Aliases for NFKBIE Gene
External Ids for NFKBIE Gene
Previous GeneCards Identifiers for NFKBIE Gene
The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]
GeneCards Summary for NFKBIE Gene
NFKBIE (NFKB Inhibitor Epsilon) is a Protein Coding gene. Diseases associated with NFKBIE include ebola hemorrhagic fever and pleural empyema. Among its related pathways are Immune System and Development_Leptin signaling via PI3K-dependent pathway. An important paralog of this gene is BCL3.
UniProtKB/Swiss-Prot for NFKBIE Gene
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.