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Aliases for NFATC3 Gene

Aliases for NFATC3 Gene

  • Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 3 2 3
  • NF-ATc3 3 4
  • NFATX 3 4
  • NFAT4 3 4
  • Nuclear Factor Of Activated T-Cells C3 Isoform IE-Xa 3
  • Nuclear Factor Of Activated T-Cells, Cytoplasmic 3 3
  • T Cell Transcription Factor NFAT4 3
  • T-Cell Transcription Factor NFAT4 4
  • NF-AT4 4
  • NFATc3 4

External Ids for NFATC3 Gene

Summaries for NFATC3 Gene

Entrez Gene Summary for NFATC3 Gene

  • The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for NFATC3 Gene

NFATC3 (Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 3) is a Protein Coding gene. Among its related pathways are PI-3K cascade and MAPK signaling pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is NFATC4.

UniProtKB/Swiss-Prot for NFATC3 Gene

  • Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.

Gene Wiki entry for NFATC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFATC3 Gene

Genomics for NFATC3 Gene

Genomic Location for NFATC3 Gene

Start:
68,084,751 bp from pter
End:
68,229,259 bp from pter
Size:
144,509 bases
Orientation:
Plus strand

Genomic View for NFATC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFATC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFATC3 Gene

Regulatory Elements for NFATC3 Gene

Proteins for NFATC3 Gene

  • Protein details for NFATC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12968-NFAC3_HUMAN
    Recommended name:
    Nuclear factor of activated T-cells, cytoplasmic 3
    Protein Accession:
    Q12968
    Secondary Accessions:
    • O75211
    • Q14516
    • Q99840
    • Q99841
    • Q99842

    Protein attributes for NFATC3 Gene

    Size:
    1075 amino acids
    Molecular mass:
    115594 Da
    Quaternary structure:
    • Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers

    Three dimensional structures from OCA and Proteopedia for NFATC3 Gene

    Alternative splice isoforms for NFATC3 Gene

neXtProt entry for NFATC3 Gene

Proteomics data for NFATC3 Gene at MOPED

Post-translational modifications for NFATC3 Gene

  • Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NFATC3 Gene

Domains for NFATC3 Gene

Gene Families for NFATC3 Gene

HGNC:
  • NFAT :Nuclear factor of activated T-cells

UniProtKB/Swiss-Prot:

NFAC3_HUMAN
Domain:
  • Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors:
    • Q12968
  • Contains 1 RHD (Rel-like) domain.:
    • Q12968
genes like me logo Genes that share domains with NFATC3: view

Function for NFATC3 Gene

Molecular function for NFATC3 Gene

UniProtKB/Swiss-Prot Function: Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.

Gene Ontology (GO) - Molecular Function for NFATC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 15173172
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IMP 15173172
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
genes like me logo Genes that share ontologies with NFATC3: view
genes like me logo Genes that share phenotypes with NFATC3: view

Animal Models for NFATC3 Gene

MGI Knock Outs for NFATC3:

miRNA for NFATC3 Gene

Transcription Factor Targeting for NFATC3 Gene

Selected GeneGlobe predicted Target genes for NFATC3

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for NFATC3 Gene

Localization for NFATC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFATC3 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFATC3 Gene COMPARTMENTS Subcellular localization image for NFATC3 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for NFATC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NFATC3: view

Pathways for NFATC3 Gene

genes like me logo Genes that share pathways with NFATC3: view

Gene Ontology (GO) - Biological Process for NFATC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001569 patterning of blood vessels IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 7749981
GO:0006366 transcription from RNA polymerase II promoter TAS 7739550
genes like me logo Genes that share ontologies with NFATC3: view

Compounds for NFATC3 Gene

(1) HMDB Compounds for NFATC3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(4) Novoseek inferred chemical compound relationships for NFATC3 Gene

Compound -log(P) Hits PubMed IDs
ionomycin 54.4 2
cyclosporin a 43.6 3
tacrolimus 43.3 2
calcium 31.7 7
genes like me logo Genes that share compounds with NFATC3: view

