Aliases for NFIX Gene
External Ids for NFIX Gene
The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
GeneCards Summary for NFIX Gene
NFIX (Nuclear Factor I/X (CCAAT-Binding Transcription Factor)) is a Protein Coding gene. Diseases associated with NFIX include sotos syndrome 2 and marshall-smith syndrome. Among its related pathways are Gene Expression and RNA Polymerase III Transcription Initiation. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NFIA.
UniProtKB/Swiss-Prot for NFIX Gene
Recognizes and binds the palindromic sequence 5-TTGGCNNNNNGCCAA-3 present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication