Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NAIP Gene

Aliases for NAIP Gene

  • NLR Family, Apoptosis Inhibitory Protein 2 3
  • Neuronal Apoptosis Inhibitory Protein 3 4
  • BIRC1 3 4
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And BIR Domain Containing 1 3
  • Leucine Rich Repeat And BIR Domain Containing 1 2
  • Baculoviral IAP Repeat-Containing Protein 1 3
  • Nucleotide-Binding Oligomerization Domain 2
  • Psi Neuronal Apoptosis Inhibitory Protein 3
  • Baculoviral IAP Repeat-Containing 1 2
  • BIR Domain Containing 1 2
  • NLR Family 2
  • PsiNAIP 3
  • BIRC1, 6
  • NLRB1 3

External Ids for NAIP Gene

Previous HGNC Symbols for NAIP Gene

  • BIRC1

Previous GeneCards Identifiers for NAIP Gene

  • GC05M070401
  • GC05M070301
  • GC05M070267

Summaries for NAIP Gene

Entrez Gene Summary for NAIP Gene

  • This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NAIP Gene

NAIP (NLR Family, Apoptosis Inhibitory Protein) is a Protein Coding gene. Diseases associated with NAIP include juvenile spinal muscular atrophy and spinal muscular atrophy-2. Among its related pathways are Legionellosis and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. GO annotations related to this gene include nucleoside-triphosphatase activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is XIAP.

UniProtKB/Swiss-Prot for NAIP Gene

  • Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at Asp-315 and decreasing the rate of auto proteolysis at Asp-330. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy

  • Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila

Gene Wiki entry for NAIP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAIP Gene

Genomics for NAIP Gene

Regulatory Elements for NAIP Gene

Genomic Location for NAIP Gene

Start:
70,968,483 bp from pter
End:
71,025,114 bp from pter
Size:
56,632 bases
Orientation:
Minus strand

Genomic View for NAIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAIP Gene

Proteins for NAIP Gene

  • Protein details for NAIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13075-BIRC1_HUMAN
    Recommended name:
    Baculoviral IAP repeat-containing protein 1
    Protein Accession:
    Q13075
    Secondary Accessions:
    • B9EG72
    • E9PHD1
    • O75857
    • Q13730
    • Q59GI6
    • Q8TDZ4
    • Q99796

    Protein attributes for NAIP Gene

    Size:
    1403 amino acids
    Molecular mass:
    159582 Da
    Quaternary structure:
    • Interacts (via NACHT domain) with APAF1 (via CARD and NACHT domains). Interacts with C.violaceum needle protein CprI.
    SequenceCaution:
    • Sequence=AAC62261.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NAIP Gene

    Alternative splice isoforms for NAIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAIP Gene

Proteomics data for NAIP Gene at MOPED

Post-translational modifications for NAIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAIP Gene

Domains for NAIP Gene

Gene Families for NAIP Gene

HGNC:
  • BIRC :Baculoviral IAP repeat containing
  • NLR :Nucleotide-binding domain and leucine rich repeat containing
IUPHAR :

Suggested Antigen Peptide Sequences for NAIP Gene

Graphical View of Domain Structure for InterPro Entry

Q13075

UniProtKB/Swiss-Prot:

BIRC1_HUMAN :
  • Q13075
Domain:
  • Both the BIR and NACHT domains are essential for effective inhibition of pro-CASP9 cleavage. BIR3 domain binds to procaspase-9 and the NACHT domain interacts with the NACHT domain of APAF1 forming a bridge between pro-CASP9 and APAF1.
  • Contains 1 NACHT domain.
Similarity:
  • Contains 3 BIR repeats.
genes like me logo Genes that share domains with NAIP: view

Function for NAIP Gene

Molecular function for NAIP Gene

UniProtKB/Swiss-Prot Function: Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at Asp-315 and decreasing the rate of auto proteolysis at Asp-330. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy
UniProtKB/Swiss-Prot Function: Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila

Gene Ontology (GO) - Molecular Function for NAIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding IPI 21371431
GO:0005524 ATP binding IMP 21371431
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NAIP: view

Phenotypes for NAIP Gene

genes like me logo Genes that share phenotypes with NAIP: view

Animal Models for NAIP Gene

MGI Knock Outs for NAIP:

Animal Model Products

CRISPR Products

miRNA for NAIP Gene

miRTarBase miRNAs that target NAIP

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NAIP Gene

Localization for NAIP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAIP Gene COMPARTMENTS Subcellular localization image for NAIP gene
Compartment Confidence
plasma membrane 4
cytosol 2
nucleus 2
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NAIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm ISS --
GO:0005876 NOT spindle microtubule IBA --
GO:0016323 basolateral plasma membrane ISS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NAIP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NAIP Gene

Pathways for NAIP Gene

genes like me logo Genes that share pathways with NAIP: view

Pathways by source for NAIP Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NAIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0007399 nervous system development TAS 7813013
GO:0009966 regulation of signal transduction IBA --
GO:0016567 protein ubiquitination IBA --
GO:0043066 negative regulation of apoptotic process ISS --
genes like me logo Genes that share ontologies with NAIP: view

Compounds for NAIP Gene

(4) Novoseek inferred chemical compound relationships for NAIP Gene

Compound -log(P) Hits PubMed IDs
peptidoglycan 23.5 1
cisplatin 20.1 3
calcium 0 5
cysteine 0 1
genes like me logo Genes that share compounds with NAIP: view

Transcripts for NAIP Gene

mRNA/cDNA for NAIP Gene

Unigene Clusters for NAIP Gene

NLR family, apoptosis inhibitory protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAIP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NAIP
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAIP Gene

No ASD Table

Relevant External Links for NAIP Gene

GeneLoc Exon Structure for
NAIP
ECgene alternative splicing isoforms for
NAIP

Expression for NAIP Gene

mRNA expression in normal human tissues for NAIP Gene

mRNA differential expression in normal tissues according to GTEx for NAIP Gene

This gene is overexpressed in Whole Blood (21.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NAIP Gene

SOURCE GeneReport for Unigene cluster for NAIP Gene Hs.654500

mRNA Expression by UniProt/SwissProt for NAIP Gene

Q13075-BIRC1_HUMAN
Tissue specificity: Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to a lesser extent in spinal cord
genes like me logo Genes that share expressions with NAIP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NAIP Gene

Orthologs for NAIP Gene

This gene was present in the common ancestor of animals.

Orthologs for NAIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAIP 35
  • 99.19 (n)
  • 98.57 (a)
NAIP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAIP 35
  • 81.18 (n)
  • 71.98 (a)
NAIP 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Naip1 16
Naip1 36
  • 68 (a)
OneToMany
Naip2 35
  • 76.84 (n)
  • 67.36 (a)
Naip2 36
  • 65 (a)
OneToMany
Naip5 36
  • 67 (a)
OneToMany
Naip6 36
  • 66 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia NAIP 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490991 35
  • 52.86 (n)
  • 40.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta Iap2 36
  • 20 (a)
ManyToMany
th 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 14 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 13 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
-- 36
  • 11 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 18 (a)
ManyToMany
Species with no ortholog for NAIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NAIP Gene

ENSEMBL:
Gene Tree for NAIP (if available)
TreeFam:
Gene Tree for NAIP (if available)

Paralogs for NAIP Gene

Paralogs for NAIP Gene

Selected SIMAP similar genes for NAIP Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for NAIP Gene

genes like me logo Genes that share paralogs with NAIP: view

Variants for NAIP Gene

Sequence variations from dbSNP and Humsavar for NAIP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs150290 -- 70,978,659(-) ACTAC(A/G)GATTA intron-variant
rs150441 -- 70,978,829(+) GGAAC(A/G)AGAGC intron-variant
rs150442 -- 70,977,867(-) atggg(C/T)gcctg intron-variant
rs154426 -- 71,002,318(+) gtact(A/G)ctcgg intron-variant
rs207719 -- 70,994,764(-) tggga(A/T)tacag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAIP Gene

