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Aliases for ATOH1 Gene

Aliases for ATOH1 Gene

  • Atonal Homolog 1 (Drosophila) 2 3
  • ATH1 3 4 6
  • Class A Basic Helix-Loop-Helix Protein 14 3 4
  • Helix-Loop-Helix Protein HATH-1 3 4
  • BHLHa14 3 4
  • HATH1 3 4
  • Protein Atonal Homolog 1 3
  • MATH-1 3

External Ids for ATOH1 Gene

Previous GeneCards Identifiers for ATOH1 Gene

  • GC04P094907
  • GC04P095051
  • GC04P095208
  • GC04P095107
  • GC04P094750
  • GC04P090487

Summaries for ATOH1 Gene

Entrez Gene Summary for ATOH1 Gene

  • This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATOH1 Gene

ATOH1 (Atonal Homolog 1 (Drosophila)) is a Protein Coding gene. Diseases associated with ATOH1 include goblet cell carcinoid and cerebellar liponeurocytoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein dimerization activity. An important paralog of this gene is BHLHA15.

UniProtKB/Swiss-Prot for ATOH1 Gene

  • Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).

Gene Wiki entry for ATOH1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATOH1 Gene

Genomics for ATOH1 Gene

Regulatory Elements for ATOH1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATOH1 Gene

Start:
93,828,753 bp from pter
End:
93,830,964 bp from pter
Size:
2,212 bases
Orientation:
Plus strand

Genomic View for ATOH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATOH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATOH1 Gene

Proteins for ATOH1 Gene

  • Protein details for ATOH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92858-ATOH1_HUMAN
    Recommended name:
    Protein atonal homolog 1
    Protein Accession:
    Q92858
    Secondary Accessions:
    • Q14CT9

    Protein attributes for ATOH1 Gene

    Size:
    354 amino acids
    Molecular mass:
    38160 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein

neXtProt entry for ATOH1 Gene

Proteomics data for ATOH1 Gene at MOPED

Post-translational modifications for ATOH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATOH1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ATOH1 Gene

Domains for ATOH1 Gene

Gene Families for ATOH1 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for ATOH1 Gene

Suggested Antigen Peptide Sequences for ATOH1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92858

UniProtKB/Swiss-Prot:

ATOH1_HUMAN :
  • Q92858
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with ATOH1: view

Function for ATOH1 Gene

Molecular function for ATOH1 Gene

GENATLAS Biochemistry:
Drosophila atonal proneural gene homolog,involved in the development of nervous system
UniProtKB/Swiss-Prot Function:
Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).

Gene Ontology (GO) - Molecular Function for ATOH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 8872459
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ATOH1: view
genes like me logo Genes that share phenotypes with ATOH1: view

Animal Models for ATOH1 Gene

MGI Knock Outs for ATOH1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ATOH1 NOD - NOD

miRNA for ATOH1 Gene

miRTarBase miRNAs that target ATOH1
Targeting motifs for ATOH1 Gene
HOMER Transcription Factor Regulatory Elements motif ATOH1
  • Consensus sequence: VNAVCAGCTGGC Submotif: canonical Cell Type: Cerebellum GeoId: GSE22111

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATOH1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for ATOH1 Gene

Localization for ATOH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATOH1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATOH1 Gene COMPARTMENTS Subcellular localization image for ATOH1 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ATOH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with ATOH1: view

Pathways for ATOH1 Gene

SuperPathways for ATOH1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATOH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 8872459
GO:0007411 axon guidance IEA --
GO:0007417 central nervous system development TAS 8872459
GO:0007420 brain development --
genes like me logo Genes that share ontologies with ATOH1: view

No data available for Pathways by source for ATOH1 Gene

Transcripts for ATOH1 Gene

mRNA/cDNA for ATOH1 Gene

(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATOH1 Gene

Atonal homolog 1 (Drosophila):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATOH1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATOH1 Gene

No ASD Table

Relevant External Links for ATOH1 Gene

GeneLoc Exon Structure for
ATOH1
ECgene alternative splicing isoforms for
ATOH1

Expression for ATOH1 Gene

mRNA expression in normal human tissues for ATOH1 Gene

mRNA differential expression in normal tissues according to GTEx for ATOH1 Gene

This gene is overexpressed in Colon - Transverse (32.4) and Small Intestine - Terminal Ileum (17.9).

