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Aliases for NEDD8 Gene

Aliases for NEDD8 Gene

  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 2 3
  • Ubiquitin-Like Protein Nedd8 3 4
  • Neddylin 3 4
  • NEDD-8 3 4
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8 4

External Ids for NEDD8 Gene

Previous GeneCards Identifiers for NEDD8 Gene

  • GC14M022058
  • GC14M018473
  • GC14M022674
  • GC14M022676
  • GC14M023755
  • GC14M024686
  • GC14M004801

Summaries for NEDD8 Gene

GeneCards Summary for NEDD8 Gene

NEDD8 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot for NEDD8 Gene

  • Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.

Gene Wiki entry for NEDD8 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEDD8 Gene

Genomics for NEDD8 Gene

Regulatory Elements for NEDD8 Gene

Genomic Location for NEDD8 Gene

Start:
24,216,851 bp from pter
End:
24,232,454 bp from pter
Size:
15,604 bases
Orientation:
Minus strand

Genomic View for NEDD8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEDD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEDD8 Gene

Proteins for NEDD8 Gene

  • Protein details for NEDD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15843-NEDD8_HUMAN
    Recommended name:
    NEDD8
    Protein Accession:
    Q15843
    Secondary Accessions:
    • Q3SXN8
    • Q6LES6

    Protein attributes for NEDD8 Gene

    Size:
    81 amino acids
    Molecular mass:
    9072 Da
    Quaternary structure:
    • Directly interacts with NUB1 and AHR. Covalently attached to cullins and p53.

    Three dimensional structures from OCA and Proteopedia for NEDD8 Gene

neXtProt entry for NEDD8 Gene

Proteomics data for NEDD8 Gene at MOPED

Post-translational modifications for NEDD8 Gene

  • Cleavage of precursor form by UCHL3 or SENP8 is necessary for function
  • Ubiquitination at Lys11, Lys22, Lys48, Lys54, and Lys60
  • Modification sites at PhosphoSitePlus

Other Protein References for NEDD8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NEDD8 (NEDD8)

Protein Products

No data available for DME Specific Peptides for NEDD8 Gene

Domains for NEDD8 Gene

Protein Domains for NEDD8 Gene

Suggested Antigen Peptide Sequences for NEDD8 Gene

Graphical View of Domain Structure for InterPro Entry

Q15843

UniProtKB/Swiss-Prot:

NEDD8_HUMAN :
  • Q15843
Family:
  • Belongs to the ubiquitin family.
genes like me logo Genes that share domains with NEDD8: view

No data available for Gene Families for NEDD8 Gene

Function for NEDD8 Gene

Molecular function for NEDD8 Gene

UniProtKB/Swiss-Prot Function: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.

Gene Ontology (GO) - Molecular Function for NEDD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15988528
GO:0031625 ubiquitin protein ligase binding IPI 15694336
genes like me logo Genes that share ontologies with NEDD8: view

Phenotypes for NEDD8 Gene

GenomeRNAi human phenotypes for NEDD8:
genes like me logo Genes that share phenotypes with NEDD8: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEDD8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NEDD8 Gene

Localization for NEDD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEDD8 Gene

Nucleus. Note=Mainly nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEDD8 Gene COMPARTMENTS Subcellular localization image for NEDD8 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NEDD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with NEDD8: view

Pathways for NEDD8 Gene

genes like me logo Genes that share pathways with NEDD8: view

Pathways by source for NEDD8 Gene

1 Qiagen pathway for NEDD8 Gene
1 Cell Signaling Technology pathway for NEDD8 Gene
1 BioSystems pathway for NEDD8 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NEDD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006464 cellular protein modification process TAS 9694792
GO:0006508 proteolysis TAS 9694792
GO:0006511 ubiquitin-dependent protein catabolic process TAS 9353319
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with NEDD8: view

Compounds for NEDD8 Gene

(5) Novoseek inferred chemical compound relationships for NEDD8 Gene

Compound -log(P) Hits PubMed IDs
lysine 52 8
cysteine 30.7 2
atp 0 1
steroid 0 1
arginine 0 1
genes like me logo Genes that share compounds with NEDD8: view

