Aliases for NAIP Gene
Aliases for NAIP Gene
External Ids for NAIP Gene
- HGNC: 7634
- Entrez Gene: 4671
- Ensembl: ENSG00000249437
- OMIM: 600355
- UniProtKB: Q13075
Previous HGNC Symbols for NAIP Gene
- BIRC1
Previous GeneCards Identifiers for NAIP Gene
- GC05M070401
- GC05M070301
- GC05M070267
Summaries for NAIP Gene
-
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]
GeneCards Summary for NAIP Gene
NAIP (NLR Family Apoptosis Inhibitory Protein) is a Protein Coding gene. Diseases associated with NAIP include Muscular Atrophy and Spinal Muscular Atrophy. Among its related pathways are Legionellosis and Apoptosis Modulation and Signaling. GO annotations related to this gene include ubiquitin-protein transferase activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is NLRC4.
UniProtKB/Swiss-Prot for NAIP Gene
-
Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at Asp-315 and decreasing the rate of auto proteolysis at Asp-330. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.
-
Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAIP Gene
Genomics for NAIP Gene
Regulatory Elements for NAIP Gene
Enhancers for NAIP Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH05G071481 | 0.8 | ENCODE | 4.6 | -458.1 | -458113 | 2.8 | ELF3 FOXA2 NFIB RARA RFX5 GATA2 ZSCAN5C FOS ZNF362 CEBPB | MCCC2 NAIP LOC100419852 HMGN1P12 |
| GH05G071025 | 0.2 | Ensembl | 0.7 | -0.7 | -687 | 0.4 | NAIP GTF2H2 | |
| GH05G071030 | 0.2 | Ensembl | 0.4 | -6.4 | -6387 | 1.8 | SERF1A NAIP GTF2H2 | |
| GH05G071017 | 0.2 | Ensembl | 0.4 | +5.7 | 5714 | 4.8 | NAIP SMN1 | |
| GH05G071002 | 0.2 | Ensembl | 0.3 | +21.8 | 21814 | 1.0 | NAIP SMN1 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around NAIP on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for NAIP Gene
- Chromosome:
- 5
- Start:
- 70,968,483 bp from pter
- End:
- 71,025,114 bp from pter
- Size:
- 56,632 bases
- Orientation:
- Minus strand
Genomic View for NAIP Gene
Genes around NAIP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q13.2 by Ensembl
- 5q13.2 by Entrez Gene
- 5q13.2 by HGNC
NAIP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NAIP Gene
Proteins for NAIP Gene
-
Protein details for NAIP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13075-BIRC1_HUMAN
- Recommended name:
- Baculoviral IAP repeat-containing protein 1
- Protein Accession:
- Q13075
- B9EG72
- E9PHD1
- O75857
- Q13730
- Q59GI6
- Q8TDZ4
- Q99796
Protein attributes for NAIP Gene
- Size:
- 1403 amino acids
- Molecular mass:
- 159582 Da
- Quaternary structure:
-
- Interacts (via NACHT domain) with APAF1 (via CARD and NACHT domains). Interacts with C.violaceum needle protein CprI.
- SequenceCaution:
-
- Sequence=AAC62261.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for NAIP Gene
Post-translational modifications for NAIP Gene
Other Protein References for NAIP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for NAIP
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-
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- antibodies-online Antibodies for NAIP: See all 54
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-
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Protein Products
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-
Cloud-Clone Corp. Proteins for NAIP
- antibodies-online Proteins for NAIP: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for NAIP
No data available for DME Specific Peptides for NAIP Gene
Domains & Families for NAIP Gene
Gene Families for NAIP Gene
- HGNC:
- IUPHAR :
Protein Domains for NAIP Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NAIP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13075UniProtKB/Swiss-Prot:
BIRC1_HUMAN :- Both the BIR and NACHT domains are essential for effective inhibition of pro-CASP9 cleavage. BIR3 domain binds to procaspase-9 and the NACHT domain interacts with the NACHT domain of APAF1 forming a bridge between pro-CASP9 and APAF1.
- Domain:
-
- Both the BIR and NACHT domains are essential for effective inhibition of pro-CASP9 cleavage. BIR3 domain binds to procaspase-9 and the NACHT domain interacts with the NACHT domain of APAF1 forming a bridge between pro-CASP9 and APAF1.
