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Aliases for ATF4 Gene

Aliases for ATF4 Gene

  • Activating Transcription Factor 4 2 3 4 5
  • Tax-Responsive Enhancer Element-Binding Protein 67 3 4
  • Cyclic AMP-Responsive Element-Binding Protein 2 3 4
  • CAMP-Responsive Element-Binding Protein 2 3 4
  • CAMP-Dependent Transcription Factor ATF-4 3 4
  • Tax-Responsive Enhancer Element B67 2 3
  • DNA-Binding Protein TAXREB67 3 4
  • TAXREB67 3 4
  • CREB-2 3 4
  • CREB2 3 4
  • TXREB 3 4
  • Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) 2
  • Cyclic AMP-Dependent Transcription Factor ATF-4 3
  • CAMP Response Element-Binding Protein 2 3

External Ids for ATF4 Gene

Previous HGNC Symbols for ATF4 Gene

  • TXREB

Previous GeneCards Identifiers for ATF4 Gene

  • GC22P036531
  • GC22P038158
  • GC22P038159
  • GC22P038241
  • GC22P039916
  • GC22P022881

Summaries for ATF4 Gene

Entrez Gene Summary for ATF4 Gene

  • This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

GeneCards Summary for ATF4 Gene

ATF4 (Activating Transcription Factor 4) is a Protein Coding gene. Diseases associated with ATF4 include Coffin-Lowry Syndrome and Leukoencephalopathy With Vanishing White Matter. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is ATF5.

UniProtKB/Swiss-Prot for ATF4 Gene

  • Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088).

Gene Wiki entry for ATF4 Gene

Additional gene information for ATF4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATF4 Gene

Genomics for ATF4 Gene

GeneHancer (GH) Regulatory Elements for ATF4 Gene

Promoters and enhancers for ATF4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I039518 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 583.9 +4.7 4688 12.3 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 ATF4 ENSG00000272834 ENSG00000230912 RPL3 TAB1 CBY1 SNORD83B ENSG00000228274 CBX6 CBX7
GH22I039530 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 24.6 +12.4 12436 2.7 HDGF FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 RPS19BP1 PIR58856 ATF4 RPL3 TNRC6B ENSG00000228274 GC22P039523 PIR62526
GH22I039500 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 20.2 -17.3 -17260 3.8 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF143 LOC105373035 GC22P039502 GC22P039503 GC22P039504 GC22P039505 GC22P039506 GC22P039507 MIEF1 GC22P039509 ATF4
GH22I039232 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 -280.6 -280563 12.4 HDGF FOXA2 PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A PDGFB TAB1 CBX7 CSNK1E DDX17 ENSG00000230912 FUNDC2P4 CBY1 TNRC6B ATF4
GH22I040175 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 +658.2 658240 5.6 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 TNRC6B EP300 ENSG00000272834 RPL3 SNORD83B ATF4 PIR61047 RPL7P52
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ATF4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ATF4 gene promoter:

Genomic Locations for ATF4 Gene

Genomic Locations for ATF4 Gene
chr22:39,519,695-39,522,686
(GRCh38/hg38)
Size:
2,992 bases
Orientation:
Plus strand
chr22:39,915,700-39,918,691
(GRCh37/hg19)

Genomic View for ATF4 Gene

Genes around ATF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATF4 Gene

Proteins for ATF4 Gene

  • Protein details for ATF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18848-ATF4_HUMAN
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-4
    Protein Accession:
    P18848
    Secondary Accessions:
    • Q96AQ3
    • Q9UH31

    Protein attributes for ATF4 Gene

    Size:
    351 amino acids
    Molecular mass:
    38590 Da
    Quaternary structure:
    • Binds DNA as a homodimer and as a heterodimer (PubMed:11018027). Interacts with CEBPB and binds DNA as a heterodimer with CEBPB (PubMed:11018027). Interacts (via its leucine zipper domain) with GABBR1 and GABBR2 (via their C-termini). Interacts (via its DNA binding domain) with FOXO1 (C-terminal half); the interaction occurs in osteoblasts and regulates glucose homeostasis through suppression of beta-cell proliferation and a decrease in insulin production. Interacts with SATB2; the interaction results in enhanced DNA binding and transactivation by these transcription factors (By similarity). Interacts with CEP290 (via an N-terminal region) (PubMed:16682973). Interacts with NEK6, DAPK2 (isoform 2) and ZIPK/DAPK3 (PubMed:20873783, PubMed:21408167). Forms a heterodimer with TXLNG in osteoblasts (PubMed:15911876). Interacts with DDIT3/CHOP (PubMed:18940792). Interacts with ABRAXAS2 (PubMed:22974638).

