Aliases for NFIX Gene
External Ids for NFIX Gene
Previous GeneCards Identifiers for NFIX Gene
The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
GeneCards Summary for NFIX Gene
NFIX (Nuclear Factor I X) is a Protein Coding gene. Diseases associated with NFIX include sotos syndrome 2 and marshall-smith syndrome. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. An important paralog of this gene is NFIA.
UniProtKB/Swiss-Prot for NFIX Gene
Recognizes and binds the palindromic sequence 5-TTGGCNNNNNGCCAA-3 present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.