Variant ID Type Subtype PubMed ID
nsv821643 CNV Loss 15273396
nsv881768 CNV Loss 21882294
nsv428117 CNV Gain+Loss 18775914
dgv6086n71 CNV Gain 21882294
nsv10707 CNV Gain+Loss 18304495
esv22113 CNV Gain+Loss 19812545
dgv1805e1 CNV Complex 17122850
dgv1806e1 CNV Complex 17122850
esv32787 CNV Gain+Loss 17666407
dgv1807e1 CNV Complex 17122850
nsv511106 OTHER Inversion 20534489
nsv7371 OTHER Inversion 18451855
dgv6132n71 CNV Loss 21882294
nsv881986 CNV Gain 21882294
dgv6135n71 CNV Loss 21882294
nsv882003 CNV Gain 21882294
dgv6136n71 CNV Loss 21882294
nsv882006 CNV Gain 21882294
dgv6137n71 CNV Loss 21882294
dgv1808e1 CNV Complex 17122850
dgv6139n71 CNV Loss 21882294
dgv6140n71 CNV Gain+Loss 21882294
dgv6141n71 CNV Gain 21882294
dgv6142n71 CNV Gain 21882294
nsv882034 CNV Loss 21882294
dgv6143n71 CNV Gain+Loss 21882294
dgv6144n71 CNV Loss 21882294
dgv6145n71 CNV Loss 21882294
nsv469668 CNV Gain 16826518
dgv6146n71 CNV Gain+Loss 21882294
dgv6147n71 CNV Gain 21882294
dgv6148n71 CNV Loss 21882294
dgv6149n71 CNV Loss 21882294
dgv6150n71 CNV Loss 21882294
nsv882064 CNV Gain+Loss 21882294
dgv6151n71 CNV Loss 21882294
dgv6152n71 CNV Loss 21882294
dgv6153n71 CNV Gain 21882294
nsv830339 CNV Gain 17160897
esv2590135 CNV Gain 19546169
dgv19n31 CNV Duplication 19718026
nsv882084 CNV Gain+Loss 21882294
dgv6154n71 CNV Loss 21882294
dgv6155n71 CNV Gain+Loss 21882294
dgv6156n71 CNV Gain+Loss 21882294
dgv6157n71 CNV Gain+Loss 21882294
dgv1809e1 CNV Complex 17122850
dgv1810e1 CNV Complex 17122850
dgv6158n71 CNV Loss 21882294
nsv882104 CNV Gain 21882294
dgv6159n71 CNV Gain 21882294
dgv6160n71 CNV Gain 21882294
nsv882112 CNV Gain 21882294
nsv882114 CNV Gain+Loss 21882294
nsv882115 CNV Loss 21882294
dgv6161n71 CNV Gain+Loss 21882294
nsv882118 CNV Loss 21882294
dgv6162n71 CNV Loss 21882294
nsv471434 CNV Duplication 19718026
dgv6163n71 CNV Loss 21882294
dgv6164n71 CNV Gain 21882294
dgv27n14 CNV Loss 18776910
dgv6165n71 CNV Gain+Loss 21882294
nsv882135 CNV Gain 21882294
dgv6166n71 CNV Loss 21882294
nsv433373 CNV Gain 18776910
esv2673843 CNV Deletion 23128226
dgv6167n71 CNV Gain+Loss 21882294
esv1011240 CNV Gain 20482838
nsv823094 CNV Loss 20364138
nsv823095 CNV Gain 20364138
nsv823096 CNV Gain+Loss 20364138
nsv511290 CNV Gain 21212237

Relevant External Links for NAIP Gene

HapMap Linkage Disequilibrium report
NAIP
Human Gene Mutation Database (HGMD)
NAIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAIP Gene

Disorders for NAIP Gene

(2) University of Copenhagen DISEASES for NAIP Gene

(18) Novoseek inferred disease relationships for NAIP Gene

Disease -log(P) Hits PubMed IDs
muscular atrophy spinal 96.1 60
sma ii 94.1 7
sma iii 92.2 5
werdnig-hoffmann disease 81.5 1
paralysis progressive 69.8 1

Relevant External Links for NAIP

Genetic Association Database (GAD)
NAIP
Human Genome Epidemiology (HuGE) Navigator
NAIP
genes like me logo Genes that share disorders with NAIP: view

No data available for UniProtKB/Swiss-Prot for NAIP Gene

Publications for NAIP Gene

  1. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. (PMID: 7813013) Roy N. … Mackenzie A. (Cell 1995) 2 3 4 23
  2. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. (PMID: 8552191) Liston P. … Korneluk R.G. (Nature 1996) 3 4 23
  3. Sequence of a 131-kb region of 5q13.1 containing the spinal muscular atrophy candidate genes SMN and NAIP. (PMID: 9503025) Chen Q. … MacKenzie A.E. (Genomics 1998) 3 4 23
  4. The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7. (PMID: 11896143) Maier J.K. … MacKenzie A.E. (J. Neurosci. 2002) 3 4 23
  5. Functional human NAIP promoter transcription regulatory elements for the NAIP and PsiNAIP genes. (PMID: 11955612) Xu M. … Ikeda J.-E. (Biochim. Biophys. Acta 2002) 3 4 23

Products for NAIP Gene

Sources for NAIP Gene

Back to Top

Content