Transcripts for NFATC3 Gene

Unigene Clusters for NFATC3 Gene

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NFATC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - - -
SP5: - -
SP6: -
SP7:

Relevant External Links for NFATC3 Gene

GeneLoc Exon Structure for
NFATC3
ECgene alternative splicing isoforms for
NFATC3

Expression for NFATC3 Gene

mRNA expression in normal human tissues for NFATC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NFATC3 Gene

This gene is overexpressed in Muscle - Skeletal (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NFATC3 Gene

SOURCE GeneReport for Unigene cluster for NFATC3 Gene Hs.436585

mRNA Expression by UniProt/SwissProt for NFATC3 Gene

Q12968-NFAC3_HUMAN
Tissue specificity: Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle
genes like me logo Genes that share expressions with NFATC3: view

Orthologs for NFATC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NFATC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFATC3 36
  • 99.6 (n)
  • 99.44 (a)
NFATC3 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFATC3 36
  • 93.2 (n)
  • 93.76 (a)
NFATC3 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFATC3 36
  • 93.27 (n)
  • 93.49 (a)
NFATC3 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfatc3 36
  • 89.79 (n)
  • 89.61 (a)
Nfatc3 16
Nfatc3 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NFATC3 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFATC3 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfatc3 36
  • 90.1 (n)
  • 90.33 (a)
chicken
(Gallus gallus)
Aves NFATC3 36
  • 77.04 (n)
  • 77.08 (a)
NFATC3 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFATC3 37
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia nf-at 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nfatc3 36
  • 65.34 (n)
  • 64.58 (a)
Str.18348 36
zebrafish
(Danio rerio)
Actinopterygii nfatc3 36
  • 62.48 (n)
  • 64.57 (a)
NFATC3 37
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NFAT 37
  • 12 (a)
OneToMany
Species with no ortholog for NFATC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFATC3 Gene

ENSEMBL:
Gene Tree for NFATC3 (if available)
TreeFam:
Gene Tree for NFATC3 (if available)

Paralogs for NFATC3 Gene

Paralogs for NFATC3 Gene

genes like me logo Genes that share paralogs with NFATC3: view

Variants for NFATC3 Gene

Sequence variations from dbSNP and Humsavar for NFATC3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs11871 -- 68,227,531(+) GATGG(A/G)AAGGT utr-variant-3-prime
rs12598 -- 68,191,612(+) AGTAC(A/G)GGCCA synonymous-codon, reference
rs237833 -- 68,098,300(-) aaaaa(A/T)aataa intron-variant
rs237834 -- 68,091,413(-) CAAAC(C/T)TCAAA intron-variant
rs237835 -- 68,083,921(-) TATTG(C/G)TTCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NFATC3 Gene

Variant ID Type Subtype PubMed ID
nsv906817 CNV Loss 21882294
nsv1846 CNV Insertion 18451855

Relevant External Links for NFATC3 Gene

HapMap Linkage Disequilibrium report
NFATC3

Disorders for NFATC3 Gene

Relevant External Links for NFATC3

Genetic Association Database (GAD)
NFATC3
Human Genome Epidemiology (HuGE) Navigator
NFATC3
genes like me logo Genes that share disorders with NFATC3: view

No data available for UniProtKB/Swiss-Prot for NFATC3 Gene

Publications for NFATC3 Gene

  1. Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. (PMID: 9630228) Zhu J. … McKeon F. (Cell 1998) 3 4 23
  2. Carboxy-terminal 15 amino acids sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells. (PMID: 9759864) Imamura R. … Arai N. (J. Immunol. 1998) 3 4 23
  3. NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus. (PMID: 7739550) Masuda E.S. … Arai N. (Mol. Cell. Biol. 1995) 3 4 23
  4. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. (PMID: 7749981) Hoey T. … Xu X. (Immunity 1995) 2 3 4
  5. Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway. (PMID: 9374467) Chow C.W. … Davis R.J. (Science 1997) 3 23

Products for NFATC3 Gene

Sources for NFATC3 Gene

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