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Aliases for NFKBIE Gene

Aliases for NFKBIE Gene

  • Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Epsilon 2 3
  • I-Kappa-B-Epsilon 3 4
  • IkappaBepsilon 3 4
  • NF-Kappa-BIE 3 4
  • IkB-Epsilon 3 4
  • IkB-E 3 4
  • IKBE 3 4
  • NF-Kappa-B Inhibitor Epsilon 3

External Ids for NFKBIE Gene

Summaries for NFKBIE Gene

Entrez Gene Summary for NFKBIE Gene

  • The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]

GeneCards Summary for NFKBIE Gene

NFKBIE (Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Epsilon) is a Protein Coding gene. Among its related pathways are Downstream Signaling Events Of B Cell Receptor (BCR) and Downstream Signaling Events Of B Cell Receptor (BCR). An important paralog of this gene is BCL3.

UniProtKB/Swiss-Prot for NFKBIE Gene

  • Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.

Gene Wiki entry for NFKBIE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFKBIE Gene

Genomics for NFKBIE Gene

Genomic Location for NFKBIE Gene

44,258,166 bp from pter
44,265,788 bp from pter
7,623 bases
Minus strand

Genomic View for NFKBIE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFKBIE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFKBIE Gene

Regulatory Elements for NFKBIE Gene

Proteins for NFKBIE Gene

  • Protein details for NFKBIE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NF-kappa-B inhibitor epsilon
    Protein Accession:
    Secondary Accessions:
    • Q5T9V9

    Protein attributes for NFKBIE Gene

    500 amino acids
    Molecular mass:
    52864 Da
    Quaternary structure:
    • Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit.
    • Sequence=AAC51216.1; Type=Frameshift; Positions=339, 351; Evidence={ECO:0000305};

neXtProt entry for NFKBIE Gene

Proteomics data for NFKBIE Gene at MOPED

Post-translational modifications for NFKBIE Gene

  • Serine phosphorylated; followed by proteasome-dependent degradation
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NFKBIE Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NFKBIE Gene

Domains for NFKBIE Gene

Gene Families for NFKBIE Gene

  • ANKRD :Ankyrin repeat domain containing

Protein Domains for NFKBIE Gene


  • Belongs to the NF-kappa-B inhibitor family.:
    • O00221
  • Contains 6 ANK repeats.:
    • O00221
genes like me logo Genes that share domains with NFKBIE: view

Function for NFKBIE Gene

Molecular function for NFKBIE Gene

UniProtKB/Swiss-Prot Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.

Gene Ontology (GO) - Molecular Function for NFKBIE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14743216
genes like me logo Genes that share ontologies with NFKBIE: view

Phenotypes for NFKBIE Gene

genes like me logo Genes that share phenotypes with NFKBIE: view

miRNA for NFKBIE Gene

miRTarBase miRNAs that target NFKBIE

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NFKBIE Gene

Localization for NFKBIE Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFKBIE Gene


Subcellular locations from

Jensen Localization Image for NFKBIE Gene COMPARTMENTS Subcellular localization image for NFKBIE gene
Compartment Confidence
cytosol 4
golgi apparatus 2
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NFKBIE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9135156
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with NFKBIE: view

Pathways for NFKBIE Gene

genes like me logo Genes that share pathways with NFKBIE: view

Gene Ontology (GO) - Biological Process for NFKBIE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042942 D-serine transport IEA --
GO:0042994 cytoplasmic sequestering of transcription factor TAS 9135156
genes like me logo Genes that share ontologies with NFKBIE: view

Transcripts for NFKBIE Gene


Unigene Clusters for NFKBIE Gene

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NFKBIE Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP3: -

Relevant External Links for NFKBIE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NFKBIE Gene

mRNA expression in normal human tissues for NFKBIE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NFKBIE Gene

SOURCE GeneReport for Unigene cluster for NFKBIE Gene Hs.458276

mRNA Expression by UniProt/SwissProt for NFKBIE Gene

Tissue specificity: Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages
genes like me logo Genes that share expressions with NFKBIE: view

Orthologs for NFKBIE Gene

This gene was present in the common ancestor of animals.

