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Aliases for NFKB1 Gene

Aliases for NFKB1 Gene

  • Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 1 2 3 4
  • DNA-Binding Factor KBF1 3 4
  • EBP-1 3 4
  • Nuclear Factor Kappa-B DNA Binding Subunit 3
  • Nuclear Factor NF-Kappa-B P105 Subunit 3
  • Nuclear Factor NF-Kappa-B P50 Subunit 3
  • DNA Binding Factor KBF1 3
  • NF-Kappabeta 3
  • NF-Kappa-B 3
  • NF-KappaB 3
  • NFKB-P105 3
  • NFKB-P50 3
  • NFkappaB 3
  • NF-KB1 3
  • P105 3
  • KBF1 3
  • P50 3

External Ids for NFKB1 Gene

Summaries for NFKB1 Gene

Entrez Gene Summary for NFKB1 Gene

  • This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for NFKB1 Gene

NFKB1 (Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 1) is a Protein Coding gene. Diseases associated with NFKB1 include aneurysmal bone cysts and hepatitis d. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is RELB.

UniProtKB/Swiss-Prot for NFKB1 Gene

  • NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5-GGRNNYYCC-3, located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.

Tocris Summary for NFKB1 Gene

  • NF-kappaB (nuclear factor-kappa B) is a rapidly acting primary transcription factor found in all cell types. It is involved in cellular responses to stimuli such as cytokines and stress and plays a key role in regulating the immune response to infection. In unstimulated cells NF-kappaB dimers are sequestered inactively in the cytoplasm by a protein complex called inhibitor of kappa B (IkappaB). IkappaB inactivates NF-kappaB by masking the nuclear localization signals (NLS). Activation of NF-kappaB occurs via degradation of IkappaB, a process that is initiated by its phosphorylation by IkappaB kinase (IKK). Phosphorylated IvB becomes dissociated from NF-kappaB, unmasking the NLS. Phosphorylation also results in IkappaB ubiquitination and targeting to the proteasome. NF-kappaB can now enter the nucleus and regulate gene expression. NF-kappaB turns on expression of IkappaB forming a negative feedback loop.

Gene Wiki entry for NFKB1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFKB1 Gene

Genomics for NFKB1 Gene

Genomic Location for NFKB1 Gene

Start:
102,501,329 bp from pter
End:
102,617,302 bp from pter
Size:
115,974 bases
Orientation:
Plus strand

Genomic View for NFKB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFKB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFKB1 Gene

Regulatory Elements for NFKB1 Gene

Proteins for NFKB1 Gene

  • Protein details for NFKB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19838-NFKB1_HUMAN
    Recommended name:
    Nuclear factor NF-kappa-B p105 subunit
    Protein Accession:
    P19838
    Secondary Accessions:
    • A8K5Y5
    • B3KVE8
    • Q68D84
    • Q86V43
    • Q8N4X7
    • Q9NZC0

    Protein attributes for NFKB1 Gene

    Size:
    968 amino acids
    Molecular mass:
    105356 Da
    Quaternary structure:
    • Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-p50 complex. Homodimer; component of the NF-kappa-B p50-p50 complex. Component of the NF-kappa-B p105-p50 complex. Component of the NF-kappa-B p50-c-Rel complex. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Also interacts with MAP3K8. NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity. Interacts with DSIPI; this interaction prevents nuclear translocation and DNA-binding. Interacts with SPAG9 and UNC5CL. NFKB1/p105 interacts with CFLAR; the interaction inhibits p105 processing into p50. NFKB1/p105 forms a ternary complex with MAP3K8 and TNIP2. Interacts with GSK3B; the interaction prevents processing of p105 to p50. NFKB1/p50 interacts with NFKBIE. NFKB1/p50 interacts with NFKBIZ. Nuclear factor NF-kappa-B p50 subunit interacts with NFKBID (By similarity). Directly interacts with MEN1. Interacts with HIF1AN.

