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Aliases for MYO1C Gene

Aliases for MYO1C Gene

  • Myosin IC 2 3
  • Myosin I Beta 3 4
  • MMI-Beta 3 4
  • MMIb 3 4
  • Unconventional Myosin-Ic 3
  • Nuclear Myosin I 3
  • Myosin-I Beta 3
  • Myosin-Ic 3
  • Myr2 3
  • Nmi 3

External Ids for MYO1C Gene

Previous GeneCards Identifiers for MYO1C Gene

  • GC17M001501
  • GC17M001704
  • GC17M001319
  • GC17M001574
  • GC17M001314
  • GC17M001367

Summaries for MYO1C Gene

Entrez Gene Summary for MYO1C Gene

  • This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYO1C Gene

MYO1C (Myosin IC) is a Protein Coding gene. Diseases associated with MYO1C include glomerulosclerosis, focal segmental, 6 and autosomal dominant non-syndromic sensorineural deafness type dfna. Among its related pathways are RhoGDI Pathway and ERK Signaling. GO annotations related to this gene include actin binding and calmodulin binding. An important paralog of this gene is MYO1D.

UniProtKB/Swiss-Prot for MYO1C Gene

  • Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cells (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes.

  • Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation (By similarity).

Gene Wiki entry for MYO1C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO1C Gene

Genomics for MYO1C Gene

Regulatory Elements for MYO1C Gene

Genomic Location for MYO1C Gene

Start:
1,464,098 bp from pter
End:
1,492,812 bp from pter
Size:
28,715 bases
Orientation:
Minus strand

Genomic View for MYO1C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYO1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO1C Gene

Proteins for MYO1C Gene

  • Protein details for MYO1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00159-MYO1C_HUMAN
    Recommended name:
    Unconventional myosin-Ic
    Protein Accession:
    O00159
    Secondary Accessions:
    • Q4LE56
    • Q6NVJ7
    • Q86Y95

    Protein attributes for MYO1C Gene

    Size:
    1063 amino acids
    Molecular mass:
    121682 Da
    Quaternary structure:
    • Interacts with GLUT4 (By similarity). Interacts (via its IQ motifs) with CABP1 and CIB1; the interaction with CABP1 and CIB1 is calcium-dependent. Interacts (via tail domain) with PLEKHB1 (via PH domain); the interaction is not affected by the presence or absence of calcium and CALM. Interacts with POLR1A and POLR2A. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Interacts (via its IQ motifs) with CALM; this precludes interaction with YWHAB. Interacts with YWHAB; this precludes interaction with CALM. Interacts with RPS6 and actin.
    SequenceCaution:
    • Sequence=AAH68013.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAE06097.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAF85599.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MYO1C Gene

    Alternative splice isoforms for MYO1C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO1C Gene

Proteomics data for MYO1C Gene at MOPED

Post-translational modifications for MYO1C Gene

  • Isoform 2 contains a N-acetylmethionine at position 1
  • Ubiquitination at Lys188, Lys404, Lys740, and Lys868
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MYO1C Gene

Domains for MYO1C Gene

Gene Families for MYO1C Gene

HGNC:
  • MYOI :Myosins / Myosin superfamily : Class I

Suggested Antigen Peptide Sequences for MYO1C Gene

Graphical View of Domain Structure for InterPro Entry

O00159

UniProtKB/Swiss-Prot:

MYO1C_HUMAN :
  • O00159
Domain:
  • Binds directly to large unilamellar vesicles (LUVs) containing phosphatidylinositol 4,5-bisphosphate (PIP2) or inositol 1,4,5-trisphosphate (InsP3). The PIP2-binding site corresponds to the myosin tail domain (PH-like) present in its tail domain (By similarity).
  • Contains 2 IQ domains.
  • Contains 1 myosin motor domain.
  • Contains 1 myosin tail domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO1C: view

Function for MYO1C Gene

Molecular function for MYO1C Gene

GENATLAS Biochemistry: myosin IC,unconventional,apparently non filamentous,homologous to mouse Myo1e
UniProtKB/Swiss-Prot Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cells (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes.
UniProtKB/Swiss-Prot Function: Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation (By similarity).

Gene Ontology (GO) - Molecular Function for MYO1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005102 receptor binding IPI 21402783
GO:0005515 protein binding IPI 21402783
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with MYO1C: view
genes like me logo Genes that share phenotypes with MYO1C: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MYO1C Gene

Localization for MYO1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO1C Gene

Isoform 1: Cytoplasm. Nucleus. Note=Colocalizes with RNA polymerase II. Absent from nucleoli and does not colocalize with RNA polymerase I. Translocates to nuclear speckles upon exposure to inhibitors of RNA polymerase II transcription.
Isoform 2: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, stereocilium membrane. Cell projection, ruffle. Cytoplasmic vesicle. Note=Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane. Colocalizes in adipocytes with GLUT4 at actin-based membranes. Colocalizes with GLUT4 at insulin-induced ruffles at the cell membrane. Localizes transiently at cell membrane to region known to be enriched in PIP2. Activation of phospholipase C results in its redistribution to the cytoplasm (By similarity). {ECO:0000250}.
Isoform 3: Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus, nuclear pore complex. Note=Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli (By similarity). In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC). Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with transcription sites. Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear pore level. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO1C Gene COMPARTMENTS Subcellular localization image for MYO1C gene
Compartment Confidence
cytoskeleton 5
extracellular 5
nucleus 5
plasma membrane 5
cytosol 4
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MYO1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 NOT stress fiber IDA 9858156
GO:0001726 ruffle IEA --
GO:0005634 nucleus --
GO:0005643 nuclear pore IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with MYO1C: view

