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Aliases for NEK3 Gene

Aliases for NEK3 Gene

  • NIMA Related Kinase 3 2 3
  • NIMA (Never In Mitosis Gene A)-Related Kinase 3 2 3
  • Never In Mitosis A-Related Kinase 3 3 4
  • Phosphorylase B Kinase Kinase 2 3
  • NimA-Related Protein Kinase 3 3 4
  • Hydroxyalkyl-Protein Kinase 2 3
  • Glycogen Synthase A Kinase 2 3
  • NIMA-Related Kinase 3 3 5
  • EC 2.7.11.1 4 63
  • HSPK 36 3 4
  • Serine/Threonine-Protein Kinase NEK3 2
  • EC 2.7.11 63
  • HSPK36 3

External Ids for NEK3 Gene

Previous GeneCards Identifiers for NEK3 Gene

  • GC13U990024
  • GC13M046694
  • GC13M051643
  • GC13M050504
  • GC13M051604
  • GC13M052706
  • GC13M033494

Summaries for NEK3 Gene

Entrez Gene Summary for NEK3 Gene

  • This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

GeneCards Summary for NEK3 Gene

NEK3 (NIMA Related Kinase 3) is a Protein Coding gene. Diseases associated with NEK3 include muscular phosphorylase kinase deficiency and phosphorylase kinase deficiency. Among its related pathways are Prolactin Signaling Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NEK2.

UniProtKB/Swiss-Prot for NEK3 Gene

  • Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.

Gene Wiki entry for NEK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEK3 Gene

Genomics for NEK3 Gene

Regulatory Elements for NEK3 Gene

Promoters for NEK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NEK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEK3 Gene

Chromosome:
13
Start:
52,132,639 bp from pter
End:
52,159,861 bp from pter
Size:
27,223 bases
Orientation:
Minus strand

Genomic View for NEK3 Gene

Genes around NEK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK3 Gene

Proteins for NEK3 Gene

  • Protein details for NEK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51956-NEK3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Nek3
    Protein Accession:
    P51956
    Secondary Accessions:
    • A8K2J4
    • Q5TAP2
    • Q8J023
    • Q8WUN5

    Protein attributes for NEK3 Gene

    Size:
    506 amino acids
    Molecular mass:
    57705 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PXN, PRLR, VAV1 and VAV2 and this interaction is prolactin-dependent.
    SequenceCaution:
    • Sequence=CAI12895.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAX08907.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NEK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEK3 Gene

Proteomics data for NEK3 Gene at MOPED

Selected DME Specific Peptides for NEK3 Gene

Post-translational modifications for NEK3 Gene

  • Phosphorylation at Thr-479 regulates its catalytic activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NEK3 Gene

Gene Families for NEK3 Gene

Graphical View of Domain Structure for InterPro Entry

P51956

UniProtKB/Swiss-Prot:

NEK3_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
genes like me logo Genes that share domains with NEK3: view

Function for NEK3 Gene

Molecular function for NEK3 Gene

GENATLAS Biochemistry:
never in mitosis gene A-related kinase 3,predominantly cytoplasmic,widely expressed in a non dependent cell cycle pattern
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Prolactin stimulates its activity.
UniProtKB/Swiss-Prot Function:
Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.

Enzyme Numbers (IUBMB) for NEK3 Gene

genes like me logo Genes that share phenotypes with NEK3: view

Animal Model Products

miRNA for NEK3 Gene

miRTarBase miRNAs that target NEK3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEK3 Gene

Localization for NEK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEK3 Gene

Cytoplasm. Cell projection, axon.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEK3 Gene COMPARTMENTS Subcellular localization image for NEK3 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for NEK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 7522034
genes like me logo Genes that share ontologies with NEK3: view

Pathways & Interactions for NEK3 Gene

genes like me logo Genes that share pathways with NEK3: view

Pathways by source for NEK3 Gene

1 BioSystems pathway for NEK3 Gene
1 GeneGo (Thomson Reuters) pathway for NEK3 Gene

Interacting Proteins for NEK3 Gene

Selected Interacting proteins: P51956-NEK3_HUMAN for NEK3 Gene via I2D UniProtKB

Gene Ontology (GO) - Biological Process for NEK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,ISS --
GO:0007017 microtubule-based process IBA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with NEK3: view

