Aliases for MYO5B Gene
External Ids for MYO5B Gene
Previous GeneCards Identifiers for MYO5B Gene
The protein encoded by this gene, together with other proteins, may be involved in plasma membrane recycling. Mutations in this gene are associated with microvillous inclusion disease. [provided by RefSeq, Sep 2009]
GeneCards Summary for MYO5B Gene
MYO5B (Myosin VB) is a Protein Coding gene. Diseases associated with MYO5B include Microvillus Inclusion Disease and Cholestasis, Progressive Familial Intrahepatic 2. Among its related pathways are Regulation of CFTR activity (norm and CF) and wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF). GO annotations related to this gene include actin binding and Rab GTPase binding. An important paralog of this gene is MYO5A.
UniProtKB/Swiss-Prot for MYO5B Gene
May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis.