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NAIP Gene(Protein Coding)

NLR Family Apoptosis Inhibitory Protein

GCID:
GC05M070968
GIFtS:
50
Genes Participants
UDN Logo

Aliases for NAIP Gene

Aliases for NAIP Gene

  • NLR Family Apoptosis Inhibitory Protein 2 3 5
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And BIR Domain Containing 1 2 3
  • Neuronal Apoptosis Inhibitory Protein 3 4
  • BIRC1 3 4
  • Baculoviral IAP Repeat-Containing Protein 1 3
  • Psi Neuronal Apoptosis Inhibitory Protein 3
  • NLR Family, BIR Domain Containing 1 2
  • Baculoviral IAP Repeat-Containing 1 2
  • PsiNAIP 3
  • NLRB1 3

External Ids for NAIP Gene

Previous HGNC Symbols for NAIP Gene

  • BIRC1

Previous GeneCards Identifiers for NAIP Gene

  • GC05M070401
  • GC05M070301
  • GC05M070267

Summaries for NAIP Gene

Entrez Gene Summary for NAIP Gene

  • This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]

GeneCards Summary for NAIP Gene

NAIP (NLR Family Apoptosis Inhibitory Protein) is a Protein Coding gene. Diseases associated with NAIP include Spinal Muscular Atrophy, Type I and Spinal Muscular Atrophy. Among its related pathways are Apoptosis Modulation and Signaling and Toll-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is NLRC4.

UniProtKB/Swiss-Prot for NAIP Gene

  • Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at Asp-315 and decreasing the rate of auto proteolysis at Asp-330. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.

  • Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.

Gene Wiki entry for NAIP Gene

Additional gene information for NAIP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAIP Gene

Genomics for NAIP Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for NAIP Gene

Promoters and enhancers for NAIP Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH05I071025 Enhancer 0.2 Ensembl 550.8 -0.7 -686 0.4 NAIP GTF2H2
GH05I071481 Enhancer 0.8 ENCODE 4.6 -458.1 -458112 2.8 ELF3 FOXA2 NFIB RARA RFX5 ZSCAN5C FOS ZNF362 CEBPB SP1 MCCC2 BDP1 LOC653080 GUSBP9 SMN1 MRPS27 NAIP LOC100419852 HMGN1P12
GH05I071066 Promoter 1 EPDnew Ensembl 0.3 -42.5 -42486 1.6 GTF2H2 NAIP
GH05I070924 Promoter 1.2 EPDnew Ensembl 0.2 +99.7 99713 2 ZSCAN4 ZNF407 MLLT1 SMN1 NAIP
GH05I071063 Promoter 0.5 EPDnew 0.3 -38.0 -38004 0.1 GTF2H2 NAIP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NAIP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NAIP gene promoter:

Genomic Locations for NAIP Gene

Genomic Locations for NAIP Gene
chr5:70,968,483-71,025,114
(GRCh38/hg38)
Size:
56,632 bases
Orientation:
Minus strand
chr5:70,264,310-70,320,941
(GRCh37/hg19)

Genomic View for NAIP Gene

Genes around NAIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAIP Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NAIP Gene

Proteins for NAIP Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NAIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13075-BIRC1_HUMAN
    Recommended name:
    Baculoviral IAP repeat-containing protein 1
    Protein Accession:
    Q13075
    Secondary Accessions:
    • B9EG72
    • E9PHD1
    • O75857
    • Q13730
    • Q59GI6
    • Q8TDZ4
    • Q99796

    Protein attributes for NAIP Gene

    Size:
    1403 amino acids
    Molecular mass:
    159582 Da
    Quaternary structure:
    • Interacts (via NACHT domain) with APAF1 (via CARD and NACHT domains). Interacts with C.violaceum needle protein CprI.
    SequenceCaution:
    • Sequence=AAC62261.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NAIP Gene

    Alternative splice isoforms for NAIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAIP Gene

Protein Expression for NAIP Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NAIP Gene

No Post-translational modifications

Other Protein References for NAIP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAIP Gene

Domains & Families for NAIP Gene

Gene Families for NAIP Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for NAIP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NAIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13075

UniProtKB/Swiss-Prot:

BIRC1_HUMAN :
  • Both the BIR and NACHT domains are essential for effective inhibition of pro-CASP9 cleavage. BIR3 domain binds to procaspase-9 and the NACHT domain interacts with the NACHT domain of APAF1 forming a bridge between pro-CASP9 and APAF1.
Domain:
  • Both the BIR and NACHT domains are essential for effective inhibition of pro-CASP9 cleavage. BIR3 domain binds to procaspase-9 and the NACHT domain interacts with the NACHT domain of APAF1 forming a bridge between pro-CASP9 and APAF1.
genes like me logo Genes that share domains with NAIP: view

Function for NAIP Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for NAIP Gene

UniProtKB/Swiss-Prot Function:
Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at Asp-315 and decreasing the rate of auto proteolysis at Asp-330. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.
UniProtKB/Swiss-Prot Function:
Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.

Gene Ontology (GO) - Molecular Function for NAIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 21371431
GO:0005524 ATP binding IMP 21371431
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with NAIP: view
genes like me logo Genes that share phenotypes with NAIP: view

miRNA for NAIP Gene

miRTarBase miRNAs that target NAIP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAIP Gene

Localization for NAIP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAIP gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 4
cytosol 3
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NAIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA,ISS --
GO:0016323 basolateral plasma membrane ISS --
GO:0043005 neuron projection IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with NAIP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for NAIP Gene

Pathways & Interactions for NAIP Gene

genes like me logo Genes that share pathways with NAIP: view

Pathways by source for NAIP Gene

2 KEGG pathways for NAIP Gene

SIGNOR curated interactions for NAIP Gene

Inactivates:

Gene Ontology (GO) - Biological Process for NAIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response IEA --
GO:0007399 nervous system development TAS 7813013
GO:0010466 negative regulation of peptidase activity IEA --
genes like me logo Genes that share ontologies with NAIP: view

Drugs & Compounds for NAIP Gene

Products:

  1. Drug

(8) Drugs for NAIP Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AEG40826 Pharma Antagonist Inhibitor of apoptosis proteins (IAPS) antagonist 0
GDC0917 Pharma Antagonist Inhibitor of apoptosis proteins (IAPS) antagonist 0
LCL161 Pharma Antagonist Antagonist of IAPs inhibitor, Inhibitor of apoptosis proteins (IAPS) antagonist 0
TL 32711 Pharma Antagonist Inhibitor of apoptosis proteins (IAPS) antagonist 0
genes like me logo Genes that share compounds with NAIP: view

Transcripts for NAIP Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NAIP Gene

(5) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NAIP Gene

NLR family, apoptosis inhibitory protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAIP Gene

No ASD Table

Relevant External Links for NAIP Gene

GeneLoc Exon Structure for
NAIP
ECgene alternative splicing isoforms for
NAIP

Expression for NAIP Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAIP Gene

mRNA expression in normal human tissues for NAIP Gene
mRNA expression by BioGPS for NAIP GenemRNA expression by GTEx for NAIP Gene

mRNA differential expression in normal tissues according to GTEx for NAIP Gene

This gene is overexpressed in Whole Blood (x21.0).

Protein differential expression in normal tissues from HIPED for NAIP Gene

This gene is overexpressed in Heart (19.2), Monocytes (18.9), Lymph node (10.1), Peripheral blood mononuclear cells (8.7), and Blymphocyte (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NAIP Gene



Protein tissue co-expression partners for NAIP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAIP Gene:

NAIP

SOURCE GeneReport for Unigene cluster for NAIP Gene:

Hs.654500

mRNA Expression by UniProt/SwissProt for NAIP Gene:

Q13075-BIRC1_HUMAN
Tissue specificity: Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to a lesser extent in spinal cord.

