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Aliases for NEK3 Gene

Aliases for NEK3 Gene

  • NIMA-Related Kinase 3 2 3
  • NIMA (Never In Mitosis Gene A)-Related Kinase 3 2 3
  • Never In Mitosis A-Related Kinase 3 3 4
  • Phosphorylase B Kinase Kinase 2 3
  • NimA-Related Protein Kinase 3 3 4
  • Hydroxyalkyl-Protein Kinase 2 3
  • Glycogen Synthase A Kinase 2 3
  • EC 2.7.11.1 4 63
  • HSPK 36 3 4
  • Serine/Threonine-Protein Kinase NEK3 2
  • Serine/Threonine-Protein Kinase Nek3 3
  • EC 2.7.11 63
  • HSPK36 3

External Ids for NEK3 Gene

Summaries for NEK3 Gene

Entrez Gene Summary for NEK3 Gene

  • This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

GeneCards Summary for NEK3 Gene

NEK3 (NIMA-Related Kinase 3) is a Protein Coding gene. Diseases associated with NEK3 include muscle glycogenosis and phosphorylase kinase deficiency. Among its related pathways are Prolactin Signaling Pathway and Prolactin Signaling Pathway. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is NEK2.

UniProtKB/Swiss-Prot for NEK3 Gene

  • Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.

Gene Wiki entry for NEK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEK3 Gene

Genomics for NEK3 Gene

Genomic Location for NEK3 Gene

Start:
52,132,639 bp from pter
End:
52,159,861 bp from pter
Size:
27,223 bases
Orientation:
Minus strand

Genomic View for NEK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK3 Gene

Regulatory Elements for NEK3 Gene

Proteins for NEK3 Gene

  • Protein details for NEK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51956-NEK3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Nek3
    Protein Accession:
    P51956
    Secondary Accessions:
    • A8K2J4
    • Q5TAP2
    • Q8J023
    • Q8WUN5

    Protein attributes for NEK3 Gene

    Size:
    506 amino acids
    Molecular mass:
    57705 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PXN, PRLR, VAV1 and VAV2 and this interaction is prolactin-dependent.
    SequenceCaution:
    • Sequence=CAI12895.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAX08907.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NEK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEK3 Gene

Proteomics data for NEK3 Gene at MOPED

Selected DME Specific Peptides for NEK3 Gene

Post-translational modifications for NEK3 Gene

  • Phosphorylation at Thr-479 regulates its catalytic activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for NEK3 Gene

Graphical View of Domain Structure for InterPro Entry

P51956

UniProtKB/Swiss-Prot:

NEK3_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • P51956
Family:
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.:
    • P51956
genes like me logo Genes that share domains with NEK3: view

Function for NEK3 Gene

Molecular function for NEK3 Gene

GENATLAS Biochemistry: never in mitosis gene A-related kinase 3,predominantly cytoplasmic,widely expressed in a non dependent cell cycle pattern
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Prolactin stimulates its activity.
UniProtKB/Swiss-Prot Function: Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.

Enzyme Numbers (IUBMB) for NEK3 Gene

Gene Ontology (GO) - Molecular Function for NEK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity NAS 7522034
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 15618286
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NEK3: view
genes like me logo Genes that share phenotypes with NEK3: view

miRNA for NEK3 Gene

miRTarBase miRNAs that target NEK3

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for NEK3 Gene

Localization for NEK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEK3 Gene

Cytoplasm. Cell projection, axon.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEK3 Gene COMPARTMENTS Subcellular localization image for NEK3 gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for NEK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 7522034
GO:0005737 cytoplasm IEA --
GO:0030424 axon IEA --
GO:0042995 cell projection --
genes like me logo Genes that share ontologies with NEK3: view

Pathways for NEK3 Gene

genes like me logo Genes that share pathways with NEK3: view

Pathways by source for NEK3 Gene

1 GeneGo (Thomson Reuters) pathway for NEK3 Gene
1 BioSystems pathway for NEK3 Gene

Interacting Proteins for NEK3 Gene

Selected Interacting proteins: P51956-NEK3_HUMAN for NEK3 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for NEK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation ISS --
GO:0007067 mitotic nuclear division NAS 7522034
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with NEK3: view

Compounds for NEK3 Gene

(3) HMDB Compounds for NEK3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(5) Novoseek inferred chemical compound relationships for NEK3 Gene