    Three dimensional structures from OCA and Proteopedia for ATF4 Gene

neXtProt entry for ATF4 Gene

Post-translational modifications for ATF4 Gene

  • Phosphorylated by NEK6 (By similarity). Phosphorylated on the betaTrCP degron motif at Ser-219, followed by phosphorylation at Thr-213, Ser-224, Ser-231, Ser-235 and Ser-248, promoting interaction with BTRC and ubiquitination. Phosphorylation is promoted by mTORC1 (By similarity).
  • Phosphorylated by NEK6.
  • Ubiquitinated by SCF(BTRC) in response to mTORC1 signal, followed by proteasomal degradation and leading to down-regulate expression of SIRT4.
  • Ubiquitination at Lys329

Other Protein References for ATF4 Gene

No data available for DME Specific Peptides for ATF4 Gene

Domains & Families for ATF4 Gene

Gene Families for ATF4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ATF4 Gene

Graphical View of Domain Structure for InterPro Entry

P18848

UniProtKB/Swiss-Prot:

ATF4_HUMAN :
  • The BetaTrCP degron motif promotes binding to BTRC when phosphorylated.
  • Belongs to the bZIP family.
Domain:
  • The BetaTrCP degron motif promotes binding to BTRC when phosphorylated.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with ATF4: view

Function for ATF4 Gene

Molecular function for ATF4 Gene

GENATLAS Biochemistry:
activation transcription factor 4,cAMP dependent,for a tax responsive enhancer element B67 in the long terminal repeat of human T cell leukemia virus type I
UniProtKB/Swiss-Prot Function:
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088).

Phenotypes From GWAS Catalog for ATF4 Gene

Gene Ontology (GO) - Molecular Function for ATF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA 11478948
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IC 12871976
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ATF4: view
genes like me logo Genes that share phenotypes with ATF4: view

Animal Models for ATF4 Gene

MGI Knock Outs for ATF4:

miRNA for ATF4 Gene

Targeted motifs for ATF4 Gene
HOMER Transcription Factor Regulatory Elements motif ATF4
  • Consensus sequence: MTGATGCAAT Submotif: canonical Cell Type: MEF GEO ID: GSE35681

Clone Products

  • Addgene plasmids for ATF4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for ATF4 Gene

Localization for ATF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF4 Gene

Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Colocalizes with NEK6 at the centrosome (PubMed:20873783). {ECO:0000250 UniProtKB:Q9ES19, ECO:0000269 PubMed:20873783}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATF4 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
plasma membrane 3
endoplasmic reticulum 3
cytosol 3
mitochondrion 2
extracellular 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Microtubule organizing center (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ATF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IDA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm ISS,IDA --
GO:0005813 colocalizes_with centrosome IDA 20873783
genes like me logo Genes that share ontologies with ATF4: view

Pathways & Interactions for ATF4 Gene

genes like me logo Genes that share pathways with ATF4: view

SIGNOR curated interactions for ATF4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ATF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006094 gluconeogenesis ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated ISS --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006366 transcription by RNA polymerase II ISS --
genes like me logo Genes that share ontologies with ATF4: view

Drugs & Compounds for ATF4 Gene

(21) Drugs for ATF4 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pseudoephedrine Approved Pharma Target 666
cyclic amp Experimental Pharma 0

(11) Additional Compounds for ATF4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ATF4: view

Transcripts for ATF4 Gene

Unigene Clusters for ATF4 Gene

Activating transcription factor 4 (tax-responsive enhancer element B67):
Representative Sequences:

