Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NEUROD2 Gene

Aliases for NEUROD2 Gene

  • Neuronal Differentiation 2 2 3
  • Class A Basic Helix-Loop-Helix Protein 1 3 4
  • Neurogenic Differentiation 2 2 3
  • NeuroD-Related Factor 3 4
  • BHLHa1 3 4
  • NDRF 3 4
  • Neurogenic Basic-Helix-Loop-Helix Protein 3
  • Neurogenic Differentiation Factor 2 3
  • NeuroD2 4

External Ids for NEUROD2 Gene

Previous GeneCards Identifiers for NEUROD2 Gene

  • GC17M037260
  • GC17M039758
  • GC17M037670
  • GC17M038136
  • GC17M038135
  • GC17M035014
  • GC17M037760
  • GC17M033554

Summaries for NEUROD2 Gene

Entrez Gene Summary for NEUROD2 Gene

  • This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates. [provided by RefSeq, Jul 2008]

GeneCards Summary for NEUROD2 Gene

NEUROD2 (Neuronal Differentiation 2) is a Protein Coding gene. Diseases associated with NEUROD2 include alcohol dependence. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is BHLHA15.

UniProtKB/Swiss-Prot for NEUROD2 Gene

  • Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity).

Gene Wiki entry for NEUROD2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEUROD2 Gene

Genomics for NEUROD2 Gene

Regulatory Elements for NEUROD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NEUROD2 Gene

Start:
39,603,536 bp from pter
End:
39,609,777 bp from pter
Size:
6,242 bases
Orientation:
Minus strand

Genomic View for NEUROD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEUROD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEUROD2 Gene

Proteins for NEUROD2 Gene

  • Protein details for NEUROD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15784-NDF2_HUMAN
    Recommended name:
    Neurogenic differentiation factor 2
    Protein Accession:
    Q15784
    Secondary Accessions:
    • Q8TBI7
    • Q9UQC6

    Protein attributes for NEUROD2 Gene

    Size:
    382 amino acids
    Molecular mass:
    41361 Da
    Quaternary structure:
    • Interacts with TCF3, TCF4 and TCF12. Interacts with CDC20. Efficient DNA-binding and transcription activation require dimerization with another bHLH protein (By similarity).

neXtProt entry for NEUROD2 Gene

Proteomics data for NEUROD2 Gene at MOPED

Post-translational modifications for NEUROD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEUROD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NEUROD2 Gene

Domains for NEUROD2 Gene

Gene Families for NEUROD2 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for NEUROD2 Gene

Suggested Antigen Peptide Sequences for NEUROD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15784

UniProtKB/Swiss-Prot:

NDF2_HUMAN :
  • Q15784
Domain:
  • The C-terminal region is necessary for depolarization-induced and calcium-dependent transcription activation.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with NEUROD2: view

Function for NEUROD2 Gene

Molecular function for NEUROD2 Gene

GENATLAS Biochemistry: neurogenesis regulator D2,with transcriptional activity,expressed in the developing nervous system and in adult cortex,hippocampus cerebellum
UniProtKB/Swiss-Prot Function: Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity).

Gene Ontology (GO) - Molecular Function for NEUROD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 8816493
GO:0003714 transcription corepressor activity ISS --
genes like me logo Genes that share ontologies with NEUROD2: view
genes like me logo Genes that share phenotypes with NEUROD2: view

Animal Model Products

CRISPR Products

miRNA for NEUROD2 Gene

miRTarBase miRNAs that target NEUROD2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEUROD2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NEUROD2 Gene

Localization for NEUROD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEUROD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEUROD2 Gene COMPARTMENTS Subcellular localization image for NEUROD2 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for NEUROD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with NEUROD2: view

Pathways for NEUROD2 Gene

SuperPathways for NEUROD2 Gene

No Data Available

Interacting Proteins for NEUROD2 Gene

Gene Ontology (GO) - Biological Process for NEUROD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8816493
GO:0007399 nervous system development TAS 8816493
GO:0008306 associative learning IEA --
genes like me logo Genes that share ontologies with NEUROD2: view

No data available for Pathways by source for NEUROD2 Gene

Transcripts for NEUROD2 Gene

mRNA/cDNA for NEUROD2 Gene

(22) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEUROD2 Gene

Neuronal differentiation 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEUROD2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEUROD2 Gene

