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Aliases for NFE2L1 Gene

Aliases for NFE2L1 Gene

  • Nuclear Factor, Erythroid 2-Like 1 2 3
  • NRF1 3 4 6
  • Nuclear Factor (Erythroid-Derived 2)-Like 1 2 3
  • Nuclear Factor, Erythroid Derived 2, Like 1 3 4
  • Locus Control Region-Factor 1 3 4
  • Transcription Factor LCR-F1 3 4
  • Transcription Factor HBZ17 3 4
  • NF-E2-Related Factor 1 3 4
  • NFE2-Related Factor 1 3 4
  • TCF-11 3 4
  • TCF11 3 4
  • Transcription Factor 11 (Basic Leucine Zipper Type) 3
  • Nuclear Factor Erythroid 2-Related Factor 1 3
  • Transcription Factor 11 4
  • LCR-F1 3
  • HBZ17 4

External Ids for NFE2L1 Gene

Previous Symbols for NFE2L1 Gene

  • TCF11

Summaries for NFE2L1 Gene

Entrez Gene Summary for NFE2L1 Gene

  • This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]

GeneCards Summary for NFE2L1 Gene

NFE2L1 (Nuclear Factor, Erythroid 2-Like 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription cofactor activity. An important paralog of this gene is NFE2.

UniProtKB/Swiss-Prot for NFE2L1 Gene

  • Activates erythroid-specific, globin gene expression

Gene Wiki entry for NFE2L1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFE2L1 Gene

Genomics for NFE2L1 Gene

Genomic Location for NFE2L1 Gene

Start:
48,048,324 bp from pter
End:
48,061,545 bp from pter
Size:
13,222 bases
Orientation:
Plus strand

Genomic View for NFE2L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFE2L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFE2L1 Gene

Regulatory Elements for NFE2L1 Gene

Proteins for NFE2L1 Gene

  • Protein details for NFE2L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14494-NF2L1_HUMAN
    Recommended name:
    Nuclear factor erythroid 2-related factor 1
    Protein Accession:
    Q14494
    Secondary Accessions:
    • D3DTU3
    • D3DTU5
    • Q12877
    • Q96FN6

    Protein attributes for NFE2L1 Gene

    Size:
    772 amino acids
    Molecular mass:
    84704 Da
    Quaternary structure:
    • Interacts with KEAP1.

    Alternative splice isoforms for NFE2L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFE2L1 Gene

Proteomics data for NFE2L1 Gene at MOPED

Post-translational modifications for NFE2L1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys70

No data available for DME Specific Peptides for NFE2L1 Gene

Domains for NFE2L1 Gene

Gene Families for NFE2L1 Gene

HGNC:
  • bZIP :basic leucine zipper proteins

Protein Domains for NFE2L1 Gene

UniProtKB/Swiss-Prot:

NF2L1_HUMAN
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.:
    • Q14494
Family:
  • Belongs to the bZIP family. CNC subfamily.:
    • Q14494
genes like me logo Genes that share domains with NFE2L1: view

Function for NFE2L1 Gene

Molecular function for NFE2L1 Gene

GENATLAS Biochemistry: nuclear factor,erythroid derived 2-like 1,Capncollar (CNC) family of transcription factor,expressed in many tissues
UniProtKB/Swiss-Prot Function: Activates erythroid-specific, globin gene expression

Gene Ontology (GO) - Molecular Function for NFE2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 8248256
genes like me logo Genes that share ontologies with NFE2L1: view
genes like me logo Genes that share phenotypes with NFE2L1: view

Animal Models for NFE2L1 Gene

MGI Knock Outs for NFE2L1:

Transcription Factor Targeting for NFE2L1 Gene

Selected GeneGlobe predicted Target genes for NFE2L1

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for NFE2L1 Gene

Localization for NFE2L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFE2L1 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFE2L1 Gene COMPARTMENTS Subcellular localization image for NFE2L1 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5

Gene Ontology (GO) - Cellular Components for NFE2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NFE2L1: view

Pathways for NFE2L1 Gene

genes like me logo Genes that share pathways with NFE2L1: view

Gene Ontology (GO) - Biological Process for NFE2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter TAS 9826775
GO:0006783 heme biosynthetic process TAS 9501099
GO:0006954 inflammatory response TAS 9826775
GO:0009653 anatomical structure morphogenesis TAS 9501099
genes like me logo Genes that share ontologies with NFE2L1: view

Compounds for NFE2L1 Gene

(1) HMDB Compounds for NFE2L1 Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8

(1) Drugbank Compounds for NFE2L1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Lauryl Dimethylamine-N-Oxide
target

