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Aliases for NEDD8 Gene

Aliases for NEDD8 Gene

  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 2 3 5
  • Ubiquitin-Like Protein Nedd8 3 4
  • Neddylin 3 4
  • NEDD-8 3 4
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8 4

External Ids for NEDD8 Gene

Previous GeneCards Identifiers for NEDD8 Gene

  • GC14M022058
  • GC14M018473
  • GC14M022674
  • GC14M022676
  • GC14M023755
  • GC14M024686
  • GC14M004801

Summaries for NEDD8 Gene

GeneCards Summary for NEDD8 Gene

NEDD8 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p53 pathway (Pathway Interaction Database). GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is UBA52.

UniProtKB/Swiss-Prot for NEDD8 Gene

  • Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.

Gene Wiki entry for NEDD8 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEDD8 Gene

Genomics for NEDD8 Gene

Regulatory Elements for NEDD8 Gene

Promoters for NEDD8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NEDD8 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEDD8 Gene

Chromosome:
14
Start:
24,216,851 bp from pter
End:
24,232,454 bp from pter
Size:
15,604 bases
Orientation:
Minus strand

Genomic View for NEDD8 Gene

Genes around NEDD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEDD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEDD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEDD8 Gene

Proteins for NEDD8 Gene

  • Protein details for NEDD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15843-NEDD8_HUMAN
    Recommended name:
    NEDD8
    Protein Accession:
    Q15843
    Secondary Accessions:
    • Q3SXN8
    • Q6LES6

    Protein attributes for NEDD8 Gene

    Size:
    81 amino acids
    Molecular mass:
    9072 Da
    Quaternary structure:
    • Directly interacts with NUB1 and AHR. Covalently attached to cullins and p53.

    Three dimensional structures from OCA and Proteopedia for NEDD8 Gene

neXtProt entry for NEDD8 Gene

Proteomics data for NEDD8 Gene at MOPED

Post-translational modifications for NEDD8 Gene

  • Cleavage of precursor form by UCHL3 or SENP8 is necessary for function.
  • Ubiquitination at Lys 11, Lys 22, Lys 48, Lys 54, and Lys 60
  • Modification sites at PhosphoSitePlus

Other Protein References for NEDD8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NEDD8 (NEDD8)

No data available for DME Specific Peptides for NEDD8 Gene

Domains & Families for NEDD8 Gene

Protein Domains for NEDD8 Gene

Suggested Antigen Peptide Sequences for NEDD8 Gene

Graphical View of Domain Structure for InterPro Entry

Q15843

UniProtKB/Swiss-Prot:

NEDD8_HUMAN :
  • Belongs to the ubiquitin family.
Family:
  • Belongs to the ubiquitin family.
genes like me logo Genes that share domains with NEDD8: view

No data available for Gene Families for NEDD8 Gene

Function for NEDD8 Gene

Molecular function for NEDD8 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
genes like me logo Genes that share phenotypes with NEDD8: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NEDD8 Gene

Localization for NEDD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEDD8 Gene

Nucleus. Note=Mainly nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEDD8 Gene COMPARTMENTS Subcellular localization image for NEDD8 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for NEDD8 Gene

Pathways & Interactions for NEDD8 Gene

genes like me logo Genes that share pathways with NEDD8: view

Pathways by source for NEDD8 Gene

1 BioSystems pathway for NEDD8 Gene
1 GeneGo (Thomson Reuters) pathway for NEDD8 Gene
1 Qiagen pathway for NEDD8 Gene

Gene Ontology (GO) - Biological Process for NEDD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 9694792
GO:0006508 proteolysis TAS 9694792
GO:0008104 protein localization IEA --
GO:0009653 anatomical structure morphogenesis TAS 9694792
GO:0014070 response to organic cyclic compound IEA --
genes like me logo Genes that share ontologies with NEDD8: view