    Three dimensional structures from OCA and Proteopedia for NFKB1 Gene

    Alternative splice isoforms for NFKB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFKB1 Gene

Proteomics data for NFKB1 Gene at MOPED

Post-translational modifications for NFKB1 Gene

  • Phosphorylation at Ser-903 and Ser-907 primes p105 for proteolytic processing in response to TNF-alpha stimulation. Phosphorylation at Ser-927 and Ser-932 are required for BTRC/BTRCP-mediated proteolysis.
  • Polyubiquitination seems to allow p105 processing.
  • S-nitrosylation of Cys-61 affects DNA binding.
  • The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation
  • While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p50 making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys856

Other Protein References for NFKB1 Gene

No data available for DME Specific Peptides for NFKB1 Gene

Domains for NFKB1 Gene

Gene Families for NFKB1 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Suggested Antigen Peptide Sequences for NFKB1 Gene

Graphical View of Domain Structure for InterPro Entry

P19838

UniProtKB/Swiss-Prot:

NFKB1_HUMAN
Domain:
  • The C-terminus of p105 might be involved in cytoplasmic retention, inhibition of DNA-binding, and transcription activation:
    • P19838
  • Glycine-rich region (GRR) appears to be a critical element in the generation of p50:
    • P19838
  • Contains 1 death domain.:
    • P19838
  • Contains 1 RHD (Rel-like) domain.:
    • P19838
Similarity:
  • Contains 7 ANK repeats.:
    • P19838
genes like me logo Genes that share domains with NFKB1: view

Function for NFKB1 Gene

Molecular function for NFKB1 Gene

GENATLAS Biochemistry: nuclear transcription factor of kappa light chain gene enhancer in B cells,1,(encoding the p105 precursor and the amino-terminal active p50 subunit),NF-kappa B/REL family
UniProtKB/Swiss-Prot Function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5-GGRNNYYCC-3, located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.
UniProtKB/Swiss-Prot Induction: By phorbol ester and TNF

Gene Ontology (GO) - Molecular Function for NFKB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000975 regulatory region DNA binding IDA 17426251
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 18718911
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 7959007
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 1406630
GO:0001071 nucleic acid binding transcription factor activity --
genes like me logo Genes that share ontologies with NFKB1: view
genes like me logo Genes that share phenotypes with NFKB1: view

Animal Models for NFKB1 Gene

MGI Knock Outs for NFKB1:

Transcription Factor Targeting for NFKB1 Gene

Selected GeneGlobe predicted Target genes for NFKB1
Targeting motifs for NFKB1 Gene
HOMER Transcription Factor Regulatory Elements motif NFKB1
  • Consensus sequence: GGGGGAATCCCC Submotif: canonical Cell Type: Monocyte

No data available for Enzyme Numbers (IUBMB) for NFKB1 Gene

Localization for NFKB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFKB1 Gene

Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFKB1 Gene COMPARTMENTS Subcellular localization image for NFKB1 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 4
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NFKB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11819787
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NFKB1: view

Pathways for NFKB1 Gene

SuperPathways for NFKB1 Gene

Superpath Contained pathways
1 TWEAK Pathway
2 4-1BB Pathway
3 NOD-like Receptor Signaling Pathways
4 Cytosolic sensors of pathogen-associated DNA
5 RANK Signaling in Osteoclasts
genes like me logo Genes that share pathways with NFKB1: view

Pathways by source for NFKB1 Gene

Gene Ontology (GO) - Biological Process for NFKB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 19881551
GO:0001818 negative regulation of cytokine production --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with NFKB1: view

Compounds for NFKB1 Gene

(5) Tocris Compounds for NFKB1 Gene

Compound Action Cas Number
Bay 11-7085 Irreversible inhibitor of TNF-alpha-induced IkappaBalpha phosphorylation [196309-76-9]
Celastrol Inhibits TNF-alpha-induced NF-kappaB activation [34157-83-0]
IMD 0354 Inhibitor of IKKbeta [978-62-1]
Ro 106-9920 Inhibitor of NF-kappaB activation [62645-28-7]
SC 514 IKKbeta inhibitor; attenuates NF-kappaB-induced gene expression [354812-17-2]

(3) Drugbank Compounds for NFKB1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Pranlukast
103177-37-3 target other/unknown
Thalidomide
  • alpha-phthalimidoglutarimide
50-35-1 target antagonist
Triflusal
target antagonist

(2) Novoseek inferred chemical compound relationships for NFKB1 Gene

Compound -log(P) Hits PubMed IDs
etoposide 3.68 1
nitric oxide 0 1
genes like me logo Genes that share compounds with NFKB1: view

Transcripts for NFKB1 Gene

Unigene Clusters for NFKB1 Gene

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NFKB1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - -
SP2: - - -
SP3: -
SP4:
SP5:

ExUns: 22 ^ 23 ^ 24a · 24b · 24c
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for NFKB1 Gene