Function for NAIP Gene
Molecular function for NAIP Gene
- UniProtKB/Swiss-Prot Function:
- Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at Asp-315 and decreasing the rate of auto proteolysis at Asp-330. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.
- UniProtKB/Swiss-Prot Function:
- Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | IBA | -- |
| GO:0004869 | cysteine-type endopeptidase inhibitor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 21371431 |
| GO:0005524 | ATP binding | IMP | 21371431 |
| GO:0030414 | peptidase inhibitor activity | IEA | -- |
Phenotypes for NAIP Gene
- GenomeRNAi human phenotypes for NAIP:
Animal Model Products
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-
-
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miRNA for NAIP Gene
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-
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
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Horizon Cell Lines for NAIP
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAIP Gene
Localization for NAIP Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 4 |
| nucleus | 4 |
| cytosol | 3 |
| mitochondrion | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
| GO:0005737 | cytoplasm | ISS,IBA | -- |
| GO:0016323 | basolateral plasma membrane | ISS | -- |
| GO:0043005 | neuron projection | IEA | -- |
| GO:0043025 | neuronal cell body | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for NAIP Gene
Pathways & Interactions for NAIP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Toll-Like receptor Signaling Pathways | ||
| 2 | Apoptosis Modulation and Signaling | ||
| 3 | Legionellosis | ||
| 4 | Nucleotide-binding Oligomerization Domain (NOD) pathway | ||
Pathways by source for NAIP Gene
2 BioSystems pathways for NAIP Gene
2 KEGG pathways for NAIP Gene
2 R&D Systems pathways for NAIP Gene
Interacting Proteins for NAIP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0006954 | inflammatory response | IEA | -- |
| GO:0007399 | nervous system development | TAS | 7813013 |
| GO:0010466 | negative regulation of peptidase activity | IEA | -- |
Drugs & Compounds for NAIP Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| AEG40826 | Pharma | Antagonist | Inhibitor of apoptosis proteins (IAPS) antagonist | 0 | ||
| GDC0917 | Pharma | Antagonist | Inhibitor of apoptosis proteins (IAPS) antagonist | 0 | ||
| LCL161 | Pharma | Antagonist | Antagonist of IAPs inhibitor, Inhibitor of apoptosis proteins (IAPS) antagonist | 0 | ||
| TL 32711 | Pharma | Antagonist | Inhibitor of apoptosis proteins (IAPS) antagonist | 0 |
Transcripts for NAIP Gene
mRNA/cDNA for NAIP Gene
- (5) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (8) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NAIP Gene
CRISPR Products
-
OriGene CRISPR knockouts for NAIP
-
Santa Cruz Biotechnology (SCBT) CRISPR for NAIP
- GenScript: Design CRISPR guide RNA sequences for NAIP
miRNA Products
- Search ViGene Biosciences for NAIP
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for NAIP
- Browse OriGene Inhibitory RNA Products For NAIP
-
ViGene Biosciences ready-to-package AAV shRNAs for NAIP gene
Clone Products
-
GenScript: Next-day shipping cDNA ORF clone for NAIP in any vector
- XM_011547349
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- XM_005248524
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- NM_022892
- NM_004536
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NAIP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NAIP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for NAIP Gene
mRNA differential expression in normal tissues according to GTEx for NAIP Gene
This gene is overexpressed in Whole Blood (x21.0).
This gene is overexpressed in Heart (19.2), Monocytes (18.9), Lymph node (10.1), Peripheral blood mononuclear cells (8.7), and Blymphocyte (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NAIP Gene
NURSA nuclear receptor signaling pathways regulating expression of NAIP Gene:
NAIPSOURCE GeneReport for Unigene cluster for NAIP Gene:
Hs.654500mRNA Expression by UniProt/SwissProt for NAIP Gene:
Q13075-BIRC1_HUMAN
Tissue specificity:
Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to a lesser extent in spinal cord.