No data available for SIGNOR curated interactions for NEDD8 Gene

Drugs & Compounds for NEDD8 Gene

(4) Drugs for NEDD8 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for NEDD8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NEDD8: view

Transcripts for NEDD8 Gene

Unigene Clusters for NEDD8 Gene

Neural precursor cell expressed, developmentally down-regulated 8:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEDD8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for NEDD8 Gene

GeneLoc Exon Structure for
NEDD8
ECgene alternative splicing isoforms for
NEDD8

Expression for NEDD8 Gene

mRNA expression in normal human tissues for NEDD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEDD8 Gene

This gene is overexpressed in Amniocyte (10.0) and Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NEDD8 Gene



SOURCE GeneReport for Unigene cluster for NEDD8 Gene Hs.531064

mRNA Expression by UniProt/SwissProt for NEDD8 Gene

Q15843-NEDD8_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.
genes like me logo Genes that share expression patterns with NEDD8: view

Protein tissue co-expression partners for NEDD8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NEDD8 Gene

Orthologs for NEDD8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEDD8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEDD8 35
  • 99.59 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 80 (a)
OneToMany
NEDD8 36
  • 96 (a)
OneToMany
NEDD8 35
  • 95.06 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia NEDD8 35
  • 96.71 (n)
  • 100 (a)
NEDD8 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nedd8 35
  • 92.18 (n)
  • 98.77 (a)
Nedd8 36
  • 99 (a)
OneToOne
Nedd8 16
oppossum
(Monodelphis domestica)
Mammalia NEDD8 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nedd8 35
  • 92.59 (n)
  • 98.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2952 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nedd8 35
  • 79.82 (n)
  • 98.68 (a)
Str.10937 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12683 35
zebrafish
(Danio rerio)
Actinopterygii nedd8 35
  • 81.58 (n)
  • 98.68 (a)
nedd8 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007913 35
  • 75 (n)
  • 92.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nedd8 36
  • 85 (a)
OneToOne
Nedd8 37
  • 89 (a)
Nedd8 35
  • 75.53 (n)
  • 89.87 (a)
worm
(Caenorhabditis elegans)
Secernentea ned-8 36
  • 87 (a)
OneToOne
ned-8 35
  • 74.12 (n)
  • 88.16 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL185W 35
  • 60.09 (n)
  • 64.47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RUB1 36
  • 57 (a)
OneToOne
RUB1 35
  • 60.61 (n)
  • 58.44 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17974g 35
  • 60.53 (n)
  • 57.89 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03309 35
  • 67.54 (n)
  • 75 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ned8 35
  • 68.42 (n)
  • 81.58 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2781 35
Species with no ortholog for NEDD8:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEDD8 Gene

ENSEMBL:
Gene Tree for NEDD8 (if available)
TreeFam:
Gene Tree for NEDD8 (if available)

Paralogs for NEDD8 Gene

Paralogs for NEDD8 Gene

(15) SIMAP similar genes for NEDD8 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for NEDD8 Gene

genes like me logo Genes that share paralogs with NEDD8: view

Variants for NEDD8 Gene

Variation tolerance for NEDD8 Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEDD8 Gene

HapMap Linkage Disequilibrium report
NEDD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for NEDD8 Gene

Disorders for NEDD8 Gene

Relevant External Links for NEDD8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEDD8

No disorders were found for NEDD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEDD8 Gene

Publications for NEDD8 Gene

  1. Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein. (PMID: 9353319) Kamitani T. … Yeh E.T.H. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity. (PMID: 19328766) Engels I.H. … Brinker A. (Anal. Biochem. 2009) 3 23
  3. Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail. (PMID: 18723677) Yamoah K. … Pan Z.Q. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23
  4. Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. (PMID: 18851830) Saha A. … Deshaies R.J. (Mol. Cell 2008) 3 23
  5. Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. (PMID: 18805092) Duda D.M. … Schulman B.A. (Cell 2008) 3 23

Products for NEDD8 Gene

Sources for NEDD8 Gene

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