Aliases for ATP1A2 Gene
External Ids for ATP1A2 Gene
Previous HGNC Symbols for ATP1A2 Gene
Previous GeneCards Identifiers for ATP1A2 Gene
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008]
GeneCards Summary for ATP1A2 Gene
ATP1A2 (ATPase, Na+/K+ Transporting, Alpha 2 Polypeptide) is a Protein Coding gene. Diseases associated with ATP1A2 include migraine, familial hemiplegic, 2 and alternating hemiplegia of childhood. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Ion channel transport. GO annotations related to this gene include sodium:potassium-exchanging ATPase activity. An important paralog of this gene is ATP4A.
UniProtKB/Swiss-Prot for ATP1A2 Gene
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients
Na+,K+-ATPase is an ion pump responsible for maintaining sodium and potassium electrochemical gradients across the plasma membrane.