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Aliases for NFATC2 Gene

Aliases for NFATC2 Gene

  • Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 2 3
  • T-Cell Transcription Factor NFAT1 3 4
  • NFAT Pre-Existing Subunit 3 4
  • NF-ATc2 3 4
  • NFAT1 3 4
  • NFATP 3 4
  • Nuclear Factor Of Activated T-Cells, Preexisting Component 3
  • NFAT Transcription Complex, Preexisting Component 3
  • Preexisting Nuclear Factor Of Activated T-Cells 2 3
  • T Cell Transcription Factor NFAT1 3
  • NF-ATp 4
  • NFATc2 4

External Ids for NFATC2 Gene

Previous GeneCards Identifiers for NFATC2 Gene

  • GC20M049743
  • GC20M050646
  • GC20M050693
  • GC20M049442
  • GC20M050003
  • GC20M046756

Summaries for NFATC2 Gene

Entrez Gene Summary for NFATC2 Gene

  • This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]

GeneCards Summary for NFATC2 Gene

NFATC2 (Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2) is a Protein Coding gene. Diseases associated with NFATC2 include fibrosarcoma of bone and narcolepsy. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is NFATC4.

UniProtKB/Swiss-Prot for NFATC2 Gene

  • Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.

Gene Wiki entry for NFATC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFATC2 Gene

Genomics for NFATC2 Gene

Regulatory Elements for NFATC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NFATC2 Gene

Chromosome:
20
Start:
51,386,957 bp from pter
End:
51,562,858 bp from pter
Size:
175,902 bases
Orientation:
Minus strand

Genomic View for NFATC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFATC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFATC2 Gene

Proteins for NFATC2 Gene

  • Protein details for NFATC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13469-NFAC2_HUMAN
    Recommended name:
    Nuclear factor of activated T-cells, cytoplasmic 2
    Protein Accession:
    Q13469
    Secondary Accessions:
    • B5B2N8
    • B5B2N9
    • B5B2P0
    • B5B2P2
    • B5B2P3
    • Q13468
    • Q5TFW7
    • Q5TFW8
    • Q9NPX6
    • Q9NQH3
    • Q9UJR2

    Protein attributes for NFATC2 Gene

    Size:
    925 amino acids
    Molecular mass:
    100146 Da
    Quaternary structure:
    • Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. The phosphorylated form specifically interacts with XPO1; which mediates nuclear export. NFATC proteins bind to DNA as monomers. Interacts with NFATC2IP (By similarity). Interacts with FOXP3.

    Three dimensional structures from OCA and Proteopedia for NFATC2 Gene

    Alternative splice isoforms for NFATC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFATC2 Gene

Proteomics data for NFATC2 Gene at MOPED

Post-translational modifications for NFATC2 Gene

  • In resting cells, phosphorylated by NFATC-kinase on at least 18 sites in the 99-363 region. Upon cell stimulation, all these sites except Ser-243 are dephosphorylated by calcineurin. Dephosphorylation induces a conformational change that simultaneously exposes an NLS and masks an NES, which results in nuclear localization. Simultaneously, Ser-53 or Ser-56 is phosphorylated; which is required for full transcriptional activity
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NFATC2 (NFAT1)

No data available for DME Specific Peptides for NFATC2 Gene

Domains & Families for NFATC2 Gene

Gene Families for NFATC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q13469

UniProtKB/Swiss-Prot:

NFAC2_HUMAN :
  • the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Domain:
  • the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
  • Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.
  • Contains 1 RHD (Rel-like) domain.
genes like me logo Genes that share domains with NFATC2: view

Function for NFATC2 Gene

Molecular function for NFATC2 Gene

GENATLAS Biochemistry:
nuclear factor activated T cells c2,pre-existing,component,related to the NFKB/REL proteins and forming cooperative complexes with FOS and JUN on DNA,calcineurin dependent,involved in expression of genes collectively coordinating immune response
UniProtKB/Swiss-Prot Function:
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.
UniProtKB/Swiss-Prot Induction:
Inducibly expressed in T-lymphocytes upon activation of the T-cell receptor (TCR) complex. Induced after co-addition of phorbol 12-myristate 13-acetate (PMA) and ionomycin

Gene Ontology (GO) - Molecular Function for NFATC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding TAS 8668213
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with NFATC2: view
genes like me logo Genes that share phenotypes with NFATC2: view

Animal Models for NFATC2 Gene

MGI Knock Outs for NFATC2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NFATC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NFATC2 Gene

Localization for NFATC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFATC2 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFATC2 Gene COMPARTMENTS Subcellular localization image for NFATC2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for NFATC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8668213
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex --
GO:0005737 cytoplasm TAS 8668213
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NFATC2: view

Pathways & Interactions for NFATC2 Gene

genes like me logo Genes that share pathways with NFATC2: view

PCR Array Products

SIGNOR curated interactions for NFATC2 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NFATC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001816 cytokine production IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006355 regulation of transcription, DNA-templated TAS 8668213
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with NFATC2: view

Drugs & Compounds for NFATC2 Gene

(6) Drugs for NFATC2 Gene - From: NovoSeek, PharmGKB, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Asparaginase Approved Pharma 196
Tacrolimus Approved, Investigational Pharma 992
cyclic amp Experimental Pharma 0
Calcium Nutra 0
Cyclosporin A Pharma Inhibition, Inhibitor Immunosuppressive agent, Calcineurin inhibitor 0

