36
  • 47.03 (n)
  • 41.09 (a)
rice
(Oryza sativa)
Liliopsida Os06g0252300 36
  • 47.49 (n)
  • 43.33 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC18.03 36
  • 47.58 (n)
  • 40.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1841 37
  • 36 (a)
OneToOne
Species with no ortholog for NFX1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NFX1 Gene

ENSEMBL:
Gene Tree for NFX1 (if available)
TreeFam:
Gene Tree for NFX1 (if available)

Paralogs for NFX1 Gene

Paralogs for NFX1 Gene

genes like me logo Genes that share paralogs with NFX1: view

Variants for NFX1 Gene

Sequence variations from dbSNP and Humsavar for NFX1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs581880 -- 33,354,085(+) TTTCA(A/G)AATAG splice-acceptor-variant
rs583428 -- 33,315,727(+) AACAA(A/C)AACAA intron-variant
rs583431 -- 33,315,730(+) AACAA(A/C)AAAAA intron-variant
rs587608 -- 33,296,725(-) CCCCC(C/G)CAaaa intron-variant
rs588676 -- 33,333,098(-) gaggc(C/T)gaggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFX1 Gene

Variant ID Type Subtype PubMed ID
nsv6524 CNV Loss 18451855
nsv8439 CNV Loss 18304495

Relevant External Links for NFX1 Gene

HapMap Linkage Disequilibrium report
NFX1

Disorders for NFX1 Gene

No disorders were found for NFX1 Gene.

No data available for UniProtKB/Swiss-Prot for NFX1 Gene

Publications for NFX1 Gene

  1. A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor. (PMID: 7964459) Song Z. … Ono S.J. (J. Exp. Med. 1994) 2 3 4 23
  2. Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors. (PMID: 2511169) Hume C.R. … Lee J.S. (Hum. Immunol. 1989) 2 3
  3. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. (PMID: 10500182) Lorick K.L. … Weissman A.M. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4
  4. Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex. (PMID: 15371341) Gewin L. … Galloway D.A. (Genes Dev. 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for NFX1 Gene

Sources for NFX1 Gene

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