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Aliases for NCK1 Gene

Aliases for NCK1 Gene

  • NCK Adaptor Protein 1 2 3 4
  • NCK 3 4 6
  • SH2/SH3 Adaptor Protein NCK-Alpha 3 4
  • Nck-1 3 4
  • Non-Catalytic Region Of Tyrosine Kinase 3
  • Cytoplasmic Protein NCK1 3
  • Melanoma NCK Protein 3
  • NCK Tyrosine Kinase 3
  • NCKalpha 3

External Ids for NCK1 Gene

Previous HGNC Symbols for NCK1 Gene

  • NCK

Previous GeneCards Identifiers for NCK1 Gene

  • GC03P133543
  • GC03P137332
  • GC03P137862
  • GC03P137901
  • GC03P138063
  • GC03P136581
  • GC03P133957

Summaries for NCK1 Gene

Entrez Gene Summary for NCK1 Gene

  • The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]

GeneCards Summary for NCK1 Gene

NCK1 (NCK Adaptor Protein 1) is a Protein Coding gene. Diseases associated with NCK1 include wiskott-aldrich syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include receptor binding and protein kinase inhibitor activity. An important paralog of this gene is GRAPL.

UniProtKB/Swiss-Prot for NCK1 Gene

  • Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.

Gene Wiki entry for NCK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCK1 Gene

Genomics for NCK1 Gene

Regulatory Elements for NCK1 Gene

Genomic Location for NCK1 Gene

Start:
136,862,208 bp from pter
End:
136,951,604 bp from pter
Size:
89,397 bases
Orientation:
Plus strand

Genomic View for NCK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCK1 Gene

Proteins for NCK1 Gene

  • Protein details for NCK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16333-NCK1_HUMAN
    Recommended name:
    Cytoplasmic protein NCK1
    Protein Accession:
    P16333
    Secondary Accessions:
    • B7Z751
    • D3DNE3

    Protein attributes for NCK1 Gene

    Size:
    377 amino acids
    Molecular mass:
    42864 Da
    Quaternary structure:
    • Interacts (via SH2 domain and SH3 domain 2) with EGFR. Interacts with PAK1 and SOS1. Interacts (via SH3 domains) with PKN2. Associates with BLNK, PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with SOCS7. This interaction is required for nuclear import. Part of a complex containing PPP1R15B, PP1 and NCK1. Interacts with RALGPS1. Interacts with CAV2 (tyrosine phosphorylated form). Interacts with ADAM15. Interacts with FASLG. Directly interacts with RASA1. Interacts with isoform 4 of MINK1. Interacts with FLT1 (tyrosine phosphorylated). Interacts with KDR (tyrosine phosphorylated). Interacts (via SH2 domain) with EPHB1; activates the JUN cascade to regulate cell adhesion. Interacts with EPHA2. Interacts (via SH2 domain) with PDGFRB (tyrosine phosphorylated). Interacts with the inactive form of EIF2AK2/PKR.

    Three dimensional structures from OCA and Proteopedia for NCK1 Gene

    Alternative splice isoforms for NCK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCK1 Gene

Proteomics data for NCK1 Gene at MOPED

Post-translational modifications for NCK1 Gene

  • Phosphorylated on Ser and Tyr residues. Phosphorylated in response to activation of EGFR and FcERI. Phosphorylated by activated PDGFRB.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NCK1 Gene

Domains for NCK1 Gene

Gene Families for NCK1 Gene

HGNC:
  • SH2D :SH2 domain containing

Protein Domains for NCK1 Gene

Suggested Antigen Peptide Sequences for NCK1 Gene

Graphical View of Domain Structure for InterPro Entry

P16333

UniProtKB/Swiss-Prot:

NCK1_HUMAN :
  • P16333
Domain:
  • Only the first and third SH3 domains seem to be involved in RASA1-binding; the second SH3 domain and the SH2 domains do not seeem to be involved
  • Contains 1 SH2 domain.
  • Contains 3 SH3 domains.
genes like me logo Genes that share domains with NCK1: view

Function for NCK1 Gene

Molecular function for NCK1 Gene

GENATLAS Biochemistry: transduction adaptor protein 1
UniProtKB/Swiss-Prot Function: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.

Gene Ontology (GO) - Molecular Function for NCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IDA 18835251
GO:0005070 SH3/SH2 adaptor activity NAS 16835242
GO:0005102 receptor binding IPI 12110186
GO:0005515 protein binding IPI 10026169
GO:0008093 cytoskeletal adaptor activity NAS 12110186
genes like me logo Genes that share ontologies with NCK1: view
genes like me logo Genes that share phenotypes with NCK1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NCK1 Gene

Localization for NCK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCK1 Gene

Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCK1 Gene COMPARTMENTS Subcellular localization image for NCK1 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytosol 4
plasma membrane 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for NCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000164 protein phosphatase type 1 complex IDA 16835242
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm NAS 12110186
GO:0005783 endoplasmic reticulum IDA 16835242
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NCK1: view