(2) Additional Compounds for NFATC2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
IONOMYCIN
Oligonucleotide
genes like me logo Genes that share compounds with NFATC2: view

Transcripts for NFATC2 Gene

Unigene Clusters for NFATC2 Gene

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NFATC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFATC2 Gene

No ASD Table

Relevant External Links for NFATC2 Gene

GeneLoc Exon Structure for
NFATC2
ECgene alternative splicing isoforms for
NFATC2

Expression for NFATC2 Gene

mRNA expression in normal human tissues for NFATC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NFATC2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.5), NK cells (19.6), and CD8 Tcells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NFATC2 Gene



SOURCE GeneReport for Unigene cluster for NFATC2 Gene Hs.744148

mRNA Expression by UniProt/SwissProt for NFATC2 Gene

Q13469-NFAC2_HUMAN
Tissue specificity: Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas. Isoform 1 is highly expressed in the small intestine, heart, testis, prostate, thymus, placenta and thyroid. Isoform 3 is highly expressed in stomach, uterus, placenta, trachea and thyroid.
genes like me logo Genes that share expression patterns with NFATC2: view

Protein tissue co-expression partners for NFATC2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NFATC2 Gene

Orthologs for NFATC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NFATC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NFATC2 35
  • 89.65 (n)
  • 92.92 (a)
NFATC2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFATC2 35
  • 91.8 (n)
  • 94.99 (a)
NFATC2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfatc2 35
  • 87.14 (n)
  • 90.14 (a)
Nfatc2 16
Nfatc2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NFATC2 35
  • 99.57 (n)
  • 99.57 (a)
NFATC2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfatc2 35
  • 86.7 (n)
  • 90.7 (a)
oppossum
(Monodelphis domestica)
Mammalia NFATC2 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFATC2 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves NFATC2 35
  • 73.87 (n)
  • 78.28 (a)
NFATC2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFATC2 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfatc2 35
  • 69.66 (n)
  • 71.15 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100333254 35
  • 59.19 (n)
  • 56.55 (a)
CABZ01041608.1 36
  • 47 (a)
OneToMany
NFATC2 (1 of 2) 36
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta NFAT 36
  • 11 (a)
OneToMany
Species with no ortholog for NFATC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFATC2 Gene

ENSEMBL:
Gene Tree for NFATC2 (if available)
TreeFam:
Gene Tree for NFATC2 (if available)

Paralogs for NFATC2 Gene

Paralogs for NFATC2 Gene

(1) SIMAP similar genes for NFATC2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NFATC2: view

Variants for NFATC2 Gene

Sequence variations from dbSNP and Humsavar for NFATC2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs228827 -- 51,440,066(+) ACCCC(A/G)TCTCT intron-variant
rs228828 -- 51,441,099(+) ccaac(A/G)tggcg intron-variant
rs228829 -- 51,441,111(+) aaccc(C/G)atctc intron-variant
rs228830 -- 51,441,422(+) caaaa(A/G)tgata intron-variant
rs228831 -- 51,443,351(+) CATAA(C/T)AGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFATC2 Gene

Variant ID Type Subtype PubMed ID
esv2751917 CNV Gain 17911159
esv2722509 CNV Deletion 23290073
esv2722510 CNV Deletion 23290073
esv2722511 CNV Deletion 23290073
esv2722512 CNV Deletion 23290073
esv2722513 CNV Deletion 23290073
esv2534215 CNV Insertion 19546169
nsv912921 CNV Loss 21882294

Variation tolerance for NFATC2 Gene

Residual Variation Intolerance Score: 13.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFATC2 Gene

HapMap Linkage Disequilibrium report
NFATC2
Human Gene Mutation Database (HGMD)
NFATC2

PCR Panel Products

  • Copy Number PCR Panels: for NFATC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFATC2 Gene

Disorders for NFATC2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NFATC2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
fibrosarcoma of bone
  • fibrosarcoma of the bone
narcolepsy
  • paroxysmal sleep
- elite association

Relevant External Links for NFATC2

Genetic Association Database (GAD)
NFATC2
Human Genome Epidemiology (HuGE) Navigator
NFATC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFATC2
genes like me logo Genes that share disorders with NFATC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NFATC2 Gene

Publications for NFATC2 Gene

  1. NFAT1 mediates placental growth factor-induced myelomonocytic cell recruitment via the induction of TNF-alpha. (PMID: 20097868) Ding Y. … Luo Y. (J. Immunol. 2010) 23 67
  2. GATA3 siRNA inhibits the binding of NFAT1 to interleukin-13 promoter in human T cells. (PMID: 20368097) Yao X. … Huang M. (Chin. Med. J. 2010) 23 67
  3. FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression. (PMID: 19564342) Torgerson T.R. … Cron R.Q. (J. Immunol. 2009) 23 67
  4. Transcriptional activation of hTERT, the human telomerase reverse transcriptase, by nuclear factor of activated T cells. (PMID: 19843528) Chebel A. … Ffrench M. (J. Biol. Chem. 2009) 23 67
  5. microRNA 184 regulates expression of NFAT1 in umbilical cord blood CD4+ T cells. (PMID: 19286996) Weitzel R.P. … Laughlin M.J. (Blood 2009) 23 67

Products for NFATC2 Gene

Sources for NFATC2 Gene

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