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Aliases for NFE2L1 Gene

Aliases for NFE2L1 Gene

  • Nuclear Factor, Erythroid 2 Like 1 2 3 5
  • Nuclear Factor (Erythroid-Derived 2)-Like 1 2 3
  • Nuclear Factor, Erythroid Derived 2, Like 1 3 4
  • Nuclear Factor, Erythroid 2-Like 1 2 3
  • Locus Control Region-Factor 1 3 4
  • Transcription Factor LCR-F1 3 4
  • Transcription Factor HBZ17 3 4
  • NF-E2-Related Factor 1 3 4
  • NFE2-Related Factor 1 3 4
  • TCF-11 3 4
  • TCF11 3 4
  • NRF1 3 4
  • Transcription Factor 11 (Basic Leucine Zipper Type) 3
  • Transcription Factor 11 4
  • LCR-F1 3
  • HBZ17 4

External Ids for NFE2L1 Gene

Previous HGNC Symbols for NFE2L1 Gene

  • TCF11

Previous GeneCards Identifiers for NFE2L1 Gene

  • GC17P045831
  • GC17P048606
  • GC17P046467
  • GC17P046600
  • GC17P043480
  • GC17P046125
  • GC17P041494

Summaries for NFE2L1 Gene

Entrez Gene Summary for NFE2L1 Gene

  • This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]

GeneCards Summary for NFE2L1 Gene

NFE2L1 (Nuclear Factor, Erythroid 2 Like 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and WNT Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription cofactor activity. An important paralog of this gene is NFE2.

UniProtKB/Swiss-Prot for NFE2L1 Gene

  • Activates erythroid-specific, globin gene expression.

Gene Wiki entry for NFE2L1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFE2L1 Gene

Genomics for NFE2L1 Gene

Regulatory Elements for NFE2L1 Gene

Enhancers for NFE2L1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NFE2L1 on UCSC Golden Path with GeneCards custom track

Promoters for NFE2L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NFE2L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NFE2L1 Gene

Chromosome:
17
Start:
48,048,324 bp from pter
End:
48,061,545 bp from pter
Size:
13,222 bases
Orientation:
Plus strand

Genomic View for NFE2L1 Gene

Genes around NFE2L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFE2L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFE2L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFE2L1 Gene

Proteins for NFE2L1 Gene

  • Protein details for NFE2L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14494-NF2L1_HUMAN
    Recommended name:
    Nuclear factor erythroid 2-related factor 1
    Protein Accession:
    Q14494
    Secondary Accessions:
    • D3DTU3
    • D3DTU5
    • Q12877
    • Q96FN6

    Protein attributes for NFE2L1 Gene

    Size:
    772 amino acids
    Molecular mass:
    84704 Da
    Quaternary structure:
    • Interacts with KEAP1.

    Alternative splice isoforms for NFE2L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFE2L1 Gene

Proteomics data for NFE2L1 Gene at MOPED

Post-translational modifications for NFE2L1 Gene

  • Ubiquitination at Lys 70
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NFE2L1 (NFE2L1)

No data available for DME Specific Peptides for NFE2L1 Gene

Domains & Families for NFE2L1 Gene

Gene Families for NFE2L1 Gene

Protein Domains for NFE2L1 Gene

Suggested Antigen Peptide Sequences for NFE2L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14494

UniProtKB/Swiss-Prot:

NF2L1_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. CNC subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. CNC subfamily.
genes like me logo Genes that share domains with NFE2L1: view

Function for NFE2L1 Gene

Molecular function for NFE2L1 Gene

GENATLAS Biochemistry:
nuclear factor,erythroid derived 2-like 1,Capncollar (CNC) family of transcription factor,expressed in many tissues
UniProtKB/Swiss-Prot Function:
Activates erythroid-specific, globin gene expression.

Gene Ontology (GO) - Molecular Function for NFE2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,TAS 8248256
GO:0005515 protein binding IPI 20102225
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with NFE2L1: view
genes like me logo Genes that share phenotypes with NFE2L1: view

Animal Models for NFE2L1 Gene

MGI Knock Outs for NFE2L1:

Animal Model Products

CRISPR Products

miRNA for NFE2L1 Gene

miRTarBase miRNAs that target NFE2L1

Transcription Factor Targets for NFE2L1 Gene

Selected GeneGlobe predicted Target genes for NFE2L1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for NFE2L1 Gene

Localization for NFE2L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFE2L1 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFE2L1 Gene COMPARTMENTS Subcellular localization image for NFE2L1 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4

No data available for Gene Ontology (GO) - Cellular Components for NFE2L1 Gene

Pathways & Interactions for NFE2L1 Gene

genes like me logo Genes that share pathways with NFE2L1: view

SIGNOR curated interactions for NFE2L1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NFE2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 9826775
GO:0030218 erythrocyte differentiation IEA --
GO:0045893 positive regulation of transcription, DNA-templated IBA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with NFE2L1: view

Drugs & Compounds for NFE2L1 Gene

(4) Drugs for NFE2L1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lauryl Dimethylamine-N-Oxide Experimental Pharma Target 0
heme Pharma Agonist 0
genes like me logo Genes that share compounds with NFE2L1: view

Transcripts for NFE2L1 Gene

Unigene Clusters for NFE2L1 Gene

Nuclear factor (erythroid-derived 2)-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NFE2L1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - -
SP5: -
SP6: - - - - -
SP7: - - -
SP8: - - - - - -
SP9: - - - - - - -
SP10: -
SP11: - -

Relevant External Links for NFE2L1 Gene

GeneLoc Exon Structure for
NFE2L1
ECgene alternative splicing isoforms for
NFE2L1

Expression for NFE2L1 Gene

mRNA expression in normal human tissues for NFE2L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NFE2L1 Gene

This gene is overexpressed in Muscle - Skeletal (x8.9).

Protein differential expression in normal tissues from HIPED for NFE2L1 Gene

This gene is overexpressed in Liver, secretome (31.0), Liver (20.4), and Pancreatic juice (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NFE2L1 Gene



SOURCE GeneReport for Unigene cluster for NFE2L1 Gene Hs.514284

genes like me logo Genes that share expression patterns with NFE2L1: view

Protein tissue co-expression partners for NFE2L1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NFE2L1 Gene

Orthologs for NFE2L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NFE2L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NFE2L1 35
  • 90.58 (n)
  • 95.27 (a)
NFE2L1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFE2L1 35
  • 92.14 (n)
  • 95.6 (a)
NFE2L1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfe2l1 35
  • 90.5 (n)
  • 96.76 (a)
Nfe2l1 16
Nfe2l1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NFE2L1 35
  • 99.78 (n)
  • 100 (a)
NFE2L1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfe2l1 35
  • 89.97 (n)
  • 97.02 (a)
oppossum
(Monodelphis domestica)
Mammalia NFE2L1 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFE2L1 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves NFE2L1 35
  • 78.7 (n)
  • 83.64 (a)
NFE2L1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFE2L1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfe2l1 35
  • 65 (n)
  • 65.88 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68992 35
zebrafish
(Danio rerio)
Actinopterygii nfe2l1b 35
  • 64.11 (n)
  • 62.62 (a)
nfe2l1b 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cnc 37
  • 52 (a)
cnc 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for NFE2L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFE2L1 Gene

ENSEMBL:
Gene Tree for NFE2L1 (if available)
TreeFam:
Gene Tree for NFE2L1 (if available)

Paralogs for NFE2L1 Gene

Paralogs for NFE2L1 Gene

genes like me logo Genes that share paralogs with NFE2L1: view

Variants for NFE2L1 Gene

Sequence variations from dbSNP and Humsavar for NFE2L1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2229367 - 48,051,305(+) CCTTG(C/G)ATGGC reference, missense
rs15719 -- 48,061,331(-) CTATC(C/T)CTACT utr-variant-3-prime
rs1051001 -- 48,060,543(+) CCACC(C/G/T)CTCAC utr-variant-3-prime
rs2229368 -- 48,057,436(+) CTGAC(C/T)GGGAC reference, synonymous-codon
rs2229369 -- 48,058,771(+) GACTC(C/G)AGCCA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for NFE2L1 Gene

Variant ID Type Subtype PubMed ID
nsv469808 CNV Complex 16826518

Variation tolerance for NFE2L1 Gene

Residual Variation Intolerance Score: 7.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NFE2L1 Gene

Disorders for NFE2L1 Gene

Relevant External Links for NFE2L1

Genetic Association Database (GAD)
NFE2L1
Human Genome Epidemiology (HuGE) Navigator
NFE2L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFE2L1

No disorders were found for NFE2L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFE2L1 Gene

Publications for NFE2L1 Gene

  1. Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast. (PMID: 8248256) Chan J.Y. … Kan Y.W. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 23 67
  2. Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells. (PMID: 20385086) Radhakrishnan S.K. … Deshaies R.J. (Mol. Cell 2010) 3 23
  3. The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription. (PMID: 17609210) Wang W. … Chan J.Y. (J. Biol. Chem. 2007) 3 23
  4. Nrf1 is targeted to the endoplasmic reticulum membrane by an N- terminal transmembrane domain. Inhibition of nuclear translocation and transacting function. (PMID: 16687406) Wang W. … Chan J.Y. (J. Biol. Chem. 2006) 3 23
  5. Cellular localisation and nuclear export of the human bZIP transcription factor TCF11. (PMID: 12729924) Husberg C. … A.B. (Biochim. Biophys. Acta 2003) 3 23

Products for NFE2L1 Gene

Sources for NFE2L1 Gene

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