Orthologs for NFKBIE Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NFKBIE 36
  • 99.33 (n)
  • 99.2 (a)
  • 99 (a)
(Bos Taurus)
Mammalia NFKBIE 36
  • 86.43 (n)
  • 87.53 (a)
  • 81 (a)
(Canis familiaris)
Mammalia NFKBIE 36
  • 84.72 (n)
  • 83 (a)
  • 82 (a)
(Mus musculus)
Mammalia Nfkbie 36
  • 82.41 (n)
  • 83.06 (a)
Nfkbie 16
Nfkbie 37
  • 82 (a)
(Monodelphis domestica)
Mammalia NFKBIE 37
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia NFKBIE 37
  • 72 (a)
(Rattus norvegicus)
Mammalia Nfkbie 36
  • 82.27 (n)
  • 81.44 (a)
(Gallus gallus)
Aves NFKBIE 36
  • 66.37 (n)
  • 59.94 (a)
  • 52 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 17 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145466 36
  • 60.08 (n)
  • 56.53 (a)
Str.672 36
(Danio rerio)
Actinopterygii nfkbie 36
  • 53.35 (n)
  • 45.12 (a)
nfkbie 37
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta cact 37
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 20 (a)
Species with no ortholog for NFKBIE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFKBIE Gene

Gene Tree for NFKBIE (if available)
Gene Tree for NFKBIE (if available)

Paralogs for NFKBIE Gene

Paralogs for NFKBIE Gene

Selected SIMAP similar genes for NFKBIE Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NFKBIE: view

Variants for NFKBIE Gene

Sequence variations from dbSNP and Humsavar for NFKBIE Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs730775 -- 44,264,337(+) GAGTG(A/G)GACAC intron-variant
rs1051839 -- 44,265,067(-) ACCCG(C/G)CCCCA missense, reference
rs1409112 -- 44,263,378(+) AGTCT(C/T)GGGGT intron-variant
rs2233420 -- 44,266,644(-) AAAGA(A/T)GTTTT upstream-variant-2KB
rs2233421 -- 44,266,559(-) CCCCA(C/T)TTCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NFKBIE Gene

Variant ID Type Subtype PubMed ID
nsv885851 CNV Loss 21882294
nsv5282 CNV Insertion 18451855
nsv462936 CNV Loss 19166990
dgv6843n71 CNV Loss 21882294
nsv524398 CNV Loss 19592680
dgv6844n71 CNV Loss 21882294
nsv885857 CNV Loss 21882294

Relevant External Links for NFKBIE Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for NFKBIE Gene

Relevant External Links for NFKBIE

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NFKBIE: view

No data available for UniProtKB/Swiss-Prot for NFKBIE Gene

Publications for NFKBIE Gene

  1. IkappaB genetic polymorphisms and invasive pneumococcal disease. (PMID: 17463416) Chapman S.J. … Hill A.V. (Am. J. Respir. Crit. Care Med. 2007) 3 23 49
  2. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PMID: 18434448) Dieguez-Gonzalez R. … Gonzalez A. (Ann. Rheum. Dis. 2009) 3 23 49
  3. IkappaB epsilon, a novel member of the IkappaB family, controls RelA and cRel NF-kappaB activity. (PMID: 9135156) Whiteside S.T. … Israel A. (EMBO J. 1997) 2 3 4
  4. Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells. (PMID: 14595753) Emmerich F. … DAPrken B. (J. Pathol. 2003) 3 23
  5. A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription. (PMID: 9315679) Li Z. … Nabel G.J. (Mol. Cell. Biol. 1997) 3 4

Products for NFKBIE Gene

Sources for NFKBIE Gene

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