GeneLoc Exon Structure for
NFKB1
ECgene alternative splicing isoforms for
NFKB1

Expression for NFKB1 Gene

mRNA expression in normal human tissues for NFKB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NFKB1 Gene

SOURCE GeneReport for Unigene cluster for NFKB1 Gene Hs.618430

genes like me logo Genes that share expressions with NFKB1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NFKB1 Gene

Orthologs for NFKB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NFKB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFKB1 35
  • 99.69 (n)
  • 100 (a)
NFKB1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFKB1 35
  • 88.96 (n)
  • 92 (a)
NFKB1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFKB1 35
  • 89.87 (n)
  • 91.49 (a)
NFKB1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfkb1 35
  • 84.46 (n)
  • 87.75 (a)
Nfkb1 16
Nfkb1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NFKB1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nfkb1 35
  • 84.38 (n)
  • 88.13 (a)
chicken
(Gallus gallus)
Aves NFKB1 35
  • 71.87 (n)
  • 73.79 (a)
NFKB1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfkb1 35
  • 66.74 (n)
  • 68.97 (a)
Str.11435 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10943 35
fruit fly
(Drosophila melanogaster)
Insecta Rel 36
  • 23 (a)
OneToMany
dl 37
  • 41 (a)
Rel 37
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1675 36
  • 32 (a)
OneToMany
Species with no ortholog for NFKB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NFKB1 Gene

ENSEMBL:
Gene Tree for NFKB1 (if available)
TreeFam:
Gene Tree for NFKB1 (if available)

Paralogs for NFKB1 Gene

Paralogs for NFKB1 Gene

Selected SIMAP similar genes for NFKB1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NFKB1: view

Variants for NFKB1 Gene

Sequence variations from dbSNP and Humsavar for NFKB1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1287 -- 102,588,279(-) TGATG(C/T)TTTAT intron-variant
rs93059 -- 102,547,361(-) AATAC(C/T)TCTTT intron-variant
rs118882 -- 102,541,850(-) TTGGA(A/G)GGAGA intron-variant
rs170731 -- 102,527,746(-) GCACA(A/T)TAAAA intron-variant
rs230491 -- 102,563,458(+) AAACT(C/T)TCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFKB1 Gene

Variant ID Type Subtype PubMed ID
nsv830020 CNV Loss 17160897
nsv4442 CNV Insertion 18451855
esv27559 CNV Loss 19812545
esv2728077 CNV Deletion 23290073

Relevant External Links for NFKB1 Gene

HapMap Linkage Disequilibrium report
NFKB1
Human Gene Mutation Database (HGMD)
NFKB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFKB1 Gene

Disorders for NFKB1 Gene

(10) Novoseek inferred disease relationships for NFKB1 Gene

Disease -log(P) Hits PubMed IDs
leukemia t-cell 36.5 3
colitis ulcerative 35.3 4
necrosis 32.8 3
tumors 23.2 6
inflammation 21.9 1

Relevant External Links for NFKB1

Genetic Association Database (GAD)
NFKB1
Human Genome Epidemiology (HuGE) Navigator
NFKB1
Tumor Gene Database (TGDB):
NFKB1
genes like me logo Genes that share disorders with NFKB1: view

No data available for UniProtKB/Swiss-Prot for NFKB1 Gene

Publications for NFKB1 Gene

  1. The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product. (PMID: 2203531) Kieran M. … Israel A. (Cell 1990) 3 4 23
  2. The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF- kappa B and I kappa B-gamma: implications for NF-kappa B-mediated signal transduction. (PMID: 8825636) Heron E. … van Loon A.P.G.M. (Genomics 1995) 3 4 23
  3. Cotranslational dimerization of the Rel homology domain of NF-kappaB1 generates p50-p105 heterodimers and is required for effective p50 production. (PMID: 10970863) Lin L. … Greene W.C. (EMBO J. 2000) 3 4 23
  4. Mutation analysis and association studies of nuclear factor-kappaB1 in sporadic Parkinson's disease patients. (PMID: 12203044) Wintermeyer P. … KrA1ger R. (J Neural Transm 2002) 3 23 48
  5. Polymorphic variants of NFKB1 and its inhibitory protein NFKBIA, and their involvement in sporadic breast cancer. (PMID: 12406554) Curran J.E. … Griffiths L.R. (Cancer Lett. 2002) 3 23 48

Products for NFKB1 Gene

  • Addgene plasmids for NFKB1

Sources for NFKB1 Gene

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