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Aliases for NCAM1 Gene

Aliases for NCAM1 Gene

  • Neural Cell Adhesion Molecule 1 2 3 5
  • NCAM 3 4
  • Antigen Recognized By Monoclonal Antibody 5.1H11 3
  • Neural Cell Adhesion Molecule, NCAM 3
  • CD56 Antigen 4
  • N-CAM-1 4
  • NCAM-1 4
  • MSK39 3
  • CD56 3

External Ids for NCAM1 Gene

Previous GeneCards Identifiers for NCAM1 Gene

  • GC11P115185
  • GC11P114344
  • GC11P112866
  • GC11P112369
  • GC11P112337
  • GC11P112831
  • GC11P108759

Summaries for NCAM1 Gene

Entrez Gene Summary for NCAM1 Gene

  • This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

GeneCards Summary for NCAM1 Gene

NCAM1 (Neural Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with NCAM1 include rabies and subcutaneous panniculitis-like t-cell lymphoma. Among its related pathways are Degradation of the extracellular matrix and Signaling by GPCR. GO annotations related to this gene include identical protein binding. An important paralog of this gene is IGSF10.

UniProtKB/Swiss-Prot for NCAM1 Gene

  • This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

  • (Microbial infection) Acts as a receptor for rabies virus.

Tocris Summary for NCAM1 Gene

  • Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.

Gene Wiki entry for NCAM1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAM1 Gene

Genomics for NCAM1 Gene

Regulatory Elements for NCAM1 Gene

Promoters for NCAM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NCAM1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NCAM1 gene promoter:

Genomic Location for NCAM1 Gene

112,961,247 bp from pter
113,278,436 bp from pter
317,190 bases
Plus strand

Genomic View for NCAM1 Gene

Genes around NCAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAM1 Gene

Proteins for NCAM1 Gene

  • Protein details for NCAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neural cell adhesion molecule 1
    Protein Accession:
    Secondary Accessions:
    • A8K8T8
    • P13592
    • P13593
    • Q05C58
    • Q15829
    • Q16180
    • Q16209
    • Q59FL7
    • Q86X47
    • Q96CJ3

    Protein attributes for NCAM1 Gene

    858 amino acids
    Molecular mass:
    94574 Da
    Quaternary structure:
    • (Microbial infection) Interacts with rabies virus glycoprotein.
    • Sequence=BAD92680.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NCAM1 Gene

    Alternative splice isoforms for NCAM1 Gene

neXtProt entry for NCAM1 Gene

Proteomics data for NCAM1 Gene at MOPED

Post-translational modifications for NCAM1 Gene

  • Glycosylation at Thr 125, Asn 222, Asn 315, Asn 347, Asn 423, Asn 449, and Asn 478
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NCAM1 (NCAM1)

No data available for DME Specific Peptides for NCAM1 Gene

Domains & Families for NCAM1 Gene

Suggested Antigen Peptide Sequences for NCAM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 fibronectin type-III domains.
  • Contains 2 fibronectin type-III domains.
  • Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with NCAM1: view

Function for NCAM1 Gene

Molecular function for NCAM1 Gene

GENATLAS Biochemistry:
cell adhesion molecule,neural,1,immunoglobulin superfamily
UniProtKB/Swiss-Prot Function:
This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for rabies virus.
genes like me logo Genes that share phenotypes with NCAM1: view

Animal Models for NCAM1 Gene

MGI Knock Outs for NCAM1:

Animal Model Products

CRISPR Products

miRNA for NCAM1 Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCAM1 Gene

Localization for NCAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAM1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform 4: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform 5: Secreted.
Isoform 6: Secreted.

Subcellular locations from

Jensen Localization Image for NCAM1 Gene COMPARTMENTS Subcellular localization image for NCAM1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
golgi apparatus 4
cytoskeleton 3
cytosol 3
nucleus 2
vacuole 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NCAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0009897 external side of plasma membrane IDA 17213291
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with NCAM1: view

Pathways & Interactions for NCAM1 Gene

SuperPathways for NCAM1 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Signaling by GPCR
3 Immune System
4 Interferon gamma signaling
5 Developmental Biology
genes like me logo Genes that share pathways with NCAM1: view

Gene Ontology (GO) - Biological Process for NCAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0007155 cell adhesion IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007411 axon guidance TAS --
GO:0008286 insulin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with NCAM1: view

No data available for SIGNOR curated interactions for NCAM1 Gene

Drugs & Compounds for NCAM1 Gene

(30) Drugs for NCAM1 Gene - From: Novoseek, DGIdb, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
A 205804 Pharma E-selectin/ICAM-1 expression inhibitor, Selective inhibitor of E-selectin and ICAM-1 expression 0

(33) Additional Compounds for NCAM1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GR 144053 trihydrochloride
  • Acetopyrrothine
  • Farcinicine
  • N-Acetylpyrrothine
  • Thiolutin
genes like me logo Genes that share compounds with NCAM1: view

Transcripts for NCAM1 Gene

Unigene Clusters for NCAM1 Gene

Neural cell adhesion molecule 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCAM1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20
SP1: - - - - -
SP2: - -

Relevant External Links for NCAM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NCAM1 Gene

mRNA expression in normal human tissues for NCAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NCAM1 Gene

