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Aliases for MYT1 Gene

Aliases for MYT1 Gene

  • Myelin Transcription Factor 1 2 3 5
  • Neural Zinc Finger Transcription Factor 2 2 3
  • Proteolipid Protein-Binding Protein 3 4
  • Myelin Transcription Factor I 3 4
  • PLPB1 3 4
  • MTF1 3 4
  • MYTI 3 4
  • Proteolipid Protein Binding Protein 3
  • C20orf36 3
  • KIAA0835 4
  • KIAA1050 4
  • ZC2H2C1 3
  • ZC2HC4A 3
  • NZF2 3
  • MyT1 4

External Ids for MYT1 Gene

Previous HGNC Symbols for MYT1 Gene

  • PLPB1

Previous GeneCards Identifiers for MYT1 Gene

  • GC20P062673
  • GC20P063475
  • GC20P063522
  • GC20P062253
  • GC20P062266
  • GC20P062795
  • GC20P059521
  • GC20P062796

Summaries for MYT1 Gene

Entrez Gene Summary for MYT1 Gene

  • The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYT1 Gene

MYT1 (Myelin Transcription Factor 1) is a Protein Coding gene. Diseases associated with MYT1 include Leukomalacia and Periventricular Leukomalacia. Among its related pathways are Cyclins and Cell Cycle Regulation and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and enhancer sequence-specific DNA binding. An important paralog of this gene is MYT1L.

UniProtKB/Swiss-Prot for MYT1 Gene

  • Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.

Gene Wiki entry for MYT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYT1 Gene

Genomics for MYT1 Gene

Regulatory Elements for MYT1 Gene

Enhancers for MYT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MYT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MYT1 Gene

Chromosome:
20
Start:
64,151,791 bp from pter
End:
64,242,253 bp from pter
Size:
90,463 bases
Orientation:
Plus strand

Genomic View for MYT1 Gene

Genes around MYT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYT1 Gene

Proteins for MYT1 Gene

  • Protein details for MYT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01538-MYT1_HUMAN
    Recommended name:
    Myelin transcription factor 1
    Protein Accession:
    Q01538
    Secondary Accessions:
    • E1P5H0
    • F5H7M8
    • O94922
    • Q7Z5W2
    • Q9UPV2

    Protein attributes for MYT1 Gene

    Size:
    1121 amino acids
    Molecular mass:
    122329 Da
    Quaternary structure:
    • Interacts with STEAP3.
    SequenceCaution:
    • Sequence=BAA74858.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MYT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYT1 Gene

Post-translational modifications for MYT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYT1 Gene

No data available for DME Specific Peptides for MYT1 Gene

Domains & Families for MYT1 Gene

Gene Families for MYT1 Gene

Protein Domains for MYT1 Gene

Suggested Antigen Peptide Sequences for MYT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q01538

UniProtKB/Swiss-Prot:

MYT1_HUMAN :
  • Contains 7 zinc fingers of the C2HC class arranged in two widely separated clusters. These two domains of DNA binding can function independently and recognize the same DNA sequence.
  • Contains 7 CCHHC-type zinc fingers.
Domain:
  • Contains 7 zinc fingers of the C2HC class arranged in two widely separated clusters. These two domains of DNA binding can function independently and recognize the same DNA sequence.
Similarity:
  • Contains 7 CCHHC-type zinc fingers.
genes like me logo Genes that share domains with MYT1: view

Function for MYT1 Gene

Molecular function for MYT1 Gene

UniProtKB/Swiss-Prot Function:
Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.

Gene Ontology (GO) - Molecular Function for MYT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 1280325
GO:0008270 zinc ion binding NAS 1280325
genes like me logo Genes that share ontologies with MYT1: view
genes like me logo Genes that share phenotypes with MYT1: view

Animal Models for MYT1 Gene

MGI Knock Outs for MYT1:

Animal Model Products

CRISPR Products

miRNA for MYT1 Gene

miRTarBase miRNAs that target MYT1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYT1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYT1 Gene

Localization for MYT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYT1 Gene COMPARTMENTS Subcellular localization image for MYT1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MYT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 1280325
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MYT1: view

Pathways & Interactions for MYT1 Gene

genes like me logo Genes that share pathways with MYT1: view

Pathways by source for MYT1 Gene

Gene Ontology (GO) - Biological Process for MYT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 1280325
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with MYT1: view

No data available for SIGNOR curated interactions for MYT1 Gene

Drugs & Compounds for MYT1 Gene

(1) Drugs for MYT1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MYT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MYT1: view

Transcripts for MYT1 Gene

Unigene Clusters for MYT1 Gene

Myelin transcription factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c · 22d ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - -
SP8: - -
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

ExUns: 22e ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b · 30c · 30d
SP1:
SP2:
SP3: - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - - - - - - - - - -
SP7: - -
SP8: - -
SP9:
SP10: - -
SP11:
SP12: -
SP13:
SP14:
SP15: - -
SP16:

Relevant External Links for MYT1 Gene

GeneLoc Exon Structure for
MYT1
ECgene alternative splicing isoforms for
MYT1

Expression for MYT1 Gene

mRNA expression in normal human tissues for MYT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYT1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x14.9) and Brain - Cerebellum (x13.9).

Protein differential expression in normal tissues from HIPED for MYT1 Gene

This gene is overexpressed in Retina (35.0), Platelet (19.2), and NK cells (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYT1 Gene



Protein tissue co-expression partners for MYT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MYT1 Gene:

MYT1

SOURCE GeneReport for Unigene cluster for MYT1 Gene:

Hs.279562

mRNA Expression by UniProt/SwissProt for MYT1 Gene:

Q01538-MYT1_HUMAN
Tissue specificity: Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes.
genes like me logo Genes that share expression patterns with MYT1: view

Primer Products

Orthologs for MYT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MYT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYT1 34
  • 88.08 (n)
  • 89.14 (a)
MYT1 35
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYT1 34
  • 88.32 (n)
  • 90.53 (a)
MYT1 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myt1 34
  • 86.14 (n)
  • 90.72 (a)
Myt1 16
Myt1 35
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myt1 34
  • 87.52 (n)
  • 93.28 (a)
oppossum
(Monodelphis domestica)
Mammalia MYT1 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYT1 35
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYT1 35
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYT1 34
  • 79.14 (n)
  • 83.15 (a)
MYT1 35
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYT1 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490628 34
  • 75.98 (n)
  • 83.48 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397982 34
zebrafish
(Danio rerio)
Actinopterygii myt1a 34
  • 71.52 (n)
  • 74.47 (a)
myt1a 35
  • 55 (a)
OneToMany
myt1b 35
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43689 35
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ztf-11 35
  • 18 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.17722 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8435 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
OneToMany
Species where no ortholog for MYT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYT1 Gene

ENSEMBL:
Gene Tree for MYT1 (if available)
TreeFam:
Gene Tree for MYT1 (if available)

Paralogs for MYT1 Gene

Paralogs for MYT1 Gene

(2) SIMAP similar genes for MYT1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for MYT1 Gene

genes like me logo Genes that share paralogs with MYT1: view

Variants for MYT1 Gene

Sequence variations from dbSNP and Humsavar for MYT1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs23602 -- 64,221,417(-) TGGCC(C/T)GACAC intron-variant
rs168448 -- 64,221,222(-) AATCC(A/T)GTCCT intron-variant
rs184759 -- 64,227,984(-) CAGCA(C/T)GGCCC intron-variant
rs184760 -- 64,225,157(-) TGGTC(A/G)GAGGG intron-variant
rs187078 -- 64,239,294(-) CGTGG(A/G)GTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYT1 Gene

Variant ID Type Subtype PubMed ID
dgv2454e59 CNV duplication 20981092
dgv4347n100 CNV gain 25217958
dgv4348n100 CNV gain 25217958
esv1005570 CNV deletion 20482838
esv1049699 CNV insertion 17803354
esv1114131 CNV deletion 17803354
esv1143799 CNV deletion 17803354
esv1395726 CNV deletion 17803354
esv1433479 CNV insertion 17803354
esv1483804 CNV deletion 17803354
esv1552174 CNV deletion 17803354
esv2097509 CNV deletion 18987734
esv2317556 CNV deletion 18987734
esv23921 CNV gain+loss 19812545
esv24888 CNV loss 19812545
esv2559642 CNV insertion 19546169
esv2758807 CNV gain+loss 17122850
esv3568101 CNV loss 25503493
esv3646333 CNV loss 21293372
esv3646334 CNV gain 21293372
esv3646335 CNV gain 21293372
esv3646336 CNV gain 21293372
nsv1064470 CNV gain 25217958
nsv1067529 CNV gain 25217958
nsv1071718 CNV deletion 25765185
nsv1114238 CNV deletion 24896259
nsv1116883 CNV deletion 24896259
nsv1119653 CNV deletion 24896259
nsv1125223 CNV insertion 24896259
nsv1125959 CNV deletion 24896259
nsv1130775 CNV deletion 24896259
nsv1137535 CNV deletion 24896259
nsv1142316 CNV tandem duplication 24896259
nsv1143214 CNV deletion 24896259
nsv1143217 CNV deletion 24896259
nsv1143998 CNV deletion 24896259
nsv1148380 CNV deletion 26484159
nsv1151679 CNV deletion 26484159
nsv1153326 CNV deletion 26484159
nsv179382 CNV deletion 16902084
nsv179519 CNV deletion 16902084
nsv428381 CNV gain+loss 18775914
nsv470564 CNV gain 18288195
nsv524962 CNV loss 19592680
nsv527137 CNV loss 19592680
nsv586863 CNV loss 21841781
nsv821475 CNV deletion 20802225
nsv9833 CNV gain 18304495

Variation tolerance for MYT1 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.52; 55.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYT1 Gene

Human Gene Mutation Database (HGMD)
MYT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYT1 Gene

Disorders for MYT1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MYT1 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MYT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYT1

Genetic Association Database (GAD)
MYT1
Human Genome Epidemiology (HuGE) Navigator
MYT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYT1
genes like me logo Genes that share disorders with MYT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYT1 Gene

Publications for MYT1 Gene

  1. Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells. (PMID: 14962745) Nielsen J.A. … Armstrong R.C. (Mol. Cell. Neurosci. 2004) 3 4 22 65
  2. Expression of myelin transcription factor I (MyTI), a 'zinc-finger' DNA-binding protein, in developing oligodendrocytes. (PMID: 8530187) Armstrong R.C. … Hudson L.D. (Glia 1995) 3 4 22 65
  3. Novel member of the zinc finger superfamily: a C2-HC finger that recognizes a glia-specific gene. (PMID: 1280325) Kim J.G. … Hudson L.D. (Mol. Cell. Biol. 1992) 2 3 4 65
  4. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PMID: 18950845) Vega A. … Carracedo A. (Gynecol. Oncol. 2009) 3 46 65
  5. Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS. (PMID: 17330875) Vana A.C. … Armstrong R.C. (Glia 2007) 3 22 65

Products for MYT1 Gene

Sources for MYT1 Gene

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