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Aliases for NFATC4 Gene

Aliases for NFATC4 Gene

  • Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 4 2 3
  • T-Cell Transcription Factor NFAT3 3 4
  • NF-ATC4 3 4
  • NF-AT3 3 4
  • NFAT3 3 4
  • Nuclear Factor Of Activated T-Cells, Cytoplasmic 4 3
  • NFATc4 4

External Ids for NFATC4 Gene

Summaries for NFATC4 Gene

Entrez Gene Summary for NFATC4 Gene

  • This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for NFATC4 Gene

NFATC4 (Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 4) is a Protein Coding gene. Diseases associated with NFATC4 include dilated cardiomyopathy. Among its related pathways are GPCR Pathway and GPCR Pathway. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is NFATC1.

UniProtKB/Swiss-Prot for NFATC4 Gene

  • Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.

Gene Wiki entry for NFATC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFATC4 Gene

Genomics for NFATC4 Gene

Genomic Location for NFATC4 Gene

Start:
24,365,673 bp from pter
End:
24,379,604 bp from pter
Size:
13,932 bases
Orientation:
Plus strand

Genomic View for NFATC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFATC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFATC4 Gene

Regulatory Elements for NFATC4 Gene

Transcription factor binding sites by QIAGEN in the NFATC4 gene promoter:

Proteins for NFATC4 Gene

  • Protein details for NFATC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14934-NFAC4_HUMAN
    Recommended name:
    Nuclear factor of activated T-cells, cytoplasmic 4
    Protein Accession:
    Q14934
    Secondary Accessions:
    • B4DDG5
    • B4DY55
    • B5B2U7
    • B5B2U8
    • B5B2U9
    • B5B2V0
    • B5B2V1
    • B5B2V2
    • B5B2V3
    • B5B2V4
    • B5B2V5
    • B5B2V7
    • B5B2V8
    • B5B2V9
    • B5B2W0
    • B5B2W1
    • B5B2W2
    • B5B2W3
    • B5B2W4
    • B5B2W5
    • B5B2W6
    • B5B2W7
    • B5B2W8
    • B5B2W9
    • B5B2X0
    • Q7Z598
    • Q96H68

    Protein attributes for NFATC4 Gene

    Size:
    902 amino acids
    Molecular mass:
    95449 Da
    Quaternary structure:
    • Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers. Interacts with CREBBP, GATA4, IRAK1, MAPK8, MAPK9 and RPS6KA3.

    Three dimensional structures from OCA and Proteopedia for NFATC4 Gene

neXtProt entry for NFATC4 Gene

Proteomics data for NFATC4 Gene at MOPED

Post-translational modifications for NFATC4 Gene

  • Phosphorylated by NFATC-kinases; dephosphorylated by calcineurin. Phosphorylated on Ser-168 and Ser-170 by MTOR, IRAK1, MAPK7 and MAPK14, on Ser-213 and Ser-217 by MAPK8 and MAPK9, and on Ser-289 and Ser-344 by RPS6KA3. Phosphorylated by GSK3B.
  • Ubiquitinated, leading to its degradation by the proteasome and reduced transcriptional activity. Ubiquitination and reduction in transcriptional activity can be further facilitated through GSK3B-dependent phosphorylation. Polyubiquitin linkage is mainly through Lys-48.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NFATC4 Gene

Domains for NFATC4 Gene

Gene Families for NFATC4 Gene

HGNC:
  • NFAT :Nuclear factor of activated T-cells

UniProtKB/Swiss-Prot:

NFAC4_HUMAN
Domain:
  • Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.:
    • Q14934
  • Contains 1 IPT/TIG domain.:
    • Q14934
  • Contains 1 RHD (Rel-like) domain.:
    • Q14934
genes like me logo Genes that share domains with NFATC4: view

Function for NFATC4 Gene

Molecular function for NFATC4 Gene

UniProtKB/Swiss-Prot Function: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.

Gene Ontology (GO) - Molecular Function for NFATC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity --
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
genes like me logo Genes that share ontologies with NFATC4: view
genes like me logo Genes that share phenotypes with NFATC4: view

Animal Models for NFATC4 Gene

MGI Knock Outs for NFATC4:

Transcription Factor Targeting for NFATC4 Gene

Selected GeneGlobe predicted Target genes for NFATC4

No data available for Enzyme Numbers (IUBMB) , miRNA and HOMER Transcription for NFATC4 Gene

Localization for NFATC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFATC4 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFATC4 Gene COMPARTMENTS Subcellular localization image for NFATC4 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NFATC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12370307
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA --
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with NFATC4: view

Pathways for NFATC4 Gene

genes like me logo Genes that share pathways with NFATC4: view

Gene Ontology (GO) - Biological Process for NFATC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001569 patterning of blood vessels IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006954 inflammatory response TAS 7749981
genes like me logo Genes that share ontologies with NFATC4: view