No data available for SIGNOR curated interactions for NEK3 Gene

Drugs & Compounds for NEK3 Gene

(4) Drugs for NEK3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(4) Additional Compounds for NEK3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with NEK3: view

Transcripts for NEK3 Gene

Unigene Clusters for NEK3 Gene

NIMA-related kinase 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEK3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - -
SP2: -
SP3: -
SP4: - -
SP5: -

Relevant External Links for NEK3 Gene

GeneLoc Exon Structure for
NEK3
ECgene alternative splicing isoforms for
NEK3

Expression for NEK3 Gene

mRNA expression in normal human tissues for NEK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEK3 Gene

This gene is overexpressed in Testis (65.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for NEK3 Gene



SOURCE GeneReport for Unigene cluster for NEK3 Gene Hs.409989

mRNA Expression by UniProt/SwissProt for NEK3 Gene

P51956-NEK3_HUMAN
Tissue specificity: Up-regulated in malignant versus normal breast tissue. Isoform 2 shows a high level of expression in testis, ovary and brain.
genes like me logo Genes that share expression patterns with NEK3: view

Protein tissue co-expression partners for NEK3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NEK3 Gene

Orthologs for NEK3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NEK3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NEK3 35
  • 87.11 (n)
  • 86.84 (a)
NEK3 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nek3 35
  • 79.45 (n)
  • 75.86 (a)
Nek3 16
Nek3 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NEK3 35
  • 99.87 (n)
  • 100 (a)
NEK3 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nek3 35
  • 79.96 (n)
  • 76.84 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
chicken
(Gallus gallus)
Aves NEK3 35
  • 68.44 (n)
  • 63.93 (a)
NEK3 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEK3 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nek3 35
  • 61.8 (n)
  • 57.61 (a)
Str.19964 35
zebrafish
(Danio rerio)
Actinopterygii LOC100536894 35
  • 68.68 (n)
  • 69.78 (a)
NEK3 36
  • 67 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons NEK5 35
  • 47.95 (n)
  • 38.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for NEK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEK3 Gene

ENSEMBL:
Gene Tree for NEK3 (if available)
TreeFam:
Gene Tree for NEK3 (if available)

Paralogs for NEK3 Gene

Paralogs for NEK3 Gene

genes like me logo Genes that share paralogs with NEK3: view

Variants for NEK3 Gene

Sequence variations from dbSNP and Humsavar for NEK3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs17482764 - 52,156,124(+) TTTCA(A/T)GCTGA nc-transcript-variant, reference, missense
rs55946204 - 52,154,112(+) TATTA(C/G)GGTGT nc-transcript-variant, reference, missense
rs56190615 - 52,152,637(+) GCACA(C/T)GTTTC nc-transcript-variant, reference, missense
rs56021040 - 52,151,185(+) CTGGA(A/G)GCACA nc-transcript-variant, reference, missense
rs34077016 - 52,144,720(+) AAGCC(A/C/G)AGCTA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NEK3 Gene

Variant ID Type Subtype PubMed ID
nsv900082 CNV Gain 21882294
nsv428288 CNV Loss 18775914

Variation tolerance for NEK3 Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.71; 94.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEK3 Gene

HapMap Linkage Disequilibrium report
NEK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEK3 Gene

Disorders for NEK3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NEK3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
muscular phosphorylase kinase deficiency
phosphorylase kinase deficiency
  • glycogen storage disease type ix
muscle glycogenosis
  • muscle phosphorylase kinase deficiency
- elite association - COSMIC cancer census association via MalaCards
Search NEK3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NEK3

Genetic Association Database (GAD)
NEK3
Human Genome Epidemiology (HuGE) Navigator
NEK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEK3
genes like me logo Genes that share disorders with NEK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEK3 Gene

Publications for NEK3 Gene

  1. Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans. (PMID: 7522034) Schultz S.J. … Nigg E.A. (Cell Growth Differ. 1994) 2 3 4 23 67
  2. Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor. (PMID: 15618286) Miller S.L. … Clevenger C.V. (Mol. Endocrinol. 2005) 3 23
  3. Molecular cloning and characterization of the human NIMA-related protein kinase 3 gene (NEK3). (PMID: 12063396) Kimura M. … Okano Y. (Cytogenet. Cell Genet. 2001) 3 23
  4. Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. (PMID: 8274451) Schultz S.J. … Nigg E.A. (Cell Growth Differ. 1993) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for NEK3 Gene

Sources for NEK3 Gene

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