Clone Products

  • Addgene plasmids for ATF4

Alternative Splicing Database (ASD) splice patterns (SP) for ATF4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3
SP1: -
SP2:

Relevant External Links for ATF4 Gene

GeneLoc Exon Structure for
ATF4
ECgene alternative splicing isoforms for
ATF4

Expression for ATF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATF4 Gene

This gene is overexpressed in Platelet (66.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATF4 Gene



Protein tissue co-expression partners for ATF4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATF4 Gene:

ATF4

SOURCE GeneReport for Unigene cluster for ATF4 Gene:

Hs.496487

Evidence on tissue expression from TISSUES for ATF4 Gene

  • Intestine(4.9)
  • Lung(4.9)
  • Nervous system(4.9)
  • Liver(4.7)
  • Eye(4.4)
  • Blood(4.3)
  • Kidney(4.3)
  • Pancreas(4.3)
  • Muscle(4.2)
  • Skin(3.9)
  • Stomach(3.6)
  • Bone(3.4)
  • Heart(3.1)
  • Bone marrow(2.9)
  • Adrenal gland(2.6)
  • Gall bladder(2.2)
  • Lymph node(2.1)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with ATF4: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATF4 Gene

Orthologs for ATF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATF4 33 34
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia ATF4 33 34
  • 90.45 (n)
cow
(Bos Taurus)
Mammalia ATF4 33 34
  • 88.05 (n)
mouse
(Mus musculus)
Mammalia Atf4 33 16 34
  • 86.49 (n)
rat
(Rattus norvegicus)
Mammalia Atf4 33
  • 86.46 (n)
oppossum
(Monodelphis domestica)
Mammalia ATF4 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATF4 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATF4 33 34
  • 68.4 (n)
lizard
(Anolis carolinensis)
Reptilia ATF4 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atf4 33
  • 63.8 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68539 33
zebrafish
(Danio rerio)
Actinopterygii atf4b2 33 34
  • 49.2 (n)
atf4b1 34
  • 35 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.832 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2035 34
  • 21 (a)
OneToMany
Species where no ortholog for ATF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATF4 Gene

ENSEMBL:
Gene Tree for ATF4 (if available)
TreeFam:
Gene Tree for ATF4 (if available)

Paralogs for ATF4 Gene

Paralogs for ATF4 Gene

Pseudogenes.org Pseudogenes for ATF4 Gene

genes like me logo Genes that share paralogs with ATF4: view

Variants for ATF4 Gene

Sequence variations from dbSNP and Humsavar for ATF4 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000100497 -- 39,519,789(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001072408 -- 39,521,307(+) C/T 5_prime_UTR_variant, intron_variant
rs1001545052 -- 39,521,413(+) G/A 5_prime_UTR_variant
rs1001677346 -- 39,520,065(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001737141 -- 39,519,994(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ATF4 Gene

Variant ID Type Subtype PubMed ID
nsv3629 CNV insertion 18451855
nsv834199 CNV loss 17160897
nsv964633 CNV duplication 23825009

Variation tolerance for ATF4 Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.54; 88.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATF4 Gene

Human Gene Mutation Database (HGMD)
ATF4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF4 Gene

Disorders for ATF4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ATF4 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ATF4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ATF4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ATF4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATF4 Gene

Publications for ATF4 Gene

  1. Associations of ATF4 gene polymorphisms with schizophrenia in male patients. (PMID: 18163433) Qu M … Zhang D (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 22 44 58
  2. Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder. (PMID: 17346882) Kakiuchi C … Kato T (Neuroscience letters 2007) 3 22 44 58
  3. TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. (PMID: 15775988) Ohoka N … Hayashi H (The EMBO journal 2005) 3 4 22 58
  4. Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA. (PMID: 11018027) Podust LM … Kim Y (The Journal of biological chemistry 2001) 3 4 22 58
  5. Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element. (PMID: 1534408) Karpinski BA … Leiden JM (Proceedings of the National Academy of Sciences of the United States of America 1992) 2 3 4 58

Products for ATF4 Gene

Sources for ATF4 Gene

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