No ASD Table

Relevant External Links for NEUROD2 Gene

GeneLoc Exon Structure for
NEUROD2
ECgene alternative splicing isoforms for
NEUROD2

Expression for NEUROD2 Gene

mRNA expression in normal human tissues for NEUROD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEUROD2 Gene

This gene is overexpressed in Brain - Cerebellum (13.9), Brain - Cerebellar Hemisphere (13.7), Brain - Cortex (5.4), Brain - Hippocampus (5.4), Brain - Frontal Cortex (BA9) (5.1), and Brain - Anterior cingulate cortex (BA24) (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NEUROD2 Gene

SOURCE GeneReport for Unigene cluster for NEUROD2 Gene Hs.322431

genes like me logo Genes that share expressions with NEUROD2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NEUROD2 Gene

Orthologs for NEUROD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEUROD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEUROD2 35
  • 99.91 (n)
  • 99.74 (a)
NEUROD2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEUROD2 35
  • 93.89 (n)
  • 97.64 (a)
NEUROD2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEUROD2 35
  • 95.29 (n)
  • 97.91 (a)
NEUROD2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neurod2 35
  • 92.23 (n)
  • 98.17 (a)
Neurod2 16
Neurod2 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEUROD2 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neurod2 35
  • 88.19 (n)
  • 91.6 (a)
chicken
(Gallus gallus)
Aves LOC100859203 35
  • 81.69 (n)
  • 82.25 (a)
NEUROD2 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEUROD2 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neurod2 35
  • 70.75 (n)
  • 73.5 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2662 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
neurod2 35
  • 59.91 (n)
  • 61.69 (a)
neurod2 36
  • 61 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cnd-1 36
  • 35 (a)
ManyToMany
ngn-1 36
  • 33 (a)
ManyToMany
Species with no ortholog for NEUROD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEUROD2 Gene

ENSEMBL:
Gene Tree for NEUROD2 (if available)
TreeFam:
Gene Tree for NEUROD2 (if available)

Paralogs for NEUROD2 Gene

Selected SIMAP similar genes for NEUROD2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NEUROD2: view

Variants for NEUROD2 Gene

Sequence variations from dbSNP and Humsavar for NEUROD2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs378062 -- 39,604,541(-) gcctg(C/G)gggcc utr-variant-3-prime
rs380373 -- 39,605,229(-) AAGGG(G/T)TTCCC utr-variant-3-prime
rs401641 -- 39,606,399(-) ACGGA(C/G)GCCAC missense, reference
rs408262 -- 39,605,254(-) CAGGG(A/G)ACTCG utr-variant-3-prime
rs449430 -- 39,605,253(-) AGGGG(A/C)CTCGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NEUROD2 Gene

Variant ID Type Subtype PubMed ID
dgv40n68 CNV Loss 17160897
nsv521294 CNV Loss 19592680
dgv3162n71 CNV Loss 21882294
nsv908207 CNV Loss 21882294
dgv3163n71 CNV Loss 21882294
nsv2047 CNV Insertion 18451855
dgv3164n71 CNV Loss 21882294

Relevant External Links for NEUROD2 Gene

HapMap Linkage Disequilibrium report
NEUROD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEUROD2 Gene

Disorders for NEUROD2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NEUROD2 Gene including...

Search for NEUROD2 Gene in MalaCards »

Relevant External Links for NEUROD2

Genetic Association Database (GAD)
NEUROD2
Human Genome Epidemiology (HuGE) Navigator
NEUROD2
genes like me logo Genes that share disorders with NEUROD2: view

No data available for UniProtKB/Swiss-Prot for NEUROD2 Gene

Publications for NEUROD2 Gene

  1. Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF). (PMID: 10209266) Kitamura T. … Kawakami H. (Biochim. Biophys. Acta 1999) 3 4 23
  2. NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family. (PMID: 8816493) McCormick M.B. … Tapscott S.J. (Mol. Cell. Biol. 1996) 3 4
  3. NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively. (PMID: 9119405) Tamimi R.M. … Tapscott S.J. (Genomics 1997) 2 3
  4. NeuroD/beta2 gene G-->A polymorphism may affect onset pattern of type 1 diabetes in Japanese. (PMID: 11473083) Yamada S. … Saruta T. (Diabetes Care 2001) 3 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NEUROD2 Gene

Sources for NEUROD2 Gene

Back to Top

Content