Compound -log(P) Hits PubMed IDs
glycogen 72.7 5
lactate 27.2 2
creatinine 7.05 1
calcium 5.32 2
serine 0 1
genes like me logo Genes that share compounds with NEK3: view

Transcripts for NEK3 Gene

Unigene Clusters for NEK3 Gene

NIMA-related kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEK3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - -
SP2: -
SP3: -
SP4: - -
SP5: -

Relevant External Links for NEK3 Gene

GeneLoc Exon Structure for
NEK3
ECgene alternative splicing isoforms for
NEK3

Expression for NEK3 Gene

mRNA expression in normal human tissues for NEK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NEK3 Gene

SOURCE GeneReport for Unigene cluster for NEK3 Gene Hs.409989

mRNA Expression by UniProt/SwissProt for NEK3 Gene

P51956-NEK3_HUMAN
Tissue specificity: Up-regulated in malignant versus normal breast tissue. Isoform 2 shows a high level of expression in testis, ovary and brain.
genes like me logo Genes that share expressions with NEK3: view

No data available for mRNA differential expression in normal tissues for NEK3 Gene

Orthologs for NEK3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NEK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEK3 35
  • 99.87 (n)
  • 100 (a)
NEK3 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEK3 35
  • 87.11 (n)
  • 86.84 (a)
NEK3 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nek3 35
  • 79.45 (n)
  • 75.86 (a)
Nek3 16
Nek3 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nek3 35
  • 79.96 (n)
  • 76.84 (a)
chicken
(Gallus gallus)
Aves NEK3 35
  • 68.44 (n)
  • 63.93 (a)
NEK3 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEK3 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nek3 35
  • 61.8 (n)
  • 57.61 (a)
Str.19964 35
zebrafish
(Danio rerio)
Actinopterygii LOC100536894 35
  • 68.68 (n)
  • 69.78 (a)
NEK3 36
  • 67 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons NEK5 35
  • 47.95 (n)
  • 38.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for NEK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEK3 Gene

ENSEMBL:
Gene Tree for NEK3 (if available)
TreeFam:
Gene Tree for NEK3 (if available)

Paralogs for NEK3 Gene

Paralogs for NEK3 Gene

genes like me logo Genes that share paralogs with NEK3: view

Variants for NEK3 Gene

Sequence variations from dbSNP and Humsavar for NEK3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1056447 -- 52,145,628(-) AGTTT(A/T)AAATT intron-variant
rs1134727 -- 52,145,527(-) AAGAC(C/T)AGCCT intron-variant
rs1571189 -- 52,156,869(-) TGTTG(A/T)ATGTA intron-variant
rs1886539 -- 52,151,955(-) AGCCT(A/G)TTGCT intron-variant
rs2274202 -- 52,148,663(-) AAGGG(G/T)GTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEK3 Gene

Variant ID Type Subtype PubMed ID
nsv900082 CNV Gain 21882294
nsv428288 CNV Loss 18775914

Relevant External Links for NEK3 Gene

HapMap Linkage Disequilibrium report
NEK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEK3 Gene

Disorders for NEK3 Gene

(5) Novoseek inferred disease relationships for NEK3 Gene

Disease -log(P) Hits PubMed IDs
glycogen storage disease 87 6
glycogen storage disease type i 72.9 3
enzyme deficiency 69.6 2
hepatomegaly 55.6 1
hypoglycemia 31.3 1

Relevant External Links for NEK3

Genetic Association Database (GAD)
NEK3
Human Genome Epidemiology (HuGE) Navigator
NEK3
genes like me logo Genes that share disorders with NEK3: view

No data available for UniProtKB/Swiss-Prot for NEK3 Gene

Publications for NEK3 Gene

  1. Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans. (PMID: 7522034) Schultz S.J. … Nigg E.A. (Cell Growth Differ. 1994) 2 3 4 23
  2. Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor. (PMID: 15618286) Miller S.L. … Clevenger C.V. (Mol. Endocrinol. 2005) 3 4 23
  3. Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. (PMID: 8274451) Schultz S.J. … Nigg E.A. (Cell Growth Differ. 1993) 2 3 4
  4. Molecular cloning and characterization of the human NIMA-related protein kinase 3 gene (NEK3). (PMID: 12063396) Kimura M. … Okano Y. (Cytogenet. Cell Genet. 2001) 3 4 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NEK3 Gene

  • Addgene plasmids for NEK3

Sources for NEK3 Gene

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