Pathways for NCK1 Gene

genes like me logo Genes that share pathways with NCK1: view

Gene Ontology (GO) - Biological Process for NCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation --
GO:0006469 negative regulation of protein kinase activity IDA 18835251
GO:0006930 substrate-dependent cell migration, cell extension IEA --
GO:0007015 actin filament organization IEA --
GO:0007172 signal complex assembly NAS 12110186
genes like me logo Genes that share ontologies with NCK1: view

Compounds for NCK1 Gene

(11) Novoseek inferred chemical compound relationships for NCK1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 72.2 66
phosphotyrosine 65.1 6
phosphatidylinositol 40.2 7
serine 38.2 11
threonine 36.1 6
genes like me logo Genes that share compounds with NCK1: view

Transcripts for NCK1 Gene

Unigene Clusters for NCK1 Gene

NCK adaptor protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCK1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - -
SP7:
SP8:

Relevant External Links for NCK1 Gene

GeneLoc Exon Structure for
NCK1
ECgene alternative splicing isoforms for
NCK1

Expression for NCK1 Gene

mRNA expression in normal human tissues for NCK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCK1 Gene

SOURCE GeneReport for Unigene cluster for NCK1 Gene Hs.477693

genes like me logo Genes that share expressions with NCK1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NCK1 Gene

Orthologs for NCK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NCK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCK1 35
  • 99.73 (n)
  • 100 (a)
NCK1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NCK1 35
  • 95.31 (n)
  • 98.94 (a)
NCK1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCK1 35
  • 95.84 (n)
  • 99.2 (a)
NCK1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nck1 35
  • 92.84 (n)
  • 98.94 (a)
Nck1 16
Nck1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCK1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCK1 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nck1 35
  • 92.66 (n)
  • 99.2 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.379 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nck1 35
  • 78.04 (n)
  • 87.73 (a)
Str.18569 35
zebrafish
(Danio rerio)
Actinopterygii nck1a 36
  • 64 (a)
OneToMany
nck1b 35
  • 68.79 (n)
  • 77.72 (a)
nck1b 36
  • 77 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010135 35
  • 54.41 (n)
  • 52.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta dock 35
  • 52.86 (n)
  • 51.43 (a)
dock 36
  • 32 (a)
OneToMany
dock 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea nck-1 36
  • 44 (a)
OneToMany
ZK470.5b 37
  • 40 (a)
ZK470.5a 37
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for NCK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCK1 Gene

ENSEMBL:
Gene Tree for NCK1 (if available)
TreeFam:
Gene Tree for NCK1 (if available)

Paralogs for NCK1 Gene

Paralogs for NCK1 Gene

Selected SIMAP similar genes for NCK1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NCK1: view

Variants for NCK1 Gene

Sequence variations from dbSNP and Humsavar for NCK1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs835647 -- 136,950,237(-) TGGGG(A/G)AAAAC utr-variant-3-prime
rs856662 -- 136,949,783(+) ATAAA(C/T)AGATA utr-variant-3-prime
rs1048145 -- 136,948,563(+) AAATC(C/T)ATATG utr-variant-3-prime
rs1298139 -- 136,897,157(-) gagct(A/G)agatc intron-variant
rs1299289 -- 136,888,837(-) tgaaa(A/G)aaagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCK1 Gene

Variant ID Type Subtype PubMed ID
nsv877530 CNV Gain 21882294
dgv5262n71 CNV Loss 21882294
esv2725958 CNV Deletion 23290073

Relevant External Links for NCK1 Gene

HapMap Linkage Disequilibrium report
NCK1
Human Gene Mutation Database (HGMD)
NCK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCK1 Gene

Disorders for NCK1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NCK1 Gene including...

Search for NCK1 Gene in MalaCards »

(4) Novoseek inferred disease relationships for NCK1 Gene

Disease -log(P) Hits PubMed IDs
wiskott-aldrich syndrome 81.9 7
tumors 3.34 1
leukemia 0 1
immunodeficiency 0 2

Relevant External Links for NCK1

Genetic Association Database (GAD)
NCK1
Human Genome Epidemiology (HuGE) Navigator
NCK1
genes like me logo Genes that share disorders with NCK1: view

No data available for UniProtKB/Swiss-Prot for NCK1 Gene

Publications for NCK1 Gene

  1. The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment. (PMID: 1448108) Meisenhelder J. … Hunter T. (Mol. Cell. Biol. 1992) 3 4 23
  2. Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2). (PMID: 7806213) Huebner K. … Cannizzaro L. (Genomics 1994) 2 3 23
  3. A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. (PMID: 9344857) Matuoka K. … Takenawa T. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  4. Identification of Nck family genes, chromosomal localization, expression, and signaling specificity. (PMID: 9737977) Chen M. … Li W. (J. Biol. Chem. 1998) 2 3 23
  5. Identification of Grb4/Nckbeta, a src homology 2 and 3 domain- containing adapter protein having similar binding and biological properties to Nck. (PMID: 10026169) Braverman L.E. … Quilliam L.A. (J. Biol. Chem. 1999) 3 4 23

Products for NCK1 Gene

  • Addgene plasmids for NCK1

Sources for NCK1 Gene

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