Protein differential expression in normal tissues for ATOH1 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ATOH1 Gene

SOURCE GeneReport for Unigene cluster for ATOH1 Gene Hs.532680

genes like me logo Genes that share expressions with ATOH1: view

Expression partners for ATOH1 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ATOH1 Gene

Orthologs for ATOH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATOH1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATOH1 35
  • 88.64 (n)
  • 92.33 (a)
ATOH1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATOH1 35
  • 89.02 (n)
  • 90.06 (a)
ATOH1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atoh1 35
  • 84.62 (n)
  • 87.18 (a)
Atoh1 16
Atoh1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATOH1 35
  • 99.15 (n)
  • 98.59 (a)
ATOH1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atoh1 35
  • 84.81 (n)
  • 87.46 (a)
oppossum
(Monodelphis domestica)
Mammalia ATOH1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATOH1 35
  • 61.64 (n)
  • 54.76 (a)
lizard
(Anolis carolinensis)
Reptilia ATOH1 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atoh1 35
  • 65.44 (n)
  • 64.34 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
atoh1a 35
  • 62.1 (n)
  • 57.68 (a)
atoh1a 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ato 36
  • 20 (a)
OneToOne
Species with no ortholog for ATOH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATOH1 Gene

ENSEMBL:
Gene Tree for ATOH1 (if available)
TreeFam:
Gene Tree for ATOH1 (if available)

Paralogs for ATOH1 Gene

Selected SIMAP similar genes for ATOH1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATOH1: view

Variants for ATOH1 Gene

Sequence variations from dbSNP and Humsavar for ATOH1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs10009502 -- 93,828,907(+) TGAGC(C/G)TCCGA upstream-variant-2KB
rs10015253 -- 93,827,138(+) CATTC(C/T)GTATC upstream-variant-2KB
rs11312657 -- 93,828,533(+) GAAGG(-/A)AAAAA upstream-variant-2KB
rs34477680 -- 93,829,373(+) CTTCC(-/A)AGCAA reference, frameshift-variant
rs34543561 -- 93,829,499(+) AACAA(C/T)GACAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ATOH1 Gene

Variant ID Type Subtype PubMed ID
nsv821636 CNV Gain 15273396

Relevant External Links for ATOH1 Gene

HapMap Linkage Disequilibrium report
ATOH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATOH1 Gene

Disorders for ATOH1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ATOH1 Gene in MalaCards »

(3) Diseases for ATOH1 Gene including...

(3) University of Copenhagen DISEASES for ATOH1 Gene

(2) Novoseek inferred disease relationships for ATOH1 Gene

Disease -log(P) Hits PubMed IDs
colon tumor 42.5 2
colon cancer 26.2 5

Relevant External Links for ATOH1

Genetic Association Database (GAD)
ATOH1
genes like me logo Genes that share disorders with ATOH1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for ATOH1 Gene

Publications for ATOH1 Gene

  1. Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis. (PMID: 8872459) Ben-Arie N. … Zoghbi H.Y. (Hum. Mol. Genet. 1996) 2 3 4
  2. Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer. (PMID: 18275842) Aragaki M. … Watanabe M. (Biochem. Biophys. Res. Commun. 2008) 3 23
  3. Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development. (PMID: 11889557) Brown N.L. … Glaser T. (Mamm. Genome 2002) 3 23
  4. A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma. (PMID: 16382053) Leow C.C. … Gao W.Q. (Ann. N. Y. Acad. Sci. 2005) 3 23
  5. The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1. (PMID: 16831200) Mutoh H. … Sugano K. (Differentiation 2006) 3 23

Products for ATOH1 Gene

Sources for ATOH1 Gene

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