Aliases for NFE2L2 Gene
- Nuclear Factor, Erythroid 2-Like 2 2 3
- NF-E2-Related Factor 2 2 3 4
- NRF2 3 4 6
- Nuclear Factor (Erythroid-Derived 2)-Like 2 2 3
- Nuclear Factor, Erythroid Derived 2, Like 2 3 4
- NFE2-Related Factor 2 3 4
- HEBP1 3 4
- Nuclear Factor Erythroid 2-Related Factor 2 3
- Nuclear Factor Erythroid-Derived 2-Like 2 3
External Ids for NFE2L2 Gene
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for NFE2L2 Gene
NFE2L2 (Nuclear Factor, Erythroid 2-Like 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein domain specific binding. An important paralog of this gene is NFE2.
UniProtKB/Swiss-Prot for NFE2L2 Gene
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.