Evidence on tissue expression from TISSUES for NAIP Gene

  • Nervous system(4.5)
  • Blood(4.2)
  • Liver(4.2)
  • Spleen(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NAIP Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • nervous
  • respiratory
  • skeletal muscle
Organs:
Head and neck:
  • brain
  • cerebellum
  • ear
  • head
  • mouth
  • tongue
Thorax:
  • heart
  • heart valve
  • lung
Limb:
  • lower limb
  • upper limb
General:
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • spinal cord
genes like me logo Genes that share expression patterns with NAIP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NAIP Gene

Orthologs for NAIP Gene

This gene was present in the common ancestor of animals.

Orthologs for NAIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia NAIP 34 33
  • 99.19 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia NAIP 33 34
  • 81.18 (n)
mouse
(Mus musculus)
 Mammalia Naip2 34 16 33
  • 76.84 (n)
 OneToMany
Naip1 34
  • 68 (a)
 OneToMany
Naip5 34
  • 67 (a)
 OneToMany
Naip6 34
  • 66 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia NAIP 34
  • 44 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100490991 33
  • 52.86 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Iap2 34
  • 20 (a)
 ManyToMany
th 34
  • 20 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 23 (a)
 ManyToMany
-- 34
  • 22 (a)
 ManyToMany
-- 34
  • 20 (a)
 ManyToMany
-- 34
  • 19 (a)
 ManyToMany
-- 34
  • 18 (a)
 ManyToMany
-- 34
  • 14 (a)
 ManyToMany
-- 34
  • 13 (a)
 ManyToMany
-- 34
  • 11 (a)
 ManyToMany
Species where no ortholog for NAIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NAIP Gene

ENSEMBL:
Gene Tree for NAIP (if available)
TreeFam:
Gene Tree for NAIP (if available)

Paralogs for NAIP Gene

Paralogs for NAIP Gene

(8) SIMAP similar genes for NAIP Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for NAIP Gene

genes like me logo Genes that share paralogs with NAIP: view

Variants for NAIP Gene

Sequence variations from dbSNP and Humsavar for NAIP Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000028176 -- 71,010,889(-) T/A genic_upstream_transcript_variant, intron_variant
rs1000318405 -- 70,997,565(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000384897 -- 71,017,469(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000417888 -- 71,016,152(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000751547 -- 70,989,256(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NAIP Gene