Evidence on tissue expression from TISSUES for NAIP Gene
- Nervous system(4.5)
- Blood(4.2)
- Liver(4.2)
- Spleen(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for NAIP Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- nervous
- respiratory
- skeletal muscle
Organs:
Head and neck:
- brain
- cerebellum
- ear
- head
- mouth
- tongue
Thorax:
- heart
- heart valve
- lung
Limb:
- lower limb
- upper limb
General:
- blood vessel
- peripheral nerve
- peripheral nervous system
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for NAIP
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NAIP Gene
Orthologs for NAIP Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NAIP 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | NAIP 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Naip2 34 16 35 |
|
||
| Naip1 35 |
|
OneToMany | |||
| Naip5 35 |
|
OneToMany | |||
| Naip6 35 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | NAIP 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100490991 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Iap2 35 |
|
ManyToMany | |
| th 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany |
- Species where no ortholog for NAIP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for NAIP Gene
(8) SIMAP similar genes for NAIP Gene using alignment to 5 proteins:
Pseudogenes.org Pseudogenes for NAIP Gene
Variants for NAIP Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000971094 | -- | 69,601,849(+) | GGTTT(A/C)TTGGG | upstream-variant-2KB | |
| rs1001920962 | -- | 69,610,783(+) | GGAGG(A/G)TCACT | intron-variant | |
| rs1002015714 | -- | 69,605,286(+) | ACATT(C/G)CTTTC | intron-variant | |
| rs1008257867 | -- | 69,612,013(+) | TGGGT(C/T)CAAGC | intron-variant | |
| rs1013251127 | -- | 69,603,393(+) | CCTTT(C/T)TCTTT | intron-variant, upstream-variant-2KB |
Gene Damage Index Score:
1.67;
31.89% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for NAIP Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAIP Gene
Disorders for NAIP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| muscular atrophy |
|
|
| spinal muscular atrophy |
|
|
| spinal muscular atrophy-1 |
|
|
| spinal muscular atrophy-2 |
|
|
| spinal muscular atrophy-3 |
|
Search NAIP in MalaCards
View complete list of genes associated with diseases
Relevant External Links for NAIP
No data available for UniProtKB/Swiss-Prot and Genatlas for NAIP Gene
Publications for NAIP Gene
- The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. (PMID: 7813013) Roy N. … Mackenzie A. (Cell 1995) 2 3 4 22 64
- Structures of BIR domains from human NAIP and cIAP2. (PMID: 19923725) Herman M.D. … Nyman T. (Acta Crystallogr. F 2009) 3 4 22 64
- Combination of SMN2 copy number and NAIP deletion predicts disease severity in spinal muscular atrophy. (PMID: 18842367) Watihayati M.S. … Zilfalil B.A. (Brain Dev. 2009) 3 22 46 64
- Deletion analysis of SMN1 and NAIP genes in Southern Chinese children with spinal muscular atrophy. (PMID: 19198020) Liang Y.H. … Zhang X.N. (J Zhejiang Univ Sci B 2009) 3 22 46 64
- Phenotype modifiers of spinal muscular atrophy: the number of SMN2 gene copies, deletion in the NAIP gene and probably gender influence the course of the disease. (PMID: 19287802) Jedrzejowska M. … Hausmanowa-Petrusewicz I. (Acta Biochim. Pol. 2009) 3 22 46 64
Products for NAIP Gene
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- Cloud-Clone Corp. Proteins for NAIP
- Cloud-Clone Corp Assay Kits for NAIP
- antibodies-online Antibodies for NAIP: See all 54
- antibodies-online Kits for NAIP: See all 25
- antibodies-online Proteins for NAIP: See all 5
- Search antibodies-online for peptides
- GeneTex NAIP antibody for NAIP
- Search GeneTex for Proteins for NAIP
- ViGene Biosciences adenoviral particle packaged cDNA for NAIP gene
- ViGene Biosciences lentiviral particle packaged cDNA for NAIP gene
- ViGene Biosciences ready-to-package AAV shRNAs for NAIP gene
- Search ViGene Biosciences for NAIP
- Custom Antibody ServicesProSci Antibodies for NAIP
- Search for NAIP Proteins at ProSci
- Horizon Cell Lines for NAIP
- Cyagen custom Knockout/knockin (KOKI) mouse models for NAIP
- VectorBuilder custom plasmid, inducible vectors for NAIP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NAIP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for NAIP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer