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Aliases for ATF3 Gene

Aliases for ATF3 Gene

  • Activating Transcription Factor 3 2 3 4
  • CAMP-Dependent Transcription Factor ATF-3 4

External Ids for ATF3 Gene

Previous GeneCards Identifiers for ATF3 Gene

  • GC01P211461
  • GC01P208625
  • GC01P209398
  • GC01P209838
  • GC01P209170
  • GC01P210805
  • GC01P212738
  • GC01P183415

Summaries for ATF3 Gene

Entrez Gene Summary for ATF3 Gene

  • This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]

GeneCards Summary for ATF3 Gene

ATF3 (Activating Transcription Factor 3) is a Protein Coding gene. Diseases associated with ATF3 include hypospadias. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and identical protein binding. An important paralog of this gene is JDP2.

UniProtKB/Swiss-Prot for ATF3 Gene

  • This protein binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters

Gene Wiki entry for ATF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATF3 Gene

Genomics for ATF3 Gene

Regulatory Elements for ATF3 Gene

Genomic Location for ATF3 Gene

Start:
212,565,334 bp from pter
End:
212,620,777 bp from pter
Size:
55,444 bases
Orientation:
Plus strand

Genomic View for ATF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATF3 Gene

Proteins for ATF3 Gene

  • Protein details for ATF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18847-ATF3_HUMAN
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-3
    Protein Accession:
    P18847
    Secondary Accessions:
    • Q5VTZ2
    • Q6ICQ9
    • Q7Z566
    • Q8WYM6

    Protein attributes for ATF3 Gene

    Size:
    181 amino acids
    Molecular mass:
    20576 Da
    Quaternary structure:
    • Binds DNA as a homodimer or a heterodimer

    Alternative splice isoforms for ATF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATF3 Gene

Proteomics data for ATF3 Gene at MOPED

Post-translational modifications for ATF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ATF3 Gene

Domains for ATF3 Gene

Gene Families for ATF3 Gene

HGNC:
  • bZIP :basic leucine zipper proteins

Protein Domains for ATF3 Gene

Graphical View of Domain Structure for InterPro Entry

P18847

UniProtKB/Swiss-Prot:

ATF3_HUMAN :
  • P18847
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. ATF subfamily.
genes like me logo Genes that share domains with ATF3: view

Function for ATF3 Gene

Molecular function for ATF3 Gene

UniProtKB/Swiss-Prot Function: This protein binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters

Gene Ontology (GO) - Molecular Function for ATF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 24939851
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 2516827
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA --
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IC --
genes like me logo Genes that share ontologies with ATF3: view
genes like me logo Genes that share phenotypes with ATF3: view

Animal Models for ATF3 Gene

MGI Knock Outs for ATF3:

miRNA for ATF3 Gene

miRTarBase miRNAs that target ATF3
Targeting motifs for ATF3 Gene
HOMER Transcription Factor Regulatory Elements motif ATF3
  • Consensus sequence: DATGASTCATHN Submotif: canonical Cell Type: GBM GeoId: GSE33912

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for ATF3 Gene

Localization for ATF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATF3 Gene COMPARTMENTS Subcellular localization image for ATF3 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ATF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:1990622 CHOP-ATF3 complex IDA 8622660
genes like me logo Genes that share ontologies with ATF3: view

Pathways for ATF3 Gene

genes like me logo Genes that share pathways with ATF3: view

Gene Ontology (GO) - Biological Process for ATF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 8622660
GO:0006094 gluconeogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
genes like me logo Genes that share ontologies with ATF3: view

Compounds for ATF3 Gene

(1) HMDB Compounds for ATF3 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4

(30) Novoseek inferred chemical compound relationships for ATF3 Gene

Compound -log(P) Hits PubMed IDs
sulindac sulfide 73.1 7
amino acid 59.7 7
anisomycin 55.1 6
deoxynivalenol 41.5 4
indole-3-carbinol 39.5 1
genes like me logo Genes that share compounds with ATF3: view

Transcripts for ATF3 Gene

Unigene Clusters for ATF3 Gene

Activating transcription factor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATF3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - - - - - -
SP2: - -
SP3: - - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - -
SP8: - -
SP9: -
SP10: - - -
SP11: -

Relevant External Links for ATF3 Gene

GeneLoc Exon Structure for
ATF3
ECgene alternative splicing isoforms for
ATF3

Expression for ATF3 Gene

mRNA expression in normal human tissues for ATF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATF3 Gene

SOURCE GeneReport for Unigene cluster for ATF3 Gene Hs.460

genes like me logo Genes that share expressions with ATF3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATF3 Gene

Orthologs for ATF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATF3 35
  • 99.63 (n)
  • 100 (a)
ATF3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATF3 35
  • 93.74 (n)
  • 95.58 (a)
ATF3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATF3 35
  • 93.37 (n)
  • 96.69 (a)
ATF3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atf3 35
  • 88.95 (n)
  • 95.03 (a)
Atf3 16
Atf3 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATF3 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATF3 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atf3 35
  • 88.03 (n)
  • 95.03 (a)
chicken
(Gallus gallus)
Aves ATF3 35
  • 76.06 (n)
  • 85.64 (a)
ATF3 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATF3 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atf3 35
  • 74.22 (n)
  • 81.22 (a)
zebrafish
(Danio rerio)
Actinopterygii atf3 35
  • 67.8 (n)
  • 75 (a)
atf3 36
  • 55 (a)
OneToOne
zgc55526 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for ATF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATF3 Gene

ENSEMBL:
Gene Tree for ATF3 (if available)
TreeFam:
Gene Tree for ATF3 (if available)

Paralogs for ATF3 Gene

Paralogs for ATF3 Gene

Selected SIMAP similar genes for ATF3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ATF3: view

Variants for ATF3 Gene

Sequence variations from dbSNP and Humsavar for ATF3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10475 -- 212,620,271(+) GGCAG(C/T)ATGAT utr-variant-3-prime
rs685330 -- 212,566,803(-) CAGGA(C/G)GCTGC intron-variant
rs1008737 -- 212,595,234(-) ATTTT(C/G)TACTG intron-variant
rs1105899 -- 212,585,262(-) AGGAG(A/G)CTCCA intron-variant
rs1126526 -- 212,620,163(+) GGGGG(C/T)GGGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ATF3 Gene

Variant ID Type Subtype PubMed ID
dgv178e1 CNV Complex 17122850
esv268560 CNV Insertion 20981092

Relevant External Links for ATF3 Gene

HapMap Linkage Disequilibrium report
ATF3
Human Gene Mutation Database (HGMD)
ATF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF3 Gene

Disorders for ATF3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ATF3 Gene including...

Search for ATF3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ATF3 Gene

(21) Novoseek inferred disease relationships for ATF3 Gene

Disease -log(P) Hits PubMed IDs
hypospadias 59.6 28
tumors 34.3 26
adenovirus infections 28.2 1
colon cancer 23.9 7
cancer 23.3 14

Relevant External Links for ATF3

Genetic Association Database (GAD)
ATF3
Human Genome Epidemiology (HuGE) Navigator
ATF3
genes like me logo Genes that share disorders with ATF3: view

No data available for UniProtKB/Swiss-Prot for ATF3 Gene

Publications for ATF3 Gene

  1. ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms. (PMID: 7515060) Chen B.P.C. … Hai T. (J. Biol. Chem. 1994) 2 3 4 23
  2. Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter. (PMID: 12881527) Pan Y. … Kilberg M.S. (J. Biol. Chem. 2003) 3 4 23
  3. Activating transcription factor 3: a hormone responsive gene in the etiology of hypospadias. (PMID: 18426833) Beleza-Meireles A. … NordenskjAPld A. (Eur. J. Endocrinol. 2008) 3 23 48
  4. Genetics of hypospadias: are single-nucleotide polymorphisms in SRD5A2, ESR1, ESR2, and ATF3 really associated with the malformation? (PMID: 20215396) van der Zanden L.F. … Franke B. (J. Clin. Endocrinol. Metab. 2010) 3 23 48
  5. Activating transcription factor 3 is a positive regulator of human IFNG gene expression. (PMID: 20304822) FilAcn S. … Lahesmaa R. (J. Immunol. 2010) 3 23

Products for ATF3 Gene

Sources for ATF3 Gene

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