Variant ID Type Subtype PubMed ID
dgv1106e214 CNV gain 21293372
dgv134e203 CNV gain+loss 21179565
dgv19n31 CNV gain 19718026
dgv27n14 CNV loss 18776910
dgv3323e59 CNV duplication 20981092
dgv5695n100 CNV gain 25217958
dgv5696n100 CNV loss 25217958
dgv5697n100 CNV gain+loss 25217958
dgv7e224 CNV loss 25118596
dgv9838n54 CNV loss 21841781
dgv9845n54 CNV loss 21841781
dgv9857n54 CNV loss 21841781
dgv9859n54 CNV gain 21841781
dgv9860n54 CNV gain 21841781
dgv9861n54 CNV gain 21841781
dgv9862n54 CNV loss 21841781
dgv9863n54 CNV gain 21841781
dgv9864n54 CNV loss 21841781
dgv9865n54 CNV loss 21841781
dgv9866n54 CNV gain 21841781
dgv9867n54 CNV gain 21841781
dgv9868n54 CNV gain 21841781
dgv9869n54 CNV loss 21841781
dgv9870n54 CNV loss 21841781
dgv9871n54 CNV loss 21841781
dgv9872n54 CNV loss 21841781
dgv9876n54 CNV loss 21841781
esv1011240 CNV gain 20482838
esv22113 CNV gain+loss 19812545
esv2590135 CNV gain 19546169
esv2673843 CNV deletion 23128226
esv2759348 CNV gain+loss 17122850
esv32787 CNV gain+loss 17666407
esv3349626 CNV duplication 20981092
esv3379231 CNV duplication 20981092
esv3380146 CNV duplication 20981092
esv3380184 CNV duplication 20981092
esv3570183 CNV loss 25503493
esv3605385 CNV loss 21293372
esv3605386 CNV loss 21293372
esv3890644 CNV gain+loss 25118596
esv3890645 CNV loss 25118596
esv3890647 CNV loss 25118596
esv3890650 CNV loss 25118596
esv3890652 CNV loss 25118596
esv3890655 CNV gain 25118596
esv3890656 CNV loss 25118596
nsv1033366 CNV gain 25217958
nsv1034703 CNV gain 25217958
nsv10707 CNV gain+loss 18304495
nsv1074306 CNV deletion 25765185
nsv1119034 CNV deletion 24896259
nsv428117 CNV gain+loss 18775914
nsv433373 CNV gain 18776910
nsv469668 CNV gain 16826518
nsv471434 CNV gain 19718026
nsv4870 CNV insertion 18451855
nsv511106 OTHER inversion 20534489
nsv511107 OTHER complex 20534489
nsv511278 CNV gain 21212237
nsv511290 CNV gain 21212237
nsv598462 CNV gain 21841781
nsv598533 CNV loss 21841781
nsv598536 CNV gain 21841781
nsv598543 CNV loss 21841781
nsv598545 CNV loss 21841781
nsv598560 CNV loss 21841781
nsv598561 CNV loss 21841781
nsv598573 CNV loss 21841781
nsv598578 CNV loss 21841781
nsv598583 CNV loss 21841781
nsv598584 CNV gain 21841781
nsv598587 CNV gain+loss 21841781
nsv598637 CNV loss 21841781
nsv7371 OTHER inversion 18451855
nsv821643 CNV loss 15273396
nsv823094 CNV loss 20364138
nsv823095 CNV gain 20364138
nsv823096 CNV gain+loss 20364138
nsv830339 CNV gain 17160897
nsv964885 CNV duplication 23825009
nsv964886 CNV duplication 23825009
nsv964887 CNV duplication 23825009
nsv980677 CNV duplication 23825009

Variation tolerance for NAIP Gene

Gene Damage Index Score: 1.67; 31.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAIP Gene

Human Gene Mutation Database (HGMD)
NAIP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAIP Gene

Disorders for NAIP Gene

MalaCards: The human disease database

(16) MalaCards diseases for NAIP Gene - From: HGMD, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NAIP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NAIP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NAIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAIP Gene

Publications for NAIP Gene

  1. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. (PMID: 7813013) Roy N … Kang X (Cell 1995) 2 3 4 22 58
  2. Combination of SMN2 copy number and NAIP deletion predicts disease severity in spinal muscular atrophy. (PMID: 18842367) Watihayati MS … Zilfalil BA (Brain & development 2009) 3 22 44 58
  3. Deletion analysis of SMN1 and NAIP genes in Southern Chinese children with spinal muscular atrophy. (PMID: 19198020) Liang YH … Zhang XN (Journal of Zhejiang University. Science. B 2009) 3 22 44 58
  4. Phenotype modifiers of spinal muscular atrophy: the number of SMN2 gene copies, deletion in the NAIP gene and probably gender influence the course of the disease. (PMID: 19287802) Jedrzejowska M … Hausmanowa-Petrusewicz I (Acta biochimica Polonica 2009) 3 22 44 58
  5. Structures of BIR domains from human NAIP and cIAP2. (PMID: 19923725) Herman MD … Nyman T (Acta crystallographica. Section F, Structural biology and crystallization communications 2009) 3 4 22 58

Products for NAIP Gene

Sources for NAIP Gene

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