Compounds for NFATC4 Gene

(1) HMDB Compounds for NFATC4 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Novoseek inferred chemical compound relationships for NFATC4 Gene

Compound -log(P) Hits PubMed IDs
calcium 0 1
genes like me logo Genes that share compounds with NFATC4: view

Transcripts for NFATC4 Gene

Unigene Clusters for NFATC4 Gene

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NFATC4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - - -
SP2: - - - -
SP3: - -
SP4: -
SP5: -
SP6:
SP7: - -

Relevant External Links for NFATC4 Gene

GeneLoc Exon Structure for
NFATC4
ECgene alternative splicing isoforms for
NFATC4

Expression for NFATC4 Gene

mRNA expression in normal human tissues for NFATC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NFATC4 Gene

SOURCE GeneReport for Unigene cluster for NFATC4 Gene Hs.77810

mRNA Expression by UniProt/SwissProt for NFATC4 Gene

Q14934-NFAC4_HUMAN
Tissue specificity: Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus.
genes like me logo Genes that share expressions with NFATC4: view

Orthologs for NFATC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NFATC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFATC4 36
  • 98.73 (n)
  • 98.54 (a)
NFATC4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFATC4 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFATC4 36
  • 90.46 (n)
  • 93.83 (a)
NFATC4 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfatc4 36
  • 87.47 (n)
  • 91.81 (a)
Nfatc4 16
Nfatc4 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NFATC4 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 21 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Nfatc4 36
  • 87.21 (n)
  • 92.03 (a)
lizard
(Anolis carolinensis)
Reptilia NFATC4 37
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfatc4 36
  • 58.9 (n)
  • 63.35 (a)
zebrafish
(Danio rerio)
Actinopterygii nfatc4 36
  • 57.93 (n)
  • 55.13 (a)
NFATC4 37
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NFAT 37
  • 10 (a)
OneToMany
Species with no ortholog for NFATC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFATC4 Gene

ENSEMBL:
Gene Tree for NFATC4 (if available)
TreeFam:
Gene Tree for NFATC4 (if available)

Paralogs for NFATC4 Gene

Paralogs for NFATC4 Gene

Selected SIMAP similar genes for NFATC4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NFATC4: view

Variants for NFATC4 Gene

Sequence variations from dbSNP and Humsavar for NFATC4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2666 -- 24,377,935(-) TTCAC(A/C)CTCCT utr-variant-3-prime
rs10362 -- 24,377,755(+) GCCCT(G/T)CCCCC utr-variant-3-prime
rs1050295 -- 24,377,873(+) GGTGT(G/T)GCCCT utr-variant-3-prime
rs1050318 -- 24,377,983(+) CGTGT(C/T)TAGAG utr-variant-3-prime
rs1955915 -- 24,369,415(-) AGGCC(A/G)CAAGT intron-variant

Relevant External Links for NFATC4 Gene

HapMap Linkage Disequilibrium report
NFATC4
Human Gene Mutation Database (HGMD)
NFATC4

No data available for Structural Variations from Database of Genomic Variants (DGV) for NFATC4 Gene

Disorders for NFATC4 Gene

(1) MalaCards Diseases for NFATC4 Gene

Search for NFATC4 Gene in MalaCards »

(3) Novoseek inferred disease relationships for NFATC4 Gene

Disease -log(P) Hits PubMed IDs
cardiac hypertrophy 70.8 2
dilated cardiomyopathy 44.9 2
heart failure 16.4 2

Relevant External Links for NFATC4

Genetic Association Database (GAD)
NFATC4
Human Genome Epidemiology (HuGE) Navigator
NFATC4
genes like me logo Genes that share disorders with NFATC4: view

No data available for UniProtKB/Swiss-Prot for NFATC4 Gene

Publications for NFATC4 Gene

  1. Polymorphisms of genes of the cardiac calcineurin pathway and cardiac hypertrophy. (PMID: 12939651) Poirier O. … Cambien F. (Eur. J. Hum. Genet. 2003) 3 23 49
  2. Alternative splicing and expression of human and mouse NFAT genes. (PMID: 18675896) Vihma H. … Timmusk T. (Genomics 2008) 3 4 23
  3. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. (PMID: 7749981) Hoey T. … Xu X. (Immunity 1995) 2 3 4
  4. Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases. (PMID: 11997522) Yang T.T.C. … Chow C.-W. (Mol. Cell. Biol. 2002) 3 4
  5. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. (PMID: 9568714) Molkentin J.D. … Olson E.N. (Cell 1998) 3 23

Products for NFATC4 Gene

Sources for NFATC4 Gene

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