Pathways for MYO1C Gene

genes like me logo Genes that share pathways with MYO1C: view

Gene Ontology (GO) - Biological Process for MYO1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006605 protein targeting IDA 21402783
GO:0006612 protein targeting to membrane IDA 21402783
GO:0006810 transport --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with MYO1C: view

Compounds for MYO1C Gene

(1) Novoseek inferred chemical compound relationships for MYO1C Gene

Compound -log(P) Hits PubMed IDs
atp 14.2 3
genes like me logo Genes that share compounds with MYO1C: view

Transcripts for MYO1C Gene

Unigene Clusters for MYO1C Gene

Myosin IC:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYO1C Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - - - - - - - - -
SP2: - - - -
SP3: - - - - - - - -
SP4: -
SP5: - - - - - - -
SP6:
SP7: - -
SP8:
SP9: - - -
SP10:
SP11:
SP12:
SP13:

ExUns: 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b · 29c ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b ^ 38 ^
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MYO1C Gene

GeneLoc Exon Structure for
MYO1C
ECgene alternative splicing isoforms for
MYO1C

Expression for MYO1C Gene

mRNA expression in normal human tissues for MYO1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYO1C Gene

SOURCE GeneReport for Unigene cluster for MYO1C Gene Hs.286226

genes like me logo Genes that share expressions with MYO1C: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MYO1C Gene

Orthologs for MYO1C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYO1C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO1C 35
  • 97.45 (n)
  • 96.94 (a)
MYO1C 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYO1C 35
  • 91.66 (n)
  • 96.61 (a)
MYO1C 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYO1C 35
  • 91.16 (n)
  • 97.37 (a)
MYO1C 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo1c 35
  • 88.76 (n)
  • 96.72 (a)
Myo1c 16
Myo1c 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYO1C 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYO1C 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myo1c 35
  • 88.28 (n)
  • 96.82 (a)
chicken
(Gallus gallus)
Aves MYO1C 35
  • 75.1 (n)
  • 82.78 (a)
MYO1C 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYO1C 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68653 35
tropical clawed frog
(Silurana tropicalis)
Amphibia myo1c 35
  • 69.99 (n)
  • 79.3 (a)
Str.15016 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8702 35
zebrafish
(Danio rerio)
Actinopterygii myo1c 35
  • 69.84 (n)
  • 74.53 (a)
myo1c 36
  • 75 (a)
OneToMany
MYO1C 36
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Myo61F 35
  • 59.17 (n)
  • 52.2 (a)
Myo61F 36
  • 51 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO3 36
  • 27 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.198 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11244 36
  • 52 (a)
OneToMany
Species with no ortholog for MYO1C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO1C Gene

ENSEMBL:
Gene Tree for MYO1C (if available)
TreeFam:
Gene Tree for MYO1C (if available)

Paralogs for MYO1C Gene

Paralogs for MYO1C Gene

genes like me logo Genes that share paralogs with MYO1C: view

Variants for MYO1C Gene

Sequence variations from dbSNP and Humsavar for MYO1C Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs14269 -- 1,464,674(+) TGTTT(A/G)GGCAT utr-variant-3-prime
rs1138599 -- 1,465,024(-) GACCA(A/G)CCTGA utr-variant-3-prime
rs1138604 -- 1,464,990(-) tagta(A/G)aaata utr-variant-3-prime
rs1138605 -- 1,464,989(-) agtaa(A/G)aatac utr-variant-3-prime
rs1138606 -- 1,464,988(-) gtaaa(A/G)ataca utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MYO1C Gene

Variant ID Type Subtype PubMed ID
nsv833334 CNV Loss 17160897
dgv3028n71 CNV Loss 21882294
nsv516805 CNV Loss 19592680
nsv907502 CNV Loss 21882294
dgv3029n71 CNV Loss 21882294
nsv907504 CNV Loss 21882294
esv2676177 CNV Deletion 23128226
esv2715464 CNV Deletion 23290073

Relevant External Links for MYO1C Gene

HapMap Linkage Disequilibrium report
MYO1C
Human Gene Mutation Database (HGMD)
MYO1C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO1C Gene

Disorders for MYO1C Gene

(1) University of Copenhagen DISEASES for MYO1C Gene

Relevant External Links for MYO1C

Genetic Association Database (GAD)
MYO1C
Human Genome Epidemiology (HuGE) Navigator
MYO1C
genes like me logo Genes that share disorders with MYO1C: view

No data available for UniProtKB/Swiss-Prot for MYO1C Gene

Publications for MYO1C Gene

  1. Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. (PMID: 9119401) Crozet F. … Petit C. (Genomics 1997) 2 3 4 23
  2. Nuclear distribution of actin and myosin I depends on transcriptional activity of the cell. (PMID: 16133118) Kysela K. … Hozak P. (Histochem. Cell Biol. 2005) 3 4
  3. A myosin I isoform in the nucleus. (PMID: 11030652) Pestic-Dragovich L. … de Lanerolle P. (Science 2000) 3 23
  4. Crystal structure of human myosin 1c - the motor in GLUT4 exocytosis: implications for Ca(2+)-regulation and 14-3-3 binding. (PMID: 24636949) Stefan Munnich M.H. … Manstein D.J. (J. Mol. Biol. 2014) 3 4
  5. Are MYO1C and MYO1F associated with hearing loss? (PMID: 19027848) Zadro C. … Carella M. (Biochim. Biophys. Acta 2009) 3 48

Products for MYO1C Gene

Sources for MYO1C Gene

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