(2) Novoseek inferred chemical compound relationships for NFE2L1 Gene

Compound -log(P) Hits PubMed IDs
gamma-glutamylcysteine 68.9 1
leucine 62.1 7
genes like me logo Genes that share compounds with NFE2L1: view

Transcripts for NFE2L1 Gene

Unigene Clusters for NFE2L1 Gene

Nuclear factor (erythroid-derived 2)-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NFE2L1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - -
SP5: -
SP6: - - - - -
SP7: - - -
SP8: - - - - - -
SP9: - - - - - - -
SP10: -
SP11: - -

Relevant External Links for NFE2L1 Gene

GeneLoc Exon Structure for
NFE2L1
ECgene alternative splicing isoforms for
NFE2L1

Expression for NFE2L1 Gene

mRNA expression in normal human tissues for NFE2L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NFE2L1 Gene

This gene is overexpressed in Muscle - Skeletal (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NFE2L1 Gene

SOURCE GeneReport for Unigene cluster for NFE2L1 Gene Hs.514284

genes like me logo Genes that share expressions with NFE2L1: view

Orthologs for NFE2L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NFE2L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFE2L1 36
  • 99.78 (n)
  • 100 (a)
NFE2L1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFE2L1 36
  • 90.58 (n)
  • 95.27 (a)
NFE2L1 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFE2L1 36
  • 92.14 (n)
  • 95.6 (a)
NFE2L1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfe2l1 36
  • 90.5 (n)
  • 96.76 (a)
Nfe2l1 16
Nfe2l1 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NFE2L1 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFE2L1 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfe2l1 36
  • 89.97 (n)
  • 97.02 (a)
chicken
(Gallus gallus)
Aves NFE2L1 36
  • 78.7 (n)
  • 83.64 (a)
NFE2L1 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFE2L1 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68992 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nfe2l1 36
  • 65 (n)
  • 65.88 (a)
zebrafish
(Danio rerio)
Actinopterygii nfe2l1b 36
  • 64.11 (n)
  • 62.62 (a)
nfe2l1b 37
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cnc 37
  • 15 (a)
OneToMany
cnc 38
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 18 (a)
OneToMany
Species with no ortholog for NFE2L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFE2L1 Gene

ENSEMBL:
Gene Tree for NFE2L1 (if available)
TreeFam:
Gene Tree for NFE2L1 (if available)

Paralogs for NFE2L1 Gene

Paralogs for NFE2L1 Gene

genes like me logo Genes that share paralogs with NFE2L1: view

Variants for NFE2L1 Gene

Sequence variations from dbSNP and Humsavar for NFE2L1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs15719 -- 48,061,331(-) CTATC(C/T)CTACT utr-variant-3-prime
rs1051001 -- 48,060,543(+) CCACC(C/G/T)CTCAC utr-variant-3-prime
rs2301264 -- 48,060,524(+) GGTCC(A/G)GTGTT utr-variant-3-prime
rs7212037 -- 48,060,223(+) GAGGG(A/C/G)CGGTG utr-variant-3-prime
rs8182234 -- 48,061,847(+) TTCTA(G/T)TGGCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NFE2L1 Gene

Variant ID Type Subtype PubMed ID
nsv469808 CNV Complex 16826518

Relevant External Links for NFE2L1 Gene

HapMap Linkage Disequilibrium report
NFE2L1

Disorders for NFE2L1 Gene

(1) University of Copenhagen DISEASES for NFE2L1 Gene

Relevant External Links for NFE2L1

Genetic Association Database (GAD)
NFE2L1
Human Genome Epidemiology (HuGE) Navigator
NFE2L1
genes like me logo Genes that share disorders with NFE2L1: view

No data available for UniProtKB/Swiss-Prot for NFE2L1 Gene

Publications for NFE2L1 Gene

  1. Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast. (PMID: 8248256) Chan J.Y. … Kan Y.W. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 23
  2. Nrf1 is targeted to the endoplasmic reticulum membrane by an N- terminal transmembrane domain. Inhibition of nuclear translocation and transacting function. (PMID: 16687406) Wang W. … Chan J.Y. (J. Biol. Chem. 2006) 3 4 23
  3. Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression. (PMID: 8036168) Caterina J.J. … Townes T.M. (Nucleic Acids Res. 1994) 3 4 23
  4. Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells. (PMID: 20385086) Radhakrishnan S.K. … Deshaies R.J. (Mol. Cell 2010) 3 23
  5. Molecular cloning of a putative novel human bZIP transcription factor on chromosome 17q22. (PMID: 8001966) Luna L. … Kolstoe A.-B. (Genomics 1994) 3 4

Products for NFE2L1 Gene

Sources for NFE2L1 Gene

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