This gene is overexpressed in Fetal Brain (17.6), Frontal cortex (11.4), Retina (11.0), and Brain (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCAM1 Gene

SOURCE GeneReport for Unigene cluster for NCAM1 Gene Hs.503878

genes like me logo Genes that share expression patterns with NCAM1: view

Protein tissue co-expression partners for NCAM1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NCAM1 Gene

Orthologs for NCAM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NCAM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NCAM1 36
  • 98 (a)
NCAM1 35
  • 99.51 (n)
  • 99.55 (a)
(Bos Taurus)
Mammalia NCAM1 35
  • 91.72 (n)
  • 96.71 (a)
NCAM1 36
  • 94 (a)
(Canis familiaris)
Mammalia NCAM1 36
  • 73 (a)
NCAM1 35
  • 92.42 (n)
  • 97 (a)
(Mus musculus)
Mammalia Ncam1 16
Ncam1 36
  • 95 (a)
Ncam1 35
  • 89.27 (n)
  • 94.81 (a)
(Monodelphis domestica)
Mammalia NCAM1 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
-- 36
  • 80 (a)
(Rattus norvegicus)
Mammalia Ncam1 35
  • 89.19 (n)
  • 95.1 (a)
(Gallus gallus)
Aves NCAM1 35
  • 81.84 (n)
  • 88.09 (a)
NCAM1 36
  • 66 (a)
(Anolis carolinensis)
Reptilia NCAM1 36
  • 64 (a)
African clawed frog
(Xenopus laevis)
Amphibia NCAM 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ncam1 35
  • 70.66 (n)
  • 74.49 (a)
(Danio rerio)
Actinopterygii ncam1a 36
  • 65 (a)
ncam1b 36
  • 49 (a)
-- 35
ncam1a 35
  • 68.35 (n)
  • 65.59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002802 35
  • 44.49 (n)
  • 30.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15630 36
  • 21 (a)
CG33543 36
  • 21 (a)
Fas2 36
  • 24 (a)
Fas2 37
  • 26 (a)
Fas2 35
  • 43.13 (n)
  • 28.19 (a)
(Caenorhabditis elegans)
Secernentea ncam-1 35
  • 41.33 (n)
  • 28.19 (a)
ncam-1 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for NCAM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCAM1 Gene

Gene Tree for NCAM1 (if available)
Gene Tree for NCAM1 (if available)

Paralogs for NCAM1 Gene

Paralogs for NCAM1 Gene

(5) SIMAP similar genes for NCAM1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NCAM1: view

Variants for NCAM1 Gene

Sequence variations from dbSNP and Humsavar for NCAM1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs17115160 - 113,207,864(+) AAGAC(A/G)ATGAG reference, missense
rs17115280 - 113,260,229(+) GCTGA(G/T)TATGA reference, missense
VAR_049962 -
VAR_061331 -
rs1061 -- 113,118,576(+) TTTAT(C/T)GTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCAM1 Gene

Variant ID Type Subtype PubMed ID
nsv832271 CNV Gain 17160897
nsv526604 CNV Loss 19592680
nsv468870 CNV Loss 19166990
nsv832272 CNV Gain 17160897
esv2745085 CNV Deletion 23290073
esv2664094 CNV Deletion 23128226
esv24924 CNV Loss 19812545
nsv516224 CNV Loss 19592680
nsv515828 CNV Loss 19592680

Variation tolerance for NCAM1 Gene

Gene Damage Index Score: 7.28; 81.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCAM1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAM1 Gene

Disorders for NCAM1 Gene

MalaCards: The human disease database

(85) MalaCards diseases for NCAM1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • lyssa
subcutaneous panniculitis-like t-cell lymphoma
  • sptcl
blastic plasmacytoid dendritic cell
  • blastic nk-cell lymphoma
orbit lymphoma
  • lymphoma of the orbit
solitary osseous plasmacytoma
  • isolated osseous plasmacytoma
- elite association - COSMIC cancer census association via MalaCards
Search NCAM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NCAM1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NCAM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCAM1 Gene

Publications for NCAM1 Gene

  1. Molecular and functional analysis of human natural killer cell- associated neural cell adhesion molecule (N-CAM/CD56). (PMID: 1710251) Lanier L.L. … Phillips J.H. (J. Immunol. 1991) 3 4 23 67
  2. Altered NCAM expression associated with the cholinergic system in Alzheimer's disease. (PMID: 20164549) Aisa B. … RamA-rez M.J. (J. Alzheimers Dis. 2010) 3 23
  3. Developmental regulation of neural cell adhesion molecule in human prefrontal cortex. (PMID: 19393299) Cox E.T. … Jarskog L.F. (Neuroscience 2009) 3 23
  4. Universal expression of cell adhesion molecule NCAM in neuroblastoma in contrast to L1: implications for different roles in tumor biology of neuroblastoma? (PMID: 18972120) Wachowiak R. … Till H. (Pediatr. Surg. Int. 2008) 3 23
  5. Clinicopathological correlates of plasma cell CD56 (NCAM) expression in multiple myeloma. (PMID: 18231917) Kraj M. … Szpila T. (Leuk. Lymphoma 2008) 3 23

Products for NCAM1 Gene

Sources for NCAM1 Gene

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