Aliases for ATP1A2 Gene
- ATPase Na+/K+ Transporting Subunit Alpha 2 2 3 5
- Sodium Pump Subunit Alpha-2 2 3 4
- Sodium/Potassium-Transporting ATPase Subunit Alpha-2 2 3
- Sodium-Potassium ATPase Catalytic Subunit Alpha-2 2 3
- Na(+)/K(+) ATPase Alpha-2 Subunit 3 4
- EC 126.96.36.199 4 58
- ATPase, Na+/K+ Transporting, Alpha 2 (+) Polypeptide 2
- Sodium/Potassium-Transporting ATPase Alpha-2 Chain 3
- ATPase, Na+/K+ Transporting, Alpha 2 Polypeptide 2
External Ids for ATP1A2 Gene
Previous HGNC Symbols for ATP1A2 Gene
Previous GeneCards Identifiers for ATP1A2 Gene
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008]
GeneCards Summary for ATP1A2 Gene
ATP1A2 (ATPase Na+/K+ Transporting Subunit Alpha 2) is a Protein Coding gene. Diseases associated with ATP1A2 include Alternating Hemiplegia Of Childhood and Migraine, Familial Hemiplegic, 2. Among its related pathways are Hepatic ABC Transporters and Insulin secretion. GO annotations related to this gene include nucleotide binding and cation-transporting ATPase activity. An important paralog of this gene is ATP1A3.
UniProtKB/Swiss-Prot for ATP1A2 Gene
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.
The Na+/K+ ATPase is a membrane protein that is composed of two subunits - alpha and beta. The pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions.