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Aliases for NDUFC1 Gene

Aliases for NDUFC1 Gene

  • NADH Dehydrogenase (Ubiquinone) 1, Subcomplex Unknown, 1, 6kDa 2 3
  • NADH-Ubiquinone Oxidoreductase KFYI Subunit 3 4
  • Complex I KFYI Subunit 2 3
  • Complex I-KFYI 3 4
  • CI-KFYI 3 4
  • NADH Dehydrogenase (Ubiquinone) 1, Subcomplex Unknown, 1 (6kD, KFYI) 2
  • NADH Dehydrogenase [Ubiquinone] 1 Subunit C1, Mitochondrial 3
  • KFYI 3

External Ids for NDUFC1 Gene

Previous GeneCards Identifiers for NDUFC1 Gene

  • GC04M141092
  • GC04M140510
  • GC04M140677
  • GC04M140788
  • GC04M140568
  • GC04M140430
  • GC04M140212
  • GC04M135941

Summaries for NDUFC1 Gene

Entrez Gene Summary for NDUFC1 Gene

  • The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for NDUFC1 Gene

NDUFC1 (NADH Dehydrogenase (Ubiquinone) 1, Subcomplex Unknown, 1, 6kDa) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFC1 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFC1 Gene

Genomics for NDUFC1 Gene

Regulatory Elements for NDUFC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NDUFC1 Gene

Start:
139,266,880 bp from pter
End:
139,302,551 bp from pter
Size:
35,672 bases
Orientation:
Minus strand

Genomic View for NDUFC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFC1 Gene

Proteins for NDUFC1 Gene

  • Protein details for NDUFC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43677-NDUC1_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
    Protein Accession:
    O43677
    Secondary Accessions:
    • A8K532
    • Q3MIJ9

    Protein attributes for NDUFC1 Gene

    Size:
    76 amino acids
    Molecular mass:
    8734 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits

neXtProt entry for NDUFC1 Gene

Proteomics data for NDUFC1 Gene at MOPED

Post-translational modifications for NDUFC1 Gene

No Post-translational modifications

Antibody Products

No data available for DME Specific Peptides for NDUFC1 Gene

Domains for NDUFC1 Gene

Gene Families for NDUFC1 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Protein Domains for NDUFC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDUFC1 Gene

Graphical View of Domain Structure for InterPro Entry

O43677

UniProtKB/Swiss-Prot:

NDUC1_HUMAN :
  • O43677
Family:
  • Belongs to the complex I NDUFC1 subunit family.
genes like me logo Genes that share domains with NDUFC1: view

Function for NDUFC1 Gene

Molecular function for NDUFC1 Gene

GENATLAS Biochemistry:
NADH ubiquinone oxidoreductase (Q reductase),6kDa,subcomplex unkknown,1
UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFC1: view

Phenotypes for NDUFC1 Gene

genes like me logo Genes that share phenotypes with NDUFC1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NDUFC1 Gene

Localization for NDUFC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFC1 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFC1 Gene COMPARTMENTS Subcellular localization image for NDUFC1 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for NDUFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NDUFC1: view

Pathways for NDUFC1 Gene

genes like me logo Genes that share pathways with NDUFC1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat

Interacting Proteins for NDUFC1 Gene

Gene Ontology (GO) - Biological Process for NDUFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS 9878551
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NDUFC1: view

Compounds for NDUFC1 Gene

(8) HMDB Compounds for NDUFC1 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFC1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFC1: view

Transcripts for NDUFC1 Gene

Unigene Clusters for NDUFC1 Gene

NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFC1 Gene

No ASD Table

Relevant External Links for NDUFC1 Gene

GeneLoc Exon Structure for
NDUFC1
ECgene alternative splicing isoforms for
NDUFC1

Expression for NDUFC1 Gene

mRNA expression in normal human tissues for NDUFC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for NDUFC1 Gene

This gene is overexpressed in Nasal epithelium (67.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NDUFC1 Gene

SOURCE GeneReport for Unigene cluster for NDUFC1 Gene Hs.84549

genes like me logo Genes that share expressions with NDUFC1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for NDUFC1 Gene

Orthologs for NDUFC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for NDUFC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDUFC1 35
  • 81.14 (n)
  • 78.95 (a)
NDUFC1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFC1 35
  • 77.19 (n)
  • 76.32 (a)
NDUFC1 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndufc1 35
  • 79.39 (n)
  • 75 (a)
Ndufc1 16
Ndufc1 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufc1 35
  • 82.02 (n)
  • 77.63 (a)
oppossum
(Monodelphis domestica)
Mammalia NDUFC1 36
  • 66 (a)
OneToOne
Species with no ortholog for NDUFC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NDUFC1 Gene

ENSEMBL:
Gene Tree for NDUFC1 (if available)
TreeFam:
Gene Tree for NDUFC1 (if available)

Paralogs for NDUFC1 Gene

No data available for Paralogs for NDUFC1 Gene

Variants for NDUFC1 Gene

Sequence variations from dbSNP and Humsavar for NDUFC1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs6536040 -- 139,294,988(+) TTATG(C/T)CATTC intron-variant
rs6815500 -- 139,295,376(+) TTAAG(A/G)GCTTG intron-variant
rs6816703 -- 139,295,258(+) CATCT(C/T)CCACT intron-variant
rs6826290 -- 139,292,340(+) CCCCA(C/T)CCCCC intron-variant
rs6833101 -- 139,299,404(+) ATTTT(A/C)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFC1 Gene

Variant ID Type Subtype PubMed ID
nsv880160 CNV Gain 21882294

Relevant External Links for NDUFC1 Gene

HapMap Linkage Disequilibrium report
NDUFC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFC1 Gene

Disorders for NDUFC1 Gene

No disorders were found for NDUFC1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for NDUFC1 Gene

Publications for NDUFC1 Gene

  1. Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits. (PMID: 9425316) Ton C. … Liew C.-C. (Biochem. Biophys. Res. Commun. 1997) 2 3 4
  2. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4
  3. Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PMID: 9763677) Emahazion T. … Brookes A.J. (Cytogenet. Cell Genet. 1998) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NDUFC1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NDUFC1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFC1
    • Block miRNA regulation of NDUFC1 using miScript Target Protectors

    Sources for NDUFC1 Gene

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