Transcripts for NEDD8 Gene

Unigene Clusters for NEDD8 Gene

Neural precursor cell expressed, developmentally down-regulated 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEDD8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEDD8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for NEDD8 Gene

GeneLoc Exon Structure for
NEDD8
ECgene alternative splicing isoforms for
NEDD8

Expression for NEDD8 Gene

mRNA expression in normal human tissues for NEDD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NEDD8 Gene

SOURCE GeneReport for Unigene cluster for NEDD8 Gene Hs.531064

mRNA Expression by UniProt/SwissProt for NEDD8 Gene

Q15843-NEDD8_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.
genes like me logo Genes that share expressions with NEDD8: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NEDD8 Gene

Orthologs for NEDD8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEDD8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEDD8 35
  • 99.59 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 80 (a)
OneToMany
NEDD8 35
  • 95.06 (n)
  • 100 (a)
NEDD8 36
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NEDD8 35
  • 96.71 (n)
  • 100 (a)
NEDD8 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nedd8 35
  • 92.18 (n)
  • 98.77 (a)
Nedd8 16
Nedd8 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEDD8 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nedd8 35
  • 92.59 (n)
  • 98.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2952 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nedd8 35
  • 79.82 (n)
  • 98.68 (a)
Str.10937 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12683 35
zebrafish
(Danio rerio)
Actinopterygii nedd8 35
  • 81.58 (n)
  • 98.68 (a)
nedd8 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007913 35
  • 75 (n)
  • 92.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nedd8 35
  • 75.53 (n)
  • 89.87 (a)
Nedd8 36
  • 85 (a)
OneToOne
Nedd8 37
  • 89 (a)
worm
(Caenorhabditis elegans)
Secernentea ned-8 35
  • 74.12 (n)
  • 88.16 (a)
ned-8 36
  • 87 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL185W 35
  • 60.09 (n)
  • 64.47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RUB1 35
  • 60.61 (n)
  • 58.44 (a)
RUB1 36
  • 57 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17974g 35
  • 60.53 (n)
  • 57.89 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03309 35
  • 67.54 (n)
  • 75 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ned8 35
  • 68.42 (n)
  • 81.58 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2781 35
Species with no ortholog for NEDD8:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEDD8 Gene

ENSEMBL:
Gene Tree for NEDD8 (if available)
TreeFam:
Gene Tree for NEDD8 (if available)

Paralogs for NEDD8 Gene

Selected SIMAP similar genes for NEDD8 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for NEDD8 Gene

genes like me logo Genes that share paralogs with NEDD8: view

No data available for Paralogs for NEDD8 Gene

Variants for NEDD8 Gene

Relevant External Links for NEDD8 Gene

HapMap Linkage Disequilibrium report
NEDD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for NEDD8 Gene

Disorders for NEDD8 Gene

(1) University of Copenhagen DISEASES for NEDD8 Gene

(3) Novoseek inferred disease relationships for NEDD8 Gene

Disease -log(P) Hits PubMed IDs
parkinson disease 15.5 1
alzheimers disease 0.569 1
tumors 0 4
genes like me logo Genes that share disorders with NEDD8: view

No data available for UniProtKB/Swiss-Prot for NEDD8 Gene

Publications for NEDD8 Gene

  1. Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein. (PMID: 9353319) Kamitani T. … Yeh E.T.H. (J. Biol. Chem. 1997) 2 3 4 23
  2. Cleavage of the C-terminus of NEDD8 by UCH-L3. (PMID: 9790970) Wada H. … Kamitani T. (Biochem. Biophys. Res. Commun. 1998) 3 4 23
  3. Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes. (PMID: 9857030) Whitby F.G. … Hill C.P. (J. Biol. Chem. 1998) 3 4 23
  4. Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function. (PMID: 10318914) Liakopoulos D. … Pause A. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23
  5. Covalent modification of all members of human cullin family proteins by NEDD8. (PMID: 10597293) Hori T. … Tanaka K. (Oncogene 1999) 3 4 23

Products for NEDD8 Gene

  • Addgene plasmids for NEDD8

Sources for NEDD8 Gene

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